Drug Discovery World

JUNE 1, 2023

Antibody-drug conjugates (ADCs) are biopharmaceutical products in which a monoclonal antibody (mAB) is linked to a small molecule drug with a stable linker 1. According to NCBI, most of the ADCs developed so far are for use in the treatment of cancer, but there is plenty of potential for using ADCs to treat other diseases 1. A Nature publication confirmed that there are currently 12 FDA-approved ADCs on the market, and nine of these secured FDA approval in the past six years 2.

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Drug Hunter

MAY 31, 2023

This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available. Capacity Bio’s MAS Receptor Agonists with $35M Raised for FIH Clinical Trials MAS modulator from WO2022165189 example 107 New start-up Capacity Bio backed by RA Capital, Insight Partners, and Remiges Ventures with $35 million funding is working on taking first-in-class mitophagy agonists into clinical trials, which are expected to start in 2024.

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Chemical Biology and Drug Design

MAY 31, 2023

Hydrazide-hydrazone derivatives were synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). In addition, molecular docking and ADME studies were carried out. Abstract A series of hydrazide-hydrazone imine derivative compounds (3a–k) were synthesized and their structures characterized using FTIR, 1 H, and 13 C (NMR) spectroscopic methods.

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Pharmacokinetics Research 100

Science Daily: Pharmacology News

MAY 31, 2023

Even without nerves, plants can sense when something touches them and when it lets go, a study has found. In a set of experiments, individual plant cells responded to the touch of a very fine glass rod by sending slow waves of calcium signals to other plant cells, and when that pressure was released, they sent much more rapid waves. While scientists have known that plants can respond to touch, this study shows that plant cells send different signals when touch is initiated and ended.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JUNE 2, 2023

Lab automation company Opentrons has launched the Opentrons Flex robot. The company says that these are affordable and easy-to-programme liquid-handling lab robots which are designed to level the playing field for labs of all sizes and bring advanced lab automation to more researchers. Fusing advanced robotics with open-source software, the Flex is compatible with AI tools and has near-limitless potential to learn new protocols.

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ProRelix Research

MAY 31, 2023

Introduction: Clinical trials are a crucial component of the pharmaceutical and medical research industry, aimed at evaluating the safety and effectiveness of new drugs, treatments, or medical devices before they […] The post Successful Clinical Trial With ProRelix Research: Phase 1, 2, 3 & 4 Clinical Trial Services at … appeared first on ProRelix Research.

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biobide

JUNE 2, 2023

Chronic Toxicity studies are a form of assays that are likely to affect the health of a subject if exposed to a substance repeatedly or constantly over an extended period of time to know the long-term effects.

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Drugs 98

Drug Discovery World

JUNE 2, 2023

News round-up for 29 May – 2 June by DDW Digital Content Editor Diana Spencer. With National Cancer Research Month coming to an end and the American Society of Clinical Oncology Annual Meeting currently taking place in Chicago (2-6 June), it’s been another busy week for cancer drug development news. The top stories: Janssen seeks EU approval of new indication for CAR-T therapy The Janssen Pharmaceutical Companies of Johnson & Johnson have submitted a Type II variation application to the Euro

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Pharmaceutical Companies Clinical Trials Drugs Pharmaceuticals 130

Drug Target Review

JUNE 1, 2023

In a recent study , found in Cell Reports. La Jolla Institute for Immunology (LJI), US, scientists demonstrated how antibodies obtained from a clinical study participant attach to the SARS-CoV-2 spike protein and neutralise the virus. The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. 1 New research from Moderna shows that their original SARS-CoV-2 vaccine can prompt the body to produce antibodies against the more recent Omicron

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Virus Vaccine Immune Response Research 97

Chemical Biology and Drug Design

MAY 29, 2023

Talaromyces flavus , an endophytic fungus isolated from marine algae Grateloupia lithophila. Cytotoxicity compound substance in T. flavus ethyl acetate extract and purification by column chromatography, preparative thin layer chromatography-bioassay guide. Purified ambuic acid derivative was evaluated in vitro using the human cancer cell line MDA-MB-231.

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Drugs Research 100

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Drug Channels

JUNE 1, 2023

Today’s guest post comes from Vishali Amin, Chief of Staff to the Office of the President and Senior Director of Customer Success at Kalderos. Vishali discusses the persistent challenges of duplicate discounts between the 340B Drug Pricing Program and the Medicaid Drug Rebate Program. The Inflation Reduction Act of 2022 will further complicate duplicate discount issues.

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Drugs 97

Drug Discovery World

JUNE 2, 2023

Lifebit and Flatiron Health have announced a multi-year strategic partnership with the aim of improving scientific discoveries by learning from the experience of cancer patients. Health data generated by hospitals, healthcare providers, research organisations and clinical trials hold the potential to advance research and innovation, improve patient care and accelerate drug development.

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Antidote

MAY 30, 2023

To successfully advertise a clinical trial , it is important to create materials that engage patients and adhere to the strict guidelines of the Food and Drug Administration (FDA) in equal measure. It can be challenging to come up with creative and captivating material within these confines, but by developing a strategic advertising plan , it’s possible to find the appropriate balance.

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Clinical Trials Trials FDA Drugs 96

NIOSH Science Blog: Drugs

JUNE 1, 2023

Each June, we celebrate National Safety Month. Safety matters every day of the year, but during June it gets the extra attention it deserves so we can all stay safe from the workplace to anyplace. As part of the celebration of safety, the National Safety Council (NSC) selects themes for each week of the month. This blog will highlight research and prevention efforts from the National Institute for Occupational Safety and Health (NIOSH) and NSC in this year’s focus areas of emergency preparedness

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Research 89

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Science Daily: Pharmacology News

JUNE 1, 2023

After the Big Bang, the universe expanded and cooled sufficiently for hydrogen atoms to form. In the absence of light from the first stars and galaxies, the universe entered a period known as the cosmic dark ages. The first stars and galaxies appeared several hundred million years later and began burning away the hydrogen fog left over from the Big Bang, rendering the universe transparent, like it is today.

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Research 92

Drug Discovery World

JUNE 2, 2023

Lynparza (olaparib) has been approved in the US for the treatment of adult patients with deleterious or suspected deleterious BRCA-mutated (BRCAm) metastatic castration-resistant prostate cancer (mCRPC). The PARP inhibitor, developed by AstraZeneca and Merck (MSD), is approved in combination with abiraterone and prednisone or prednisolone. This approval was based on a subgroup analysis of the Phase III PROpel trial.

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Antidote

JUNE 1, 2023

The Antidote partner network is a key element of our ability to build relationships with patients and increase awareness surrounding medical research. By providing Match, our clinical trial search tool, free of charge , we are able to assist advocacy groups, nonprofits, and more in providing patient-centric clinical trial listings to empower their audiences.

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Clinical Trials Disease Trials Research 92

addgene Blog

JUNE 1, 2023

Using AAV vectors in complex biological systems can be tricky at best, and downright infuriating at worst. While it is tempting to just dive right in and start injecting your virus, a successful AAV experiment starts with validation and optimization. Although there are different ways to ultimately achieve success, we find it is usually faster and easier to do the validation first.

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Virus 80

Science Daily: Pharmacology News

JUNE 1, 2023

Researchers have discovered they can detect atomic 'breathing,' or the mechanical vibration between two layers of atoms, by observing the type of light those atoms emitted when stimulated by a laser. The sound of this atomic 'breath' could help researchers encode and transmit quantum information.

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Research 88

Drug Discovery World

JUNE 2, 2023

Meet Revvity: a first of its kind provider of health science technologies. Tackling the impossible from target to cure. When it comes to health and lives, accuracy and urgency are essential to Revvity. Revvity aims to deliver solutions that power leading precision and performance, as rapidly as possible, in order to: Diagnose diseases earlier Develop new treatments and cures sooner Forge new pathways, faster.

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Science Treatment Disease Drugs 130

Drug Channels

MAY 30, 2023

Summer unofficially began over the weekend. Check out these noteworthy delicacies, seared to perfection on the Drug Channels grill: Fresh evidence of 340B abuses by hospitals and contract pharmacies OptumRx rewrites its biosimilar Humira strategy ICER discovers channel markups Tax-exempt hospitals are not holding up their end of the bargain Plus, Dr.

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Biosimilars Hospitals Pharmacy Drugs 98

LifeSciVC

MAY 31, 2023

By Ankit Mahadevia, CEO of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC This time a quarter ago organizations large and small were in the thick of the “to hybrid or not to hybrid” debate. Each pole across the hybrid continuum has had staunch acolytes. The “all in person” crowd lamented the loss of effectiveness when we work remotely.

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Trials 74

Science Daily: Pharmacology News

MAY 29, 2023

Researchers show how their multilegged walking robot can be steered by inducing a dynamic instability. By making the couplings between segments more flexible, the robot changes from walking straight to moving in a curved path. This work can lead to more energy-efficient and reliable robotic navigation of terrain.

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Research 82

Drug Discovery World

JUNE 2, 2023

This latest eBook sponsored by Benchling features insight on how artificial intelligence is helping advance drug discovery efforts. Download this exclusive eBook to learn more about: The latest advancements in artificial intelligence How machine learning is being used across cancer research Why AI is critical to solving challenges in drug discovery How AI can improve drug development for rare diseases The post AI and drug development: Using AI and machine learning to expedite drug discovery appe

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Drug Development Drugs Disease Research 130

FDA Law Blog: Biosimilars

MAY 31, 2023

By John A. Gilbert — CBS News caused a bit of commotion last week in reporting that after a four-year delay, DEA issued a final order revoking Morris & Dickson’s DEA registration. However, until today there had been no public information about this decision. This morning, the Federal Register published two DEA notices on the Morris & Dickson matter ( here and here ).

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Compliance Government Regulations Drugs 59

Collaborative Drug

JUNE 1, 2023

PhoreMost Enhances Drug Discovery Process with CDD Vault

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Research Drugs 96

Science Daily: Pharmacology News

MAY 31, 2023

For over a century, researchers have thought that the patterns of brain activity that define our experiences, hopes and dreams are determined by how different brain regions communicate with each other through a complex web of trillions of cellular connections. Now, a study has examined more than 10,000 different maps of human brain activity and found that the overall shape of a person's brain exerts a far greater influence on how we think, feel and behave than its intricate neuronal connectivity

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Research 86

Drug Discovery World

JUNE 2, 2023

The latest eBook by DDW is out now. This 28-page eBook, sponsored by Benchling, examines the ways in which artificial intelligence and machine learning are expediting drug discovery efforts. Download this exclusive eBook to learn more about: The latest advancements in artificial intelligence How machine learning is being used across cancer research Why AI is critical to solving challenges in drug discovery How AI can improve drug development for rare diseases Access the eBook here.

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Drug Development Drugs Disease Research 130

The Pharma Data

JUNE 2, 2023

Lilly Highlights Verzenio® (abemaciclib) and Jaypirca™ (pirtobrutinib) Data at 2023 ASCO® Annual Meeting Eli Lilly and Company (NYSE: LLY) today announced Verzenio ® (abemaciclib; CDK4/6 inhibitor) and Jaypirca™ (pirtobrutinib; non-covalent (reversible) BTK inhibitor) data to be presented at the 2023 ASCO ® Annual Meeting in Chicago, June 2 – 6, 2023.

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Collaborative Drug

JUNE 2, 2023

Drug Discovery Industry Roundup with Barry Bunin — May 17, 2023

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Drugs 89

Science Daily: Pharmacology News

MAY 31, 2023

There's an intriguing exoplanet out there -- 400 light-years out there -- that is so tantalizing that astronomers have been studying it since its discovery in 2009. One orbit for WASP-18 b around its star that is slightly larger than our Sun takes just 23 hours. There is nothing like it in our Solar System. A new study about this exoplanet, an ultra-hot gas giant 10 times more massive than Jupiter.

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Drug Discovery World

JUNE 1, 2023

Sales of branded anti-obesity drugs (AOB) could hit $44 billion in 2030 vs $2.5 billion in 2022, with just under 70% stemming from the US. The predictions come from analysts at Bloomberg Intelligence (BI), who believe securing broad reimbursement and supply are key, with a possible upside from further innovations including combination products. Michael Shah, Senior Industry Analyst at Bloomberg Intelligence, commented: “We expect Novo Nordisk’s franchise (Wegovy, Saxenda, oral semaglutide,

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The Pharma Data

JUNE 2, 2023

Gilead and Kite Oncology Demonstrate Growing Hematology Pipeline and Strength of Leading Cell Therapy Portfolio at EHA FOSTER CITY, Calif. & SANTA MONICA, Calif.–(BUSINESS WIRE)– Gilead Sciences, Inc. (Nasdaq: GILD) and Kite, a Gilead Company, will present 17 abstracts from its industry-leading cell therapy portfolio and growing blood cancer pipeline at the upcoming 2023 European Hematology Association (EHA) Annual Congress being held in Frankfurt, Germany, June 8-11, and virtual

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Drug Patent Watch

JUNE 2, 2023

Annual Drug Patent Expirations for LUPRON+DEPOT-PED+KIT Lupron Depot-ped Kit is a drug marketed by Abbvie Endocrine Inc and is included in one NDA. It is available from one supplier. The… The post New patent for Abbvie Endocrine drug LUPRON DEPOT-PED KIT appeared first on DrugPatentWatch - Make Better Decisions.

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