Sat.Jul 15, 2023 - Fri.Jul 21, 2023

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Cell therapy startup Turnstone adds to biotech IPO flurry with $80M raise

BioPharma Drive: Drug Pricing

The offering is a financial lifeline for Turnstone and the fourth for the sector this month, the first time that’s happened in nearly a year and a half, according to BioPharma Dive data.

Therapies 246
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How NSAIDs Can Make a C. Difficile Infection Worse

Drugs.com

FRIDAY, July 21, 2023 -- Aspirin, naproxen and other common pain medications known as NSAIDs worsen gastrointestinal infections caused by a bacterium known as Clostridioides difficile (C. diff), new research shows. NSAIDs (nonsteroidal.

Research 246
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Life on Earth didn't arise as described in textbooks

Science Daily: Pharmacology News

No, oxygen didn't catalyze the swift blossoming of Earth's first multicellular organisms. The result defies a 70-year-old assumption about what caused an explosion of oceanic fauna hundreds of millions of years ago.

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Drug Discovery Industry Roundup with Barry Bunin — July 19, 2023

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin — July 11, 2021

Drugs 246
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Idorsia warns of up to 500 layoffs as part of cost-cutting initiative

BioPharma Drive: Drug Pricing

The Swiss drugmaker now joins a lengthy list of biotechs that, amid a drawn-out market downturn, have turned to job cuts and research re-evaluations to save money.

Marketing 246

More Trending

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Greenland melted recently, shows high risk of sea level rise today

Science Daily: Pharmacology News

A large portion of Greenland was an ice-free tundra landscape -- perhaps covered by trees and roaming woolly mammoths -- in the recent geologic past (about 416,000 years ago), a new study shows. The results help overturn a previous view that much of the Greenland ice sheet persisted for most of the last two and a half million years. Instead, moderate warming, from 424,000 to 374,000 years ago, led to dramatic melting.

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Molecules of the Month – June 2023

Drug Hunter

With the popular success of diabetes and weight-loss peptide drugs from Novo (e.g. semaglutide/Ozempic), this month features a pair of ultra-hot non-peptide oral GLP-1R modulators in clinical development. Other notable Molecules of the Month include vorasidenib, which demonstrated headline-generating efficacy in brain cancers, as well as controversial billion-dollar molecule atrasentan, the subject of a short-seller report by Muddy Waters.

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Pfizer, Flagship join forces to hunt for 10 new drugs

BioPharma Drive: Drug Pricing

The unusual research alliance involves the startup creator’s Pioneering Medicines initiative, which previously struck pacts with Novo Nordisk and the Cystic Fibrosis Foundation.

Drugs 246
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Scientists Spot 32 Proteins That Hint at Alzheimer's Risk

Drugs.com

THURSDAY, July 20, 2023 -- It’s difficult to fully predict who will develop Alzheimer’s disease in advance. Now, a new study suggests that certain markers in the blood may occur 10 to 20 years before the start of symptoms and could help.

Disease 246
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Miocene period fossil forest of Wataria found in Japan

Science Daily: Pharmacology News

An exquisitely preserved fossil forest from Japan provides missing links and helps reconstruct a whole Eurasia plant from the late Miocene epoch.

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U.S Government Wants Reasonably Priced Covid-19 Vaccines

Forbes: Drug Truths

Unfortunately, Becerra’s rhetoric reinforces many misconceptions about the history of the discovery and development of the Covid-19 vaccines, work that was critical in.

Vaccine 203
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Wilson Bryan, former FDA gene therapy leader, joins consulting firm

BioPharma Drive: Drug Pricing

The agency veteran, who led the Office of Tissues and Advanced Therapies during a boom in gene and cell therapy research, retired in March.

Therapies 246
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Experimental Shot Given Every Six Months Controlled High Blood Pressure in Early Trial

Drugs.com

THURSDAY, July 20, 2023 -- Every day, millions of people must take one or more pills to control their blood pressure and reduce their risk for heart attack or stroke, but if new research pans out, some may be able to scrap their pills for a.

Trials 246
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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These bones were made for walking

Science Daily: Pharmacology News

The genetic changes that made it possible for humans to walk upright have been uncovered in a study that also shows how slight variations in skeletal proportions are linked to arthritis.

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Fattening Doctors To Promote Weight Loss Drugs

Forbes: Drug Truths

In order to promote its weight-loss and diabetes drugs, Novo Nordisk bought doctors almost a half a million meals in 2022.

Doctors 188
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The rise of the new pharma marketer in an evolving commercial model

BioPharma Drive: Drug Pricing

Meet the pharma marketer of the future, primed for personalization and powered by technology.

Marketing 246
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AHA News: Warnings – And Hope – From New Heart Disease Treatment Guidelines

Drugs.com

THURSDAY, July 20, 2023 (American Heart Association News) -- New guidelines detailing how to care for people with heart disease come with some easy-to-grasp warnings for patients. The chronic coronary disease guidelines from the American Heart.

Disease 246
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Shark shock -- scientists discover filter-feeding basking sharks are warm-bodied like great whites

Science Daily: Pharmacology News

Approximately 99.9% of fish and shark species are 'cold-blooded', meaning their body tissues generally match the temperature of the water they swim in -- but researchers have just discovered the mighty basking shark is a one-in-a-thousand exception. Instead, these sharks keep the core regions of their bodies warmer than the water like the most athletic swimmers in the sea such as great white sharks, mako sharks and tuna.

Research 190
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Cell Surface Labeling and Detection of Protein Tyrosine Kinase 7 via Covalent Aptamers

Covalent Modifiers

Savannah Albright, Mary Cacace, Yaniv Tivon, and Alexander Deiters Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.3c02752 Covalent aptamers are novel biochemical tools for fast and selective transfer of labels to target proteins. Equipped with cleavable electrophiles, these nucleic acid probes enable the installation of functional handles onto native proteins.

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Novartis buys a preclinical biotech and its RNA drug technology

BioPharma Drive: Drug Pricing

For $500 million, Novartis will acquire DTx Pharma and its preclinical neurological disease drugs, marking the Swiss company’s latest investment in gene-silencing medicines.

RNA 246
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AHA News: Woman Survives Stroke in 2 Parts of the Brain at Age 29

Drugs.com

WEDNESDAY, July 19, 2023 (American Heart Association News) -- After a night of partying, 29-year-old Bethany Moeddel felt nauseous and had a headache. A hangover, she figured. She couldn't sleep it off, though, because it was a big day. Her.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Catalyst can control methane emissions in natural gas engines

Science Daily: Pharmacology News

A catalyst using a single or just a few palladium atoms removed 90% of unburned methane from natural gas engine exhaust at low temperatures in a recent study. While more research needs to be done, the advance in single atom catalysis has the potential to lower exhaust emissions of methane, one of the worst greenhouse gases that traps heat at about 25 times the rate of carbon dioxide.

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Proteome-wide structural analysis identifies warhead-and coverage-specific biases in cysteine-focused chemoproteomics

Covalent Modifiers

Matthew E H White, Jesús Gil, Edward W Tate [link] Covalent drug discovery has undergone a resurgence over the past two decades and reactive cysteine profiling has emerged in parallel as a platform for ligand discovery through on- and off-target profiling; however, the scope of this approach has not been fully explored at the whole-proteome level. We combined AlphaFold2-predicted side-chain accessibilities for >95% of the human proteome with a meta-analysis of eighteen public cysteine profili

Drugs 130
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A cancer biotech’s collapse gives Neurogene a path to Wall Street

BioPharma Drive: Drug Pricing

The startup, a developer of gene therapies for brain diseases like Rett Syndrome, will bypass an IPO by merging with struggling cancer drugmaker Neoleukin.

Therapies 245
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Could Your Genes Guard You From the Symptoms of COVID Infection?

Drugs.com

WEDNESDAY, July 19, 2023 -- In the world of COVID-19 infections, the majority of patients develop symptoms, while about one-fifth mysteriously don’t develop a cough, sore throat or other tell-tale signs of illness. Now, new research finds.

Research 246
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Galaxy J1135 reveals its water map

Science Daily: Pharmacology News

Researchers look at water in galaxies, its distribution and in particular its changes of state from ice to vapor, as important markers indicating areas of increased energy, in which black holes and stars are formed. A new study has now revealed the distribution of water within the J1135 galaxy, which is 12 billion light years away and formed when the Universe was a 'teenager', 1.8 billion years after the Big Bang.

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