Sat.Nov 19, 2022 - Fri.Nov 25, 2022

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Co-crystallization in drug development ~ Exploring the benefits of co-crystals ~

Drug Discovery Today

Over the last decade, co-crystallization has become an attractive alternative to improve the physiochemical properties of drugs without affecting their pharmacology. As a result of the pharmaceutical benefits co-crystals exhibit, industrial interest is on the rise. Here Dr. Thomas Kendall, application specialist at crystallization and solid-state specialist Technobis Crystallization Systems, gives a perspective on the benefits of co-crystals and explains how they can be screened.

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Anticancer and apoptotic activity in neuroblastoma SK?N?SH using phospholipid extract from bone of Scomberomorus niphonius

Chemical Biology and Drug Design

Scomberomorus niphonius is the fish eaten worldwide. In this study, we extracted phospholipids from these fish bones using an advanced supercritical CO 2 extraction technique and tested them against neuroblastoma and normal (HUVEC) cells. The molecular findings indicate phospholipids have an apoptotic activity in neuroblastoma. Abstract Among various types children's health challenges, neuroblastoma is the most serious solid neoplasm forming outside the cranium.

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A quiet revolution in the world of proteomics

DrugBaron

Proteomics – examining the panoply of proteins within a complex sample – has been around much longer than the word we use today to describe it. Proteomics the word was coined in around 1997 as a portmanteau coupling the now-ubiquitous “omics” suffix to the word protein. But two decades earlier two-dimensional gel electrophoresis was the cutting-edge technology that first visualised the “complete” catalogue of proteins in a sample, such as a cell lysate or blood sample.

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What are the types of mitral valve regurgitation?

Antidote

Mitral valve regurgitation, also known as mitral regurgitation, mitral insufficiency, or mitral incompetence, is the most common type of heart valve disease , affecting more than 2% of the population. Though mild mitral valve regurgitation does not usually cause issues, it is a condition that can worsen with time and lead to more severe symptoms. Below, we will be looking at what this condition is, what the common causes are, and some symptoms of mitral valve regurgitation that are helpful to kn

Disease 98
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Shionogi, Active Citizenship Network and MEPS Advocate for Urgent Policy Implementation In EU Member States at EU Parliament Event to Address the Growing Threat of Antimicrobial Resistance

Drug Discovery Today

Last week, Shionogi partnered with the Active Citizenship Network and members of the European Parliament (MEPs) to host an EU Parliament event calling for collaboration to drive policy change and implementation in the fight against antimicrobial resistance (AMR) within the EU and member states. Urgent action is needed to encourage and support the discovery and development of novel antibiotics as well as access models that reward innovation and appropriate use to address the growing threat of AMR

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Which pharmaceutical drugs have the most drug patents in Eurasian Patent Organization?

Drug Patent Watch

This chart shows the drugs with the most patents in Eurasian Patent Organization. Patents must be filed in each country (or, in some cases regional patent office) where patent protection…. The post Which pharmaceutical drugs have the most drug patents in Eurasian Patent Organization? appeared first on DrugPatentWatch - Make Better Decisions.

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12 fascinating clinical research blogs to follow

Antidote

There are many clinical trial blogs out there, but what sets the best ones apart? Our favorites are the ones that don’t simply cover news — instead, they aim to be go-to sources for informed positions on how to improve the medical research process.

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Biosimilar Clinical Trials and US FDA Guidance

ProRelix Research

Biological products have unlocked the potential for the management of several diseases such as cancers and autoimmune diseases for which treatment with small molecule, chemically synthesized drug molecules remain suboptimal. […]. The post Biosimilar Clinical Trials and US FDA Guidance appeared first on ProRelix Research.

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Which pharmaceutical companies have the most tablet dosed drugs?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most tablet dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most tablet dosed drugs…. The post Which pharmaceutical companies have the most tablet dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.

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Five Medical Communication Preferences, According to Patients

PPD

The medical communication experts at Thermo Fisher Scientific ’s PPD clinical research business were not satisfied with basic patient satisfaction data to inform our clients’ medical communication strategies. So, we went straight to the source: In December 2021, we directly surveyed 400 European and United States patients on their preferences for medical communications.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Everything we know about resistance arteries

Reprocell

Resistance arteries are a group of blood vessels that regulate up to 90% of peripheral vascular resistance. 1 There are three types of resistance vessels in humans: precapillary sphincters, arterioles, and small arteries. 2 They are important for controlling blood flow to vital organs, such as the heart (coronary arteries) and the brain (cerebral resistance arteries) so are often considered in cardiovascular safety studies. 1,3 In the following article, we have summarized the physiology of resis

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Shifting the crystallography bottleneck with miniaturization and automation

sptlabtech

In this article, Chris Waddling , head of our North American FAS Team, writes about his experience managing a core facility for crystallography prior to joining SPT Labtech and the benefits of automated and miniaturized workflows. Miniaturizing crystallization experiments In my previous life as a manager of a crystallography core facility, one of my duties was to find the latest equipment that would remove hurdles in the way of my users' progress toward their scientific goals.

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New patent for AADI drug FYARRO

Drug Patent Watch

Annual Drug Patent Expirations for FYARRO Fyarro is a drug marketed by Aadi and is included in one NDA. There are four patents protecting this drug. This drug has one…. The post New patent for AADI drug FYARRO appeared first on DrugPatentWatch - Make Better Decisions.

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To Save Lives, We Must Dismantle Stigma at the Intersection of HIV and Methamphetamine Use

National Institute on Drug Abuse: Nora's Blog

To Save Lives, We Must Dismantle Stigma at the Intersection of HIV and Methamphetamine Use mfleming Wed, 11/23/2022 - 12:51 Nora's Blog November 28, 2022 Image NIDA Image On World AIDS Day, December 1, we remember those lost to the HIV epidemic, take stock of how far we have come, and map the way forward. In the past decades, scientific and community leadership have achieved great things in helping people with HIV live long, healthy lives, as well as reducing HIV transmission through prevention.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Eleventh Circuit Affirms Exclusion of Flawed “Differential Diagnosis” in Pelvic Mesh Case

Drug & Device Law

We write on the heels of a long weekend layered with dogs and fun. The National Dog Show, which you may have watched on TV yesterday, is held about ten minutes from our house, and a fabulous corded Standard Poodle named Joel , who just happens to be “family” (he is the sire of our gorgeous puppy, Luca ) won Best of Opposite Sex two days running (and stayed overnight with us).

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Which pharmaceutical drugs have the most drug patents in Cyprus?

Drug Patent Watch

This chart shows the drugs with the most patents in Cyprus. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.…. The post Which pharmaceutical drugs have the most drug patents in Cyprus? appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Beigene drug BRUKINSA

Drug Patent Watch

Annual Drug Patent Expirations for BRUKINSA Brukinsa is a drug marketed by Beigene and is included in one NDA. There are four patents protecting this drug. This drug has forty-four…. The post New patent for Beigene drug BRUKINSA appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Allergan Holdings drug VIBERZI

Drug Patent Watch

Annual Drug Patent Expirations for VIBERZI Viberzi is a drug marketed by Allergan Holdings and is included in one NDA. It is available from one supplier. There are nineteen patents…. The post New patent for Allergan Holdings drug VIBERZI appeared first on DrugPatentWatch - Make Better Decisions.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New patent for Bioxcel drug IGALMI

Drug Patent Watch

Annual Drug Patent Expirations for IGALMI Igalmi is a drug marketed by Bioxcel and is included in one NDA. There is one patent protecting this drug. This drug has twenty…. The post New patent for Bioxcel drug IGALMI appeared first on DrugPatentWatch - Make Better Decisions.

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Which pharmaceutical companies have the most SPCs in Sweden?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Sweden. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating…. The post Which pharmaceutical companies have the most SPCs in Sweden? appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Therapeuticsmd Inc drug IMVEXXY

Drug Patent Watch

Annual Drug Patent Expirations for IMVEXXY Imvexxy is a drug marketed by Therapeuticsmd Inc and is included in one NDA. It is available from one supplier. There are nineteen patents…. The post New patent for Therapeuticsmd Inc drug IMVEXXY appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Am Regent drug INJECTAFER

Drug Patent Watch

Annual Drug Patent Expirations for INJECTAFER Injectafer is a drug marketed by Am Regent and is included in one NDA. It is available from one supplier. There are seven patents…. The post New patent for Am Regent drug INJECTAFER appeared first on DrugPatentWatch - Make Better Decisions.

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Which pharmaceutical drugs have the most drug patents in Yugoslavia?

Drug Patent Watch

This chart shows the drugs with the most patents in Yugoslavia. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.…. The post Which pharmaceutical drugs have the most drug patents in Yugoslavia? appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Shionogi Inc drug FETROJA

Drug Patent Watch

Annual Drug Patent Expirations for FETROJA Fetroja is a drug marketed by Shionogi Inc and is included in one NDA. It is available from one supplier. There are three patents…. The post New patent for Shionogi Inc drug FETROJA appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Cmp Dev drug CAROSPIR

Drug Patent Watch

Annual Drug Patent Expirations for CAROSPIR Carospir is a drug marketed by Cmp Dev Llc and is included in one NDA. It is available from two suppliers. There are seven…. The post New patent for Cmp Dev drug CAROSPIR appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Mylan Speciality drug TOBI PODHALER

Drug Patent Watch

Annual Drug Patent Expirations for TOBI+PODHALER Tobi Podhaler is a drug marketed by Mylan Speciality Lp and is included in one NDA. It is available from one supplier. There are…. The post New patent for Mylan Speciality drug TOBI PODHALER appeared first on DrugPatentWatch - Make Better Decisions.

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New patent for Nexus Pharms drug EMERPHED

Drug Patent Watch

Annual Drug Patent Expirations for EMERPHED Emerphed is a drug marketed by Nexus Pharms and is included in one NDA. It is available from one supplier. There are two patents…. The post New patent for Nexus Pharms drug EMERPHED appeared first on DrugPatentWatch - Make Better Decisions.

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Which pharmaceutical drugs have the most drug patents in Chile?

Drug Patent Watch

This chart shows the drugs with the most patents in Chile. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.…. The post Which pharmaceutical drugs have the most drug patents in Chile? appeared first on DrugPatentWatch - Make Better Decisions.

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New patent expiration for Endo Ventures drug SUMAVEL DOSEPRO

Drug Patent Watch

Annual Drug Patent Expirations for SUMAVEL+DOSEPRO Sumavel Dosepro is a drug marketed by Endo Ventures Ltd and is included in one NDA. There are nine patents protecting this drug. SUMAVEL…. The post New patent expiration for Endo Ventures drug SUMAVEL DOSEPRO appeared first on DrugPatentWatch - Make Better Decisions.

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Which pharmaceutical companies have the most SPCs in Slovakia?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Slovakia. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating…. The post Which pharmaceutical companies have the most SPCs in Slovakia? appeared first on DrugPatentWatch - Make Better Decisions.

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New patent expiration for Acorda drug INBRIJA

Drug Patent Watch

Annual Drug Patent Expirations for INBRIJA Inbrija is a drug marketed by Acorda and is included in one NDA. It is available from one supplier. There are ten patents protecting…. The post New patent expiration for Acorda drug INBRIJA appeared first on DrugPatentWatch - Make Better Decisions.

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New patent expiration for Synthon Pharms drug AMLODIPINE BESYLATE

Drug Patent Watch

Annual Drug Patent Expirations for AMLODIPINE+BESYLATE Amlodipine Besylate is a drug marketed by Synthon Pharms, Accord Hlthcare, Alkem, Amneal Pharms Ny, Apotex, Aurobindo Pharma, Chartwell Rx, China Resources, Cipla, Epic…. The post New patent expiration for Synthon Pharms drug AMLODIPINE BESYLATE appeared first on DrugPatentWatch - Make Better Decisions.

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New tentative approval for Amneal Pharms drug saxagliptin

Drug Patent Watch

[![saxagliptin structure]([link] Saxagliptin is the generic ingredient in one branded drug marketed by Astrazeneca Ab and is included in one NDA. There are two patents protecting this compound. There are…. The post New tentative approval for Amneal Pharms drug saxagliptin appeared first on DrugPatentWatch - Make Better Decisions.

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