Science Daily: Pharmacology News

MAY 24, 2023

Taking a daily multivitamin may help slow age-related memory decline, a new study has found.

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Drug Hunter

MAY 21, 2023

This “journal club” article highlights five recent articles of general interest to drug discovery scientists, including reviews on therapeutic areas of interest, principles and areas of medicinal chemistry and pharmacology, and a synthetic transformation worth keeping in mind. 1. A “Magic Chloro” Med. Chem. Review D. Chiodi and Y. Ishihara (Vividion) J.

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Trials Drugs 144

Covalent Modifiers

MAY 24, 2023

Burns, A.R., Baker, R.J., Kitner, M. et al. Selective control of parasitic nematodes using bioactivated nematicides. Nature (2023) [link] Parasitic nematodes are a major threat to global food security, particularly as the world amasses 10 billion people amid limited arable land. Most traditional nematicides have been banned owing to poor nematode selectivity, leaving farmers with inadequate means of pest control.

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Marketing 130

Drug Policy Alliance

MAY 24, 2023

Minnesota Becomes 2nd State to Officially Support Overdose Prevention Centers msutton Wed, 2023-05-24 17:54 Wed, 05/24/2023 - 17:54

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Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Science Daily: Pharmacology News

MAY 25, 2023

There is a massive, mineral-rich region in the Pacific Ocean -- about twice the size of India -- called the Clarion-Clipperton Zone (CCZ), which has already been divided up and assigned to companies for future deep-sea mining. To better understand what may be at risk once companies start mining, a team of biologists has built the first 'CCZ checklist' by compiling all the species records from previous research expeditions to the region.

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Science Research 255

Covalent Modifiers

MAY 23, 2023

Elena Xerxa, Filip Miljković, and Jürgen Bajorath Journal of Medicinal Chemistry 2023 DOI: 10.1021/acs.jmedchem.3c00621 Large-scale analysis of public human and mouse protein kinase inhibitor (PKI) data identified more than 155,000 human PKIs (and ∼3000 murine PKIs), for which reliable activity measurements were available. Human PKIs were active against 440 kinases (85% coverage of the kinome).

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Drug Discovery Today

MAY 26, 2023

BARCELONA/LONDON, 25.05.23: Seqera Labs, the leading provider of secure workflow orchestration software in the life sciences sector, has partnered with Genomics England, the government-owned company that launched the 100,000 Genomes Project in partnership with the NHS. The new collaboration between Seqera Labs and Genomics England will enable whole genome analysis to be carried out at a larger scale with greater efficiency, helping more patients benefit from genomic healthcare and equipping rese

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Science Daily: Pharmacology News

MAY 24, 2023

A team of engineers has recently shown that nearly any material can be turned into a device that continuously harvests electricity from humidity in the air. Researchers describe the 'generic Air-gen effect'-- nearly any material can be engineered with nanopores to harvest, cost effective, scalable, interruption-free electricity. The secret lies in being able to pepper the material with nanopores less than 100 nanometers in diameter.

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Drug Hunter

MAY 21, 2023

This article highlights six recent articles of interest in the field of targeted protein degradation including but not limited to potentially new ligases, recruiting motifs, and a discussion on the feasibility of CNS-penetrant degraders. 1. “Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings” Novartis, Basel, CH + Cambridge, MA BioRxiv , April 14, 2023 This Novartis study identified a novel non-covalent ligand for the E3 ligase receptor DCAF1 for use in

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Targeted Protein Degradation Trials Therapies Disease 131

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Covalent Modifiers

MAY 22, 2023

Yi Zhang, Hong Yang, Bingbing Li, Jiayi Li, Huaxuan Li, Qiongyu Shi, Bang Li, Zekun Wang, Jiahong Zheng, Ying Zhang, Hui Dong, Xun Huang, and Yuanxiang Wang Journal of Medicinal Chemistry 2023 DOI: 10.1021/acs.jmedchem.3c00504 The first-generation enhancer of zeste homologue 2 (EZH2) inhibitors suffer from several limitations, such as high dosage, cofactor S-adenosylmethionine (SAM) competition, and acquired drug resistance.

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Drugs 130

Drug Discovery Today

MAY 26, 2023

New branding reflects customer-centric approach and showcases pioneering, single cell analysis technology Rebrand follows a period of significant growth for the Company, including key leadership team appointments, state-of-the-art facility expansion, and new scientific partnerships

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Science Daily: Pharmacology News

MAY 24, 2023

Engineers have designed a new class of 'microrobots' several times smaller than the width of a human hair that may be able to treat human illnesses like interstitial cystitis -- a painful bladder disease that affects millions of Americans.

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Disease Engineering 228

Drug Patent Watch

MAY 22, 2023

Introducing DrugChatter.com: Empowering Access to Biopharmaceutical Drug Insights through AI Chat We are pleased to introduce DrugChatter.com, a groundbreaking platform that redefines the way professionals obtain concise, cited information on… The post DrugChatter.com: AI Chat for Biopharmaceutical Drug Insights appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs 105

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Covalent Modifiers

MAY 20, 2023

Taylor O. Hope, Tamara Reyes-Robles, Keun Ah Ryu, Steven Mauries, Nicole Removski, Jacinthe Maisonneuve, Rob C. Oslund,* Olugbeminiyi O. Fadeyi,* and Mathieu Frenette* Chemical Science , 2023 DOI: 10.1039/D3SC00638G Flavin-based photocatalysts such as riboflavin tetraacetate (RFT) serve as a robust platform for light-mediated protein labelling via phenoxy radical-mediated tyrosine-biotin phenol coupling on live cells.

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Science 130

Drug Discovery Today

MAY 25, 2023

The Facility will have capacity that exceeds today’s global plasmid DNA demand and can enable commercialisation of genetic medicines. Transformation of Grade II-listed Victorian waterworks on the River Thames in Hampton, London. Supplying many of the top biopharmaceutical companies in the world to dramatically enhance their ability to develop genetic medicines.Expansion follows recent acceptance of a Drug Master File and first investigational new drug application using doggybone DNA.

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DNA Drugs 113

Science Daily: Pharmacology News

MAY 25, 2023

New animal research is helping explain why at least five people have become HIV-free after receiving a stem cell transplant, and may bring scientists closer to developing what they hope will be a widespread cure for the virus that causes AIDS. A new study describes how two nonhuman primates were cured of the monkey form of HIV after receiving a stem cell transplant.

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Research Virus 224

Chemical Biology and Drug Design

MAY 25, 2023

PTP1B is a negative insulin signaling pathway regulator; hence, inhibiting PTP1B increases insulin sensitivity, glucose absorption, and energy expenditure. Abstract Diabetes mellitus (DM) is a serious global health concern affecting over 500 million people. To put it simply, it is one of the most dangerous metabolic illnesses. Insulin resistance is the root cause of 90% of all instances of diabetes, all of which are classified as Type 2 DM.

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Research Regulations Drugs 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Antidote

MAY 25, 2023

Lupus is a chronic, autoimmune disease that can be extremely difficult to identify and treat. Lupus can occur in anyone , and symptoms can range from mild to life threatening. Consequently, raising awareness and promoting early diagnosis is so important to identify and manage this condition.

Disease 98

Disease 98

Drug Channels

MAY 24, 2023

In The Top Pharmacy Benefit Managers of 2022: Market Share and Trends for the Biggest Companies , I shared Drug Channels Institute's analysis showing that three pharmacy benefit managers (PBMs)—the Caremark business of CVS Health, the Express Scripts business of Cigna, and the OptumRx business of UnitedHealth Group—accounted for about 80% of total equivalent prescription claims in 2022.

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Pharmacy Pharmaceuticals Marketing Drugs 98

Science Daily: Pharmacology News

MAY 25, 2023

Using AI, researchers identified a new antibiotic that can kill Acinetobacter baumannii, a type of bacteria that is responsible for many drug-resistant infections.

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Drugs Research 208

Chemical Biology and Drug Design

MAY 23, 2023

Lanosterol 14α-demethylase (CYP51) responsible for oxidative removal of 14α-methyl group of sterol precursors, lanosterol, and 24(28)-methylene-24,25-dihydrolanosterol in ergosterol biosynthesis; essential component of fungal life cycle and prominent target for antifungal drug development. This review addresses various azole- and non-azoles-based derivatives as potential antifungal agents that target fungal CYP51.

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Drug Development Drugs 100

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

KIF1A

MAY 24, 2023

What do worms, a classroom full of students, and members of the KAND family community have in common? A lot more than you’d think! In this blog post, KIF1A.ORG Chief Science Officer Dr. Dominique Lessard describes a unique cross disciplinary experience with multiple scientific stakeholders in the rare disease space, all focused around our holistic understanding of KAND.

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Drug Channels

MAY 23, 2023

In 2022, the PBM market remained highly consolidated—although there were some intriguing share shifts among the largest players. Below, you’ll find Drug Channels Institute's latest estimates of pharmacy benefit manager (PBM) market share based on equivalent prescription claims. I also provide commentary on recent market developments and offer some helpful tips for interpreting the figures.

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Pharmacy Marketing Drugs 98

Science Daily: Pharmacology News

MAY 24, 2023

A new study tracked the ability of natural, synthetic, and blended fabrics to biodegrade directly in the ocean.

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Chemical Biology and Drug Design

MAY 21, 2023

Lericiresinol inhibited RA-induced inflammation by maintaining the delicate balance of pro-inflammatory and anti-inflammatory cytokines. It exhibits a strong anti-inflammatory effect against CFA rats via interfering with TGF-α and NF-κB. Abstract Rheumatoid arthritis (RA) is a severe inflammatory auto-immune disorder affecting millions of people across the globe.

Research 100

Research 100

Antidote

MAY 22, 2023

Participating in a clinical trial can be a worthwhile opportunity for any individual. Whether taking part as a healthy volunteer or enrolling in a study for a specific condition, being a medical research participant can provide the chance to be more involved in medical treatments, gain access to potential new therapies, and pave the way for medical breakthroughs to take place.

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Clinical Trials Trials Therapies Treatment 98