Engineering - Drug Discovery Digest

Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice

Broad Institute

JANUARY 8, 2024

A team of researchers at the Broad Institute of MIT and Harvard has engineered virus-like particles to deliver prime editors to cells in mice at a high enough efficiency to rescue a genetic disorder. However, delivering the complex gene editing machinery to cells in living animals has been challenging.

Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice

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