Drugs.com
AUGUST 4, 2023
FRIDAY, Aug. 4, 2023 -- Los Angeles county is seeing more cases of flea-borne typhus, with 171 cases and three deaths reported in 2022, health officials reported Thursday. That's a big rise, they noted: Since 2010, when only 31 cases of typhus were.
BioPharma Drive: Drug Pricing
AUGUST 3, 2023
Sales of the company’s COVID-19 vaccine plummeted 94% year over year. But executives believe newer products can help revenue rebound.
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Collaborative Drug
AUGUST 4, 2023
Atropisomer Registration in CDD Vault CDD Chemistry now provides a unique, efficient, and robust way of registering atropisomers. Distinct atropisomers can be drawn and registered into CDD Vault as separate Molecules with unique IDs.
Science Daily: Pharmacology News
AUGUST 3, 2023
An international team of scientists have discovered an unusual Jupiter-sized planet orbiting a low-mass star called TOI-4860, located in the Corvus constellation.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Drugs.com
AUGUST 4, 2023
FRIDAY, Aug. 4, 2023 -- The trauma and unhappy family dynamics of childhood may follow kids into old age, affecting both their mind and body, according to new research. “We looked at self-reported disability, as well as objectively measured.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Collaborative Drug
AUGUST 1, 2023
Streamlining Collaborations and Drug Development using CDD Vault and ELN
Science Daily: Pharmacology News
AUGUST 3, 2023
In prehistoric societies, humans tended to learn from members of our ingroup or from more prestigious individuals, as this information was more likely to be reliable and result in group success. However, with the advent of diverse and complex modern communities -- and especially in social media -- these biases become less effective. For example, a person we are connected to online might not necessarily be trustworthy, and people can easily feign prestige on social media.
Drugs.com
AUGUST 3, 2023
THURSDAY, Aug. 3, 2023 -- A Louisiana woman is suing the makers of two type 2 diabetes drugs used off-label for obesity, saying they failed to adequately warn about the risk of severe stomach problems. The lawsuit seeks “very.
BioPharma Drive: Drug Pricing
AUGUST 2, 2023
Yosemite is one of a new class of biotech venture funds that also includes the recently launched Dimension and Cure Ventures.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Collaborative Drug
AUGUST 1, 2023
CDD Exhibiting and Presenting at ACS Fall 2023, August 13th to 17th.
Science Daily: Pharmacology News
AUGUST 3, 2023
A new study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers.
Drugs.com
AUGUST 3, 2023
THURSDAY, Aug. 3, 2023 -- While both the Moderna and Pfizer COVID-19 vaccines are considered safe and highly effective, new research finds the Moderna shot has been the safest and most effective for seniors. “The results of this study can help.
BioPharma Drive: Drug Pricing
AUGUST 2, 2023
Intergalactic, a developer of non-viral gene therapies built by ex-Biogen executive Michael Ehlers, is folding less than two years after its launch.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Covalent Modifiers
AUGUST 1, 2023
Corteselli, E.M., Sharafi, M., Hondal, R. et al. Nat Commun 14 , 4550 (2023). [link] Protein-S-glutathionylation is a post-translational modification involving the conjugation of glutathione to protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases that regulate this process by performing deglutathionylation.
Science Daily: Pharmacology News
AUGUST 1, 2023
Royal Ontario Museum announces the oldest swimming jellyfish in the fossil record with the newly named Burgessomedusa phasmiformis. This 505-million-year-old swimming jellyfish from the Burgess Shale highlights diversity in the Cambrian ecosystem.
Drugs.com
AUGUST 3, 2023
THURSDAY, Aug. 3, 2023 -- Yoga is known for its benefits to both the mind and body. And a gentle form of yoga may be an ideal early intervention technique for older women at risk of Alzheimer's disease, new research suggests. In a small study.
BioPharma Drive: Drug Pricing
AUGUST 3, 2023
One patient received its Duchenne gene therapy, Elevidys, this week and a handful more could follow shortly, surprising some analysts and raising near-term sales expectations.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
ASPET
AUGUST 4, 2023
The natural product goldenseal is a clinical inhibitor of CYP3A activity, as evidenced by a 40-60% increase in midazolam AUC after coadministration with goldenseal. The predominant goldenseal alkaloids berberine and (-)-β-hydrastine were previously identified as time-dependent CYP3A inhibitors using human liver microsomes. Whether these alkaloids contribute to the clinical interaction, as well as the primary anatomical site (hepatic vs. intestinal) and mode of CYP3A inhibition (reversible v
Science Daily: Pharmacology News
AUGUST 1, 2023
When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed. Participants in this study reaped a 226% increase in cognitive capacity compared to the control group. The researchers say the finding transforms the long-known tie between smell and memory into an easy, non-invasive technique for strengthening memory and potentially deterring dementia.
Drugs.com
AUGUST 3, 2023
THURSDAY, Aug. 3, 2023 -- J.D. Butler was planning a future with his girlfriend at his favorite New York City restaurant when that future came to a sudden, crushing halt. “They were planning on when she was moving in and arranging floor plans on.
BioPharma Drive: Drug Pricing
JULY 31, 2023
According to the company, FDA officials have signaled openness to using a surrogate endpoint for assessing accelerated approval of a treatment for limb-girdle muscular dystrophy.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
ASPET
AUGUST 4, 2023
Neuroblastoma (NB) is a pediatric cancer with low survival rates in high-risk patients. 131 I-mIBG has emerged as a promising therapy for high-risk NB and kills tumor cells by radiation. Consequently, 131 I-mIBG tumor uptake and retention are major determinants for its therapeutic efficacy. mIBG enters NB cells through the norepinephrine transporter (NET), and accumulates in mitochondria through unknown mechanisms.
Science Daily: Pharmacology News
AUGUST 3, 2023
The Gulf Stream system plays an important role in climate. The weakening of this system that has been observed over the last two decades is therefore a cause for concern and much debate. The question is whether the measurable changes are already due to human-induced climate change -- model simulations predict such an influence with high probability for the future.
Drugs.com
AUGUST 3, 2023
THURSDAY, Aug. 3, 2023 -- New research shows that an experimental drug fine-tuned to a specific pain pathway can ease post-surgery aches, a finding that may eventually offer an alternative to highly addictive opioids. The pill, known for now as.
BioPharma Drive: Drug Pricing
AUGUST 4, 2023
The surprise rejection of a high-dose form of Eylea could be resolved earlier than anticipated. But some of the company’s pipeline projects have stumbled.
ASPET
AUGUST 4, 2023
Inhalation of high levels of sulfur mustard (SM), a potent vesicating and alkylating agent used in chemical warfare, results in acutely lethal pulmonary damage. Sodium 2-mercaptoethane sulfonate (mesna) is an organosulfur compound that is currently FDA-approved for decreasing the toxicity of mustard-derived chemotherapeutic alkylating agents like ifosfamide and cyclophosphamide.
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