Sat.Aug 10, 2024 - Fri.Aug 16, 2024

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Cleaning up the aging brain: Scientists restore brain's trash disposal system

Science Daily: Pharmacology News

Scientists have restored the brain's waste-clearing process in aging mice, offering potential new treatment for Alzheimer's and Parkinson's using existing drugs.

Treatment 363
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FDA Authorizes First At-Home Test for Syphilis

Drugs.com

FRIDAY, Aug. 16, 2024 -- As syphilis cases surge throughout the United States, the U.S. Food and Drug Administration on Friday approved the first diagnostic at-home test to spot the bacterial disease."This is the first at-home, over-the-counter.

FDA 299
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Pfizer, BioNTech stumble in effort to develop combination flu, COVID shot

BioPharma Drive: Drug Pricing

The vaccine didn’t spur a strong enough immune response against a particular flu strain in a Phase 3 trial, leading the companies to ponder adjustments.

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CDD Vault Integrates Enamine Compound Collection into AI-Powered Structural Similarity Searches

Collaborative Drug

Burlingame, CA (USA), Kyiv (Ukraine) – August 16, 2024 — Collaborative Drug Discovery (CDD), a leader in providing scientific informatics solutions, announced today that its flagship platform, CDD Vault , now includes the complete compound collection of Enamine , a leading provider of chemical compounds and early discovery services, within its AI module for structural similarity searches.

Research 278
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Scientists achieve more than 98% efficiency removing nanoplastics from water

Science Daily: Pharmacology News

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in. Recently, researchers created a new liquid-based solution that eliminates more than 98% of these microscopic plastic particles from water.

Disease 363

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Lykos to cut 75% of staff after FDA rejection of MDMA-based therapy

BioPharma Drive: Drug Pricing

The layoffs are part of a larger reorganization that will also see the departure of Lykos’ founder, the psychedelics advocate Rick Doblin.

Therapies 288
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CDD Vault Update (August 2024)

Collaborative Drug

Inventory Search Interface: The new CDD Vault Inventory tab can be enabled by the CDD Support Team. If you wish to enable this tab in your Vault please have your vault administrator contact support@collaborativedrug.com.

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New brain-computer interface allows man with ALS to 'speak' again

Science Daily: Pharmacology News

A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic lateral sclerosis (ALS). The man was able to communicate his intended speech within minutes of activating the system.

Research 360
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Red Meat Could Be Prime Driver of Colon Cancer in the Young

Drugs.com

FRIDAY, Aug. 16, 2024 -- There are clues that red and processed meats could be driving the increased risk of colon cancer in young adults, a new study claims.Younger colon cancer patients typically have higher levels of metabolites created by the.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Medicare reveals results of drug price negotiations

BioPharma Drive: Drug Pricing

The agency said the first round of pricing talks, which involved drugs like the blood thinners Eliquis and Xarelto, will result in $6 billion in savings for taxpayers.

Drugs 287
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Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [@RulloLab]

Covalent Modifiers

Nickolas J. Serniuck, Eden Kapcan, Duane Moogk,Allyson E. Moore,Benjamin P.M. Lake, Galina Denisova,Joanne A. Hammill,Jonathan L. Bramson, Anthony F. Rullo Molecular Therapy 2024 DOI: [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. Covalent anchoring of these small molecules represents a useful chemical strategy to enforce proximity; however, it remains largely unexplored for driving cell-cell interactions

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Brain wiring is guided by activity even in very early development

Science Daily: Pharmacology News

In humans, the process of learning is driven by different groups of cells in the brain firing together. For instance, when the neurons associated with the process of recognizing a dog begin to fire in a coordinated manner in response to the cells that encode the features of a dog -- four legs, fur, a tail, etc. -- a young child will eventually be able to identify dogs going forward.

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Looking for Symptoms to Catch Ovarian Cancer Early

Drugs.com

THURSDAY, Aug. 15, 2024 -- Ovarian cancer is known as a "silent killer," since by the time symptoms arise the disease has often already spread.But in certain cases of aggressive ovarian cancer, symptoms do arise in the tumor's early stages. In.

Disease 277
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Galderma wins FDA approval for skin condition treatment

BioPharma Drive: Drug Pricing

Nemluvio is now cleared for adults with the chronic itching condition prurigo nodularis, making it a competitor to Sanofi and Regeneron’s Dupixent.

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Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells [@EvertNjomen]

Covalent Modifiers

Njomen, E., Hayward, R.E., DeMeester, K.E. et al. Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells. Nat. Chem. 2024 DOI [link] Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with broadly reactive probes.

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Engineers design tiny batteries for powering cell-sized robots

Science Daily: Pharmacology News

A zinc-air microbattery could enable the deployment of cell-sized, autonomous robots for drug delivery within in the human body, as well as other applications such as locating leaks in gas pipelines.

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Your Brain Cells 'Reset' During Sleep, Readying for Tomorrow's Memories

Drugs.com

FRIDAY, Aug. 16, 2024 -- A good night’s sleep is crucial for helping people make new memories, a new study says.Neurons that capture new memories during the day reset while you sleep, researchers reported Aug. 15 in the journal Science.“This mec.

Science 264
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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FDA approves Ascendis drug for rare endocrine condition

BioPharma Drive: Drug Pricing

The clearance of Yorvipath for hypoparathyroidism was some time coming for Ascendis, which had resubmitted after receiving a rejection last year.

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Upcoming Webinar: Generative Chemistry, Deep Learning and Traditional Models

Collaborative Drug

Upcoming Webinar 3-21 24: Interdisciplinary Pathways in Medicine: Neurodegenerative Research and Drug Discovery

Research 162
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Rethinking the dodo

Science Daily: Pharmacology News

Researchers are setting out to challenge our misconceptions about the Dodo, one of the most well-known but poorly understood species of bird. Researchers have undertaken the most comprehensive review of the taxonomy of the Dodo and its closest relative, the Rodriguez Island Solitaire.

Research 345
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Chemicals in Makeup, Sunscreen May Raise Odds for Dangerous Pregnancy Complication

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- Chemicals commonly found in sunscreen, makeup and other personal care products could be putting pregnancies at risk, a new study warns. Phenols and parabens in these products increase a pregnant woman’s risk of.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Following FDA rejection, a journal retracts papers on MDMA-assisted therapy

BioPharma Drive: Drug Pricing

Editors at Psychopharmacology cited "unethical conduct" that the study authors didn't disclose when submitting the papers. Lykos Therapeutics says it filed a complaint with a third party to review the way the journal came to its decision.

Therapies 272
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Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story

Covalent Modifiers

Ruxandra Moraru, Beatriz Valle-Argos, Annabel Minton, Lara Buermann, Suyin Pan, Thomas E. Wales, Raji E. Joseph, Amy H. Andreotti, Jonathan C. Strefford, Graham Packham, and Matthias G. J. Baud Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01927 Targeted covalent inhibitors (TCIs) directing cysteine have historically relied on a narrow set of electrophilic “warheads”.

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Smart fabric converts body heat into electricity

Science Daily: Pharmacology News

Researchers have developed a smart fabric that can convert body heat and solar energy into electricity, potentially enabling continuous operation with no need for an external power source. Different sensors monitoring temperature, stress, and more can be integrated into the material.

Research 344
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WHO Declares Africa Mpox Outbreak a Global Health Emergency

Drugs.com

THURSDAY, Aug. 15, 2024 -- The World Health Organization on Wednesday made the rare move of declaring an ongoing African outbreak of mpox a global health emergency.A new clade (strain) of the virus, plus its troubling spread throughout the.

Virus 264
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Pfizer builds case for RSV shot with data from immunocompromised adults

BioPharma Drive: Drug Pricing

Results from a Phase 3 study could help Pfizer broaden use of its vaccine Abrysvo to younger adults whose medical history puts them at higher risk.

Vaccine 265