Drug Hunter
AUGUST 9, 2023
This month features big announcements from Biogen on their acquisition of Reata and their Nrf2 activator for Friedreich’s ataxia and from BridgeBio on their TTR stabilizer with positive Ph. III data for their ATTR-CM treatment. A pair of KRAS inhibitors from Chugai (macrocycle) and AstraZeneca (brain-penetrant) also makes the list for their notable pharmacology.
Chemical Biology and Drug Design
AUGUST 10, 2023
Designed a novel of spirooxindole-pyrrolidine clubbed thiochromene and pyrazole motifs synthesized by [3+2] cycloaddition (32CA) reactions in one step process and identified as an alpha-amylase inhibitor. Mechanistic study for the 32CA reaction by Molecular Electron Density Theory (MEDT) was explored. Abstract A novel spirooxindole-pyrrolidine clubbed thiochromene and pyrazole motifs were synthesized by [3+2] cycloaddition (32CA) reactions in one step process starting from the ethylene-based thi
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Forbes: Drug Truths
AUGUST 8, 2023
The SELECT trial is a game changer. Yes, Novo Nordisk achieved winning results. But obesity patients with heart disease now have a major new drug to extend their lives – and that’s an even bigger win.
BioPharma Drive: Drug Pricing
AUGUST 10, 2023
The deal will help fund a cell-based treatment that completed Phase 1 testing last year and is designed to provide a “functional cure” for patients with HIV infections.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Antidote
AUGUST 11, 2023
Helping patients find out about clinical trials is one of the chief pillars of the work Antidote does, and one of the ways we do this is through our partners. By building a network of nonprofits and patient advocacy groups, we are able to reach patients where they are and help them find clinical trial opportunities that may be a good fit.
Drugs.com
AUGUST 11, 2023
FRIDAY, Aug. 11, 2023 -- Poor sleep takes a toll, and catching up on the weekends just won't fix it, researchers report. A small new study showed that heart rate and blood pressure, important measures of cardiovascular health, worsen as the week.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
AUGUST 10, 2023
The drug, which will be sold under the brand name Talvey, is now cleared by the FDA to treat multiple myeloma, a blood cancer that J&J has identified as a research priority.
Conversations in Drug Development Trends
AUGUST 10, 2023
As one of the more recent fields to emerge in the clinical space, psychedelics have gained significant traction as a potential treatment for various neuropsychiatric diseases. With so many exciting developments in the last few years, it’s critical for the psychedelic community to come together to reflect on our progress, share the latest discoveries, and discuss the future of psychedelic research.
PLOS: DNA Science
AUGUST 10, 2023
The history of genetics begins, not with Gregor Mendel’s pea experiments, but with people long ago noticing family resemblances and vulnerabilities so distinctive that shared environment alone can’t explain them. In the new literary fiction masterpiece The Covenant of Water , author-physician Abraham Verghese traces an unusual trait through three generations of a Christian family in India, against the historical backdrop of the coalescence of three states into Kerala, on the Malabar
Drugs.com
AUGUST 10, 2023
THURSDAY, Aug. 10, 2023 -- People with autism are over three times more likely than their peers without the developmental disorder to experience self-injury, suicidal ideation, suicide attempt, or death by suicide, new research shows. “In.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
AUGUST 8, 2023
The job cuts will affect “all areas of the company” and, combined with other cost-reduction efforts, lead to annualized savings of over $100 million, Emergent said.
Antidote
AUGUST 8, 2023
Persistent corneal epithelial defects are more than just an eye injury. The corneal epithelium is an integral part of the eye , tasked with guarding against infection and structural damage. While most injuries to the corneal epithelium are able to heal within a week , these persistent injuries will continue well past the seven-day mark. If they remain unresponsive to standard treatments, the condition is referred to as a persistent corneal epithelial defect.
Drug Target Review
AUGUST 9, 2023
Published on bit.bio’s website, this article authored by Dr Tony Oosterveen dives into the close relationship between FTD and ALS with a focus on mechanisms underlying the neuropathology of both diseases. On April 30th, 1939, baseball hall of famer Lou Gehrig stepped up to the plate with weary muscles. Over the course of Gehrig’s 15-year career, fans and teammates had dubbed him the “Ironhorse” as a nod to the fact that neither illness, injury, nor fatigue had ever caused him to miss a gam
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- If you’re one of the millions of folks bent on racking up at least 10,000 steps a day, read on. A new study finds that heart health starts to improve with as few as 2,300 steps a day. The research also indicates.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
AUGUST 8, 2023
The Indianapolis drugmaker is now worth more than $500 billion, higher than any other pharmaceutical company, as analysts project lucrative markets for its obesity and Alzheimer's drugs.
Perficient: Drug Development
AUGUST 8, 2023
Everyone is moving toward headless architecture these days and wants to take advantage of the new approach in the CMS industry to improve the CMS experience. However, in a few cases, it does not support a CMS functionality like Sitecore Form. Sitecore does not have any out of the box (OOB) component to implement Sitecore Form. Although Sitecore has provided different approaches and advice on how to integrate Sitecore Form in JSS app.
NIOSH Science Blog: Drugs
AUGUST 7, 2023
Recovery friendly workplaces (RFWs) have emerged around the United States as an important intervention to both prevent and address substance use disorders (SUD) and the opioid overdose crisis among workers. A RFW program strives to prevent SUD and overdose by creating a safe, hazard-free and healthy workplace by reducing the chance of injury and the subsequent use of opioids, providing support for workers who are struggling, and facilitating opportunities for employment for people in treatment a
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- It’s already known that the “healthy glow” of a tan actually represents damage to skin cells. But a new study of people on vacation has found that sunbathing also can disrupt the skin’s microbiome, altering the.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
AUGUST 7, 2023
The need for more research into rare diseases is clear, but researchers face significant challenges. Fortunately, technology has created opportunities to innovate in clinical trials for rare diseases.
Perficient: Drug Development
AUGUST 9, 2023
In today’s web development, being fast and responsive is really important. Users want smooth experiences, and developers work hard to make apps that do just that. This is where Node.js and Redis come in. When used together, they can make your apps work much faster and better. In this article, we’ll look at how to use Redis with Node.js to make applications that are super quick and responsive.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
In the ongoing search for a cure for Alzheimer’s disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system.
Drugs.com
AUGUST 10, 2023
THURSDAY, Aug. 10, 2023 -- Microplastics appear to be everywhere, including within the tissues of the human heart. A new Chinese report describes doctors finding microplastics in heart tissue both before and after heart surgery. The researchers also.
BioPharma Drive: Drug Pricing
AUGUST 8, 2023
Treatment with Wegovy led to a 20% reduction in the relative risk of cardiovascular complications or death, a finding that could further shift how doctors treat obesity.
biobide
AUGUST 11, 2023
Daphnia genus species, such as Daphnia magna , commonly known as daphnid or water flea, are plankton-feeding crustaceans that can be found in most bodies of water. These animals have very protuberant external features that make them unique like their single big eye and the duple pairs of branched antennae. The crustacean uses the antennae for locomotion and the thorax and the belly are covered and protected by an uncalcified translucent shell made out of chitin, which is a polysaccharide.
SCIENMAG: Medicine & Health
AUGUST 11, 2023
Forensic researchers at the University of Tennessee Knoxville’s famous Anthropological Research Facility, popularly known as the “Body Farm,” have made headlines for decades in their discoveries of what happens to human bodies after death.
Drugs.com
AUGUST 8, 2023
TUESDAY, Aug. 8, 2023 – A variant nicknamed Eris now accounts for the largest proportion of new COVID infections across America. About 17.3% of U.S. COVID cases are believed to have been caused by the variant, formally known as EG.5, in early.
BioPharma Drive: Drug Pricing
AUGUST 10, 2023
The planned facility in the biotech hotspot of Cambridge will include incubator space for startups and adds to Astellas’ R&D footprint in the Boston area.
biobide
AUGUST 8, 2023
The observation of the Zebrafish’s (Danio rerio) innate capacity to regenerate retinal cells has resulted in its identification as an ideal New Alternative Model (NAM) for ocular disease research. As a result of the negative impact on the person’s quality of life that visual impairment causes and the high amount of people suffering from this condition, an estimated 295 million people are believed to suffer from moderate to severe visual impairment worldwide, the study of eye diseases is of high
SCIENMAG: Medicine & Health
AUGUST 10, 2023
A team led by Virginia Tech researchers has developed a new method for upcycling plastics into high-value chemicals known as surfactants, which are used to create soap, detergent, and more. Credit: Photo by Steven Mackay for Virginia Tech.
Drugs.com
AUGUST 8, 2023
TUESDAY, Aug. 8, 2023 -- Top model Bella Hadid is talking about being "finally healthy" and feeling well after more than a decade of health issues, including Lyme disease. Hadid shared her struggle on Instagram after what she described as "almost.
BioPharma Drive: Drug Pricing
AUGUST 11, 2023
Filed in Maryland district court, the lawsuit claims the biotech unjustly profited from using HeLa cells to develop AAV vectors for its gene therapy products.
Perficient: Drug Development
AUGUST 10, 2023
Introduction In the ever-evolving landscape of software development, choosing the right architectural approach is crucial for building robust and scalable applications. Two popular architectural styles that often come into consideration are Monolithic and Microservice. Both have their merits and trade-offs and understanding their differences is vital for making an informed decision that aligns with your project’s goals.
SCIENMAG: Medicine & Health
AUGUST 10, 2023
BEAUFORT, N.C. – Microscopic plastic particles have been found in the fats and lungs of two-thirds of the marine mammals in a graduate student’s study of ocean microplastics. The presence of polymer particles and fibers in these animals suggests that microplastics can travel out of the digestive tract and lodge in the tissues.
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