Sat.Jul 22, 2023 - Fri.Jul 28, 2023

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Discover How Louise Kraus Paves the Way For Success

Perficient: Drug Development

At Perficient, we are proud to work with incredible people who give their time and talent to support our clients and communities. Through our People Promise , we strive to challenge, champion, and celebrate the difference that our colleagues are making. For Louise Kraus, a business coordinator based in New Jersey, each day offers the chance to discover new concepts and continue growing as a leader.

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Immunotherapy is here to stay

Drug Discovery World

DDW’s Megan Thomas spoke with Frédéric Triebel , the French immunologist/oncologist who is best known for his 1990 discovery of the LAG-3 immune control mechanism. Triebel shares insights from his career, expands on his experience with the company he founded, Immutep, and comments on the future of immuno-oncology (I-O). Background Lymphocyte-activation gene 3, or LAG-3, is a gene that provides the genetic information to make a cell surface molecule with biologic effects on T-cell function.

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AstraZeneca buys Pfizer’s early gene therapy work for up to $1B

BioPharma Drive: Drug Pricing

The British pharma is deepening its investment in genetic medicine through a deal for a group of Pfizer’s gene therapy delivery tools, while the New York giant cuts back.

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New patent expiration for Astrazeneca drug SYMBICORT

Drug Patent Watch

Annual Drug Patent Expirations for SYMBICORT Symbicort is a drug marketed by Astrazeneca and is included in one NDA. It is available from three suppliers. There are eleven patents protecting… The post New patent expiration for Astrazeneca drug SYMBICORT appeared first on DrugPatentWatch - Make Better Decisions.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Bronny James Released From Hospital Following Cardiac Arrest

Drugs.com

FRIDAY, July 28, 2023 -- Bronny James, son of basketball superstar LeBron James, was released from Cedars-Sinai Medical Center on Thursday, just three days after the 18-year-old suffered cardiac arrest during a college basketball.

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Global crisis of antibiotic resistance is “inevitable”

Drug Discovery World

A report by University of Queensland (UQ) researchers has warned a global crisis of antibiotic resistance is inevitable, despite promising developments in new antibiotics. The Centre for Superbug Solutions at UQ’s Institute for Molecular Bioscience has monitored the clinical pipeline for more than a decade, with its latest snapshot showing 62 new antibiotics in development.

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What types of clinical research are there?

Antidote

Before any new therapy can be put on the market, it must be tested to ensure its safety and effectiveness, and the research for this process is done through clinical trials. Clinical trials evaluate new drugs, devices, packaging, and behaviors in order to determine if these potential therapies work for particular conditions or patient populations.

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AHA News: Is Venting Good For Your Health?

Drugs.com

FRIDAY, July 28, 2023 (American Heart Association News) -- Venting – the release of negative, pent-up emotions – can feel good. But is it actually good for you? Or does it do more harm than good to dwell on negative thoughts and.

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GSK confident in RSV vaccine launch, but sets expectations for ‘steady build’

BioPharma Drive: Drug Pricing

GSK expects its respiratory syncytial virus vaccine will be a multibillion dollar product. But at the beginning it’s predicting a slower launch than for its fast-selling shingles shot.

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Gloomy climate calculation: Scientists predict a collapse of the Atlantic ocean current to happen mid-century

Science Daily: Pharmacology News

Important ocean currents that redistribute heat, cold and precipitation between the tropics and the northernmost parts of the Atlantic region will shut down around the year 2060 if current greenhouse gas emissions persist. This is the conclusion based on new calculations that contradict the latest report from the IPCC.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Optimizely Blocks As Properties: How To Hide Irrelevant Fields

Perficient: Drug Development

We recently ran into an issue when using shared blocks as properties on pages; some of the block’s properties don’t make any sense in this context and can lead to some confusion with editors. Instead of creating another version of the block to use specifically as a local block, I created a simple feature to control hiding properties when a block is used as a property.

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Daily Baby Aspirin Raises Odds for Brain Bleeds, With No Lowering of Stroke Risk

Drugs.com

THURSDAY, July 27, 2023 -- For years, older adults took a baby aspirin a day to help ward off a first-time heart attack or stroke. Now yet another study is showing the risks are not worth it for most. Specifically, researchers found the risk of.

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Gilead drug acquired in $5B buyout fails key blood cancer trial

BioPharma Drive: Drug Pricing

Treatment with magrolimab proved ineffective in a Phase 3 study in myelodysplastic syndrome, adding to doubts about so-called CD47 inhibitors as well as Gilead’s deal strategy.

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#ScienceSaturday: July 22, 2023

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons We’ve spoken in the past about the power of worms: C. elegans models were used by Dr.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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A Pediatric Experience Success Story: Opening a New Digital Front Door

Perficient: Drug Development

While entering a new and highly competitive pediatric market, our client needed to offer an excellent digital experience. The health system partnered with Perficient to build a frictionless and guided experience that patients and families both need and expect. Providing a Truly Patient-centered Experience First, we identified site KPIs, developed target personas, built a digital roadmap, and audited site content.

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Nearly a Half-Million Americans Might Have Tick-Borne Meat Allergy Syndrome

Drugs.com

THURSDAY, July 27, 2023 -- Tick bites can cause crippling infections like Lyme disease in humans, but new research suggests they can also trigger a serious meat allergy in far more Americans than thought. Called alpha-gal syndrome, the condition.

Disease 98
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Lilly adds to case for Mounjaro’s weight-loss benefits with new study data

BioPharma Drive: Drug Pricing

The results showed that enrollees who’d already lost weight after diet and exercise shed pounds after receiving Mounjaro, while those who stopped treatment gained weight back.

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Malaria unravelled: decoding the parasite’s gene expression control

Drug Target Review

Researchers from Tokyo Tech’s World Research Hub Initiative conducted a study to investigate the regulation of gene expression in the apicoplast of the malaria parasite Plasmodium falciparum. The results were published in Proceedings of National Academy of Sciences of United States of America (PNAS). The team, led by Professor Kan Tanaka, collaborated with scientists from Nagasaki University and the John Innes Centre in the UK.

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Microsoft Viva Insights: How to Get Started Leveraging Data for Enterprise Success

Perficient: Drug Development

In today’s business landscape, enterprises are constantly seeking ways to improve employee productivity, engagement, and well-being. Microsoft’s Viva Insights, an innovative workplace analytics solution, has emerged as a powerful tool to help organizations achieve these goals. By providing valuable data-driven insights, Viva Insights enables enterprises to make informed decisions that foster a more productive and thriving work environment.

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New U.S. Rule Mandates Easy Access to Airplane Bathrooms by People Using Wheelchairs

Drugs.com

THURSDAY, July 27, 2023 -- Airlines will now be required to make bathrooms on their planes more accessible for the disabled, the U.S. Department of Transportation announced Wednesday.

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Merck, chasing Pfizer, claims study success for new pneumonia vaccine

BioPharma Drive: Drug Pricing

The pharma said its latest shot, which covers 21 strains of bacteria, cleared two Phase 3 trials and in some cases spurred a stronger immune response than Pfizer’s Prevnar 20.

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DrugPatentWatch reveals NIH funding for patents

Drug Patent Watch

Here’s a summary of a new article that used DrugPatentWatch data: NIH Funding for Patents That Contribute to Market Exclusivity of Drugs Approved 2010–2019 and the Public Interest Protections of… The post DrugPatentWatch reveals NIH funding for patents appeared first on DrugPatentWatch - Make Better Decisions.

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HCL Commerce Customization Capabilities: Empowering Businesses with Tailored E-commerce Solutions

Perficient: Drug Development

Introduction: In the competitive world of e-commerce, delivering a personalized and flawless shopping experience is consummate to success, businesses face the challenge of delivering unique and individualized shopping experiences to their customers. Businesses must figure out how to give their customers distinctive and personalized purchasing experiences in the rapidly changing world of e-commerce.

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Minorities Miss Out on Brain-Imaging Studies for Alzheimer's

Drugs.com

THURSDAY, July 27, 2023 -- Americans in ethnic and racial minority groups are underrepresented in Alzheimer's research, a new study finds. Still, the review of U.S.-based Alzheimer’s disease brain imaging studies found the gap is closing. Compared.

Disease 98
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Roche buys into Alnylam heart drug in cardiovascular research bet

BioPharma Drive: Drug Pricing

The Swiss pharma company is the latest large drugmaker to invest big in an experimental heart treatment, after years of prioritizing medicines for cancer and immune diseases.

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Filing Strategies for Maximizing Pharma Patents

Drug Patent Watch

In a recent article published by IAM Magazine, titled “Why Pharma Companies Should File Patents Later In The R&D Process,” Alexander R. Trimble, PhD, a prominent patent attorney, explores the… The post Filing Strategies for Maximizing Pharma Patents appeared first on DrugPatentWatch - Make Better Decisions.

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Imaging shows how solar-powered microbes turn CO2 into bioplastic

SCIENMAG: Medicine & Health

ITHACA, N.Y. – When considering ways to sustainably generate environmentally friendly products, bacteria might not immediately spring to mind. However, in recent years scientists have created microbe-semiconductor biohybrids that merge the biosynthetic power of living systems with the ability of semiconductors to harvest light.

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'Swine Flu' Strain Has Passed Between Humans & Pigs Hundreds of Times

Drugs.com

FRIDAY, July 28, 2023 -- It’s well known that some viruses make the leap from animals to humans, but a new study shows the influenza strain responsible for the 2009 H1N1 pandemic has been particularly prolific in hopping between species. That.

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Biogen to acquire rare disease drugmaker Reata for $7.3B

BioPharma Drive: Drug Pricing

The deal is a major bet by Biogen and its new CEO Chris Viehbacher, who’s reorganized R&D, cut costs and laid off staff since becoming company head last year.

Disease 98
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Review of 505(b)(2) Drug Products Approved by USFDA from 2010 to 2020: A Focus on Intellectual Property and Regulatory Considerations

Drug Patent Watch

A review article in the Journal of Pharmaceutical Sciences analyzes the trends in drug repurposing through the 505(b)(2) pathway, as approved by the USFDA from 2010 to 2020. The study… The post Review of 505(b)(2) Drug Products Approved by USFDA from 2010 to 2020: A Focus on Intellectual Property and Regulatory Considerations appeared first on DrugPatentWatch - Make Better Decisions.

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Classifying Chemicals Toxicity during Drug Discovery

biobide

In Drug Discovery and Development, the determination and classification of chemical toxicity plays a pivotal role in shaping pharmaceutical development while ensuring the safety of patients. The categorization of these hazardous substances not only helps researchers identify potential risks but also provides them with a guide in the arduous journey of Drug Discovery and Development.

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Over Half of People With Autoimmune Conditions Suffer Depression, Anxiety

Drugs.com

WEDNESDAY, July 26, 2023 -- More than half of all patients with autoimmune diseases also suffer from depression and anxiety -- but most are never asked about their mental health, a new study finds. Surveying more than 1,800 patients, British.

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Blogger Meets Blogger

Molecular Design

Over the years I’ve had had some cool random encounters (some years ago I bumped into a fellow member of the Macclesfield diving club in the village of Pai in the north of Thailand) but the latest is perhaps the most remarkable (even if it's not quite in the league of Safecracker Meets Safecracker in Surely You’re Joking). I was riding the Red Line on Boston’s T en route to Belmont from a conference in Vermont when my friend Ash Jogalekar, well known for The Curious Wavefunction blog , came over

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Breakthrough in solid-state storage innovates how biological materials are stored and handled

SCIENMAG: Medicine & Health

Scientists have developed a novel method for storing biological materials such as RNA and proteins in a solid-state. The storage in solid-state resembles the form of a pill or a tablet, which dissolves in water for on-demand use.

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