Practical Cheminformatics

OCTOBER 8, 2024

“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.

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Science Daily: Pharmacology News

OCTOBER 9, 2024

Studying microscopic layers of dirt dug from the Tam Pa Ling cave site in northeastern Laos has provided a team of archaeologists further insights into some of the earliest evidence of Homo sapiens in mainland Southeast Asia. The site, which has been studied for the past 14 years, has produced some of the earliest fossil evidence of our direct ancestors in Southeast Asia but now a new study has reconstructed the ground conditions in the cave between 52,000 and 10,000 years ago.

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Drug Discovery Today

OCTOBER 7, 2024

Researchers from the Institute of Biotechnology at the Life Sciences Center of Vilnius University – Dalia Smalakyte, Audrone Rukšenaite, Dr Giedrius Sasnauskas, Dr Giedre Tamulaitiene, and Dr Gintautas Tamulaitis – have revealed the structure of the CRISPR-Cas "protein scissors" found in bacteria and provided mechanistic details on how they function.

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Drugs.com

OCTOBER 10, 2024

THURSDAY, Oct. 10, 2024 -- After Hurricane Helene knocked out a North Carolina production plant for a major supplier of IV fluids for U.S. hospitals, officials said the federal government is reaching out internationally to help restore supply.The.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 9, 2024

Microbiologists found that showerheads and toothbrushes are teeming with an extremely diverse collection of viruses -- most of which have never been seen before.

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ASPET

OCTOBER 8, 2024

Amitriptyline, a pleiotropic tricyclic antidepressant, possesses anti-oxidant and anti-inflammatory properties. Despite its diverse benefits, the specific effects of amitriptyline on IBD are not yet well defined. To explore this, we utilized a DSS-induced colitis model to examine the anti-inflammatory effects of amitriptyline and the underlying mechanisms by which it operates.

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Drugs.com

OCTOBER 11, 2024

FRIDAY, Oct. 11, 2024 -- Endometriosis could be linked to the health of a woman’s microbiome, a new study says. The discovery might help lead to an early test for the painful condition, and possible new treatments.A specific set of bacteria in w.

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Science Daily: Pharmacology News

OCTOBER 10, 2024

Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.

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ASPET

OCTOBER 8, 2024

Discoidin domain receptor 1 (DDR1) is a collagen receptor with tyrosine kinase activity, and its expression is enhanced in various disease conditions. Although previous research suggests that DDR1 contributes to renal disease progression, DDR1 inhibitors for renal fibrosis have yet to be developed. In this study, we used unilateral ureteral obstruction (UUO) mice to investigate whether CH6824025, a strong and selective DDR1 phosphorylation inhibitor, can improve renal fibrosis.

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Chemical Biology and Drug Design

OCTOBER 6, 2024

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder characterized by loss of memory and other cognitive functions. The problem of this disease is even more fundamental because the available therapies only provide symptomatic relief without addressing the basic factor of the disease. This review article comprehensively summarized the recent advancement in memantine and its hybrid analogs as potential disease-modifying agents for the management of AD.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

OCTOBER 7, 2024

The Cambridge, Massachusetts-based biotech is using what it calls ligand-siRNA conjugates to reach drug targets in the kidney, which historically have been difficult to reach with RNA therapies.

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Science Daily: Pharmacology News

OCTOBER 8, 2024

An international coalition of scientists concludes that the Earth's worsening vital signs indicate a 'critical and unpredictable new phase of the climate crisis' and that 'decisive action is needed, and fast.

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ASPET

OCTOBER 8, 2024

Progressive multiple sclerosis (PMS) represents the worsening phase of the disease by accumulative neurodegeneration and disability, mainly refractory to current treatments. The therapeutic options remain challenging based partially on the lack of understanding of the pathogenic mechanisms but also because the early dogma was centered on neuroinflammation, overshadowing the critical role of the tissue repair process.

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Drugs.com

OCTOBER 10, 2024

THURSDAY, Oct. 10, 2024 -- More than 15.5 million U.S. adults have been diagnosed with ADHD, and nearly three-quarters of those taking medication to treat it say drug shortages are hampering their ability to get help, a new report finds. According.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

OCTOBER 11, 2024

The French pharmaceutical giant said it’s in negotiations to sell a controlling stake of Opella to the private equity firm CD&R, in a deal that reportedly could be worth more than $16 billion.

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Science Daily: Pharmacology News

OCTOBER 10, 2024

A new study from The Neuro (Montreal Neurological Institute-Hospital) of McGill university, the University of Ottawa and the University of Zaragoza in Spain elaborates on bilingualism's role in cognition, showing increased efficiency of communication between brain regions.

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ASPET

OCTOBER 8, 2024

Androgen deprivation is the standard treatment for prostate cancer (PCa) patients. However, the disease eventually progresses as castration-resistant PCa (CRPC). Enzalutamide, an AR inhibitor, is a typical drug to treating CRPC and due to continuous reliance on the drug, can lead to Enzalutamide-resistance (ENZ-r). This highlights the necessity for developing novel therapeutic targets to combat the gain of resistance.

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Drugs.com

OCTOBER 9, 2024

WEDNESDAY, Oct. 9, 2024 -- When it comes to coverage for the pricey GLP-1 weight-loss drugs Wegovy and Zepbound, only a fifth of large U.S. companies cover the medications in their health insurance plans, a new survey shows. In a report published.

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BioPharma Drive: Drug Pricing

OCTOBER 10, 2024

In a letter to Pfizer’s board, the activist investor claimed former CEO Ian Read and CFO Frank D’Amelio were pressured to abandon a Starboard-led attempt to change the company’s direction.

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Science Daily: Pharmacology News

OCTOBER 9, 2024

Researchers tracked the health of nearly one thousand mice on a variety of diets to see if these diets would extend the mice's lifespan. The study was designed to ensure that each mouse was genetically distinct, which allowed the team to better represent the genetic diversity of the human population. By doing so, the results are made more clinically relevant, elevating the study to one of the most significant investigations into aging and lifespan to date.

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ASPET

OCTOBER 8, 2024

The objective of this study is to investigate whether PI3kinase (PI3K) and p38 mitogen-activated kinase contributes to the protection of irisin during hemorrhage/resuscitation. Experimental groups were divided by receiving the different treatments during resuscitation: I ) Hemorrhage: Adult male CD-1 mice were subjected to hemorrhage at a mean arterial blood pressure of 35~45 mmHg for 60 min followed by 120 min of resuscitation (n=13); II ) Hemorrhage + Irisin: receiving irisin (5µg/kg) (n=

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Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- "Black Box” warnings added to antidepressants might have contributed to an increase in suicide attempts and deaths among young people, a new evidence review claims.The warnings say that antidepressants might be associated w.

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Perficient: Drug Development

OCTOBER 11, 2024

In our ongoing Health and Life Sciences series, we’re excited to share a remarkable transformation achieved by a leading pediatric health system. This organization, renowned for its commitment to children’s health, faced challenges in scaling its outreach efforts and enhancing patient experiences. Here’s how Perficient helped revolutionize their approach using Salesforce solutions.

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Science Daily: Pharmacology News

OCTOBER 10, 2024

Skin pigmentation may act as a 'sponge' for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report.

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ASPET

OCTOBER 8, 2024

Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL fusion protein, such as imatinib (Gleevec), have revolutionized targeted cancer therapies. However, drug resistance and side effects, particularly those affecting hemostasis, continue to pose significant challenges for TKI therapies. As tyrosine kinases serve pivotal roles in platelet hemostatic function, we investigated the potential impact of both established and emerging ABL TKIs on human platelet activities ex vivo.

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Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s.

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Drug Channels

OCTOBER 11, 2024

Today’s guest post comes from Angie Franks, Chief Executive Officer of Kalderos. Angie discusses how the Maximum Fair Price provision of the Inflation Reduction Act of 2022 will challenge providers, pharmacies, and manufacturers. She explains how Kalderos’ Truzo platform could reduce duplicate claims and address compliance issues. To learn more, register for Kalderos’ October 25 webinar Cracking the MFP Code: How Flexible Technology Helps You Navigate an Evolving Landscape.

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Science Daily: Pharmacology News

OCTOBER 8, 2024

A research team describes how they engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.

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Perficient: Drug Development

OCTOBER 9, 2024

Today’s digital landscape is dynamic. It favors speed over size, agility over efficiency, and cross-functional collaboration over rigid structures. You must be prepared to adapt and scale your teams as priorities shift. Moving forward requires a comprehensive digital strategy that outlines the capabilities, agility, and alignment needed to stay ahead of digital disruption.

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Marketing 101

Drugs.com

OCTOBER 10, 2024

THURSDAY, Oct. 10, 2024 -- More than a third of women don’t know they are pregnant in time to meet the six-week abortion ban active in four U.S. states, a new study finds.About 37% of women who got an abortion in 2021 and 2022 discovered they were p.

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BioPharma Drive: Drug Pricing

OCTOBER 9, 2024

Many pharma companies are now using de-identified lab data to identify potential patients and their physicians in time to impact the patient’s treatment plan. In this Q&A, learn how lab data can be used to increase patient access.

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Science Daily: Pharmacology News

OCTOBER 9, 2024

Researchers took the imaginary scenes from Spider-Man seriously and created the first web-slinging technology in which a fluid material can shoot from a needle, immediately solidify as a string, and adhere to and lift objects.

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Drug Channels

OCTOBER 7, 2024

Informa Connect’s PBM Contracting Summit December 10-11, 2024 | Chicago, IL Drug Channels readers save 10% with code 24DRCH10 * Experts from across the US come together each year at the PBM Contracting Summit to gain innovative and practical contracting strategies, master PBM innovation and design, improve patient care management and rising costs, understand the current legislative issues impacting contract negotiations and more.

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Drugs.com

OCTOBER 7, 2024

MONDAY, Oct. 7, 2024 -- Even as folks in North Carolina continue to clean up following the devastation of Hurricane Helene, a new health danger has emerged: The massive flooding that swept away roads and towns also uprooted the underground nests of.

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