Evariste Boosts Research Operations with Adoption of CDD Vault
Collaborative Drug
JUNE 1, 2023
PhoreMost Enhances Drug Discovery Process with CDD Vault
Sat.May 27, 2023 - Fri.Jun 02, 2023
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First X-ray of a single atom
Science Daily: Pharmacology News
MAY 31, 2023
Scientists have taken the world's first X-ray SIGNAL (or SIGNATURE) of just one atom. This groundbreaking achievement could revolutionize the way scientists detect the materials.
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Molecules on the Move: April ’23
Drug Hunter
MAY 31, 2023
This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available. Capacity Bio’s MAS Receptor Agonists with $35M Raised for FIH Clinical Trials MAS modulator from WO2022165189 example 107 New start-up Capacity Bio backed by RA Capital, Insight Partners, and Remiges Ventures with $35 million funding is working on taking first-in-class mitophagy agonists into clinical trials, which are expected to start in 2024.
Multi-ancestry study reveals genetic risk factors for two common pregnancy complications
Broad Institute
JUNE 1, 2023
Multi-ancestry study reveals genetic risk factors for two common pregnancy complications By Allessandra DiCorato June 1, 2023 Breadcrumb Home Multi-ancestry study reveals genetic risk factors for two common pregnancy complications The findings could help doctors identify pregnancies at risk of preeclampsia and gestational hypertension and treat them earlier.
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Drug Discovery Industry Roundup with Barry Bunin — May 17, 2023
Collaborative Drug
JUNE 2, 2023
Drug Discovery Industry Roundup with Barry Bunin — May 17, 2023
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
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Covalent Inhibition by a Natural Product-Inspired Latent Electrophile
Covalent Modifiers
JUNE 1, 2023
David P. Byun, Jennifer Ritchie, Yejin Jung, Ronald Holewinski, Hong-Rae Kim, Ravichandra Tagirasa, Joseph Ivanic, Claire M. Weekley, Michael W. Parker, Thorkell Andresson, and Euna Yoo Journal of the American Chemical Society 2023 145 (20), 11097-11109 DOI: 10.1021/jacs.3c00598 Strategies to target specific protein cysteines are critical to covalent probe and drug discovery. 3-Bromo-4,5-dihydroisoxazole (BDHI) is a natural product-inspired, synthetically accessible electrophilic moiety that has
Synthesis, in silico and in vitro studies of hydrazide?hydrazone imine derivatives as potential cholinesterase inhibitors
Chemical Biology and Drug Design
MAY 31, 2023
Hydrazide-hydrazone derivatives were synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). In addition, molecular docking and ADME studies were carried out. Abstract A series of hydrazide-hydrazone imine derivative compounds (3a–k) were synthesized and their structures characterized using FTIR, 1 H, and 13 C (NMR) spectroscopic methods.
Successful Clinical Trial With ProRelix Research: Phase 1, 2, 3 & 4 Clinical Trial Services at …
ProRelix Research
MAY 31, 2023
Introduction: Clinical trials are a crucial component of the pharmaceutical and medical research industry, aimed at evaluating the safety and effectiveness of new drugs, treatments, or medical devices before they […] The post Successful Clinical Trial With ProRelix Research: Phase 1, 2, 3 & 4 Clinical Trial Services at … appeared first on ProRelix Research.
Astrophysicists confirm the faintest galaxy ever seen in the early universe
Science Daily: Pharmacology News
JUNE 1, 2023
After the Big Bang, the universe expanded and cooled sufficiently for hydrogen atoms to form. In the absence of light from the first stars and galaxies, the universe entered a period known as the cosmic dark ages. The first stars and galaxies appeared several hundred million years later and began burning away the hydrogen fog left over from the Big Bang, rendering the universe transparent, like it is today.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Nucleophilic covalent ligand discovery for the cysteine redoxome
Covalent Modifiers
MAY 29, 2023
Fu, L., Jung, Y., Tian, C. et al. Nat Chem Biol (2023). [link] With an eye toward expanding chemistries used for covalent ligand discovery, we elaborated an umpolung strategy that exploits the ‘polarity reversal’ of sulfur when cysteine is oxidized to sulfenic acid, a widespread post-translational modification, for selective bioconjugation with C-nucleophiles.
Xanthones as potential ??glucosidase non?competition inhibitors: Synthesis, inhibitory activities, and in silico studies
Chemical Biology and Drug Design
MAY 30, 2023
Eleven 1,6- and 1,3-substituted xanthone compounds were designed and synthesized, of which four were new compounds. Their α -glucosidase inhibitory activities in vitro and in silico were evaluated. This study provided a theoretical basis for the rapid discovery and structural modification of non-competitive xanthone inhibitors of α -glucosidase. Abstract α -glucosidase inhibitors (AGIs) were commonly used in clinical for the treatment of type 2 diabetes.
Artificial intelligence system predicts consequences of disruptions to genetic networks
Broad Institute
MAY 30, 2023
Artificial intelligence system predicts consequences of disruptions to genetic networks By Tom Ulrich May 30, 2023 Breadcrumb Home Artificial intelligence system predicts consequences of disruptions to genetic networks Computer model helps researchers understand the connections between thousands of genes, and pinpoint how those connections go awry in disease By Sarah C.P.
Robot centipedes go for a walk
Science Daily: Pharmacology News
MAY 29, 2023
Researchers show how their multilegged walking robot can be steered by inducing a dynamic instability. By making the couplings between segments more flexible, the robot changes from walking straight to moving in a curved path. This work can lead to more energy-efficient and reliable robotic navigation of terrain.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Covalent drug discovery using sulfur(VI) fluoride exchange warheads
Covalent Modifiers
MAY 28, 2023
Huang Huang, Lyn H. Jones Expert Opinion on Drug Discovery , 2023 [link] Covalent drug discovery has traditionally focused on targeting cysteine, but the amino acid is often absent in protein binding sites. This review makes the case to move beyond cysteine labeling using sulfur (VI) fluoride exchange (SuFEx) chemistry to expand the druggable proteome.
Isolation and purifications of an ambuic acid derivative compound from marine algal endophytic fungi Talaromyces flavus that induces apoptosis in MDA?MB?231 cancer cells
Chemical Biology and Drug Design
MAY 29, 2023
Talaromyces flavus , an endophytic fungus isolated from marine algae Grateloupia lithophila. Cytotoxicity compound substance in T. flavus ethyl acetate extract and purification by column chromatography, preparative thin layer chromatography-bioassay guide. Purified ambuic acid derivative was evaluated in vitro using the human cancer cell line MDA-MB-231.
OECD guidelines for Chronic Toxicity studies
biobide
JUNE 2, 2023
Chronic Toxicity studies are a form of assays that are likely to affect the health of a subject if exposed to a substance repeatedly or constantly over an extended period of time to know the long-term effects.
Saved from extinction, Southern California's Channel Island Foxes now face new threat to survival
Science Daily: Pharmacology News
MAY 30, 2023
Starting in the 1990s, Island Fox populations began to dwindle due to an outbreak of canine distemper and an increase in attacks by golden eagles. Some islands saw their population drop to as low as 15 individuals, but conservation efforts by the Federal government restored numbers by 2017. A new study reveals a worrying decrease in genetic diversity within the species, signaling a new threat to the Channel Islands foxes' survival.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Promising human antibodies fighting SARS-CoV-2
Drug Target Review
JUNE 1, 2023
In a recent study , found in Cell Reports. La Jolla Institute for Immunology (LJI), US, scientists demonstrated how antibodies obtained from a clinical study participant attach to the SARS-CoV-2 spike protein and neutralise the virus. The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. 1 New research from Moderna shows that their original SARS-CoV-2 vaccine can prompt the body to produce antibodies against the more recent Omicron
Viral Vectors 101: AAV Variables That Matter
addgene Blog
JUNE 1, 2023
Using AAV vectors in complex biological systems can be tricky at best, and downright infuriating at worst. While it is tempting to just dive right in and start injecting your virus, a successful AAV experiment starts with validation and optimization. Although there are different ways to ultimately achieve success, we find it is usually faster and easier to do the validation first.
The Drug Discount Ecosystem’s “Mission Critical”
Drug Channels
JUNE 1, 2023
Today’s guest post comes from Vishali Amin, Chief of Staff to the Office of the President and Senior Director of Customer Success at Kalderos. Vishali discusses the persistent challenges of duplicate discounts between the 340B Drug Pricing Program and the Medicaid Drug Rebate Program. The Inflation Reduction Act of 2022 will further complicate duplicate discount issues.
The 'breath' between atoms -- a new building block for quantum technology
Science Daily: Pharmacology News
JUNE 1, 2023
Researchers have discovered they can detect atomic 'breathing,' or the mechanical vibration between two layers of atoms, by observing the type of light those atoms emitted when stimulated by a laser. The sound of this atomic 'breath' could help researchers encode and transmit quantum information.
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
7 Clinical trial advertising sample ideas
Antidote
MAY 30, 2023
To successfully advertise a clinical trial , it is important to create materials that engage patients and adhere to the strict guidelines of the Food and Drug Administration (FDA) in equal measure. It can be challenging to come up with creative and captivating material within these confines, but by developing a strategic advertising plan , it’s possible to find the appropriate balance.
Capsule dosed drug patent expirations by year
Drug Patent Watch
MAY 27, 2023
This chart shows the patent expirations for capsule dosed drugs over the next decade. The term of drug patents varies. The basic term for a patent is 20 years from… The post Capsule dosed drug patent expirations by year appeared first on DrugPatentWatch - Make Better Decisions.
#ScienceSaturday: May 27, 2023
KIF1A
MAY 27, 2023
#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dominique Lessard and Dr. Dylan Verden of KIF1A.ORG summarize newly published KIF1A-related research and highlight progress in rare disease research and therapeutic development. Goodbye with Gratitude: Dr. Dominique Lessard It is with heavy hearts that this week we say goodbye to Dr.
Landmark study finds that the shape of the brain influences the way it works
Science Daily: Pharmacology News
MAY 31, 2023
For over a century, researchers have thought that the patterns of brain activity that define our experiences, hopes and dreams are determined by how different brain regions communicate with each other through a complex web of trillions of cellular connections. Now, a study has examined more than 10,000 different maps of human brain activity and found that the overall shape of a person's brain exerts a far greater influence on how we think, feel and behave than its intricate neuronal connectivity
Amplifying the rare disease experience: A Q&A with Rare Patient Voice
Antidote
JUNE 1, 2023
The Antidote partner network is a key element of our ability to build relationships with patients and increase awareness surrounding medical research. By providing Match, our clinical trial search tool, free of charge , we are able to assist advocacy groups, nonprofits, and more in providing patient-centric clinical trial listings to empower their audiences.
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