Drug Discovery World
JUNE 26, 2024
The DDW Summer issue looks at where the global biotech hubs are for drug discovery and development, asks how 3D genomics can accelerate personalised medicine, and looks at the technological advances in mass spectrometry. It also includes an exclusive global cancer research guide examining the innovation happening in this sector. DDW Summer 2024 The post DDW Summer 2024 appeared first on Drug Discovery World (DDW).
Broad Institute
JUNE 27, 2024
A therapy candidate for fatal prion diseases turns off disease-causing gene By Corie Lok June 27, 2024 Breadcrumb Home A therapy candidate for fatal prion diseases turns off disease-causing gene Whitehead and Broad scientists have developed a gene-silencing tool that could pave the way for a new class of genetic approaches to treat certain diseases.
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BioPharma Drive: Drug Pricing
JUNE 27, 2024
A growing cohort of biotechs, from Biohaven to Neurocrine to Jazz, hope research on ion channels will bring them new drugs and big business — much like it has done for Vertex.
Drugs.com
JUNE 28, 2024
FRIDAY, June 28, 2024 -- As a summer wave of COVID infections rolls across the country, U.S. health officials have recommended that all Americans over the age of 6 months get one of the updated COVID vaccines when they become available this.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JUNE 26, 2024
Spinogenix has initiated a Phase II trial to evaluate SPG302 for the treatment of adult participants with mild-to-moderate Alzheimer’s disease (AD), following approval for the trail in Australia. The study will assess the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of SPG302 in adult AD participants. The clinical trial will consist of two parts: a pilot, placebo-controlled, randomised safety and preliminary efficacy cohort (Part A) and an expansion cohort (Part
Broad Institute
JUNE 25, 2024
Gut microbiome changes align with increased risk of type 2 diabetes By Tom Ulrich June 25, 2024 Breadcrumb Home Gut microbiome changes align with increased risk of type 2 diabetes Specific species and strains of bacteria linked to changes in the functioning of the gut microbiome and a person's risk of type 2 diabetes By Jennifer Welsh, Brigham and Women's Hospital June 25, 2024 Credit: Donny Bliss, NIH Illustration depicting gut bacteria.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
JUNE 27, 2024
THURSDAY, June 27, 2024 -- It's a nasty cycle: Chronic migraine sufferers who use too much pain medication sometimes get smacked with rebound headaches. But new research suggests that a medication commonly used to prevent migraines may also help.
Drug Discovery World
JUNE 27, 2024
The DDW Summer issue is out now and looks at where the global biotech hubs are for drug discovery and development, asks how 3D genomics can accelerate personalised medicine, and looks at the technological advances in mass spectrometry. It also includes an exclusive global cancer research guide examining the innovation happening in this sector. Read the digital version here.
BioPharma Drive: Drug Pricing
JUNE 26, 2024
Obesity drugs like Wegovy are proving useful in many other diseases. Polycystic ovary syndrome, a chronic condition that can cause infertility, may be one.
Science Daily: Pharmacology News
JUNE 26, 2024
A new study documents the first case of Down syndrome in Neanderthals and reveals that they were capable of providing altruistic care and support for a vulnerable member of their social group.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JUNE 28, 2024
FRIDAY, June 28, 20204 (HealthDay news) -- An immunotherapy/chemotherapy combo drug can help early-stage breast cancer patients remain cancer-free following treatment, a new trial shows. The combo drug, Kadcyla, is already approved to treat.
Drug Discovery World
JUNE 24, 2024
Insilico Medicine has completed patient enrolment in a Phase IIa study in China, which is investigating the safety, tolerability, and preliminary efficacy of AI-designed TNIK inhibitor INS018_055 for idiopathic pulmonary fibrosis (IPF). The randomised, double-blind, placebo-controlled study is being conducted across 29 clinical centres in China and has completed enrolment of the planned target of 71 patients in four participant groups, including three experimental and one placebo.
BioPharma Drive: Drug Pricing
JUNE 26, 2024
The findings provide early proof that multiple doses of a gene editing medicine can be safely administered with additive effects, overcoming a key constraint of the complex therapies.
Science Daily: Pharmacology News
JUNE 24, 2024
Research shows that the increasingly popular weight-loss strategy is safe. Intermittent fasting has become an increasingly popular way to lose weight without counting calories. And a large body of research has shown it s safe. Still, several myths about fasting have gained traction.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
JUNE 28, 2024
FRIDAY, June 28, 2024 -- The U.S. Supreme Court on Thursday struck down a controversial settlement that drug maker Purdue Pharma had reached with victims of the opioid epidemic.The ruling threatens a massive bankruptcy plan that would have.
Drug Discovery World
JUNE 27, 2024
Genomic medicine developer Exsilio Therapeutics has emerged from stealth with $82 million in Series A financing. The funding was co-led by Novartis Venture Fund and Delos Capital, with participation from OrbiMed, Insight Partners, JP Morgan Life Sciences Private Capital, CRISPR Therapeutics, Innovation Endeavors, Invus, Arc Ventures, and Deep Insight.
Drug Patent Watch
JUNE 27, 2024
Introduction Patent portfolios are critical assets for pharmaceutical companies, providing market exclusivity and protecting revenue streams for drug products. Effective management of drug patent portfolios requires strategic planning, ongoing evaluation, and adaptation to the evolving pharmaceutical landscape. This article explores key best practices for optimizing drug patent portfolios to maximize value and maintain competitive advantage.
Science Daily: Pharmacology News
JUNE 25, 2024
In October 2013 a researcher made a surprising discovery of Painted Lady Butterflies on the Atlantic beaches of French Guiana -- a species not typically found in South America. This unusual sighting prompted an international study to investigate the origin of these butterflies.
Drugs.com
JUNE 25, 2024
TUESDAY, June 25, 2024 -- A new slow-release pill form of ketamine can quell hard-to-treat depression without producing psychedelic side effects normally associated with the drug, early research suggests. Patients on the strongest dose of ketamine.
Drug Discovery World
JUNE 28, 2024
A new Phase II trial, REGENERATE-PD, will study AB-1005, an adeno-associated virus 2 (AAV2) glial cell line-derived neurotrophic factor (GDNF) gene therapy for the treatment of moderate-stage Parkinson’s disease. The trial will include an estimated 87 subjects with study sites located in the US, UK and Europe. In January, AskBio announced that the Phase Ib trial of AB-1005 met its primary endpoint, which was to evaluate the safety of a one-time bilateral delivery of AB-1005 directly to the putam
Perficient: Drug Development
JUNE 27, 2024
In 1968, psychiatrist Stephen Karpman modeled what he called the Drama Triangle. With this, he illustrated dysfunctional mindsets that can derail social interactions. The three roles defined in this model are the rescuer (hero), persecutor (villain), and victim. This is another view of the lies we tell ourselves. Since the dawn of history, we’ve loved stories.
Science Daily: Pharmacology News
JUNE 24, 2024
A doubling of the amount of CO2 in the atmosphere could cause an increase in the average temperature on earth from 7 to even a maximum of 14 degrees. That is shown in the analysis of sediments from the Pacific Ocean off the coast of California.
Drugs.com
JUNE 25, 2024
TUESDAY, June 25, 2024 -- A well-established cholesterol-lowering drug appears to significantly slow the progression of a diabetes-related eye disease, a new trial shows. Fenofibrate (Tricor) has been approved since 2004 as a means of lowering.
Drug Discovery World
JUNE 28, 2024
EXO Biologics has completed dosing of the first cohort of patients in its EVENEW study, the first European Medicines Agency (EMA) authorised clinical trial involving mesenchymal stromal cell (MSC)-based exosomes. The Phase I/II clinical trial is testing the company’s lead candidate EXOB-001, developed to prevent bronchopulmonary dysplasia (BPD), the most common cause of death in preterm newborns.
Perficient: Drug Development
JUNE 28, 2024
If you are using ServiceNow as your IT service management platform, you might want to make your catalog items searchable in Microsoft Search. Microsoft Search is a unified search experience that helps you find what you need across your organization, including files, sites, people, and more. By connecting your ServiceNow catalog items to Microsoft Search, you can enable your users to find and request them directly from the Microsoft 365 apps.
Science Daily: Pharmacology News
JUNE 26, 2024
A new study by a team of international researchers has uncovered a biological explanation for long-term memories. It centers on the discovery of the role of a molecule, KIBRA, that serves as a 'glue' to other molecules, thereby solidifying memory formation.
Drugs.com
JUNE 28, 2024
FRIDAY, June 28, 2024 -- A new "microrobot" pill may help tame inflammatory bowel disease (IBD), a new study in mice suggests.The pill significantly reduced IBD symptoms in mice and promoted the healing of damaged colon tissue without toxic side.
Drug Discovery World
JUNE 27, 2024
Novo Nordisk has announced results from the Phase III FRONTIER2 trial of 254 adults and adolescents aged 12 years and over with haemophilia A, with and without inhibitors. The trial assessed both once-weekly and once-monthly prophylactic treatment with the investigational treatment Mim8. The data were presented at the International Society of Thrombosis and Haemostasis Annual Congress (ISTH 2024) in Bangkok, Thailand.
BioPharma Drive: Drug Pricing
JUNE 28, 2024
Federal courts will no longer have to defer to agency regulations for interpretation of ambiguous statutes, a ruling that could have significant impact on the FDA and CMS.
Drug Patent Watch
JUNE 25, 2024
DrugChatter is an innovative AI-powered search and answer engine designed to revolutionize how we access and comprehend information. Harnessing the power of advanced natural language processing, DrugChatter provides concise, accurate, and contextually relevant answers to a wide array of questions, making information retrieval faster and more intuitive than ever before.
Drugs.com
JUNE 24, 2024
MONDAY, June 24, 2024 -- Following state legislation passed in 2021 that essentially banned abortion in Texas, the rate of infant deaths rose by almost 13%, compared to a much smaller 1.8% rise nationwide, a new study finds.The number of Texan.
Drug Discovery World
JUNE 27, 2024
Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than CRISPR. SeekRNA uses a programmable ribonucleic acid (RNA) strand that can directly identify sites for insertion in genetic sequences, simplifying the editing process and reducing errors. The new gene-editing tool is being developed by a team led by Dr Sandro Ataide in the School of Life and Environmental Sciences.
Science Daily: Pharmacology News
JUNE 28, 2024
The Coral Triangle, also known as the Indo-Australian Archipelago, is renowned for having the greatest marine biodiversity on our planet. Despite its importance, the detailed evolutionary history of this biodiversity hotspot has remained largely a mystery. An international research team has now shed light on this history, reconstructing how biodiversity in the region has developed over the past 40 million years.
Drug Patent Watch
JUNE 26, 2024
This is an example from the DrugPatentWatch AI Research Assistant, which is available with DrugPatentWatch subscriptions. The DrugPatentWatch AI Research Assistantuses sophisticated AI algorithms to understand and process your questions, delivering precise answers. It goes beyond simple keyword matching, comprehending the intent and context of questions to provide meaningful and relevant responses.
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