Drug Hunter

MAY 31, 2023

This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available. Capacity Bio’s MAS Receptor Agonists with $35M Raised for FIH Clinical Trials MAS modulator from WO2022165189 example 107 New start-up Capacity Bio backed by RA Capital, Insight Partners, and Remiges Ventures with $35 million funding is working on taking first-in-class mitophagy agonists into clinical trials, which are expected to start in 2024.

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Small Molecule Clinical Trials Trials Drugs 196

Broad Institute

JUNE 1, 2023

Multi-ancestry study reveals genetic risk factors for two common pregnancy complications By Allessandra DiCorato June 1, 2023 Breadcrumb Home Multi-ancestry study reveals genetic risk factors for two common pregnancy complications The findings could help doctors identify pregnancies at risk of preeclampsia and gestational hypertension and treat them earlier.

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Doctors Medical Schools Hospitals DNA 133

Chemical Biology and Drug Design

MAY 31, 2023

Hydrazide-hydrazone derivatives were synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). In addition, molecular docking and ADME studies were carried out. Abstract A series of hydrazide-hydrazone imine derivative compounds (3a–k) were synthesized and their structures characterized using FTIR, 1 H, and 13 C (NMR) spectroscopic methods.

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Pharmacokinetics Research 100

Science Daily: Pharmacology News

MAY 31, 2023

Scientists have taken the world's first X-ray SIGNAL (or SIGNATURE) of just one atom. This groundbreaking achievement could revolutionize the way scientists detect the materials.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

ProRelix Research

MAY 31, 2023

Introduction: Clinical trials are a crucial component of the pharmaceutical and medical research industry, aimed at evaluating the safety and effectiveness of new drugs, treatments, or medical devices before they […] The post Successful Clinical Trial With ProRelix Research: Phase 1, 2, 3 & 4 Clinical Trial Services at … appeared first on ProRelix Research.

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Clinical Trials Trials Research Pharmaceuticals 98

biobide

JUNE 2, 2023

Chronic Toxicity studies are a form of assays that are likely to affect the health of a subject if exposed to a substance repeatedly or constantly over an extended period of time to know the long-term effects.

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Drugs 98

Science Daily: Pharmacology News

MAY 31, 2023

Even without nerves, plants can sense when something touches them and when it lets go, a study has found. In a set of experiments, individual plant cells responded to the touch of a very fine glass rod by sending slow waves of calcium signals to other plant cells, and when that pressure was released, they sent much more rapid waves. While scientists have known that plants can respond to touch, this study shows that plant cells send different signals when touch is initiated and ended.

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Broad Institute

MAY 30, 2023

Artificial intelligence system predicts consequences of disruptions to genetic networks By Tom Ulrich May 30, 2023 Breadcrumb Home Artificial intelligence system predicts consequences of disruptions to genetic networks Computer model helps researchers understand the connections between thousands of genes, and pinpoint how those connections go awry in disease By Sarah C.P.

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Disease Research Laboratories Science 98

Drug Target Review

JUNE 1, 2023

In a recent study , found in Cell Reports. La Jolla Institute for Immunology (LJI), US, scientists demonstrated how antibodies obtained from a clinical study participant attach to the SARS-CoV-2 spike protein and neutralise the virus. The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. 1 New research from Moderna shows that their original SARS-CoV-2 vaccine can prompt the body to produce antibodies against the more recent Omicron

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Virus Vaccine Immune Response Research 97

Chemical Biology and Drug Design

MAY 29, 2023

Talaromyces flavus , an endophytic fungus isolated from marine algae Grateloupia lithophila. Cytotoxicity compound substance in T. flavus ethyl acetate extract and purification by column chromatography, preparative thin layer chromatography-bioassay guide. Purified ambuic acid derivative was evaluated in vitro using the human cancer cell line MDA-MB-231.

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Drugs Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Antidote

MAY 30, 2023

To successfully advertise a clinical trial , it is important to create materials that engage patients and adhere to the strict guidelines of the Food and Drug Administration (FDA) in equal measure. It can be challenging to come up with creative and captivating material within these confines, but by developing a strategic advertising plan , it’s possible to find the appropriate balance.

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Clinical Trials Trials FDA Drugs 96

KIF1A

MAY 27, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dominique Lessard and Dr. Dylan Verden of KIF1A.ORG summarize newly published KIF1A-related research and highlight progress in rare disease research and therapeutic development. Goodbye with Gratitude: Dr. Dominique Lessard It is with heavy hearts that this week we say goodbye to Dr.

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Science Small Molecule Disease Research 94

NIOSH Science Blog: Drugs

JUNE 1, 2023

Each June, we celebrate National Safety Month. Safety matters every day of the year, but during June it gets the extra attention it deserves so we can all stay safe from the workplace to anyplace. As part of the celebration of safety, the National Safety Council (NSC) selects themes for each week of the month. This blog will highlight research and prevention efforts from the National Institute for Occupational Safety and Health (NIOSH) and NSC in this year’s focus areas of emergency preparedness

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Research 93

Broad Institute

MAY 30, 2023

#WhyIScience Q&A: A process development lead returns to her research roots By Corie Lok May 30, 2023 Breadcrumb Home #WhyIScience Q&A: A process development lead returns to her research roots Isabella Teixeira-Soldano reflects on her time as a technician in Broad’s COVID-19 testing lab and how that led to a position doing single-cell research. By Andrea Tamayo May 30, 2023 Credit: Allison Dougherty, Broad Communications Isabella Teixeira-Soldano studies single cells to better understand disease

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Research Medical Schools Doctors Science 89

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Clinical Trials

Antidote

JUNE 1, 2023

The Antidote partner network is a key element of our ability to build relationships with patients and increase awareness surrounding medical research. By providing Match, our clinical trial search tool, free of charge , we are able to assist advocacy groups, nonprofits, and more in providing patient-centric clinical trial listings to empower their audiences.

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Clinical Trials Disease Trials Research 92

Science Daily: Pharmacology News

JUNE 1, 2023

After the Big Bang, the universe expanded and cooled sufficiently for hydrogen atoms to form. In the absence of light from the first stars and galaxies, the universe entered a period known as the cosmic dark ages. The first stars and galaxies appeared several hundred million years later and began burning away the hydrogen fog left over from the Big Bang, rendering the universe transparent, like it is today.

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Research 93

addgene Blog

JUNE 1, 2023

Using AAV vectors in complex biological systems can be tricky at best, and downright infuriating at worst. While it is tempting to just dive right in and start injecting your virus, a successful AAV experiment starts with validation and optimization. Although there are different ways to ultimately achieve success, we find it is usually faster and easier to do the validation first.

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Virus 81

Drug Channels

JUNE 1, 2023

Today’s guest post comes from Vishali Amin, Chief of Staff to the Office of the President and Senior Director of Customer Success at Kalderos. Vishali discusses the persistent challenges of duplicate discounts between the 340B Drug Pricing Program and the Medicaid Drug Rebate Program. The Inflation Reduction Act of 2022 will further complicate duplicate discount issues.

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Drugs 74

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Patent Watch

MAY 27, 2023

This chart shows the patent expirations for capsule dosed drugs over the next decade. The term of drug patents varies. The basic term for a patent is 20 years from… The post Capsule dosed drug patent expirations by year appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs 71

Science Daily: Pharmacology News

JUNE 1, 2023

Researchers have discovered they can detect atomic 'breathing,' or the mechanical vibration between two layers of atoms, by observing the type of light those atoms emitted when stimulated by a laser. The sound of this atomic 'breath' could help researchers encode and transmit quantum information.

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Research 90

LifeSciVC

MAY 31, 2023

By Ankit Mahadevia, CEO of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC This time a quarter ago organizations large and small were in the thick of the “to hybrid or not to hybrid” debate. Each pole across the hybrid continuum has had staunch acolytes. The “all in person” crowd lamented the loss of effectiveness when we work remotely.

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Trials 71

FDA Law Blog: Biosimilars

JUNE 2, 2023

By Alan M. Kirschenbaum — Last Friday, May 26, CMS published in the Federal Register an assortment of proposals to change the regulations governing the Medicaid Drug Rebate Program. Most are new or revised definitions and administrative changes, but several proposals represent new policies that should be of concern to drug manufacturers. It is not our purpose to describe all of the nearly 20 changes proposed in this regulation, but the most noteworthy are described below, roughly in order of i

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Drugs Regulations Government Vaccine 57

Collaborative Drug

JUNE 1, 2023

PhoreMost Enhances Drug Discovery Process with CDD Vault

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Research Drugs 98

Science Daily: Pharmacology News

MAY 29, 2023

Researchers show how their multilegged walking robot can be steered by inducing a dynamic instability. By making the couplings between segments more flexible, the robot changes from walking straight to moving in a curved path. This work can lead to more energy-efficient and reliable robotic navigation of terrain.

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Research 83

Drug Channels

MAY 30, 2023

Summer unofficially began over the weekend. Check out these noteworthy delicacies, seared to perfection on the Drug Channels grill: Fresh evidence of 340B abuses by hospitals and contract pharmacies OptumRx rewrites its biosimilar Humira strategy ICER discovers channel markups Tax-exempt hospitals are not holding up their end of the bargain Plus, Dr.

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Biosimilars Hospitals Pharmacy Drugs 78

FDA Law Blog: Biosimilars

MAY 31, 2023

By John A. Gilbert — CBS News caused a bit of commotion last week in reporting that after a four-year delay, DEA issued a final order revoking Morris & Dickson’s DEA registration. However, until today there had been no public information about this decision. This morning, the Federal Register published two DEA notices on the Morris & Dickson matter ( here and here ).

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Compliance Government Regulations Drugs 57

Collaborative Drug

JUNE 2, 2023

Drug Discovery Industry Roundup with Barry Bunin — May 17, 2023

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Drugs 90

Science Daily: Pharmacology News

MAY 31, 2023

For over a century, researchers have thought that the patterns of brain activity that define our experiences, hopes and dreams are determined by how different brain regions communicate with each other through a complex web of trillions of cellular connections. Now, a study has examined more than 10,000 different maps of human brain activity and found that the overall shape of a person's brain exerts a far greater influence on how we think, feel and behave than its intricate neuronal connectivity

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Research 87

addgene Blog

MAY 30, 2023

This post was contributed by guest blogger Didem Goz Ayturk with edits and updates from Addgenies Karen Guerin and Susanna Stroik. Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. AAVs are non-pathogenic, do not integrate into the host genome, and can be specifically targeted to a number of different cell types even when systemically administered in a

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Packaging Virus DNA Laboratories 53

The Pharma Data

JUNE 2, 2023

Lilly Highlights Verzenio® (abemaciclib) and Jaypirca™ (pirtobrutinib) Data at 2023 ASCO® Annual Meeting Eli Lilly and Company (NYSE: LLY) today announced Verzenio ® (abemaciclib; CDK4/6 inhibitor) and Jaypirca™ (pirtobrutinib; non-covalent (reversible) BTK inhibitor) data to be presented at the 2023 ASCO ® Annual Meeting in Chicago, June 2 – 6, 2023.

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Trials Treatment Clinical Trials Therapies 52

Drug Patent Watch

JUNE 2, 2023

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Slovakia. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Slovakia? appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceutical Companies Pharmaceuticals 52

Science Daily: Pharmacology News

MAY 31, 2023

There's an intriguing exoplanet out there -- 400 light-years out there -- that is so tantalizing that astronomers have been studying it since its discovery in 2009. One orbit for WASP-18 b around its star that is slightly larger than our Sun takes just 23 hours. There is nothing like it in our Solar System. A new study about this exoplanet, an ultra-hot gas giant 10 times more massive than Jupiter.

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Crucial Data Solutions

JUNE 2, 2023

Clinical trials continue to move closer to patients. Improvements to data collection technologies and processes, a robust high-speed internet infrastructure, The post Modern Solutions for Modern Clinical Trials – The Benefits of Mobile EDC Access appeared first on Crucial Data Solutions.

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Clinical Trials Trials 52