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(MIAMI) Researchers at the John P. Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine have found that variations in chromatin accessibility, and thus gene expression, may explain why people of European descent with APOE4 gene variants have a greater risk of developing Alzheimer’s disease than people of African descent with similar genetics.
Ming Fang, Gangam Srikanth Kumar, Stefano Racioppi, Heyang Zhang, Johnathan D. Rabb, Eva Zurek, and Qing Lin Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.2c12325 Here we report the design and synthesis of a new class of bioorthogonal reagents called hydrazonyl sultones (HS) that serve as stable tautomers of highly reactive nitrile imines (NI).
Ketcher: Drawing all types of S-Groups Consolidated into 1 Tool Drawing all types of S-Groups (data, superatoms, polymers, etc) in Ketcher has been consolidated into a single tool located on the left side of the structure editor. CDD Vault: Batch Links in Protocol & Run Fields When creating Protocol and Run fields, the Vault Administrator may now designate Batch Link data types.
There were plenty of scientific highlights from the literature that we didn’t have space for in Molecules of the Month – here’s a reader’s digest rounding up ~20 molecules of potential interest that we didn’t have space to highlight, including Pfizer’s covalent heterobifunctional BTK degrader, BMS’ brain-penetrant GSK-3β inhibitor, the discovery story of futibatinib from Taiho, and more snippets to jumpstart your reading!
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Lisa M. Boatner , Maria F. Palafox, Devin K. Schwepp, Keriann M. Backus Cell Chem. Bio. 2023 [link] Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential “druggability” for thousands of cysteine residues. Consequently, these studies are facilitating resources for closing the druggability gap, namely, achieving pharmacological manipulation of ∼96% of the human proteome that remains untargeted by U.S.
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Lisa M. Boatner , Maria F. Palafox, Devin K. Schwepp, Keriann M. Backus Cell Chem. Bio. 2023 [link] Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential “druggability” for thousands of cysteine residues. Consequently, these studies are facilitating resources for closing the druggability gap, namely, achieving pharmacological manipulation of ∼96% of the human proteome that remains untargeted by U.S.
By Philip Won & Jeffrey K. Shapiro — Does your firm manufacture a “cyber device”? A recent amendment to the Federal Food, Drug, and Cosmetic Act (FD&C Act) added a new section about cybersecurity for “cyber devices.” If a device uses software that connects to the internet, it is most likely a cyber device and subject to new section 524B of the FD&C Act, “Ensuring Cybersecurity of Devices.
Geraniol (GE) by its antioxidant, anti-inflammatory, and anti-apoptotic properties ameliorated global ischemia-reperfusion induced cascade of events such as oxidative stress, apoptosis, and inflammation. Thus, improved functional outcomes, and prevented neuronal infarction in rats. Abstract Geraniol (GE), an acyclic monoterpene, is a chief constituent of essential oils of herbs and fruits.
In situ clinical measurement of receptor occupancy (RO) is challenging, particularly for solid tumors, necessitating the use of mathematical models that predict tumor receptor occupancy to guide dose decisions. A potency metric, average free tissue target to initial target ratio (AFTIR), was previously described based on a mechanistic compartmental model, and is informative for near-saturating dose regimens.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Pharmacovigilance is defined by the World Health Organization (WHO) as “the science and activities relating to the detection, assessment, understanding, and prevention of adverse events or any other drug-related problems.” […] The post Pharmacovigilance Services for Signal Management: Process as per US FDA appeared first on ProRelix Research.
The key virulence factors like Kinetoplastid Membrane Protein–11 (KMP-11), Leishmanolysin (GP63), Proteophosphoglycan (PPG), Lipophosphoglycan (LPG), Glycosylinositol Phospholipids (GIPL), and others that play a role in the pathogenicity-host-pathogen relationship of the parasite. Abstract In tropical and subtropical regions of the world, leishmaniasis is endemic and causes a range of clinical symptoms in people, from severe tegumentary forms (such as cutaneous, mucocutaneous, and diffuse leishm
For individuals and companies that write health-focused blogs, continually finding topics to cover can be a challenge at times. Whether you’re a health influencer, patient advocacy organization, or another player in the clinical trial industry, finding unique topics to differentiate a blog is not always easy. However, through the below ideas and a unique voice, it is possible to write a plethora of clinical trial blogs that stick out from the rest.
Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. Gene-editing methods allow researchers to modify DNA, resulting in alterations in physical characteristics such as eye colour and susceptibility to diseases.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Today’s guest post comes from Megan Marchal, Director of Specialty Strategy at CoverMyMeds. Megan shares the story of Don, a cancer patient who struggled to access and afford his medications. She describes how human care plus an innovative, technology-driven patient support solution can help patients start therapy and get on the road to recovery. To learn more about CoverMyMeds’ specialty therapy solutions , visit Booth 1519 at Asembia's Specialty Pharmacy Summit in Las Vegas, April 30-May 4
Explainable artificial intelligence transparently influences the pre-drug development process with SHAP and LIME annotation methods. Abstract Recently, artificial intelligence (AI) techniques have been increasingly used to overcome the challenges in drug discovery. Although traditional AI techniques generally have high accuracy rates, there may be difficulties in explaining the decision process and patterns.
This chart shows the pharmaceutical companies with the most spray dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most spray dosed drugs… The post Which pharmaceutical companies have the most spray dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.
In today’s Federal Register , the agency has announced that the Office of Prescription Drug Promotion (OPDP) is adding a new study effort to its research portfolio. The category of that body of research that is currently underway includes a range of topics, including an assessment of terms and phrases commonly used in prescription drug promotion, studying the comprehension and understanding of multiple indications used in consumer television advertisements, and endorser status and explicit
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Eosinophilic esophagitis, also known as EoE, is a rare condition estimated to affect just one in 2,000 individuals. It is a disorder that impacts the esophagus (the tube connecting the mouth to the stomach) and leads to swallowing difficulties in both children and adults. To learn more about the impact of eosinophilic esophagitis , check out the information below.
Synergistic combinations of inhibitors are sought after. A small helically-constrained peptide potently inhibited p53-HDM2 interaction and exerted anti-proliferative effects on p53 +/+ cells. A combination of this peptide and a USP7 inhibitor showed synergistic anti-proliferative effects. Synergistic inhibition of two important drug targets may lead to novel therapeutic strategies.
This chart shows the pharmaceutical companies with the most patents in Ukraine. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Ukraine? appeared first on DrugPatentWatch - Make Better Decisions.
Baseball season is here! While we wait for the Phillies turnaround, let’s oil up our gloves, lace up our cleats, and run the bases around this month's biggest hits: Foul ball : OptumRx prefers higher prices for the first Humira biosimilar Strikeout : Copay accumulators hurt health equity Bench warmer : Surprise? Amazon has still not disrupted healthcare Spitting mad : Shady alternative funding programs (AFPs) face more scrutiny Plus, I sit down with Mark Cuban—and take a selfie.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Each year, NIOSH pauses on April 28th, Workers’ Memorial Day, to honor those who were killed or injured on the job. While tremendous progress has been made since Congress enacted the Occupational Safety and Health Act on this day in 1970, much still needs to be done. The Bureau of Labor Statistics reports that in 2021 more than 5,100 workers were killed and 2.6 million more were injured on the job.
The binding of autoantibodies to aberrantly glycosylated regions of IgA immunoglobulins is the culprit of IgA nephropathy (IgAN). Glycopeptides mimicking the natural gd-IgA1 epitope were synthesized using optimized protocols and shown to capture anti-gd-IgA1 autoantibodies when coupled to poly-L-lysine polymers, thereby providing a potential strategy for antibody sequestration in IgAN.
This chart shows the pharmaceutical companies with the most syrup dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most syrup dosed drugs… The post Which pharmaceutical companies have the most syrup dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.
We often think about the brain’s function in terms of its regions. But equally important is the way the brain connects across these regions, a process driven by neurons. By studying how neurons are physically connected, we can begin to understand how the brain works. It’s kind of like “the head bone’s connected to the neck bone,” but with about a hundred billion neurons and six hundred trillion connections (synapses.
Overview Construction workers are at risk for injuries from many sources, but falls continue to be the leading cause of death (accounting for 37% [379 out of the 1015 fatalities] of all construction fatalities in 2021). This year marks the 10th annual National Safety Stand-Down to prevent falls in construction, an event to raise awareness that falls among construction workers are preventable.
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