Drugs.com
AUGUST 11, 2023
FRIDAY, Aug. 11, 2023 -- Poor sleep takes a toll, and catching up on the weekends just won't fix it, researchers report. A small new study showed that heart rate and blood pressure, important measures of cardiovascular health, worsen as the week.
BioPharma Drive: Drug Pricing
AUGUST 11, 2023
Filed in Maryland district court, the lawsuit claims the biotech unjustly profited from using HeLa cells to develop AAV vectors for its gene therapy products.
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Drug Hunter
AUGUST 9, 2023
This month features big announcements from Biogen on their acquisition of Reata and their Nrf2 activator for Friedreich’s ataxia and from BridgeBio on their TTR stabilizer with positive Ph. III data for their ATTR-CM treatment. A pair of KRAS inhibitors from Chugai (macrocycle) and AstraZeneca (brain-penetrant) also makes the list for their notable pharmacology.
Science Daily: Pharmacology News
AUGUST 11, 2023
Using scaffolds of folded DNA, engineers assembled arrays of quantum rods with desirable photonic properties that could enable them to be used as highly efficient micro-LEDs for televisions or virtual reality devices.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Drugs.com
AUGUST 10, 2023
THURSDAY, Aug. 10, 2023 -- People with autism are over three times more likely than their peers without the developmental disorder to experience self-injury, suicidal ideation, suicide attempt, or death by suicide, new research shows. “In.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
AUGUST 10, 2023
Designed a novel of spirooxindole-pyrrolidine clubbed thiochromene and pyrazole motifs synthesized by [3+2] cycloaddition (32CA) reactions in one step process and identified as an alpha-amylase inhibitor. Mechanistic study for the 32CA reaction by Molecular Electron Density Theory (MEDT) was explored. Abstract A novel spirooxindole-pyrrolidine clubbed thiochromene and pyrazole motifs were synthesized by [3+2] cycloaddition (32CA) reactions in one step process starting from the ethylene-based thi
Science Daily: Pharmacology News
AUGUST 10, 2023
New research has successfully reversed hearing loss in mice. Scientists used a genetic approach to fix deafness in mice, restoring their hearing abilities in low and middle frequency ranges.
Drugs.com
AUGUST 10, 2023
THURSDAY, Aug. 10, 2023 -- Microplastics appear to be everywhere, including within the tissues of the human heart. A new Chinese report describes doctors finding microplastics in heart tissue both before and after heart surgery. The researchers also.
BioPharma Drive: Drug Pricing
AUGUST 8, 2023
Treatment with Wegovy led to a 20% reduction in the relative risk of cardiovascular complications or death, a finding that could further shift how doctors treat obesity.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Forbes: Drug Truths
AUGUST 8, 2023
The SELECT trial is a game changer. Yes, Novo Nordisk achieved winning results. But obesity patients with heart disease now have a major new drug to extend their lives – and that’s an even bigger win.
Science Daily: Pharmacology News
AUGUST 10, 2023
The best heart rate for burning fat differs for each individual and often does not align with the 'fat burning zone' on commercial exercise machines, researchers report. Instead, the researchers said, clinical exercise testing -- a diagnostic procedure to measure a person's physiological response to exercise -- may be a more useful tool to help individuals achieve intended fat loss goals.
Drugs.com
AUGUST 10, 2023
THURSDAY, Aug. 10, 2023 -- The mental health crisis hitting Americans shows no sign of abating, with provisional numbers for 2022 showing suicides rose by another 2.6% last year. That follows on an overall 5% increase in suicides in 2021, noted.
BioPharma Drive: Drug Pricing
AUGUST 8, 2023
The Indianapolis drugmaker is now worth more than $500 billion, higher than any other pharmaceutical company, as analysts project lucrative markets for its obesity and Alzheimer's drugs.
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Drug Hunter
AUGUST 9, 2023
To help drug discovery professionals get the most out of your trip to ACS San Francisco 2023, we compiled a table of sessions that are likely to be of high interest to industry scientists here. Click here to access the live version of the calendar where you can expand each card for details on each session. You can filter by conference day, time, and see descriptions of the talks and key topics all in one place.
Science Daily: Pharmacology News
AUGUST 10, 2023
Scientists working on Fermilab's Muon g-2 experiment released the world's most precise measurement yet of the magnetic moment of the muon, bringing particle physics closer to the ultimate showdown between theory and experiment that may uncover new particles or forces.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- If you’re one of the millions of folks bent on racking up at least 10,000 steps a day, read on. A new study finds that heart health starts to improve with as few as 2,300 steps a day. The research also indicates.
BioPharma Drive: Drug Pricing
AUGUST 10, 2023
The planned facility in the biotech hotspot of Cambridge will include incubator space for startups and adds to Astellas’ R&D footprint in the Boston area.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Covalent Modifiers
AUGUST 8, 2023
Zhongtang Yu, Xiaoqiang He, Ruiliu Wang, Xinxin Xu, Zhang Zhang, Ke Ding, Zhi-Min Zhang, Yi Tan, and Zhengqiu Li Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.3c05899 Owing to their remarkable pharmaceutical properties compared to those of noncovalent inhibitors, the development of targeted covalent inhibitors (TCIs) has emerged as a powerful method for cancer treatment.
Science Daily: Pharmacology News
AUGUST 10, 2023
Microscopic plastic particles have been found in the fats and lungs of two-thirds of the marine mammals in a graduate student's study of ocean microplastics. The presence of polymer particles and fibers in these animals suggests that microplastics can travel out of the digestive tract and lodge in the tissues.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- It’s already known that the “healthy glow” of a tan actually represents damage to skin cells. But a new study of people on vacation has found that sunbathing also can disrupt the skin’s microbiome, altering the.
BioPharma Drive: Drug Pricing
AUGUST 5, 2023
The agency turned back the companies' attempt to also win clearance for major depressive disorder, limiting its market potential.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
ASPET
AUGUST 10, 2023
Pegozafermin (also known as BIO89-100) is a glycoPEGylated analog of fibroblast growth factor 21 (FGF21) under development to treat nonalcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG). In cell-based assays, pegozafermin had a similar receptor engagement profile as native FGF21, with approximately 8-fold higher potency at FGF receptor 1 (FGFR1).
Science Daily: Pharmacology News
AUGUST 10, 2023
A new study finds that around 1.12 million years ago a massive cooling event in the North Atlantic and corresponding shifts in climate, vegetation and food resources disrupted early human occupation of Europe.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- The U.S. Food and Drug Administration has approved Izervay (avacincaptad pegol intravitreal solution) for the treatment of geographic atrophy secondary to age-related macular degeneration. The approval was based on two.
BioPharma Drive: Drug Pricing
AUGUST 8, 2023
The job cuts will affect “all areas of the company” and, combined with other cost-reduction efforts, lead to annualized savings of over $100 million, Emergent said.
ASPET
AUGUST 10, 2023
We have previously shown that a bona fide Aryl hydrocarbon Receptor (AhR) agonist, cinnabarinic acid (CA) protect against alcohol-induced hepatocyte apoptosis via activation of a novel AhR target gene, stanniocalcin 2 (Stc2). Stc2 translates to a secreted disulfide-linked hormone, STC2 known to function in cell development, calcium and phosphate regulation, angiogenesis, and anti-apoptosis - albeit the comprehensive mechanism by which CA-AhR-STC2 axis confers anti-apoptosis is yet to be characte
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