Broad Institute

NOVEMBER 6, 2024

Study reveals how cancer immunotherapy may cause heart inflammation in some patients By Leah Eisenstadt November 6, 2024 Breadcrumb Home Study reveals how cancer immunotherapy may cause heart inflammation in some patients Myocarditis is driven by a different immune response than the anti-tumor one, suggesting that the serious complication could one day be managed without halting cancer therapy.

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BioPharma Drive: Drug Pricing

NOVEMBER 6, 2024

Pioneers like Alnylam Pharmaceuticals have led the RNA interference field for years. Now, a crop of young biotechs is building on that foundation by taking the drugmaking technology in new directions.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories. But a team of scientists has discovered that cells from other parts of the body also perform a memory function, opening new pathways for understanding how memory works and creating the potential to enhance learning and to treat memory-related afflictions.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- More than a year after its advisory panel unanimously declared the drug phenylephrine to be useless against nasal congestion, the U.S. Food and Drug Administration is proposing that it be removed from common.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Chemical Biology and Drug Design

NOVEMBER 4, 2024

Alzheimer's disease (AD) is a progressive age-related neurodegenerative brain disorder that destroys memory and other important mental functions. This review article comprehensively summarized the recent advancements in galantamine and its hybrid analogs as potential therapeutic agents for the management of AD. Furthermore, we also provided the design, synthesis, and SAR analysis of the galantamine-based compounds used in the last decades for the management of AD.

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BioPharma Drive: Drug Pricing

NOVEMBER 5, 2024

The companies’ CAR-T seemed to cause fewer movement disorders in a multiple myeloma trial than J&J's Carvykti has in other tests, although Wall Street analysts were divided on how the two drugs compare.

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Drugs.com

NOVEMBER 8, 2024

FRIDAY, Nov. 8, 2024 -- Researchers think they’ve figured out why cancer treatments that harness a person’s immune system to fight a tumor can cause heart damage in rare instances.Further, what they’ve learned sheds light on how this potentially dea.

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Codon

NOVEMBER 3, 2024

This essay by Kamal Nahas concludes Issue 04 of Asimov Press. In the 1924 novel, The Magic Mountain , Thomas Mann describes a sanatorium patient named Anton Ferge as he undergoes a painful tuberculosis (TB) treatment. “I lie there with my face covered, so I can’t see anything,” Anton says. “I feel myself being pinched and squeezed, that is the flesh they are laying back and pegging down.” Ferge’s harrowing treatment is a lung-flattening artificial pneumothorax

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BioPharma Drive: Drug Pricing

NOVEMBER 5, 2024

The death, which investigators linked to a preparatory chemo treatment rather than Beam's medicine, highlights the risks of using decades-old transplant drugs alongside cutting-edge CRISPR medicines.

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Therapies Treatment Drugs 122

Science Daily: Pharmacology News

NOVEMBER 8, 2024

When people have an audience watching them, it can change their performance for better or worse. Now, researchers have found that chimpanzees' performance on computer tasks is influenced by the number of people watching them. The findings suggest that this 'audience effect' predates the development of reputation-based human societies, the researchers say.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

NOVEMBER 5, 2024

TUESDAY, Nov. 5, 2024 -- The omega-3 and omega-6 fatty acids in fish oil supplements might help protect people from cancer, a new study claims.Study participants with higher levels of omega-3s had lower rates of colon, stomach, lung and other.

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National Institute on Drug Abuse: Nora's Blog

NOVEMBER 4, 2024

Improving community engagement in addiction science mfleming Mon, 11/04/2024 - 19:11 Nora's Blog November 12, 2024 Image ©Getty Images/ MStudioImages Medical research can sometimes become disconnected from the interests and needs of the people it is intended to serve. This is true across diseases and disorders, and addiction research is no exception.

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BioPharma Drive: Drug Pricing

NOVEMBER 7, 2024

Elevidys sales have increased since the FDA made a controversial choice to expand the therapy's use. Now, Sarepta is abandoning a successor to its drug Exondys 51, citing an “evolving" treatment landscape.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

Researchers have developed an innovative technique to search for black hole light echoes. Their novel method, which will make it easier for the mass and the spin of black holes to be measured, represents a major step forward, since it operates independently of many of the other ways in which scientists have probed these parameters in the past.

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Research 129

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Alzheimer’s disease patients prescribed fistfuls of daily drugs are at greater risk of harm, a new study warns.Patients with Alzheimer’s prescribed five or more daily medications suffer from more symptoms, falls and hos.

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Disease Drugs 116

Codon

NOVEMBER 8, 2024

An opinion essay by Liyam Chitayat The cells within our body are the remnants of an ancient alliance. In a 1967 paper called “ On the Origin of Mitosing Cells ,” American evolutionary biologist Lynn Margulis proposed an idea that, upon first hearing, seems ludicrous. Her paper, in fact, was rejected by 12 different journals before it was published.

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BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

Bio-Rad’s extensive ddPCR assay offerings help researchers leverage the full power of digital PCR.

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Research 94

Science Daily: Pharmacology News

NOVEMBER 6, 2024

New research suggests that adding a small amount of physical activity -- such as uphill walking or stair-climbing -- into your day may help to lower blood pressure.

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Research 129

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

NOVEMBER 8, 2024

THURSDAY, Nov. 7, 2024 -- Men who undergo prostate cancer treatment face a greatly increased risk of life-altering, long-term complications, a new study finds.Surgery for prostate cancers increases a man’s risk of urinary or sexual complications m.

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Broad Institute

NOVEMBER 4, 2024

A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity By Corie Lok November 4, 2024 Breadcrumb Home A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease brings together Danish and Broad scientists.

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BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

As novel therapeutics become more complex — and costly — to bring to market, drug developers are looking to unified clinical development platforms to streamline operations.

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Science Daily: Pharmacology News

NOVEMBER 6, 2024

When Mount St. Helens erupted in 1980, lava incinerated anything living for miles around. As an experiment, scientists dropped gophers onto parts of the scorched mountain for only 24 hours. The benefits from that single day were undeniable and still visible 40 years later.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- After "Friends" star Matthew Perry was found dead in his home jacuzzi just over a year ago, an autopsy later pinpointed the main cause of death as an acute ketamine overdose. The coroner's report determined that high blood.

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Covalent Modifiers

NOVEMBER 7, 2024

Thomas M. Geiger, Radosław P. Nowak Annual Reports in Medicinal Chemistry , 2024 [link] Proteolysis targeting chimeras (PROTACs) are hetero-bifunctional molecules that remove disease-causing proteins through the means of targeted protein degradation (TPD). Since their proof-of-concept over 20 years ago, PROTACs emerged as new modality in drug discovery and chemical biology.

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BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

Wall Street analysts were impressed by data showing competitive rates of weight loss for Viking’s therapy, but shares in the company still slipped.

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Science Daily: Pharmacology News

NOVEMBER 5, 2024

Romance is a complex affair in humans. There's personality, appearance, seduction, all manner of physical and social cues. Mosquitoes are much more blunt. Mating occurs for a few seconds in midair. And all it takes to woo a male is the sound of a female's wingbeats. Imagine researchers' surprise when a single change completely killed the mosquitoes' libidos.

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Research 127

Drugs.com

NOVEMBER 5, 2024

TUESDAY, Nov. 5, 2024 -- Current treatments sometimes fail to help people with “wet” age-related macular degeneration -- and researchers now think they know why.Wet AMD is caused by an overgrowth of blood vessels in the retina, the light-sensing tis.

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Treatment Research 111

addgene Blog

NOVEMBER 5, 2024

Pre-made viruses have become increasingly accessible and are useful for saving time and avoiding potentially costly set-ups. However, there are many cases where the specific viral particles you need are not available, or the cost of custom viruses are too high for your budget. In those cases, you’ll need to produce your viruses in-house.

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BioPharma Drive: Drug Pricing

NOVEMBER 5, 2024

The company, which is only three years removed from one of biotech’s most lucrative IPOs, will cut jobs for a third time and invest more heavily in cell therapies for diabetes and lupus.

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Therapies 72

Science Daily: Pharmacology News

NOVEMBER 8, 2024

Tool use isn't unique to humans. Chimpanzees use sticks as tools. Dolphins, crows, and elephants are known for their tool-use abilities, too. Now a report highlights elephants' remarkable skill in using a hose as a flexible shower head. As an unexpected bonus, researchers say they also have evidence that a fellow elephant knows how to turn the water off, perhaps as a kind of 'prank.

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Research 124

Drugs.com

NOVEMBER 8, 2024

FRIDAY, Nov. 8, 2024 -- More than 1 in 5 Americans likely suffer from long COVID, a new AI-assisted review has found. The analysis suggests that nearly 23% of U.S. adults experience the symptoms of long COVID, according to results published Nov. 8.

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DrugBank

NOVEMBER 4, 2024

The World Health Organization (WHO) estimates that if current trends persist, antibiotic resistance could cause 10 million deaths annually by 2050. The pharmaceutical industry is the primary source of antibiotic innovation; therefore, it must lead the way in combating resistance.   Urgency of Antibiotic Resistance    The escalating threat of antibiotic resistance is an incoming global crisis projected to affect international health and the economy.

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BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

Per terms, Novo could pay up to $285 million in upfront and milestone fees to Ascendis, which specializes in a kind of drug-enhancing technology.

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