Broad Institute

NOVEMBER 6, 2024

Study reveals how cancer immunotherapy may cause heart inflammation in some patients By Leah Eisenstadt November 6, 2024 Breadcrumb Home Study reveals how cancer immunotherapy may cause heart inflammation in some patients Myocarditis is driven by a different immune response than the anti-tumor one, suggesting that the serious complication could one day be managed without halting cancer therapy.

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BioPharma Drive: Drug Pricing

NOVEMBER 6, 2024

Pioneers like Alnylam Pharmaceuticals have led the RNA interference field for years. Now, a crop of young biotechs is building on that foundation by taking the drugmaking technology in new directions.

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Science Daily: Pharmacology News

NOVEMBER 8, 2024

Scientists believe individuals of the most recently discovered 'hominin' group (the Denisovans) that interbred with modern day humans passed on some of their genes via multiple, distinct interbreeding events that helped shape early human history. Scientists outline evidence suggesting that several Denisovan populations, who likely had an extensive geographical range from Siberia to Southeast Asia and from Oceania to South America, were adapted to distinct environments.

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Codon

NOVEMBER 8, 2024

An opinion essay by Liyam Chitayat The cells within our body are the remnants of an ancient alliance. In a 1967 paper called “ On the Origin of Mitosing Cells ,” American evolutionary biologist Lynn Margulis proposed an idea that, upon first hearing, seems ludicrous. Her paper, in fact, was rejected by 12 different journals before it was published.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Broad Institute

NOVEMBER 6, 2024

Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer By Leah Eisenstadt November 6, 2024 Breadcrumb Home Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer Broad and Mass General researcher Alexandra-Chloé Villani and Mass General oncologist Kerry Reynolds describe their pioneering effort to better understand, diagnose, and manage dangerous complications from cancer immunotherapy.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- More than a year after its advisory panel unanimously declared the drug phenylephrine to be useless against nasal congestion, the U.S. Food and Drug Administration is proposing that it be removed from common.

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Chemical Biology and Drug Design

NOVEMBER 4, 2024

Alzheimer's disease (AD) is a progressive age-related neurodegenerative brain disorder that destroys memory and other important mental functions. This review article comprehensively summarized the recent advancements in galantamine and its hybrid analogs as potential therapeutic agents for the management of AD. Furthermore, we also provided the design, synthesis, and SAR analysis of the galantamine-based compounds used in the last decades for the management of AD.

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ASPET

NOVEMBER 4, 2024

MK-8189 is a novel phosphodiesterase 10A (PDE10A) inhibitor being evaluated in clinical studies for the treatment of schizophrenia. PDE10A is a cyclic nucleotide phosphodiesterase enzyme highly expressed in medium spiny neurons of the striatum. MK-8189 exhibits sub-nanomolar potency on the PDE10A enzyme and has excellent pharmaceutical properties. Oral administration of MK-8189 significantly increased cGMP and pGluR1 in rat striatal tissues.

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Drugs.com

NOVEMBER 8, 2024

FRIDAY, Nov. 8, 2024 -- Researchers think they’ve figured out why cancer treatments that harness a person’s immune system to fight a tumor can cause heart damage in rare instances.Further, what they’ve learned sheds light on how this potentially dea.

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Science Daily: Pharmacology News

NOVEMBER 6, 2024

When Mount St. Helens erupted in 1980, lava incinerated anything living for miles around. As an experiment, scientists dropped gophers onto parts of the scorched mountain for only 24 hours. The benefits from that single day were undeniable and still visible 40 years later.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

NOVEMBER 5, 2024

The companies’ CAR-T seemed to cause fewer movement disorders in a multiple myeloma trial than J&J's Carvykti has in other tests, although Wall Street analysts were divided on how the two drugs compare.

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FDA Law Blog: Biosimilars

NOVEMBER 6, 2024

By Sara W. Koblitz — The fight between Jazz, Avadel, and FDA over narcolepsy drug sodium oxybate has been a long and arduous one. Starting in 2022 with a patent certification requirement, both Jazz and Avadel have sued FDA over this drug, with Jazz most recently bringing suit challenging FDA’s decision that Avadel’s Lumryz (sodium oxybate) is clinically superior to Jazz’s Xywav (sodium oxybate) in 2023.

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Drugs.com

NOVEMBER 8, 2024

THURSDAY, Nov. 7, 2024 -- Men who undergo prostate cancer treatment face a greatly increased risk of life-altering, long-term complications, a new study finds.Surgery for prostate cancers increases a man’s risk of urinary or sexual complications m.

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Science Daily: Pharmacology News

NOVEMBER 6, 2024

Older people who are sleepy during the day or lack enthusiasm for activities due to sleep issues may be more likely to develop a syndrome that can lead to dementia, according to a new study.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

NOVEMBER 5, 2024

The death, which investigators linked to a preparatory chemo treatment rather than Beam's medicine, highlights the risks of using decades-old transplant drugs alongside cutting-edge CRISPR medicines.

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NIOSH Science Blog: Drugs

NOVEMBER 7, 2024

Introduction No Shave November is a great opportunity to grow out your beard for a good cause. But if you rely on a tight-fitting respirator for work, that extra facial hair could pose a safety concern. Respirators protect workers from harmful particles, but their effectiveness depends on forming a tight seal against your skin. So, what does that mean for your growing beard during No Shave November?

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Drugs.com

NOVEMBER 5, 2024

TUESDAY, Nov. 5, 2024 -- The omega-3 and omega-6 fatty acids in fish oil supplements might help protect people from cancer, a new study claims.Study participants with higher levels of omega-3s had lower rates of colon, stomach, lung and other.

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Science Daily: Pharmacology News

NOVEMBER 8, 2024

Tool use isn't unique to humans. Chimpanzees use sticks as tools. Dolphins, crows, and elephants are known for their tool-use abilities, too. Now a report highlights elephants' remarkable skill in using a hose as a flexible shower head. As an unexpected bonus, researchers say they also have evidence that a fellow elephant knows how to turn the water off, perhaps as a kind of 'prank.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

NOVEMBER 7, 2024

Elevidys sales have increased since the FDA made a controversial choice to expand the therapy's use. Now, Sarepta is abandoning a successor to its drug Exondys 51, citing an “evolving" treatment landscape.

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thought leadership

NOVEMBER 7, 2024

Patient Support Programs (PSPs) in the pharmaceutical sector offer a range of services to help patients start and adhere to their therapies, including Patient Assistance Programs (PAPs), patient education, provider support, field role partnerships for injection and device training, concierge services for travel and lodging, and clinical trial support.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Alzheimer’s disease patients prescribed fistfuls of daily drugs are at greater risk of harm, a new study warns.Patients with Alzheimer’s prescribed five or more daily medications suffer from more symptoms, falls and hos.

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Science Daily: Pharmacology News

NOVEMBER 5, 2024

Romance is a complex affair in humans. There's personality, appearance, seduction, all manner of physical and social cues. Mosquitoes are much more blunt. Mating occurs for a few seconds in midair. And all it takes to woo a male is the sound of a female's wingbeats. Imagine researchers' surprise when a single change completely killed the mosquitoes' libidos.

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Drug Patent Watch

NOVEMBER 7, 2024

The rising cost of prescription drugs has become a significant public health concern, with millions of Americans struggling to afford their medications. One crucial factor in mitigating this issue is the increased use of generic drugs. Generic drugs have been instrumental in reducing healthcare costs, and their impact cannot be overstated.

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keypoint

NOVEMBER 7, 2024

This month's Fellows Spotlight goes to Keystone Symposia Fellow Dr. LaQuita Jones! Dr. Jones is an Assistant Professor of Pediatrics at Cincinnati Children’s Hospital and the University of Cincinnati College of Medicine , where she specializes in hematologic malignancies, targeted therapeutics and resistance. In addition, she co-leads the health equity efforts within the Division of Oncology at Cincinnati Children’s Hospital, examining the distribution of immunotherapy to children with relapsed/

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Drugs.com

NOVEMBER 8, 2024

FRIDAY, Nov. 8, 2024 -- More than 1 in 5 Americans likely suffer from long COVID, a new AI-assisted review has found. The analysis suggests that nearly 23% of U.S. adults experience the symptoms of long COVID, according to results published Nov. 8.

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Science Daily: Pharmacology News

NOVEMBER 6, 2024

Higher temperatures caused by anthropogenic climate change turned an ordinary drought into an exceptional one that parched the American West from 2020--22. A study has found that evaporation accounted for 61% of the drought's severity, while reduced precipitation accounted for 39%. The research found that since 2000, evaporative demand has played a bigger role than reduced precipitation in droughts, which may become more severe as the climate warms.

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addgene Blog

NOVEMBER 7, 2024

When Addgene opened in 2004, we focused on creating a repository that made it easy to share plasmids, both for people depositing plasmids and for people requesting them. Prior to this, many plasmids were available, but they often weren’t easily accessible, due to a wide range of logistical barriers. Addgene worked to identify, reduce, and remove these logistical barriers, allowing people to access a wide catalog of plasmids from all over the world.

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Drug Patent Watch

NOVEMBER 6, 2024

Developing a Risk Management Plan (RMP) for generic drugs is a crucial step in ensuring the safety and efficacy of these medications. An RMP provides detailed information on a medicine’s safety profile, measures to prevent or minimize risks, and plans for ongoing safety monitoring and evaluation.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- After "Friends" star Matthew Perry was found dead in his home jacuzzi just over a year ago, an autopsy later pinpointed the main cause of death as an acute ketamine overdose. The coroner's report determined that high blood.

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Science Daily: Pharmacology News

NOVEMBER 8, 2024

When people have an audience watching them, it can change their performance for better or worse. Now, researchers have found that chimpanzees' performance on computer tasks is influenced by the number of people watching them. The findings suggest that this 'audience effect' predates the development of reputation-based human societies, the researchers say.

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Drug Channels

NOVEMBER 4, 2024

Here on Drug Channels , we have long highlighted the boom in provider-administered biosimilars. In contrast to the pharmacy market, adoption of these biosimilars is growing, prices are dropping, and formulary barriers continue to fall. Novel transparency information reveals that this good news doesn’t always translate into savings. Below, we rely on a unique data set from Turquoise Health to examine how much four national commercial health plans—Aetna, Anthem, Cigna, and UnitedHealthcare—paid ho

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Drug Patent Watch

NOVEMBER 5, 2024

The development and approval of biosimilars have become increasingly important in the biopharmaceutical industry, offering cost-effective alternatives to original biological medicines. However, biosimilars pose unique challenges in terms of risk management due to their complex nature and potential for immunogenicity.

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Biosimilars 83

Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- About 7% of dairy workers exposed to the avian flu that is spreading through U.S. herds have become infected themselves, federal experts estimate.That number highlights concerns that circulating strains of bird flu might.

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