Drugs.com
AUGUST 17, 2023
THURSDAY, Aug. 17, 2023 -- Sometimes patients with pancreatic cancer are prescribed the benzodiazepine lorazepam (Ativan) for anxiety, but that may be harming their health. A new study found this treatment was linked to worse outcomes, with shorter.
Drug Hunter
AUGUST 18, 2023
The First Disclosures sessions at the 2023 ACS Fall Meeting in San Francisco, organized by Nikki Goodwin , presented a variety of new orally available small molecules. The standing room-only sessions were so highly attended that many attendees were unfortunately kicked out due to the fire code. In case you missed any of these exciting molecules, from Scorpion’s mutant-selective PI3Kα inhibitor to Nurix’s CNS-penetrant BTK degrader, here we share the structures and targets of all the novel molecu
BioPharma Drive: Drug Pricing
AUGUST 15, 2023
More than a dozen startups have joined a few publicly traded biotechs and larger pharmaceutical firms in what’s become one of the most competitive areas in drug research.
Broad Institute
AUGUST 17, 2023
#WhyIScience Q&A: A computational biologist helps build datasets for genetic disease diagnosis By Corie Lok August 17, 2023 Breadcrumb Home #WhyIScience Q&A: A computational biologist helps build datasets for genetic disease diagnosis Katherine Chao talks about her work managing the Genome Aggregation Database (gnomAD) and the importance of diverse datasets in rare disease diagnosis.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
AUGUST 18, 2023
FRIDAY, Aug. 18, 2023 -- A new COVID variant with very few known cases but many mutations has been swiftly moved into the World Health Organization’s "variant under monitoring" classification. Four known cases of the variant, dubbed BA.2.86, have.
Drug Hunter
AUGUST 15, 2023
LRRK2 has been a hotly pursued drug target for Parkinson’s Disease based on human genetics. Clinical advancement of LRRK2 inhibitors was initially stalled by concerns about on-target lung findings in primates, but these were ameliorated by a Merck/Genentech/Pfizer/MJFF study showing that these lung changes were reversible, and Biogen/Denali has currently a small molecule (BIIB122/DNL151) in Ph.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
PLOS: DNA Science
AUGUST 17, 2023
The Maui firestorm was so vast and fast that most identification of human remains will come from bits of persisting DNA from mitochondria. The “Powerhouse of the Cell” Most people likely last encountered mitochondria in high school biology class. The footprint-shaped “powerhouse of the cell” releases energy from breaking the chemical bonds that hold together nutrient molecules.
Drugs.com
AUGUST 17, 2023
THURSDAY, Aug. 17, 2023 -- Public health officials are warning people about the risks of flesh-eating bacterial infections and how to avoid them after the deaths of three older adults on the northeast coast. Two of the deaths from vibriosis — an.
SCIENMAG: Medicine & Health
AUGUST 17, 2023
Julie Carrier, professor and head of the University of Tennessee Department of Biosystems Engineering and Soil Science, was awarded the James R. and Karen A. Gilley Academic Leadership Award during the annual international meeting of the American Society of Agricultural and Biological Engineers (ASABE) in July.
BioPharma Drive: Drug Pricing
AUGUST 17, 2023
A combination of Trodelvy and Merck’s Keytruda appears active against lung tumors, but has a high bar to clear and faces competition from AstraZeneca and Daiichi Sankyo.
Advertisement
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Broad Institute
AUGUST 16, 2023
Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy. By Allessandra DiCorato August 16, 2023 Credit: Sonja Vasiljeva, Broad Communications The energy-producing machines inside cells, called mitochondria, have their
Drugs.com
AUGUST 17, 2023
THURSDAY, Aug. 17, 2023 -- A new type of medication, JAK inhibitors, can effectively treat moderate to severe alopecia areata, a hair loss condition that has been historically hard to treat. A study of its effectiveness, by Dr. Brett King and Dr.
Antidote
AUGUST 16, 2023
Primary sclerosing cholangitis (PSC) is a condition that impacts the bile ducts of the liver, causing them to become inflamed and ultimately scar. It primarily affects young and middle-aged men, and 80% of patients with PBC also have inflammatory bowel disease (IBD).
BioPharma Drive: Drug Pricing
AUGUST 14, 2023
Elrexfio is the third bispecific antibody cleared to treat the blood cancer, and will compete with other therapies that target the “BCMA” protein on myeloma cells.
Advertisement
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Broad Institute
AUGUST 14, 2023
Three studies highlight how proteins are altered in multiple cancer types By Allessandra DiCorato August 14, 2023 Breadcrumb Home Three studies highlight how proteins are altered in multiple cancer types Researchers identify protein modifications that underlie many key cancer processes. By Allessandra DiCorato August 14, 2023 Credit: Susanna Hamilton, Broad Communications Related news Proteomics moves toward the clinic International collaboration generates most complete cancer genome map to date
Drugs.com
AUGUST 18, 2023
FRIDAY, Aug. 18, 2023 -- Binge-drinking and marijuana use have reached historically high levels among U.S. adults aged 35 to 50, the U.S. National Institutes of Health announced Thursday. For these middle-aged adults, the drugs of choice are.
Drug Target Review
AUGUST 15, 2023
In a recent peer-reviewed study published in Cell Reports , the team, led by Dr Edward V. Prochownik, delved into the dual role of the Myc gene in both cancer development and ageing. The findings highlight the gene’s complex functions, opening up new avenues for cancer therapy and raising important considerations for future drug development. Myc: a crucial cancer driver with a mysterious side Myc , a gene widely recognised for its pivotal role in driving cancer progression in both mice and
Perficient: Drug Development
AUGUST 16, 2023
In today’s rapidly evolving tech landscape, staying ahead of the curve is crucial, but so is selecting the right platform. If you find yourself overwhelmed by the multitude of options and the complexities involved in the selection process, you’re not alone. To help you make an informed decision and find the ultimate technology platform for your organization, here are the top five factors you need to consider: Prioritize Your Requirements: To ensure seamless alignment with your orga
Advertisement
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
ProRelix Research
AUGUST 13, 2023
Software as a Medical Device (SaMD) refers to a class of medical software intended to be used for medical purposes or that is designed to carry out medical functions without […] The post Software as a Medical Devices (SaMD) and US FDA Guidance for their Clinical Evaluation and Clinical … appeared first on ProRelix Research.
Drugs.com
AUGUST 17, 2023
THURSDAY, Aug. 17, 2023 -- Despite what you see on TikTok, don’t consume the laundry powder borax to relieve pain and inflammation or boost bone health. Even though videos on the social media site tout it as a treatment, this substance is not safe.
Conversations in Drug Development Trends
AUGUST 15, 2023
Selecting the right CRO to partner with on your development program is a pivotal decision that can shape the trajectory of your product’s development. At Worldwide, we understand the significance of this collaboration and are dedicated to becoming an extension of your team, providing personalized clinical development solutions that align with your corporate objectives and milestones.
Perficient: Drug Development
AUGUST 14, 2023
Ready for your Google Optimize sunset replacement? Strategies for Seamless Migration and Accelerated Experimentation Growth The upcoming Google Optimize sunset has made it crucial for businesses to find reliable replacements. In today’s data-driven environment, the functionality of data experimentation tools is paramount. Relying on A/B testing tools for measuring and enhancing website optimization is key to increasing user satisfaction and conversion rates.
BioPharma Drive: Drug Pricing
AUGUST 16, 2023
The decision stands in contrast to the agency’s plans for a would-be rival gene editing treatment from Vertex Pharmaceuticals and CRISPR Therapeutics that is also under a regulatory review.
Drugs.com
AUGUST 16, 2023
WEDNESDAY, Aug. 16, 2023 -- New hospitalizations for Americans with severe COVID are climbing once again. The number of patients being admitted to hospitals has grown for each of the past four weeks, U.S. Centers for Disease Control and Prevention.
Drug Target Review
AUGUST 17, 2023
What is the main focus of the study or research mentioned in the passage? Many therapeutic monoclonal antibodies (mAb), such as Rituximab and Herceptin, deplete target cells (called direct targeting mAbs) and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are negatively regulated by the inhibitory IgG receptor, FcγRIIB (CD32B).
PPD
AUGUST 16, 2023
The COVID-19 pandemic rapidly accelerated the adoption of hybrid and decentralized clinical trial (DCT) models. However, as the world settles into its post-pandemic state and returns to pre-pandemic paradigms in many areas, the pharmaceutical industry remains dedicated to moving beyond traditional, centralized clinical trial constructs. At the end of 2022, the PPD clinical research business of Thermo Fisher Scientific surveyed key leadership and staff on the frontline of clinical trial execution
BioPharma Drive: Drug Pricing
AUGUST 14, 2023
Stephen Apps discusses how technology can help improve the speed and quality of clinical research and why a dedicated, cross-functional approach is needed to maximize its value for smaller biotechs.
Drugs.com
AUGUST 16, 2023
WEDNESDAY, Aug. 16, 2023 -- Do you have COVID-19? With a little training, your dog might be more effective at figuring that out than even at-home antigen or sophisticated hospital tests.
Drug Target Review
AUGUST 16, 2023
Cancer remains a major global health concern, often diagnosed at advanced stages when treatment options and survival rates are limited. Early detection and intervention are likely to be the most effective means of reducing morbidity and mortality of human cancer. 1 Early-stage cancers are typically asymptomatic, making routine screening challenging with traditional methods due to cost and clinical constraints.
FDA Law Blog: Biosimilars
AUGUST 16, 2023
By Douglas B. Farquhar — Francis Godwin, Director of the Office of Manufacturing Quality of the Office of Compliance at FDA’s Center for Drug Evaluation and Research provided useful information (presentation attached here ) Tuesday at the GMP by the Sea Conference. He talked about regulatory discretion being exercised for drug manufacturing facilities with serious compliance problems, about how firms should respond to FDA inspectional observations, and about an upcoming guidance that will be of
Perficient: Drug Development
AUGUST 14, 2023
Introduction: APIs (Application Programming Interfaces) indeed play a crucial role in modern software development, enabling different applications to interact and exchange data seamlessly. In the contemporary world of technology, APIs have evolved into the fundamental backbone of modern software businesses, serving as the essential means of communication and data exchange between various applications.
Drugs.com
AUGUST 16, 2023
WEDNESDAY, Aug. 16, 2023 -- Some patients with acute brain injuries can’t respond to verbal commands, making them appear to be unconscious though they still have some level of awareness. Researchers recently studied this hidden consciousness to.
SCIENMAG: Medicine & Health
AUGUST 18, 2023
Carbon capture and utilization (CCU) technologies are crucial for addressing climate change while ensuring economic viability. MES has emerged as a promising approach for CO2 reduction to biofuels and platform chemicals. However, the industrial adoption of MES has been hindered by low-value products like acetate or methane and high electric power demand.
Expert insights. Personalized for you.
98 
Let's personalize your content