Sat.Sep 30, 2023 - Fri.Oct 06, 2023

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NIH funds research for three experimental ALS drugs

BioPharma Drive: Drug Pricing

The funding, which is part of ACT for ALS, will support expanded access studies of drugs developed by Prilenia Therapeutics, Clene Nanomedicine and Rapa Therapeutics.

Research 305
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Ketamine Nasal Spray Shows Promise Against Tough-to-Treat Depression

Drugs.com

THURSDAY, Oct. 5, 2023 -- A nasal spray containing a ketamine derivative appears to beat one of the standard drugs used for people with difficult-to-treat depression, a new clinical trial has found. The trial, of nearly 700 people with.

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Instant evolution: AI designs new robot from scratch in seconds

Science Daily: Pharmacology News

Researchers developed the first AI to date that can intelligently design robots from scratch by compressing billions of years of evolution into mere seconds. It's not only fast but also runs on a lightweight computer and designs wholly novel structures from scratch — without human-labeled, bias-filled datasets.

Research 278
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Phase III is Coming!

Drug Hunter

With initial signs of efficacy and tolerability, Drug Hunter is launching into Phase III! To address your helpful feedback, we’ve rebuilt the platform from scratch to support new features and enhancements. In a few days, you’ll see the changeover to the new version go live. Show Me the Molecules! Fig. 1. The new homepage, which you can preview at v2.drughunter.com.

Trials 247
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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5 FDA decisions to watch in the fourth quarter

BioPharma Drive: Drug Pricing

The regulator is considering approval of what would be the first CRISPR medicine, as well as important clearances for Alnylam, Bristol Myers, Amgen and Pfizer.

FDA 294

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Ancient carbon in rocks releases as much carbon dioxide as the world's volcanoes

Science Daily: Pharmacology News

New research has overturned the traditional view that natural rock weathering acts as a carbon sink that removes CO2 from the atmosphere. Instead, this can also act as a large CO2 source, rivaling that of volcanoes.

Research 278
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Drug Discovery Industry Roundup with Barry Bunin — October 3, 2023

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin — October 3, 2023 The New York Times coverage of the Nobel Prize in Physiology or Medicine being awarded.

Drugs 246
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Moderna claims positive results in early study for combo COVID, flu shot

BioPharma Drive: Drug Pricing

The company is planning to start a Phase 3 trial of the vaccine this year, and is targeting a regulatory approval in 2025.

Vaccine 273
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Following One Death, FDA Warns Hospitals About Giving Probiotics to Preemies

Drugs.com

TUESDAY, Oct. 3, 2023 -- Federal regulators are cautioning doctors not to give probiotics to preterm infants. An infant given probiotics at an undisclosed hospital has died, U.S. Food and Drug Administration officials said in a recent warning.

Hospitals 290
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Study identifies jet-stream pattern that locks in extreme winter cold, wet spells

Science Daily: Pharmacology News

Winter is coming—eventually. And while the earth is warming, a new study suggests that the atmosphere is being pushed around in ways that cause long bouts of extreme winter cold or wet in some regions. The study’s authors say they have identified giant meanders in the global jet stream that bring polar air southward, locking in frigid or wet conditions concurrently over much of North America and Europe, often for weeks at a time.

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Assigning functionality to cysteines by base editing of cancer dependency genes [@davidrliu]

Covalent Modifiers

Haoxin Li, Tiantai Ma, Jarrett R. Remsberg, Sang Joon Won, Kristen E. DeMeester, Evert Njomen, Daisuke Ogasawara, Kevin T. Zhao, Tony P. Huang, Bingwen Lu, Gabriel M. Simon, Bruno Melillo, Stuart L. Schreiber, Jens Lykke-Andersen, David R. Liu & Benjamin F. Cravatt Nat Chem Biol, 2023 [link] Covalent chemistry represents an attractive strategy for expanding the ligandability of the proteome, and chemical proteomics has revealed numerous electrophile-reactive cysteines on diverse human protei

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Orchard sells to Kyowa Kirin in gene therapy buyout

BioPharma Drive: Drug Pricing

Kyowa will pay nearly $400 million to acquire Orchard, which sells the gene therapy Libmeldy in Europe but has struggled to find paths to market for other experimental treatments.

Therapies 264
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Nobel Prize for Medicine Awarded to COVID Vaccine Pioneers

Drugs.com

MONDAY, Oct. 2, 2023 -- This year’s Nobel Prize for physiology or medicine has been awarded to two scientists who laid the groundwork years ago for the mRNA research that made COVID-19 vaccines possible. Dr. Katalin Karikó, the 13th.

Vaccine 290
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Could future AI crave a favorite food?

Science Daily: Pharmacology News

Can artificial intelligence (AI) get hungry? Develop a taste for certain foods? Not yet, but a team of researchers is developing a novel electronic tongue that mimics how taste influences what we eat based on both needs and wants, providing a possible blueprint for AI that processes information more like a human being.

Research 270
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Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry

Covalent Modifiers

Roman C. Sarott, Inchul You, Yen-Der Li, Sean T. Toenjes, Katherine A. Donovan, Pooreum Seo, Martha Ordonez, Woong Sub Byun, Muhammad Murtaza Hassan, Franziska Wachter, Edward T. Chouchani, Mikołaj Słabicki, Eric S. Fischer, Benjamin L. Ebert, Stephen M. Hinshaw, and Nathanael S. Gray Journal of the American Chemical Society Article ASAP DOI: 10.1021/jacs.3c06622 Targeted protein degradation relies on small molecules that induce new protein–protein interactions between targets and the cellular p

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Apellis sales numbers show steady demand for new eye drug, despite safety worries

BioPharma Drive: Drug Pricing

The company says Syfovre prescriptions accelerated again in August after a rocky summer of side effect probes.

Drugs 264
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FDA Will Begin to Regulate Thousands of Lab Tests

Drugs.com

FRIDAY, Sept. 29, 2023 -- Faced with growing reports of inaccurate clinical lab tests, the U.S. Food and Drug Administration on Friday announced that it will for the first time regulate these vital diagnostic tools. Many Americans might have.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Scientists develop 3D printing method that shows promise for repairing brain injuries

Science Daily: Pharmacology News

Researchers have produced an engineered tissue representing a simplified cerebral cortex by 3D printing human stem cells. When implanted into mouse brain slices, the structures became integrated with the host tissue. The technique may ultimately be developed into tailored repairs to treat brain injuries.

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Broad Clinical Labs established to expand clinical services

Broad Institute

Broad Clinical Labs established to expand clinical services By Leah Eisenstadt October 3, 2023 Breadcrumb Home Broad Clinical Labs established to expand clinical services Formerly the Clinical Research Sequencing Platform, the cutting-edge laboratory at the Broad Institute is poised to further accelerate clinical genomics. By Broad Communications October 3, 2023 The Broad's Clinical Research Sequencing Platform is now Broad Clinical Labs.

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Regeneron, Intellia target neurological diseases in expanded gene editing deal

BioPharma Drive: Drug Pricing

The longtime partners believe that, by combining their technologies, they can create “in vivo” genetic medicines for nervous system and muscular disorders.

Disease 256
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Getting COVID Shot During Pregnancy Helps Protect Newborns, CDC Study Finds

Drugs.com

FRIDAY, Sept. 29, 2023 – When pregnant women get a COVID vaccine, it helps protect their newborns from the virus, a new government study shows. "These findings indicate that maternal vaccination during pregnancy could help prevent.

Vaccine 290
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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The medicine of the future could be artificial life forms

Science Daily: Pharmacology News

Imagine a life form that doesn't resemble any of the organisms found on the tree of life. One that has its own unique control system, and that a doctor would want to send into your body. It sounds like a science fiction movie, but according to nanoscientists, it can—and should—happen in the future.

Doctors 264
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Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells

Broad Institute

Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells By Allessandra DiCorato October 4, 2023 Breadcrumb Home Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells The small molecule, now in clinical trials, increases activity of immune cells and sensitivity of tumors to immune attack.

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Lilly to enter radiopharmaceutical drug field with $1.4B Point buyout

BioPharma Drive: Drug Pricing

The deal will hand Lilly a pipeline of experimental radioligand therapies, including a potential rival to Novartis’ Pluvicto, as well as a valuable manufacturing plant.

Therapies 251
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CDC Stops Issuing New COVID Vaccination Cards

Drugs.com

THURSDAY, Oct. 5, 2023 -- Wallet-friendly cards showing proof of COVID vaccinations served a purpose early in the pandemic, but they’re on their way out. The U.S.

Vaccine 279
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New discovery may 'unlock' the future of infectious disease and cancer treatment

Science Daily: Pharmacology News

Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.

Treatment 262