Sat.Aug 26, 2023 - Fri.Sep 01, 2023

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Counterfeit Pills Fuel Rising Number of Fatal Drug Overdoses

Drugs.com

FRIDAY, Sept. 1, 2023 -- A growing number of overdose deaths in the United States involve counterfeit pills, health officials reported Thursday. Overdose deaths involving counterfeit pills were twice as common in the latter half of 2021 as they were.

Drugs 338
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Groundwater depletion rates in India could triple in coming decades as climate warms, study shows

Science Daily: Pharmacology News

A new study finds that farmers in India have adapted to warming temperatures by intensifying the withdrawal of groundwater used for irrigation. If the trend continues, the rate of groundwater loss could triple by 2080, further threatening India's food and water security. Reduced water availability in India due to groundwater depletion and climate change could threaten the livelihoods of more than one-third of the country's 1.4 billion residents and has global implications.

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Medicare names first 10 drugs for price negotiations

BioPharma Drive: Drug Pricing

The list includes the top-selling blood thinners Eliquis and Xarelto, as well as the arthritis drug Enbrel and heart failure medicine Entresto.

Drugs 288
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Drug Discovery Industry Roundup with Barry Bunin — August 30, 2023

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin — August 30, 2023

Drugs 278
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Marijuana Should Be Moved to Lower-Risk Drug Category, U.S. Health Officials Say

Drugs.com

THURSDAY, Aug. 31, 2023 – The U.S. Department of Health and Human Services has asked the U.S. Drug Enforcement Agency to reclassify marijuana as a less dangerous drug under the Controlled Substances Act, a move that could potentially expand.

Drugs 306

More Trending

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Sanofi appoints a venture investor to R&D head as executive team expands

BioPharma Drive: Drug Pricing

Houman Ashrafian, currently a scientific advisor at SV Health Investors, will fill the role left by John Reed, who oversaw the transformation of research and development during his five years at Sanofi.

Research 287
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CDD Vault Update (August 2023)

Collaborative Drug

Wrapping Column Headers in Search Results Table Column headers at the top of the Search Results Table are now wrapped to ensure all text is visible without needing to hover over the text with the mouse.

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Opioid OD Rescue Drug Narcan Will Reach Drug Store Shelves Next Week

Drugs.com

WEDNESDAY, Aug. 30, 2023 -- Narcan, a lifesaving medication that reverses opioid overdose, will be available on U.S. drugstore shelves and online starting next week. People who want to carry Narcan, the nasal spray version of naloxone, will be able.

Drugs 306
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Nearly half of dog owners are hesitant to vaccinate their pets

Science Daily: Pharmacology News

A new study found that more than half of people who own dogs expressed some level of canine vaccine hesitancy -- i.e. skepticism about vaccinating their pets against rabies and other diseases. An estimated 45 percent of US households own a dog; according to the survey results, nearly 40 percent of dog owners believe that canine vaccines are unsafe, more than 20 percent believe these vaccines are ineffective, and 30 percent consider them to be medically unnecessary.

Vaccine 253
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Bristol Myers gets key FDA approval for bone marrow disease drug

BioPharma Drive: Drug Pricing

A broadened clearance for Reblozyl in myelodysplastic syndromes should help Bristol Myers offset the looming loss of revenue from top-selling medicines set to soon lose market exclusivity.

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Golgi Neurosciences Partners with CDD Vault to Drive Innovation in Neurodegenerative Disease Treatment

Collaborative Drug

Milano, Italy and San Francisco, USA, August 29th, 2023 - Golgi Neurosciences S.r.l., a new Italian incubator dedicated to the discovery and development of small molecule-based treatments for neurodegenerative diseases, announced today that it has adopted Collaborative Drug Discovery’s CDD Vault as its platform of choice for managing drug discovery data.

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Poorer Neighborhoods Linked to Higher Asthma Rates in Kids

Drugs.com

THURSDAY, Aug. 31, 2023 -- When factoring in why children get asthma, a child's neighborhood may be important to consider. New research finds that living in a neighborhood during early childhood that has better access to resources was associated.

Research 278
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Expanding the impact of CAR T cell therapy: An immunotherapy strategy against all blood cancers

Science Daily: Pharmacology News

A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists have demonstrated the potential efficacy of this approach a preclinical study.

Therapies 250
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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FTC allows Amgen’s $28B deal for Horizon to go through, with conditions

BioPharma Drive: Drug Pricing

The settlement between Amgen and the FTC may reassure those in the industry who feared a more activist regulator would gum up dealmaking.

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Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead [@LynJonesChemBio]

Covalent Modifiers

Radosław P. Nowak, Leah Ragosta, Fidel Huerta, Hu Liu, Scott B. Ficarro, Justin T. Cruite, Rebecca J. Metivier, Katherine A. Donovan, Jarrod A. Marto, Eric S. Fischer, Breanna L. Zerfas and Lyn H Jones RSC Chem. Biol. , 2023 [link] Many cereblon (CRBN) ligands have been used to develop proteolysis targeting chimeras (PROTACs), but all are reversible binders of the E3 ubiquitin ligase.

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Cardiac Arrest: Many People Experience Warning Signs the Day Before

Drugs.com

WEDNESDAY, Aug. 30, 2023 -- Sudden cardiac arrest may not come on so suddenly after all. Fully 50% of people who experienced a sudden cardiac arrest had a telling symptom 24 hours before, and these symptoms are different in men than women, a new.

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Bat study reveals how the brain is wired for collective behavior

Science Daily: Pharmacology News

Researchers used wireless neural recording and imaging devices to 'listen in' on the hippocampal brain activity of groups of Egyptian fruit bats as they flew freely within a large flight room. The researchers were surprised to find that, in this social setting, the bat's 'place' neurons encoded not only the animal's location, but also information about the presence or absence of other bats, and even the identity of bats in their path.

Research 250
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Sage, reeling from depression drug decision, to lay off 40% of workforce

BioPharma Drive: Drug Pricing

Two founding executives are leaving Sage alongside a major restructuring announced weeks after the FDA approved the medicine, Zurzuvae, for much narrower use than the company had hoped.

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Evolved prime editors are smaller and more efficient for therapeutic applications

Broad Institute

Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome. By Sarah C.P.

DNA 145
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Poll: Only Half of Older Adults Have Heard of the New RSV Vaccines, Arexvy and Abrysvo

Drugs.com

MONDAY, Aug. 28, 2023 -- About half of older adults (52 percent) have heard of the new vaccines against respiratory syncytial virus (RSV), Arexvy and Abrysvo, according to the National Poll on Healthy Aging released online on Aug. 22.

Vaccine 279
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Algae provide clues about 600 million years of plant evolution

Science Daily: Pharmacology News

The Earth's surface is covered by plants. They make up the majority of biomass on land and exhibit a wide range of diversity, from mosses to trees. This astounding biodiversity came into existence due to a fateful evolutionary event that happened just once: plant terrestrialization. This describes the point where one group of algae, whose modern descendants can still be studied in the lab, evolved into plants and invaded land around the world.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Roche claims study success for targeted drug in early lung cancer

BioPharma Drive: Drug Pricing

The Swiss pharma said, without details, that it observed “unprecedented” results that could make Alecensa the first treatment specifically available after surgery for ALK-positive lung tumors.

Treatment 264
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Schizophrenia gene mutation causes many changes in the mouse brain

Broad Institute

Schizophrenia gene mutation causes many changes in the mouse brain By Leah Eisenstadt August 31, 2023 Breadcrumb Home Schizophrenia gene mutation causes many changes in the mouse brain A study of a genetic mouse model of schizophrenia supports two long-debated hypotheses, and unveils additional new clues about the biological roots of the disorder. By Leah Eisenstadt August 31, 2023 Credit: Susanna Hamilton, Broad Communications Researchers studied the effects of a schizophrenia gene mutation in

RNA 143
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Do Most Americans Know How to Help Loved Ones Battling Addictions? New Poll Says Yes

Drugs.com

THURSDAY, Aug. 31, 2023 -- If a loved one were living with addiction, a majority of Americans say they would know how to get help. About 71% of 2,200 respondents to an American Psychiatric Association poll said they would know how to assist a friend.

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New research explains 'Atlantification' of the Arctic Ocean

Science Daily: Pharmacology News

New research by an international team of scientists explains what's behind a stalled trend in Arctic Ocean sea ice loss since 2007. The findings indicate that stronger declines in sea ice will occur when an atmospheric feature known as the Arctic dipole reverses itself in its recurring cycle. The many environmental responses to the Arctic dipole are described in a recent article.

Research 244
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Novo, continuing deal streak, buys another obesity drug startup

BioPharma Drive: Drug Pricing

The acquisition of Embark Biotech, which Novo helped found, gives the company another prospect to add to its arsenal of weight-loss medicines.

Drugs 257