Practical Cheminformatics

JUNE 12, 2023

Introduction If you believe everything you read in the popular press, this AI business is easy. Just ask ChatGPT, and the perfect solution magically appears. Unfortunately, that's not the reality. In this post, I'll walk through a predictive modeling example and demonstrate that there are still a lot of subtleties to consider. In addition, I want to show that data is critical to building good machine learning (ML) models.

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Drugs.com

JUNE 14, 2023

WEDNESDAY, June 14, 2023 -- Most women diagnosed with early breast cancer will become long-term survivors, according to new research that finds a substantial reduction in the risk of death since the 1990s. This news should reassure both patients and.

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Fierce BioTech

JUNE 13, 2023

Puerto Rico: A Hub of Opportunity for Non-Dilutive Funding | Puerto Rico is becoming the best place in the world to conduct R&D activities for emerging technologies. Could your organization maximize growth potential by capitalizing on Puerto Rico’s unique tax incentives & culture of innovation?

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BioPharma Drive: Drug Pricing

JUNE 14, 2023

The FDA last year turned back an approval request from the drug’s former developer, Levo Therapeutics. That biotech is now owned by Acadia, which will run a new study designed to boost its odds of success.

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FDA Drugs 118

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Broad Institute

JUNE 14, 2023

Researchers identify gut microbiome signatures linked to precancerous colon polyps By Tom Ulrich June 14, 2023 Breadcrumb Home Researchers identify gut microbiome signatures linked to precancerous colon polyps New study looks at gut microbes' influence, findings may help with prevention By MGH News And Public Affairs June 14, 2023 Credit: NCI Center for Cancer Research Human colon cancer cells.

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Drugs.com

JUNE 14, 2023

WEDNESDAY, June 14, 2023 -- When a loved one is diagnosed with Alzheimer's disease, it can be a challenging and emotional journey for the individual and their family. Understanding the progression of the disease and recognizing the changes in.

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Disease 119

BioPharma Drive: Drug Pricing

JUNE 15, 2023

Lilly will pay the genetic medicine specialist $60 million upfront to work together on a treatment targeting a risk factor known as Lp(a).

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Disease Therapies Treatment 128

Antidote

JUNE 12, 2023

High blood pressure, also known as hypertension, is one of the most common conditions impacting U.S. adults. Often called the “silent killer” because it often presents no symptoms, hypertension is responsible for a vast majority of premature deaths around the world.

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Drugs.com

JUNE 14, 2023

WEDNESDAY, June 14, 2023 -- The U.S. Food and Drug Administration approved Linzess (linaclotide) as a once-daily treatment for pediatric patients ages 6 to 17 years with functional constipation. The approval was based on data from 328 participants.

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FDA Approval FDA Treatment Drugs 119

KIF1A

JUNE 10, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research A Sideroflexin/Connexin adaptor ties kinesin-3 to mitochondria in neurons If your grocery store was out of both apples and oranges, you might think there are two shortages: apples and oranges.

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Clinical Trials FDA Regulations Disease 98

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 12, 2023

Decentralized clinical trials (DCTs) bring many benefits to the clinical research process, and more importantly, the patients. However, it is important to remember the risks if there is no data security process in place.

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Clinical Trials Trials Clinical Research Research 109

Drug Channels

JUNE 13, 2023

Time for Drug Channels ’ annual update on pricing at the largest pharmaceutical manufacturers. This year’s review includes the following 10 companies: Eli Lilly and Company, Genentech, GlaxoSmithKline, Janssen, Merck, Novartis, Novo Nordisk, Sanofi, Takeda, and UCB. You can find links to each company’s data below. When rebates and discounts were factored in, brand-name drug prices again declined—or grew slowly—in 2022.

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Pharmaceuticals Drugs 98

Drugs.com

JUNE 14, 2023

WEDNESDAY, June 14, 2023 -- Lesbians, gays and bisexuals are experiencing more mental health and substance use issues than their heterosexual peers, researchers say. According to a new government report released Tuesday, this includes major.

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Government Drugs Research 117

The ChEMBL-og

JUNE 13, 2023

We are pleased to announce the release of ChEMBL 33! This fresh release comes with a few new data soures and also some new features: we added bioactivity data for understudied SLC targets from the RESOLUTE project and included a flag for Natural Products and for Chemical Probes. An an annotation for the ACTION_TYPE of a measurement was included for approx. 270 K bioactivities.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 12, 2023

DeSouza is departing unrepentant about his decision to close the Grail deal, telling colleagues his belief in the merger “remains unshakeable.

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Science Daily: Pharmacology News

JUNE 13, 2023

Computer models confirm that the African Superplume is responsible for the unusual deformations, as well as rift-parallel seismic anisotropy observed beneath the East African Rift System.

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Drugs.com

JUNE 15, 2023

THURSDAY, June 15, 2023 -- An advisory panel to the U.S. Food and Drug Administration voted unanimously on Thursday to recommend that COVID booster shots be updated for the fall to protect solely against one of the three XBB variants that have taken.

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FDA Drugs 116

biobide

JUNE 16, 2023

Muscular diseases encompass a broad range of debilitating conditions that affect muscle structure and function, resulting in a significant impairment in mobility and overall quality of life. These diseases, which embrace muscular dystrophies, myopathies, and other neuromuscular disorders, pose substantial challenges for patients, their families, and the healthcare system due to the high dependence on the affected patients, caregivers, and healthcare professionals.

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Drug Target Review

JUNE 15, 2023

In this article Drug Target Review’s Izzy Wood spoke to Sam Hasson, Director of Target Biology at Rgenta Therapeutics, a biotech firm in Massachusetts, US, that aims to develop small molecule therapeutics to target RNA processing. We discussed the challenges and opportunities in the field of RNA-centric drug discovery and the potential impact of their work in oncology and neurological indications.

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Perficient: Drug Development

JUNE 15, 2023

The dreaded Sitecore upgrade. What seems like it should be straightforward can be deceptively complex. From architectural shifts like the move from Mongo to SQL for xDB, the addition of additional services like Identity Server or the move from Azure Search back to SOLR all add complexity to the upgrade process. You’ll also need to account for depreciated code in both dot net versions as well as Sitecore.

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Licensing Licensing Production 96

Drugs.com

JUNE 16, 2023

FRIDAY, June 16, 2023 -- Is heartburn keeping you awake? Do you experience a bitter taste in your mouth? Your doctor says you have GERD, but what is GERD? Gastroesophageal reflux disease (GERD) occurs when the contents of your stomach move up into.

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Doctors Disease 111

Antidote

JUNE 16, 2023

Despite being relatively small organs, the kidneys are extremely important to the functioning of the human body. Their main function is to filter the blood, eliminating wastes, toxins, and excess fluids. They also are responsible for producing hormones and regulating various salts and minerals that are necessary for bodily functions.

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Disease Regulations 96

SCIENMAG: Medicine & Health

JUNE 14, 2023

People in the earliest stage of Alzheimer’s disease — after brain changes have begun but before cognitive symptoms become apparent — harbor an assortment of bacteria in their intestines that differs from the gut bacteria of healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

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Disease Research 96

Crown Bioscience

JUNE 13, 2023

Cancer research studies have traditionally relied on 2D systems, but researchers are increasingly turning to 3D cell cultures. This is because they better recapitulate the original tissue architecture, which is known to affect key cellular processes, including cell signaling, proliferation, viability, and drug response. By providing more physiologically relevant models, 3D cell cultures can bridge the gap between in vitro and in vivo models.

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Drugs.com

JUNE 15, 2023

THURSDAY, June 15, 2023 (American Heart Association News) -- Dads get plenty of attention on Father's Day, but they've sometimes been overlooked in research about how they affect their children's health. But from the start, fathers shape their.

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Research 111

Drug Target Review

JUNE 12, 2023

Insilico Medicine’s revolutionary AI (Artificial Intelligence) platform, Chemistry42, has successfully developed a ground-breaking molecule called ISM6331. This molecule shows immense potential as a pan-TEAD inhibitor, targeting advanced solid tumours. TEAD proteins are crucial for tumour progression and drug resistance, making them an attractive focus for therapeutic interventions.

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SCIENMAG: Medicine & Health

JUNE 14, 2023

Latest Consensus Statement on Concussion in Sport includes: New and updated age appropriate tools to aid identification and management of condition New versions of return to active sport and education strategies Stronger evidence for benefits of light intensity exercise within first 48 hours to aid recovery New targeted approach to rehabilitation Call for interdisciplinary working […]

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International 95

Science Daily: Pharmacology News

JUNE 15, 2023

Research team predicts Arctic without ice by the end of 2030s if current increasing rate of greenhouse gas emission continues.

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Research 110

Drugs.com

JUNE 15, 2023

THURSDAY, June 15, 2023 -- For the first time, researchers at the U.S. Centers for Disease Control and Prevention have broken down statistics on depression among Americans, pinpointing which states the debilitating illness is most likely to.

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Disease Research 110

BioPharma Drive: Drug Pricing

JUNE 13, 2023

In a sign of the impact the downturn has had on young biotechs, Turnstone Biologics, a former partner of Takeda and AbbVie, is seeking an IPO while acknowledging there is “substantial doubt” it can survive.

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Therapies 83

SCIENMAG: Medicine & Health

JUNE 14, 2023

On Friday, May 19, 2023, Impossible Sensing, along with a team of scientists and engineers from SETI Institute, NASA JPL, University of Washington’s Applied Physics Laboratory and other institutions onboard Ocean Exploration Trust’s Exploration Vessel Nautilus expedition, successfully launched InVADER Mission’s Laser Divebot into the deep waters surrounding Kingman Reef and Palmyra Atoll.

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Science Daily: Pharmacology News

JUNE 15, 2023

Researchers have used the genome-editing tool CRISPR-Cas to create disease resistant rice plants, according to a new study. Small-scale field trials in China show that the newly created rice variety exhibited both high yields and resistance to the fungus that causes a serious disease called rice blast.

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Drugs.com

JUNE 16, 2023

FRIDAY, June 16, 2023 -- A new study has unearthed significant racial disparities in both treatment and outcomes for peripheral artery disease (PAD). Black patients with this condition, where plaque builds up in the arteries of the legs, were more.

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addgene Blog

JUNE 15, 2023

If you study proteins, you’re probably quite interested in the canonical 20 amino acids. But in your quest to learn more about your protein of interest, you may find the available amino acids a bit…limiting. It may be time, then, to look towards genetic code expansion (GCE): techniques in which non-canonical amino acids (ncAAs, also sometimes called unnatural amino acids) are placed in a protein site-specifically to alter its function, mimic a biologically relevant modification, or add in fluore

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