Drug Discovery World

AUGUST 13, 2024

Professor Andy Whiting , CEO of Nevrargenics, asks whether animal models should be used as the default regulatory requirement and explores the times to use them. Animal models (AMs) have generally been seen as useful for drug development and biomedical research for many years. They are assumed to closely mimic human disease progression and act as a good testing ground for toxicology studies and pharmacokinetics 1.

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Drug Development Animal Testing Regulations Drugs 162

Science Daily: Pharmacology News

AUGUST 13, 2024

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in. Recently, researchers created a new liquid-based solution that eliminates more than 98% of these microscopic plastic particles from water.

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Disease Research 145

Chemical Biology and Drug Design

AUGUST 16, 2024

Baicalein (BE) augments radiosensitivity in colorectal cancer (CRC) by inhibiting the JAK2/STAT3 pathway. In vitro and in vivo experiments demonstrate BE's ability to enhance apoptosis and suppress PD-L1 expression, suggesting its potential as a radiosensitizer in CRC therapy. ABSTRACT Radiation resistance is a crucial factor influencing therapeutic outcomes in colorectal cancer (CRC).

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Therapies Research 100

Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- As syphilis cases surge throughout the United States, the U.S. Food and Drug Administration on Friday approved the first diagnostic at-home test to spot the bacterial disease."This is the first at-home, over-the-counter.

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FDA Disease Drugs 119

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 13, 2024

The Memorial Sloan Kettering Cancer Center (MSK) will be collaborating with Absci Corporation to discover and develop novel cancer therapeutics using generative artificial intelligence (AI) for up to six programmes. Under the terms of the collaboration, Absci and MSK’s cancer research teams will co-develop therapeutics using Absci’s platform. “At MSK, we are committed to continuous innovation as we strive toward our mission of ending cancer for life, and we expect cancer care AI to play an incre

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Pharma Companies International Research Therapies 162

Science Daily: Pharmacology News

AUGUST 14, 2024

A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic lateral sclerosis (ALS). The man was able to communicate his intended speech within minutes of activating the system.

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Research 143

BioPharma Drive: Drug Pricing

AUGUST 15, 2024

The agency said the first round of pricing talks, which involved drugs like the blood thinners Eliquis and Xarelto, will result in $6 billion in savings for taxpayers.

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Drugs 120

Drug Discovery World

AUGUST 12, 2024

A new study has provided the most comprehensive analysis to date of the genetic makeup of colorectal cancer (CRC), providing unique understanding of its response to treatment. The research was led by UK universities, including the University of Oxford, The Institute of Cancer Research, London, the University of Manchester and the University of Leeds.

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Treatment Research Drugs 162

Science Daily: Pharmacology News

AUGUST 15, 2024

Scientists have restored the brain's waste-clearing process in aging mice, offering potential new treatment for Alzheimer's and Parkinson's using existing drugs.

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Treatment Drugs 145

Drugs.com

AUGUST 12, 2024

MONDAY, Aug. 12, 2024 -- Advocates for the use of the psychedelic drug MDMA (midomafetamine) to treat mental health conditions were delivered a setback on Friday after the U.S. Food and Drug Administration declined to approve it as treatment for.

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Therapies FDA Treatment Drugs 115

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

AUGUST 16, 2024

The vaccine didn’t spur a strong enough immune response against a particular flu strain in a Phase 3 trial, leading the companies to ponder adjustments.

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Immune Response Vaccine Trials 122

Drug Discovery World

AUGUST 16, 2024

News round-up for 12-16 August by DDW Senior Digital Content Editor Diana Spencer. The chosen news highlights this week all feature advances in drug development in oncology indications and reflect the breadth of therapeutic approaches to cancer treatment. The top stories: Genetic causes of colorectal cancer revealed in new study A new study has provided the most comprehensive analysis to date of the genetic makeup of colorectal cancer (CRC), providing unique understanding of its response to trea

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Licensing Licensing Drugs Clinical Trials 147

Science Daily: Pharmacology News

AUGUST 15, 2024

In humans, the process of learning is driven by different groups of cells in the brain firing together. For instance, when the neurons associated with the process of recognizing a dog begin to fire in a coordinated manner in response to the cells that encode the features of a dog -- four legs, fur, a tail, etc. -- a young child will eventually be able to identify dogs going forward.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- There are clues that red and processed meats could be driving the increased risk of colon cancer in young adults, a new study claims.Younger colon cancer patients typically have higher levels of metabolites created by the.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

AUGUST 12, 2024

Editors at Psychopharmacology cited "unethical conduct" that the study authors didn't disclose when submitting the papers. Lykos Therapeutics says it filed a complaint with a third party to review the way the journal came to its decision.

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Therapies FDA 113

Drug Discovery World

AUGUST 16, 2024

New published data have demonstrated positive monotherapy results for misetionamide as well as synergistic activity with PARP inhibitors (PARPis) and bevacizumab antineoplastic in ovarian cancer. Misetionamide is a tumour cell selective small molecule drug that is broadly active in multiple cancer models. Misetionamide’s inhibition of hexokinase-2 (HK-2), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and pyruvate dehydrogenase (PVD) in aerobic glycolysis inhibits ATP production for cancer ce

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Small Molecule Drugs Clinical Trials Therapies 147

Science Daily: Pharmacology News

AUGUST 16, 2024

A zinc-air microbattery could enable the deployment of cell-sized, autonomous robots for drug delivery within in the human body, as well as other applications such as locating leaks in gas pipelines.

Engineering 136

Engineering Drugs 136

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Ovarian cancer is known as a "silent killer," since by the time symptoms arise the disease has often already spread.But in certain cases of aggressive ovarian cancer, symptoms do arise in the tumor's early stages. In.

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Disease 110

BioPharma Drive: Drug Pricing

AUGUST 15, 2024

The layoffs are part of a larger reorganization that will also see the departure of Lykos’ founder, the psychedelics advocate Rick Doblin.

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Therapies FDA 120

Drug Discovery World

AUGUST 15, 2024

Scale Biosciences (Scale Bio) has launched the ‘100 Million Cell Challenge’, which hopes to push the boundaries of single-cell genomics research, in collaboration with Ultima Genomics and NVIDIA. The programme calls on researchers worldwide to submit proposals for large-scale single cell projects, with the goal of collectively analysing 100 million cells or more across diverse biological systems and research areas.

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Research Disease Drugs 147

Science Daily: Pharmacology News

AUGUST 16, 2024

Researchers are setting out to challenge our misconceptions about the Dodo, one of the most well-known but poorly understood species of bird. Researchers have undertaken the most comprehensive review of the taxonomy of the Dodo and its closest relative, the Rodriguez Island Solitaire.

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Research 135

Drug Target Review

AUGUST 16, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I grew up in California where I developed a natural curiosity to understand how a living organism functions. Majoring in physiology in college allowed me to nourish this interest, and I knew medicine would be my path as it enabled me to learn the structure and function of the human body.

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Medical Schools Nurses Research Production 106

Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- A good night’s sleep is crucial for helping people make new memories, a new study says.Neurons that capture new memories during the day reset while you sleep, researchers reported Aug. 15 in the journal Science.“This mec.

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Science Research 105

Drug Discovery World

AUGUST 15, 2024

OpenFold, a non-profit artificial intelligence (AI) research consortium focused on developing free and open-source software tools for biology and drug discovery, has added six new industry members. Joining the consortium are Astex Pharmaceuticals, Biogen, Congruence Therapeutics, Polaris Quantum Biotech, Psivant Therapeutics, and SandboxAQ. “This expansion marks a significant stride forward in advancing AI-driven solutions for healthcare and life sciences,” said Christina Taylor, Senior Science

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Research Laboratories Drugs Science 147

Science Daily: Pharmacology News

AUGUST 14, 2024

Researchers have developed a smart fabric that can convert body heat and solar energy into electricity, potentially enabling continuous operation with no need for an external power source. Different sensors monitoring temperature, stress, and more can be integrated into the material.

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Research 134

Perficient: Drug Development

AUGUST 15, 2024

At Perficient, we take immense pride in igniting positive change around the world. Since Perficient’s Giving Employee Resource Group (ERG) launching the Perficient Global Grants Program earlier this year, we have seen remarkable enthusiasm and commitment from our global colleagues, each championing their favorite charitable causes with passion and purpose.

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Engineering 105

Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- As an outbreak of a new strain of mpox continues in Africa, Sweden announced Thursday that it has confirmed the first case in that country.Known as the clade I strain, this latest iteration of mpox appears to be spread.

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Drug Discovery World

AUGUST 15, 2024

A Phase IIa clinical trial has begun evaluating the safety and efficacy of Pelage Pharmaceuticals’ PP405, a novel topical small molecule, for the treatment of androgenetic alopecia (pattern baldness). The company is enrolling 60 women and men for the clinical study. PP405 is designed to reactivate dormant hair follicle stem cells to stimulate hair growth.

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Small Molecule Medical Schools Clinical Trials Pharmaceuticals 147

Science Daily: Pharmacology News

AUGUST 16, 2024

Barely audible to human ears, healthy soils produce a cacophony of sounds in many forms -- a bit like an underground rave concert of bubble pops and clicks. Special recordings made by ecologists show this chaotic mixture of soundscapes can be a measure of the diversity of tiny living animals in the soil, which create sounds as they move and interact with their environment.

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Collaborative Drug

AUGUST 16, 2024

Burlingame, CA (USA), Kyiv (Ukraine) – August 16, 2024 — Collaborative Drug Discovery (CDD), a leader in providing scientific informatics solutions, announced today that its flagship platform, CDD Vault , now includes the complete compound collection of Enamine , a leading provider of chemical compounds and early discovery services, within its AI module for structural similarity searches.

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Research Drugs 103

Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- Kids considering suicide after receiving mental health care at a hospital can be helped by automated text messages that help them feel hopeful and supported, a new study finds.Children receiving the texts as part of a.

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Hospitals 105

Drug Discovery World

AUGUST 14, 2024

AstraZeneca’s Imfinzi (durvalumab) and Lynparza (olaparib) have been approved in the European Union (EU) as treatment for certain patients with primary advanced or recurrent endometrial cancer. Imfinzi plus chemotherapy as first-line treatment followed by Lynparza and Imfinzi has been approved for patients with mismatch repair proficient (pMMR) disease.

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Trials Disease Treatment Therapies 147

Science Daily: Pharmacology News

AUGUST 12, 2024

Common push puppet toys in the shapes of animals and popular figures can move or collapse with the push of a button at the bottom of the toys' base. Now, a team of engineers has created a new class of tunable dynamic material that mimics the inner workings of push puppets, with applications for soft robotics, reconfigurable architectures and space engineering.

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Engineering 135

BioPharma Drive: Drug Pricing

AUGUST 12, 2024

The clearance of Yorvipath for hypoparathyroidism was some time coming for Ascendis, which had resubmitted after receiving a rejection last year.

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