Drug Discovery World

FEBRUARY 12, 2024

DDW’s Megan Thomas spoke to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. This is part of a series of predictions based on different themes. Here, experts weigh in on the impact of artificial intelligence (AI), machine learning (ML) and automation in the sector. Updesh Dosanjh, Practice Leader for Pharmacovigilance Technology Solutions, IQVIA “In 2024, the traditional pain points of the pharmacovigilance (PV) space will not disappear.

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Chemical Biology and Drug Design

FEBRUARY 15, 2024

Role of serotonin, dopamine, and norepinephrine in neural functions and symptoms involved during their altered levels. Abstract Depression is not similar to daily mood fluctuations and temporary emotional responses to day-to-day activities. Depression is not a passing problem; it is an ongoing problem. It deals with different episodes consisting of several symptoms that last for at least 2 weeks.

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Science Daily: Pharmacology News

FEBRUARY 15, 2024

Our brains are 'programmed' to learn more from people we like -- and less from those we dislike. This has been shown by researchers in cognitive neuroscience in a series of experiments.

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BioPharma Drive: Drug Pricing

FEBRUARY 15, 2024

Analysts pressed Alnylam executives on the reasons for the changes to HELIOS-B, a Phase 3 study in ATTR amyloidosis with cardiomyopathy that is important to the company’s future.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Discovery World

FEBRUARY 12, 2024

A team from Aston University and the University of Warwick has secured a £1.8 ($2.2) million grant to engineer microbial cell factories to produce membrane proteins which will support future drug screening and sustainable chemical production. The Engineering Biology Mission Award was given by UK Research and Innovation (UKRI). Membrane proteins are crucial molecules on the surface of cells with numerous biological functions, such as sensing hormones or cell communication.

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Drugs.com

FEBRUARY 14, 2024

WEDNESDAY, Feb. 14, 2024 -- An Oregonian who was diagnosed with the bubonic plague -- the disease that killed millions of Europeans in the Middle Ages -- probably got it from an infected pet cat, health officials said. The patient and all close.

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BioPharma Drive: Drug Pricing

FEBRUARY 14, 2024

Latigo Biotherapeutics has raised $135 million to develop drugs that block NaV1.8, a target shared by a Vertex therapy that just succeeded in Phase 3 testing.

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Drug Discovery World

FEBRUARY 16, 2024

Novartis’ Cosentyx (secukinumab) is now available in Scotland, following positive advice from the Scottish Medicines Consortium (SMC). It is licensed for adults with active moderate to severe hidradenitis suppurativa (HS) (acne inversa) who have responded inadequately to conventional systemic HS therapy. The advice applies for use in adult patients with active moderate to severe HS for whom adalimumab is contraindicated or otherwise unsuitable, including those who have failed to respond or have

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Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- Mammograms are a lifesaving misery for middle-aged women, but a new tool could make getting a breast cancer screening as easy as spitting.Literally.A new hand-held biosensor can detect breast cancer biomarkers from a tiny.

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Science Daily: Pharmacology News

FEBRUARY 12, 2024

Growing cartilage tissue in the lab could help patiens with injuries, but it is very hard to make the tissue grow in exactly the right shape. A new approach could solve this problem: Tiny spherical containers are created with a high-resolution 3D printer. These containers are then filled with cells and assembled into the desired shape. The cells from different containers connect, the container itself is degradable and eventually disappears.

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Perficient: Drug Development

FEBRUARY 14, 2024

Revolutionizing B2C Commerce: The Impact of Generative AI In the dynamic landscape of commerce and consumer-driven markets, Business-to-Consumer (B2C) organizations are increasingly turning to generative AI to revolutionize their operations and enhance customer experiences. Generative AI, a subset of artificial intelligence, empowers these organizations to create content, personalize interactions, and optimize various aspects of their business processes.

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Drug Discovery World

FEBRUARY 16, 2024

Belfast-based techbio company AMPLY Discovery has raised over £1.4 ($1.7) million in grant funding to develop new drugs using its AI-driven drug discovery platform. The company, which is a spin-out from the Queen’s University Belfast, was established in 2021 to commercialise a drug discovery platform developed by researchers in the School of Biological Science at Queen’s.

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Drugs.com

FEBRUARY 16, 2024

FRIDAY, Feb. 16, 2024 (HealthDay news) -- A drug first developed to treat cocaine addiction might also help slow the spread of advanced colon cancer, a new study suggests.The drug vanoxerine appears to suppress cancer stem cell activity by.

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BioPharma Drive: Drug Pricing

FEBRUARY 14, 2024

The company and partner Biogen say signs from payers and doctors suggest the launch of Zurzuvae, the first oral therapy for PPD, is off to a good start.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Drug Target Review

FEBRUARY 12, 2024

Denise, could you share some insights into your journey at Onyx Scientific, highlighting key milestones and challenges you’ve faced during your nearly 25 years with the company? At the turn of the millennium in early 2000, I was approached by the founders of Onyx Scientific to join the company as their Business Development Manager. I considered this to be an exciting opportunity and became part of the original team that established the company.

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Drug Discovery World

FEBRUARY 15, 2024

DDW Editor Reece Armstrong speaks to Tracy M Woody , President and Chief Executive Officer of Cessation Therapeutics, about the company’s goal to develop an antibody therapy to prevent fentanyl overdoses. Cessation Therapeutics is a pharmaceutical company that is developing antibody therapies to prevent and reverse overdosing caused by fentanyl. Recently, the company was awarded an additional grant from the National Institute on Drug Abuse (NIDA) to support the development of its anti- fentanyl

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Drugs.com

FEBRUARY 16, 2024

FRIDAY, Feb. 16, 2024 -- The U.S. Centers for Disease Control and Prevention is weighing whether to recommend another COVID booster shot this spring, most likely for those who are vulnerable to severe illness.An advisory panel to the CDC is.

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Disease 116

KIF1A

FEBRUARY 10, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Unraveling the genetic landscape of undiagnosed cerebellar ataxia in Brazilian patients In this week’s article, researchers in Brazil performed genetic sequencing on 87 patients with cerebe

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National Drug & Alcohol Research Centre Blog

FEBRUARY 12, 2024

Who’s most likely to die from alcohol poisoning, and what do they drink? A new study led by researchers at the National Drug and Alcohol Research Centre (NDARC), UNSW Sydney, has explored the circumstances of death and characteristics of fatal alcohol poisoning cases. The study, published in Drug and Alcohol Review, examined deaths from acute alcohol poisoning in Australia, 2011–2022.

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Drug Discovery World

FEBRUARY 14, 2024

Gain Therapeutics has announced preclinical data demonstrating that its clinical-stage GCase regulator GT-02287 provided neuroprotection and restored motor function in Parkinson’s disease models following delayed administration. The data was accepted as a late-breaker abstract and was presented at the 20 th Annual WORLDSymposium. “We believe the data showing complete restoration of motor function in a therapeutic model are remarkable and further support the potential of GT-02287 to slow or

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Drugs.com

FEBRUARY 16, 2024

FRIDAY, Feb. 16, 2024 -- A standard blood test can reveal whether a person is at high risk of having a heart attack within six months, a new study shows.Researchers identified dozens of biomarkers in blood linked to the risk of a first heart.

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NIOSH Science Blog: Drugs

FEBRUARY 14, 2024

Finding the right fit is one of the most important parts of a relationship. You don’t just grab any old fish from the sea that swims by and hope for the best. First, it’s necessary to test the waters and ensure you’re simpatico before settling on a partner. It’s Valentine’s Day, and yes, this advice could apply to your romantic life, but we also love to use today to show our love of respirators and we love to play matchmaker on your behalf as well.

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Science Daily: Pharmacology News

FEBRUARY 13, 2024

Babies playfully tease others as young as eight months of age. Since language is not required for this behavior, similar kinds of playful teasing might be present in non-human animals. Now cognitive biologists and primatologists have documented playful teasing in four species of great apes. Like joking behavior in humans, ape teasing is provocative, persistent, and includes elements of surprise and play.

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Drug Discovery World

FEBRUARY 14, 2024

Vaccination responses need to be rapid, efficacious and cost-effective if they are to outpace new viral threats emerging across the globe, says Jian He (Jason) , Chemistry, Manufacturing and Controls (CMC) Head, WuXi Vaccines. Technologies that hasten the pathway from vaccine discovery to commercialisation form an important part of the world’s ongoing quest to outpace emerging viral threats.

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Drugs.com

FEBRUARY 16, 2024

FRIDAY, Feb. 16, 2024 -- People threatened by accidental exposure to foods they're allergic to may have a new weapon of defense: On Friday, the U.S. Food and Drug Administration expanded the use of the asthma drug Xolair to help prevent.

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Drug Target Review

FEBRUARY 16, 2024

Scientists at the University of Pittsburgh have discovered that tumours with a greater intragenic rearrangement (IGR) burden may respond better to immune checkpoint blockades (ICB). This could lead to more precise treatment for patients with cancers like oesophageal, breast, ovarian and endometrial, which solves an unmet need to discover genetic abnormalities that predict ICB responses in these tumour types.

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Science Daily: Pharmacology News

FEBRUARY 15, 2024

New research reveals the scale of inappropriate reforestation projects across Africa. A new study reveals that an area the size of France is threatened by forest restoration initiatives, such as the AFR100 initiative (African Forest Landscape Restoration Initiative), due to inappropriate restoration in the form of tree-planting.

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Drug Discovery World

FEBRUARY 13, 2024

DDW Editor Reece Armstrong asks whether artificial intelligence (AI) is the magic bullet many think it is. To reflect on another year in pharma is to think of the major stories and trends that have made impact within the industry. Often this can be drug approvals, exciting research into hard-to-treat indications, or even regulatory updates that enable players within the sector to utilise the latest technologies and drive therapies to market faster, ultimately benefitting patients.

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Drugs.com

FEBRUARY 16, 2024

FRIDAY, Feb. 16, 2024 -- A little-known pesticide is likely present in the bodies of most U.S. residents, raising concerns of potential reproductive and developmental problems, researchers report.In the study, the pesticide chlormequat was found in.

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Drug Patent Watch

FEBRUARY 15, 2024

Elevate your excipient business strategies with the comprehensive Drug Excipient Business Development Reports from DrugPatentWatch. Designed for excipient manufacturers seeking lucrative opportunities in the pharmaceutical industry, these reports offer invaluable… The post Drug Excipient Business Development Reports now Available on Amazon appeared first on DrugPatentWatch - Make Better Decisions.

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Science Daily: Pharmacology News

FEBRUARY 16, 2024

A research team that had previously succeeded in synthesizing fumaric acid using bicarbonate and pyruvic acid, and carbon dioxide collected directly from the gas phase as one of the raw materials, has now created a new photosensitizer and developed a new artificial photosynthesis technology, effectively doubling the yield of fumaric acid production compared to the previous method.

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Drug Discovery World

FEBRUARY 12, 2024

Dr Pandora Pound , Fellow Oxford Centre for Animal Ethics explores the hinderances of animal testing in pharma and why new technologies such AI, genomics and synthetic biology c an further drug development. There was great fanfare recently for a new Alzheimer’s drug, lecanemab (brand name Leqembi), which was shown in a trial to reduce the rate of cognitive decline in people with mild impairment.

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Drugs.com

FEBRUARY 14, 2024

WEDNESDAY, Feb. 14, 2024 -- Acupuncture may protect people with rheumatoid arthritis (RA) from stroke, new research suggests.The study indicates that a course of acupuncture treatment may lower blood levels of inflammatory proteins called.

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BioPharma Drive: Drug Pricing

FEBRUARY 16, 2024

The disclosure the experimental therapy missed its trial goal comes after Sanofi had earmarked the drug for advancement into Phase 3.

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