Science Daily: Pharmacology News
AUGUST 25, 2023
'Eco-friendly' paper drinking straws contain long-lasting and potentially toxic chemicals, a new study has concluded.
Drugs.com
AUGUST 25, 2023
FRIDAY, Aug. 25, 2023 -- Paper straws, meant to be an eco-friendly alternative to plastic, may not be better for the environment, a new study concludes, warning that they also contain “forever chemicals” that can harm human.
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BioPharma Drive: Drug Pricing
AUGUST 25, 2023
Neumora’s filing late Friday, along with that of radiopharmaceutical startup RayzeBio earlier this week, could be an important test of the biotech IPO market.
Collaborative Drug
AUGUST 24, 2023
Vault Snack #20 - Manage Protocol/Assay Definitions in CDD Vault
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily: Pharmacology News
AUGUST 24, 2023
The first three weeks of July 2023 have been the hottest global three-week period so far. Researchers report that the European population's exposure to heat was highest in Italy.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
AUGUST 23, 2023
The company doesn’t know if the needles have caused retinal vasculitis in some people receiving its geographic atrophy drug Syfovre, but is no longer recommending their use.
Covalent Modifiers
AUGUST 24, 2023
Lara Ibrahim, Caroline Stanton, Kayla Nutsch, Thu Nguyen, Chloris Li-Ma, Yeonjin Ko, Gabriel C. Lander, R. Luke Wiseman, Michael J. Bollong Cell Chemical Biology, 2023 [link] Cross talk between metabolism and stress-responsive signaling is essential for maintaining cellular homeostasis. This cross talk is often achieved through covalent modification of proteins by endogenous, reactive metabolites that regulate key stress-responsive transcription factors like NRF2.
Science Daily: Pharmacology News
AUGUST 24, 2023
Emperor penguin colonies experienced unprecedented breeding failure in a region of Antarctica where there was total sea ice loss in 2022. The discovery supports predictions that over 90% of emperor penguin colonies will be quasi-extinct by the end of the century, based on current global warming trends.
Drugs.com
AUGUST 25, 2023
FRIDAY, Aug. 25, 2023 -- Alice Tapper felt deathly ill, suffering from severe abdominal pain, a 102-degree fever and vomiting. Emergency room doctors found that Alice -- the daughter of CNN anchor Jake Tapper -- had a rapid pulse of 135 beats per.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
BioPharma Drive: Drug Pricing
AUGUST 23, 2023
The job cuts are meant to preserve enough cash so the nearly three-decade-old company can potentially pursue its first drug approval next year.
Chemical Biology and Drug Design
AUGUST 24, 2023
T3BP specifically binds to TGFBR3 on cell membrane and enter cells through endocytosis. T3BP enchances antitumor efficacy of a ribosome-inactivating protein while fused to it, which results in apoptosis of cancer cells. Abstract Targeted therapy has attracted more and more attention in cancer treatment in recent years. However, due to the diversity of tumor types and the mutation of target sites on the tumor surface, some existing targets are no longer suitable for tumor therapy.
Science Daily: Pharmacology News
AUGUST 24, 2023
Scientists have developed a flexible battery as thin as a human cornea, which stores electricity when it is immersed in saline solution, and which could one day power smart contact lenses.
Drugs.com
AUGUST 25, 2023
FRIDAY, Aug. 25, 2023 -- It might not seem like constipation or difficulty swallowing could signal a neurological problem, but new research suggests that these gut conditions could be an early indicator of Parkinson’s disease. Gastrointestinal.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
AUGUST 23, 2023
Data inadvertently published from a closely watched lung cancer study suggest a drug blocking the protein TIGIT may help extend survival, a finding that boosted shares of other developers.
Chemical Biology and Drug Design
AUGUST 24, 2023
Resveratrol alleviated Aβ-induced neuronal apoptosis, inflammatory reaction, oxidative stress, and endoplasmic reticulum stress via circ_0050263/miR-361-3p/PDE4A axis. Abstract Resveratrol (Res) has been identified to reduce neurodegeneration. Circular RNAs (circRNAs) are stable noncoding RNAs that are considered to be ideal biomarkers for molecular targeting treatment.
Science Daily: Pharmacology News
AUGUST 25, 2023
Middle-aged adults with three or more unhealthy traits including slightly high waist circumference, blood pressure, cholesterol and glucose have heart attacks and strokes two years earlier than their peers, according to new research.
Drugs.com
AUGUST 25, 2023
FRIDAY, Aug. 25, 2023 -- Coupons for tobacco products appear to have a big impact on relapse rates for smokers who have recently kicked the habit, researchers report. A study of more than 5,000 former smokers who participated in a national survey.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
AUGUST 24, 2023
Bristol Myers Squibb is among those backing the startup, which claims the manufacturing capacity at its New Jersey plant can surpass that of conventional CDMO facilities.
Chemical Biology and Drug Design
AUGUST 24, 2023
Key mitochondrial folate enzyme, methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) plays crucial role in targeting folate cycle in cancer. Formate flux from mitochondria to cytosol cause folate trap-induced toxicity to kill MTHFD2-expressing cancer cell, with the MTHFD1 inhibitor. Metabolomics studies show ambiguity in data analysis if growth media is not chosen properly.
Science Daily: Pharmacology News
AUGUST 23, 2023
A researcher made a discovery that could change our understanding of the universe. He reveals that there is a range in which fundamental constants can vary, allowing for the viscosity needed for life processes to occur within and between living cells. This is an important piece of the puzzle in determining where these constants come from and how they impact life as we know it.
Drugs.com
AUGUST 25, 2023
FRIDAY, Aug. 25, 2023 -- The U.S. Food and Drug Administration approved Tyruko (natalizumab-sztn), the first biosimilar to Tysabri (natalizumab) injection, for the treatment of relapsing forms of multiple sclerosis, the agency announced.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
AUGUST 25, 2023
According to one analyst, the approval was the last hurdle keeping Sandoz’s Tyruko from directly competing in the U.S. market against Biogen’s inflammation-regulating medicine Tysabri.
Chemical Biology and Drug Design
AUGUST 23, 2023
Trauma-hemorrhagic shock (THS) is a medical emergency and can cause liver injury. Ligustrazine reduces inflammation and apoptosis induced by THS in liver and promotes survival effects. The beneficial effects of ligustrazine against THS-induced hepatic injury, and could be a potential to treat the liver injury caused by THS. Abstract Trauma-hemorrhagic shock (THS) is a medical emergency that is encountered by physicians in the emergency department.
Science Daily: Pharmacology News
AUGUST 23, 2023
Researchers have developed a brain-computer interface (BCI) that has enabled a woman with severe paralysis from a brainstem stroke to speak through a digital avatar.
Drugs.com
AUGUST 24, 2023
THURSDAY, Aug. 24, 2023 -- Cancer patients with immune systems weakened by treatment are among the groups most concerned about the continued spread of COVID-19 and the chance of the infection becoming severe. New research suggests more guidance on.
BioPharma Drive: Drug Pricing
AUGUST 21, 2023
The expanded approval follows the FDA’s May clearance of the shot, called Abrysvo, in older adults.
Chemical Biology and Drug Design
AUGUST 21, 2023
The present study's results demonstrated DEX's pharmacological benefit against myocardial reperfusion injury. It has been found that DEX showed a protective effect against MIR injury possibly via amelioration of oxidative stress and apoptosis of cardiomyocytes. It also showed a strong anti-inflammatory effect possibly via inhibition of NF-κB. Abstract The present study was conducted to determine the protective effect of Dexmedetomidine (DEX) in myocardial ischemia–reperfusion injury in hyperlipi
Science Daily: Pharmacology News
AUGUST 23, 2023
In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.
Drugs.com
AUGUST 24, 2023
THURSDAY, Aug. 24, 2023 -- Stroll past the supplements in any drugstore and you’ll find broad claims about fish oil helping everything from heart and brain health, to joints, eyes and immune systems.
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