Practical Cheminformatics

OCTOBER 8, 2024

“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.

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Science Daily: Pharmacology News

OCTOBER 9, 2024

Studying microscopic layers of dirt dug from the Tam Pa Ling cave site in northeastern Laos has provided a team of archaeologists further insights into some of the earliest evidence of Homo sapiens in mainland Southeast Asia. The site, which has been studied for the past 14 years, has produced some of the earliest fossil evidence of our direct ancestors in Southeast Asia but now a new study has reconstructed the ground conditions in the cave between 52,000 and 10,000 years ago.

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Drug Discovery Today

OCTOBER 7, 2024

Researchers from the Institute of Biotechnology at the Life Sciences Center of Vilnius University – Dalia Smalakyte, Audrone Rukšenaite, Dr Giedrius Sasnauskas, Dr Giedre Tamulaitiene, and Dr Gintautas Tamulaitis – have revealed the structure of the CRISPR-Cas "protein scissors" found in bacteria and provided mechanistic details on how they function.

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Research Science 113

Drugs.com

OCTOBER 10, 2024

THURSDAY, Oct. 10, 2024 -- After Hurricane Helene knocked out a North Carolina production plant for a major supplier of IV fluids for U.S. hospitals, officials said the federal government is reaching out internationally to help restore supply.The.

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Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 9, 2024

Microbiologists found that showerheads and toothbrushes are teeming with an extremely diverse collection of viruses -- most of which have never been seen before.

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Virus 340

Collaborative Drug

OCTOBER 7, 2024

What is a Structure Activity Relationship? Structure Activity Relationships (SAR) can be used to predict biological activity from molecular structure. This powerful technology is used in drug discovery to guide the acquisition or synthesis of desirable new compounds, as well as to further characterize existing molecules. Predicting Biological Activity from Structure The biological effects of a new chemical compound can often be predicted from its molecular structure using data about other simila

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FDA Approval Laboratories FDA Research 264

Drugs.com

OCTOBER 11, 2024

FRIDAY, Oct. 11, 2024 -- Endometriosis could be linked to the health of a woman’s microbiome, a new study says. The discovery might help lead to an early test for the painful condition, and possible new treatments.A specific set of bacteria in w.

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Treatment 290

Science Daily: Pharmacology News

OCTOBER 10, 2024

Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.

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Research 357

BioPharma Drive: Drug Pricing

OCTOBER 10, 2024

In a letter to Pfizer’s board, the activist investor claimed former CEO Ian Read and CFO Frank D’Amelio were pressured to abandon a Starboard-led attempt to change the company’s direction.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Collaborative Drug

OCTOBER 7, 2024

Chemical registration is the most critical part of your discovery engine. If you are working without a chemical registration system (or avoiding your unwieldy legacy solution), you may be missing the full value of your data – wasting time and money. CDD Vault harmonizes your compound collection and ties it to your screening data, allowing you to track screening results across compounds and families of compounds.

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Drugs Engineering Trials 262

Drugs.com

OCTOBER 10, 2024

THURSDAY, Oct. 10, 2024 -- Some people might have Long COVID symptoms because the coronavirus is still active inside their bodies, a new study finds.People with wide-ranging Long COVID symptoms were twice as likely to have SARS-CoV-2 proteins in.

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Science Daily: Pharmacology News

OCTOBER 8, 2024

An international coalition of scientists concludes that the Earth's worsening vital signs indicate a 'critical and unpredictable new phase of the climate crisis' and that 'decisive action is needed, and fast.

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International 346

BioPharma Drive: Drug Pricing

OCTOBER 7, 2024

Phase 3 findings could position the biotech’s therapy to become part of a “new standard” for SMA, its CEO said, while boosting research into whether it can preserve muscle in people with obesity.

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Therapies Drugs Research 280

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Covalent Modifiers

OCTOBER 10, 2024

Póti, Á.L., Bálint, D., Alexa, A. et al. Nat Commun 15 , 8607 (2024). [link] For mitogen-activated protein kinases (MAPKs) a shallow surface—distinct from the substrate binding pocket—called the D(ocking)-groove governs partner protein binding. Screening of broad range of Michael acceptor compounds identified a double-activated, sterically crowded cyclohexenone moiety as a promising scaffold.

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Government Drugs 147

Drugs.com

OCTOBER 10, 2024

THURSDAY, Oct.10, 2024 -- Most boys treated with breakthrough gene therapy for a rare but deadly brain illness are faring well six years later, two new reports find.The 77 boys were treated for cerebral adrenoleukodystrophy (CALD), a formerly.

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Therapies Disease 283

Science Daily: Pharmacology News

OCTOBER 10, 2024

A new study from The Neuro (Montreal Neurological Institute-Hospital) of McGill university, the University of Ottawa and the University of Zaragoza in Spain elaborates on bilingualism's role in cognition, showing increased efficiency of communication between brain regions.

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Hospitals 344

BioPharma Drive: Drug Pricing

OCTOBER 11, 2024

The French pharmaceutical giant said it’s in negotiations to sell a controlling stake of Opella to the private equity firm CD&R, in a deal that reportedly could be worth more than $16 billion.

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Pharmaceuticals 278

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Covalent Modifiers

OCTOBER 10, 2024

Bálint, D., Póti, Á.L., Alexa, A. et al. Nat Commun 15, 8606 (2024). [link] There has been a surge of interest in covalent inhibitors for protein kinases in recent years. Despite success in oncology, the off-target reactivity of these molecules is still hampering the use of covalent warhead-based strategies. Herein, we disclose the development of precision-guided warheads to mitigate the off-target challenge.

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Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- "Black Box” warnings added to antidepressants might have contributed to an increase in suicide attempts and deaths among young people, a new evidence review claims.The warnings say that antidepressants might be associated w.

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FDA 279

Science Daily: Pharmacology News

OCTOBER 7, 2024

Vegetation cover across the Antarctic Peninsula has increased more than tenfold over the last four decades, new research shows.

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Research 325

BioPharma Drive: Drug Pricing

OCTOBER 9, 2024

The company, which is building a database of biological interactions found in nature, revealed $60 million in funding and a collaboration with David Liu’s lab.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Covalent Modifiers

OCTOBER 8, 2024

Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Brendan G. Dwyer, Katherine A. Donovan, Zixuan Jiang, Hannah M. Jones, Dinah M. Abeja, Meredith N. Nix, Jianing Zhong, Mikołaj Słabicki, Eric S. Fischer, Benjamin L. Ebert, Nathanael S. Gray bioRxiv 2024.09.25.615094; doi: [link] Targeted covalent inhibition (TCI) and targeted protein degradation (TPD) have proven effective in pharmacologically addressing formerly ‘undruggable’ targets.

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Drugs.com

OCTOBER 8, 2024

TUESDAY, Oct. 8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s.

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Disease 278

Science Daily: Pharmacology News

OCTOBER 8, 2024

A new article shares findings from an extensive literature analysis of AI's current trajectory in health care.

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Research 325

BioPharma Drive: Drug Pricing

OCTOBER 10, 2024

Data readouts over the next six months could set expectations for how the highly lucrative market for weight loss therapies will look in the future.

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Trials Therapies Marketing 260

Covalent Modifiers

OCTOBER 9, 2024

NIU, G.-H., Hsiao, W.-C., Lee, P.-H., Zheng, L.-G., Yang, Y.-S., Huang, W.-C., Hsieh, C.-C., Chiu, T.-Y., Wang, J.-Y., Chen, C.-P., Huang, C.-L., You, M.-S., Kuo, Y.-P., Wang, C.-M., Wen, Z.-H., Yu, G.-Y., Chen, C.-T., Chi, Y.-H., Tung, C.-W., Hsu, S.-C., Yeh, T.-K., Sung, P.-J., Zhang, M. M., and Tsou, L. K. ChemRxiv , 2024 [link] Pharmacological inhibition of cGAS-STING-controlled innate immune pathway is an emerging therapeutic strategy for a myriad of inflammatory diseases, including autoimm

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