Forbes: Drug Truths

APRIL 6, 2023

Clearly, Canada would find such a situation untenable and the steps now being taken by British Columbia for Ozempic would be adopted across Canada.

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Chemical Biology and Drug Design

APRIL 7, 2023

Carbon–silicon bioisosteric switch as a strategy to modulate drug-like properties of anticancer agents: molecular design, biological activity modulation, computational modeling, and structure–activity relationship studies. Abstract Bioisosterism is one of the leading strategies in medicinal chemistry for the design and modification of drugs, consisting in replacing an atom or a substituent with a different atom or a group with similar chemical properties and an inherent biocompatibility.

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Antidote

APRIL 6, 2023

At any given time, there are hundreds of thousands of research studies listed on ClinicalTrials.gov actively looking for patients both in the United States and across the globe. However, the multitude of options available does not necessarily mean it’s easy for interested individuals to find opportunities they are eligible for. That’s why we created Antidote Match™, a clinical trial search tool that allows users to answer a few questions about their health and find clinical trial listings that c

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ProRelix Research

APRIL 5, 2023

Clinical trials form the decisions for regulatory approval of drugs and medical devices and as a result are the most important step of a drug development program. In addition to […] The post Investigator Initiated Trials (IITs): Introduction, regulatory view, study design preferences, and p … appeared first on ProRelix Research.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drug Patent Watch

APRIL 6, 2023

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Netherlands. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Netherlands? appeared first on DrugPatentWatch - Make Better Decisions.

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Chemical Biology and Drug Design

APRIL 3, 2023

Eight derivatives of benzyloxy-derived halogenated chalcones ( BB1-BB8 ) were synthesized and tested for their ability to inhibit monoamine oxidases (MAOs). Abstract Eight derivatives of benzyloxy-derived halogenated chalcones ( BB1-BB8 ) were synthesized and tested for their ability to inhibit monoamine oxidases (MAOs). MAO-A was less efficiently inhibited by all compounds than MAO-B.

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NIOSH Science Blog: Drugs

APRIL 4, 2023

Struck-By Injuries Struck-by injuries occur from violent contact or impact between an object or piece of equipment and a person. Struck-by injuries can be fatal, and even when a worker is not seriously injured can result in days off work to recover. To help prevent struck-by injuries, companies are encouraged to have a stand-down; a voluntary event for employers to talk directly to employees about safety.

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National Institute on Drug Abuse: Nora's Blog

APRIL 5, 2023

Creating Sustainable Homes for Prevention Services mfleming Wed, 04/05/2023 - 12:12 Nora's Blog April 12, 2023 Image ©Getty Images/ Willie B. Thomas The addiction and overdose crisis in the U.S. continues unabated, with more than 46 million people having a substance use disorder (SUD) in 2021 and more than 100,000 people dying from drug overdose annually.

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Nurses Research Drugs Regulations 59

Chemical Biology and Drug Design

APRIL 3, 2023

In this manuscript, we have discussed various biological targets of cancer with their drugs containing heterocyclic compound as benzimidazole shows effective response and better inhibitory activity against various cancer. Abstract Cancer is the second leading cause of death globally, with 9.6 million deaths yearly. As a life-threatening disease, it necessitates the emergence of new therapies.

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DNA Therapies FDA Treatment 100

FDA Law Blog: Biosimilars

APRIL 3, 2023

By Alan M. Kirschenbaum — On March 31, the Federal District Court for the District of Maryland upheld CMS’s definition of a “new formulation” under the Medicaid Drug Rebate Program (MDRP). Vanda Pharmaceuticals, Inc. v. CMS, Civ. No. MJM-22-977 (Dist. Md. 2023). By way of background, manufacturers are subject to an additional per-unit Medicaid rebate if they increase their prices greater than the rate of inflation.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

NIOSH Science Blog: Drugs

APRIL 7, 2023

Camilla started experiencing worsening respiratory symptoms while working at a plant that produces greeting cards. (Read about her symptoms here). Her doctor ordered tests to see what was happening with Camilla’s lungs. The results of two lung function tests showed concerning results. One was a carbon monoxide diffusing capacity test that estimates the ability of the lung to transfer oxygen from the air to the person’s bloodstream.

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Doctors 56

Drug Patent Watch

APRIL 7, 2023

Annual Drug Patent Expirations for KOSELUGO Koselugo is a drug marketed by Astrazeneca and is included in one NDA. It is available from one supplier. There are four patents protecting… The post New patent for Astrazeneca drug KOSELUGO appeared first on DrugPatentWatch - Make Better Decisions.

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Chemical Biology and Drug Design

APRIL 2, 2023

TFP5 treatment inhibited the overexpression of CDK5 in high glucose environment, reduced the inflammatory response, oxidative stress, and apoptosis of islet β cells. Abstract Islet β-cell damage and dysfunction represent the pathophysiological basis of diabetes. Excessive activation of cyclin-dependent kinase 5 (CDK5) is involved in the pathogenesis of type 2 diabetes mellitus (T2DM), although the exact mechanism remains unclear.

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Treatment Regulations Research 100

On Medicine

APRIL 6, 2023

Note from Prof. Steven Lipshultz, Editor-in-Chief of Cardio-Oncology , and Miriam Mestre, Managing Editor. This inaugural conference was jointly sponsored by Sofia’s Hope, the Cincinnati Children’s Heart Institute, and Oishei Children’s Hospital/Jacobs School of Medicine and Biomedical Sciences, University at Buffalo. The “ Cardio-Oncology Journal Prize” for top original research posters was sponsored by BMC.

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Clinical Trials

NIOSH Science Blog: Drugs

APRIL 3, 2023

Camilla works at a plant that produces greeting cards and ribbon products. She started working at the plant over 15 years ago when production first started. The plant is open around-the-clock for three shifts with workers in multiple departments across two floors of the building. Camilla worked in different departments over the years but spent the most time on the morning shift in greeting card production.

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Production 56

Drug Patent Watch

APRIL 7, 2023

Annual Drug Patent Expirations for TAZVERIK Tazverik is a drug marketed by Epizyme Inc and is included in one NDA. It is available from one supplier. There are twenty-four patents… The post New patent for Epizyme Inc drug TAZVERIK appeared first on DrugPatentWatch - Make Better Decisions.

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Chemical Biology and Drug Design

APRIL 1, 2023

Berberine has been shown in in vitro and in vivo studies to inhibit various types of cancer by activating the p-53 and cyclin-B expression, targeting various cell signalling pathways, to regulate the cell cycle. It also inhibits the invasion and metastasis of cancer cells. Besides this, it induces cell death by apoptosis, autophagy and necrosis in cancer cells.

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Therapies RNA Regulations Research 100

BMG Labtech

APRIL 5, 2023

The importance of drug solubility Today’s drug discovery environment demands efficiency, performance and safety. A crucial part of the process is the ability to perform ADMET (absorption, distribution, metabolism , elimination and toxicity) assays as early as possible in the drug development process. For example, researchers need to know quickly if a drug does not have the right toxicity profile before investing further resources and time in advancing it to preclinical and clinical testing.

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Clinical Trials

Cyclica

APRIL 6, 2023

As a proud “working mom,” Jen is the VP of Marketing and Communications at Cyclica. Prior to joining Cyclica, she spent 6 years working in Zürich, Switzerland, in marketing communications based roles within the biotech and tech sectors, including having led European Oncology and R&D communications at Amgen Europe. While always maintaining an active lifestyle by running, cycling, weight training, and yoga, living near the alps facilitated a newfound passion for hiking.

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Marketing 52

Drug Patent Watch

APRIL 6, 2023

Annual Drug Patent Expirations for XHANCE Xhance is a drug marketed by Optinose Us Inc and is included in one NDA. It is available from one supplier. There are thirteen… The post New patent for Optinose Us drug XHANCE appeared first on DrugPatentWatch - Make Better Decisions.

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Cytel

APRIL 5, 2023

Health technology assessment (HTA) submissions require cost effectiveness analyses based on comparative effectiveness studies of survival benefits vs. standard-of-care options in each specific geography. Ideally, these submissions are based on large, randomized control trials (RCTs), however, most new drugs approved in the last five years, specifically in oncology and rare diseases, are being approved based on small clinical trials, often un-controlled or single arm.

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Clinical Trials Trials Disease Drugs 52

H1 Blog

APRIL 5, 2023

For clinical operations and development clinical feasibility teams, diversity equity and inclusion and health equity leaders, as well as health economics and outcomes research (HEOR) teams, it is essential to understand the considerations when integrating data to help ensure inclusive and equitable compliant clinical trials that increase trust among patients, pharma, and study participants.

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Clinical Trials Trials Regulations Disease 52

BenchSci

APRIL 5, 2023

For our first Scale Up talk of the year, we hosted Luba Greenwood. Luba gracefully agreed to join us today to talk to us about her experience as a seasoned biotech, tech, pharmaceutical, and life sciences investor as well as a company builder. Luba’s career has taken her through multiple fields, including practicing law at WilmerHale, leading Business Development at Verily (Google), and serving as Vice President of Global Mergers & Acquisitions and Business Development at Roche.

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Drug Patent Watch

APRIL 6, 2023

Annual Drug Patent Expirations for BAFIERTAM Bafiertam is a drug marketed by Banner Life Sciences and is included in one NDA. It is available from one supplier. There are nineteen… The post New patent for Banner Life drug BAFIERTAM appeared first on DrugPatentWatch - Make Better Decisions.

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The Open Targets Blog

APRIL 5, 2023

Emmanouil Metzakopian is a group leader at the UK Dementia Research Institute at the University of Cambridge, as well as VP of Research and Development at bit.bio. He leads a number of neuroscience projects at Open Targets, one of which recently published a genetic screen aimed at finding genes whose inhibition could protect neurons against cell stress [1].

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Antidote

APRIL 5, 2023

Enrolling patients in clinical trials requires more than just effective outreach strategies. Even with strong recruitment, delays at the site level may cause potential participants to lose interest, while overwhelming sites with low-quality referrals can waste valuable time and resources.

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Clinical Trials Trials 52

FDA Law Blog: Biosimilars

APRIL 4, 2023

By Philip Won — South Korea has made significant achievements over the years in the biohealth industry, establishing the world’s second-largest biopharmaceutical manufacturing capacity. South Korea continues to drive the effort in the biohealth industry, which will lead to more Korean players in the U.S. market. The South Korean government has recently announced its plan to provide support for the growth of the nation’s biohealth industry, aiming to establish it as a significant and strategic se

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Production DNA Pharmaceuticals Government 52

Drug Patent Watch

APRIL 5, 2023

This chart shows which pharmaceutical companies received the most new drug approvals last year. The drug companies with the most new drugs last year are Almatica Azurity Gilead Sciences Inc… The post Pharmaceutical companies with the most drug approvals last year appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceutical Companies Pharmaceuticals Drugs Science 52

Metabolite Tales Blog

APRIL 4, 2023

Metabolism of 2022 FDA approved small molecule drugs part 2 Mixing it Up By Julia Shanu-Wilson In Part 1 of this topic we looked at metabolism of the small molecule drugs approved by the FDA in 2022 that were mediated by CYP3A4. In this follow-up blog, “Metabolism of 2022 FDA approved small molecule drugs part 2”, we dig into the other drugs in this set that are cleared by multiple CYPs, mixed phase mechanisms and through involvement of gut metabolism (see Table 1 at the end of this

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Codon

APRIL 4, 2023

Thank you for reading. 💙 If you enjoy this essay, consider subscribing. News fitting to the night, Black, fearful, comfortless and horrible. — Shakespeare, King John Only a handful of books and essays have ever made me cry. John Hershey’s “ Hiroshima ” and Atul Gawande’s “ Letting Go ,” both published in The New Yorker magazine, made me sob.

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Dark Matter Blog

APRIL 4, 2023

Prior to 2015, I had a casual relationship, at best, with targeting RNA. The bulk of my nearly three decades of experience up to that point was with drugging protein targets using a variety of modalities, but principally small molecules. This typically meant engaging with their functional pockets and thereby blocking their function. The concepts and technologies for binding to proteins and modulating their function are multifarious and mature, developed over decades of successes and failures, am

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Drug Patent Watch

APRIL 5, 2023

Annual Drug Patent Expirations for AUVELITY Auvelity is a drug marketed by Axsome and is included in one NDA. It is available from one supplier. There are one hundred patents… The post New patent for Axsome drug AUVELITY appeared first on DrugPatentWatch - Make Better Decisions.

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Crucial Data Solutions

APRIL 3, 2023

Whether you're a first-time user of electronic data capture software or you're an experienced user looking to improve your processes, this post provides some helpful insights on the benefits of EDC systems. The post Finding Efficiency – Top Three Benefits of Electronic Data Capture (EDC) appeared first on Crucial Data Solutions.

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