DrugBaron
FEBRUARY 16, 2024
“There is more than one way to skin a cat” is a rather gruesome British idiom, but its sentiment surely applies to running a successful pharmaceutical portfolio. It is now more than a decade since Francesco De Rubertis, together with Kevin Johnson and Michele Olier, coined the term “asset-centric” investing to describe the approach to portfolio creation that still underpins the strategy at Medicxi.
Forbes: Drug Truths
MARCH 6, 2024
There is another aspect of this provision of the IRA that is starting to be felt – "the small molecule penalty"
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ASPET
SEPTEMBER 20, 2024
Post-traumatic stress disorder (PTSD) is caused by exposure to a traumatic or stressful event. Symptoms related to this disorder include persistent re-experiencing of memories and fear generalization. Current pharmacological treatments for PTSD are insufficient, with fewer than 30% of patients reporting symptom remission. This study aims to determine the efficacy of acute ( R,S) ketamine and chronic fluoxetine (FLX) in reducing fear memory and fear generalization.
Chemical Biology and Drug Design
FEBRUARY 15, 2024
Role of serotonin, dopamine, and norepinephrine in neural functions and symptoms involved during their altered levels. Abstract Depression is not similar to daily mood fluctuations and temporary emotional responses to day-to-day activities. Depression is not a passing problem; it is an ongoing problem. It deals with different episodes consisting of several symptoms that last for at least 2 weeks.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Broad Institute
OCTOBER 29, 2024
New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. By Karen Zusi-Tran October 29, 2024 Credit: National Cancer Institute Human cells with acute myelocytic leukemia (AML) in the pericardial fluid.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Collaborative Drug
DECEMBER 6, 2024
We recently hosted an insightful webinar featuring the team from Congruence Therapeutics , who shared how they're using CDD Vault alongside their proprietary systems to manage complex drug discovery data. The impressive lineup of speakers included Maximilian Ebert (Executive Director of Computational Chemistry), Jeremy Dupaul-Chicoine (Associate Director of Biology), and Lee Fader (Vice President of Chemistry).
Covalent Modifiers
DECEMBER 28, 2024
Ai-Lin Chen, Zih-Jheng Lin, Hsiao-Yu Chang, and Tsung-Shing Andrew Wang Journal of the American Chemical Society , 2025 [link] Reactive carbonyl species (RCS) are important biomarkers of oxidative stress-related diseases because of their highly reactive electrophilic nature. Despite their potential as triggers for prodrug activation, selective labeling approaches for RCS remain limited.
Drug Target Review
DECEMBER 20, 2024
Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution. For years, AI and machine learning (ML) were often dismissed as little more than advanced statistics with little practical value in drug development.
BioPharma Drive: Drug Pricing
OCTOBER 4, 2024
An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
MARCH 6, 2024
WEDNESDAY, March 6, 2024 -- The U.S. Food and Drug Administration issued a health advisory Wednesday warning consumers that six brands of ground cinnamon are tainted with lead. The FDA urged folks to throw away and not buy the following brands of.
Science Daily: Pharmacology News
OCTOBER 28, 2024
Buildup of a protein called filamentous actin, or F-actin, in the brain inhibits the removal of cellular wastes, including DNA, lipids, proteins and organelles. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline. By tweaking a few very specific genes in the neurons of aging fruit flies, the researchers prevented F-actin buildup, maintained cellular recycling and extended the healthy lifespan of fruit flies by approximately 30%.
Covalent Modifiers
NOVEMBER 7, 2024
Thomas M. Geiger, Radosław P. Nowak Annual Reports in Medicinal Chemistry , 2024 [link] Proteolysis targeting chimeras (PROTACs) are hetero-bifunctional molecules that remove disease-causing proteins through the means of targeted protein degradation (TPD). Since their proof-of-concept over 20 years ago, PROTACs emerged as new modality in drug discovery and chemical biology.
Science Daily: Pharmacology News
NOVEMBER 16, 2024
The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
SEPTEMBER 17, 2024
Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.
BioPharma Drive: Drug Pricing
OCTOBER 16, 2024
The results provide the first clinical evidence of RNA editing, a burgeoning field that's drawn interest from biotechs and pharmaceutical companies alike.
Science Daily: Pharmacology News
AUGUST 13, 2024
Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind. That's where Mizzou comes in. Recently, researchers created a new liquid-based solution that eliminates more than 98% of these microscopic plastic particles from water.
Science Daily: Pharmacology News
AUGUST 5, 2024
Seeds, twigs, and insect parts found under two miles of ice confirm Greenland's ice sheet melted in the recent past, the first direct evidence that the center -- not just the edges -- of the two-mile-deep ice melted away in the recent geological past. The new research indicates that the giant ice sheet is more fragile than scientists had realized until the last few years -- and reveals increased risk of sea-level catastrophe in a warmer future.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
AUGUST 15, 2024
Scientists have restored the brain's waste-clearing process in aging mice, offering potential new treatment for Alzheimer's and Parkinson's using existing drugs.
Science Daily: Pharmacology News
AUGUST 23, 2024
A study found that nondeceptive placebos, or placebos given with people fully knowing they are placebos, effectively manage stress -- even when the placebos are administered remotely.
Science Daily: Pharmacology News
AUGUST 2, 2024
A new study suggests that Earth's natural forces could substantially reduce Antarctica's impact on rising sea levels, but only if carbon emissions are swiftly reduced in the coming decades. By the same token, if emissions continue on the current trajectory, Antarctic ice loss could lead to more future sea level rise than previously thought.
Science Daily: Pharmacology News
SEPTEMBER 9, 2024
Scientists have developed a new AI algorithm that can separate brain patterns related to a particular behavior. This work promises to improve brain-computer interfaces and aid with the discovery of new brain patterns.
Science Daily: Pharmacology News
JULY 29, 2024
SARS-CoV-2, the virus responsible for COVID-19, is widespread among wildlife species, according to new research. The virus was detected in six common backyard species, and antibodies indicating prior exposure to the virus were found in five species, with rates of exposure ranging from 40 to 60 percent depending on the species.
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.
Science Daily: Pharmacology News
OCTOBER 10, 2024
Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.
Science Daily: Pharmacology News
SEPTEMBER 11, 2024
Researchers have created microscale robots less than 1 millimeter in size that are printed as a 2D hexagonal 'metasheet' but, with a jolt of electricity, morph into preprogrammed 3D shapes and crawl.
Science Daily: Pharmacology News
OCTOBER 17, 2024
A major new study reveals that carbon dioxide emissions from forest fires have surged by 60 percent globally since 2001, and almost tripled in some of the most climate-sensitive northern boreal forests.
Science Daily: Pharmacology News
OCTOBER 3, 2024
Comamonadacae is a family of bacteria often found growing on plastics in water. New study finds a bacterium in this family can break down the plastic for food. Researchers also identified the enzyme the bacterium use to degrade plastic. The discovery opens new possibilities for developing bacteria-based engineering solutions to help clean up difficult-to-remove plastic waste.
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