Sat.Jul 22, 2023 - Fri.Jul 28, 2023

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Discover How Louise Kraus Paves the Way For Success

Perficient: Drug Development

At Perficient, we are proud to work with incredible people who give their time and talent to support our clients and communities. Through our People Promise , we strive to challenge, champion, and celebrate the difference that our colleagues are making. For Louise Kraus, a business coordinator based in New Jersey, each day offers the chance to discover new concepts and continue growing as a leader.

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AstraZeneca buys Pfizer’s early gene therapy work for up to $1B

BioPharma Drive: Drug Pricing

The British pharma is deepening its investment in genetic medicine through a deal for a group of Pfizer’s gene therapy delivery tools, while the New York giant cuts back.

Therapies 246
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Bronny James Released From Hospital Following Cardiac Arrest

Drugs.com

FRIDAY, July 28, 2023 -- Bronny James, son of basketball superstar LeBron James, was released from Cedars-Sinai Medical Center on Thursday, just three days after the 18-year-old suffered cardiac arrest during a college basketball.

Hospitals 246
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CDD Vault Update (July 2023)

Collaborative Drug

Using Protocol Forms to Annotate Assays/Runs Assay analytics plays a vital role in an organization's ability to understand the scientific domain covered by your current assays, identify potential gaps, and develop new/novel assays to advance your research. CDD Vault is an essential platform for managing your assay analytics workflow.

Research 246
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Ancient DNA reveals diverse community in 'Lost City of the Incas'

Science Daily: Pharmacology News

DNA analysis of 34 individuals buried at Machu Picchu revealed that many traveled alone from throughout the Inca Empire.

DNA 246

More Trending

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Daily Baby Aspirin Raises Odds for Brain Bleeds, With No Lowering of Stroke Risk

Drugs.com

THURSDAY, July 27, 2023 -- For years, older adults took a baby aspirin a day to help ward off a first-time heart attack or stroke. Now yet another study is showing the risks are not worth it for most. Specifically, researchers found the risk of.

Research 246
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Recap of CDD Korean Community Meeting 2023

Collaborative Drug

Recap of CDD Korean Community Meeting 2023

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Gloomy climate calculation: Scientists predict a collapse of the Atlantic ocean current to happen mid-century

Science Daily: Pharmacology News

Important ocean currents that redistribute heat, cold and precipitation between the tropics and the northernmost parts of the Atlantic region will shut down around the year 2060 if current greenhouse gas emissions persist. This is the conclusion based on new calculations that contradict the latest report from the IPCC.

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Biogen to acquire rare disease drugmaker Reata for $7.3B

BioPharma Drive: Drug Pricing

The deal is a major bet by Biogen and its new CEO Chris Viehbacher, who’s reorganized R&D, cut costs and laid off staff since becoming company head last year.

Disease 246
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Nearly a Half-Million Americans Might Have Tick-Borne Meat Allergy Syndrome

Drugs.com

THURSDAY, July 27, 2023 -- Tick bites can cause crippling infections like Lyme disease in humans, but new research suggests they can also trigger a serious meat allergy in far more Americans than thought. Called alpha-gal syndrome, the condition.

Disease 246
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CDD Vault Update (July 2023 #2)

Collaborative Drug

Easily Insert Abbreviations and Rotate Structures in Ketcher Access the structure library by simply typing the name of your desired functional group, salt, solvent, or template. A menu will appear showing the matching structures and the matching text will be shown in bold. For added convenience, matches can exist anywhere in the string.

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Scientists discover secret of virgin birth, and switch on the ability in female flies

Science Daily: Pharmacology News

Scientists have pinpointed a genetic cause for virgin birth for the first time, and once switched on the ability is passed down through generations of females.

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Moderna, Merck advance cancer vaccine into late-stage test

BioPharma Drive: Drug Pricing

The companies are enrolling people with melanoma in a Phase 3 trial aimed at testing whether the shot can prevent disease recurrence.

Vaccine 246
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AHA News: Is Venting Good For Your Health?

Drugs.com

FRIDAY, July 28, 2023 (American Heart Association News) -- Venting – the release of negative, pent-up emotions – can feel good. But is it actually good for you? Or does it do more harm than good to dwell on negative thoughts and.

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Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation

Covalent Modifiers

Thomas, A.; Serafini, M.; Grant, E.; Coombs, E.; Bluck, J.; Schiedel, M.; McDonough, M.; Reynolds, J.; Lee, B.; Platt, M.; Sharlandjieva, V.; Biggin, P.; Duarte, F.; Milne, T.; Bush, J.; Conway, S. ChemRxiv 2023. [link] Target validation remains a challenge in drug discovery, which leads to a high attrition rate in the drug discovery process, particularly in Phase II clinical trials.

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Short bursts of daily activity linked to reduced cancer risk

Science Daily: Pharmacology News

Promising new research suggests a total of just 4.5 minutes of vigorous activity that makes you huff and puff during daily tasks could reduce the risk of some cancers by up to 32 percent.

Research 190
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GSK confident in RSV vaccine launch, but sets expectations for ‘steady build’

BioPharma Drive: Drug Pricing

GSK expects its respiratory syncytial virus vaccine will be a multibillion dollar product. But at the beginning it’s predicting a slower launch than for its fast-selling shingles shot.

Vaccine 246
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New U.S. Rule Mandates Easy Access to Airplane Bathrooms by People Using Wheelchairs

Drugs.com

THURSDAY, July 27, 2023 -- Airlines will now be required to make bathrooms on their planes more accessible for the disabled, the U.S. Department of Transportation announced Wednesday.

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Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma

Chemical Biology and Drug Design

MED induced GBM apoptosis through upregulation of pro-apoptotic proteins (BID, BAX, CASP3, CASP8, and CYCS), and showed significant inhibitory effects on cell proliferation, cell migration, and anti-tumor activity in nude mice. Among them, the outstanding performance is that the IC 50 values of GEM cells (U-87 MG and U251) for 24 h were 175 μg/mL and 271 μg/mL, and the IC 50 values for 48 h were 161 μg/mL and 154 μg/mL, respectively.

Research 100
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Genome analysis of 46,000-year-old roundworm from Siberian permafrost reveals novel species

Science Daily: Pharmacology News

Some organisms, such as tardigrades, rotifers, and nematodes, can survive harsh conditions by entering a dormant state known as 'cryptobiosis.' In 2018, researchers found two roundworms (nematode) species in the Siberian Permafrost. Radiocarbon dating indicated that the nematode individuals have remained in cryptobiosis since the late Pleistocene, about 46,000 years ago.

Research 189
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Bavarian Nordic to scrap RSV vaccine after study setback

BioPharma Drive: Drug Pricing

The shot failed to meet a key goal of Bavarian Nordic’s Phase 3 study, a finding that separates it from marketed vaccines developed by Pfizer and GSK.

Vaccine 246
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Over Half of People With Autoimmune Conditions Suffer Depression, Anxiety

Drugs.com

WEDNESDAY, July 26, 2023 -- More than half of all patients with autoimmune diseases also suffer from depression and anxiety -- but most are never asked about their mental health, a new study finds. Surveying more than 1,800 patients, British.

Disease 246
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MicroRNA?577/EIF5A2 axis suppressed the proliferation of DDP?resistant nasopharyngeal carcinoma cells by blocking TGF?? signaling pathway

Chemical Biology and Drug Design

Effects of circ_0002375 on cisplatin-resistant NPC cells: After cisplatin treatment, circ_0002375 knockdown was transfected into cisplatin-resistant SUNE1/5-8F cells, which led to the inhibition of cisplatin resistance via down-regulating EIF5A2 that mediated by up-regulated miR-577. Abstract Diaminodichoroplatinum (DDP) resistance of tumor cells is the culprit of nasopharyngeal carcinoma (NPC) treatment failure.

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'Time-traveling' pathogens in melting permafrost pose likely risk to environment

Science Daily: Pharmacology News

Ancient pathogens that escape from melting permafrost have real potential to damage microbial communities and might potentially threaten human health, according to a new study.

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Hunting Host Cell Proteins (HCPs) with mass spectrometry

BioPharma Drive: Drug Pricing

Regulators are recognizing mass spectrometry as a powerful tool in Host Cell Protein analysis. Are you ready to implement HCP-MS?

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Quartz Countertops Are Damaging the Lungs of Installers: Study

Drugs.com

WEDNESDAY, July 26, 2023 -- Workers making the most popular type of countertop sold in the United States are at risk for potentially deadly lung disease, a new study finds. The risk owes to the tiny particles of dust produced while cutting, shaping.

Disease 246