Science Daily: Pharmacology News

OCTOBER 18, 2023

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

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Therapies Immune Response Research Virus 88

Drug Target Review

AUGUST 11, 2023

1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immune response. By selecting specific segments of proteins that elicit robust immune reactions, these vaccines could offer enhanced protection against diseases.

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Vaccine Immune Response Bioinformatics Virus 98

PLOS: DNA Science

FEBRUARY 8, 2024

The molecular tools of CRISPR were borrowed and developed from the natural immune response of bacteria to viruses – bacteriophages – that infect them. A recent paper in BioDesign Research , CRISPR-Cas-Based Engineering of Probiotics , from investigators at several Chinese research institutions, contributed to the report.

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Immune Response DNA Engineering Virus 98

Drug Target Review

JANUARY 2, 2024

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses.

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RNA Immune Response Therapies Disease 128

Drug Target Review

DECEMBER 28, 2023

These neoantigens are identified by T cells of the immune system as foreign proteins and thus trigger an immune response. Neoantigens are recognised as non-self and trigger an immune response.

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Bioinformatics Immune Response DNA Vaccine 105

Broad Institute

JUNE 27, 2024

To deliver CHARM throughout the brain, the team collaborated with scientists in the lab of Ben Deverman , senior director of vector engineering at the Broad and a co-author of the study. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Online June 27, 2024.

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Broad Institute

OCTOBER 11, 2023

The drugs work by blocking a protein, PD-1 — which helps keep immune responses in check — and stimulating the immune system to attack tumors. The team studied the immune response to CRISPR and designed a new technology that they published in 2021 — a way of removing immune-triggering molecules from CRISPR-edited cells.

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Research Immune Response Clinical Trials Therapies 137

Drug Target Review

JANUARY 15, 2024

To be therapeutically useful, antigenic peptides must be presented in a way that allows immune responses to destroy cancer cells without causing unacceptable damage to healthy tissue. With convergent technology, it is possible to engineer monoclonal antibodies that mimic the specificity of TCRs for tumour‑specific pHLA targets.

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Engineering DNA Virus Immune Response 110

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 9 In addition, host immune responses further add to the complexity of developing cell-specific AAV capsids for clinical applications. His mentorship produced numerous publications.

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Engineering Virus Therapies Immune Response 105

Drug Target Review

OCTOBER 2, 2023

These peptides are a vital part of the immune system’s display-recognition mechanism that enables T cells to distinguish between self and non-self-antigens, recognizing intruders to initiate immune responses.

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Immune Response Vaccine Disease Research 105

Broad Institute

JULY 11, 2024

Treatment with mIDH1 blockers unearths these remnants, triggering an immune response against the tumor cells. This immune response relies on the expression of a gene called cGAS , which produces part of a protein that detects retroviruses.

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Treatment Immune Response Virus Drugs 72

Drug Target Review

SEPTEMBER 11, 2023

This sugar-coated mucin binding to checkpoint receptors signals that the cancer cell poses no threat, consequently blocking the immune response. Tender elaborated that these results in immune cells ignoring the cancer rather than eliminating it, as they normally would.

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Immune Response Research Engineering Virus 116

Drug Target Review

OCTOBER 16, 2023

2D cell models are often engineered to over-express the target of interest and so lack its temporal behaviour in its native or disease state. This is particularly pertinent in immune-based cell therapies like CAR-T, where animals do not mimic the human immune response.

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Disease Immune Response Cell Biology Therapies 122

Codon

SEPTEMBER 29, 2024

The new viruses could shuffle surface antigens after encountering an immune response, rapidly adopt new conformations to fit through tight cellular junctions, and self-replicate at safe background levels for years on end. Prior therapeutic viruses had had their replication capabilities crippled out of fear of severe immune responses.

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Engineering Virus DNA Therapies 132

Drug Target Review

APRIL 26, 2023

We are hopeful that it can be used to treat or repair a range of genetic diseases, including cystic fibrosis,” said Daniel Anderson, a Professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science (IMES).

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RNA Medical Schools Engineering DNA 98

LifeSciVC

MAY 9, 2024

Take Janux Therapeutics, a biotech focused on developing immunotherapies that generate tumor-specific immune responses to attack and kill tumors without destroying a patient’s healthy tissue. While early, these data demonstrate clear promise to advance this modality.

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Immune Response Vaccine Therapies Engineering 73

PLOS: DNA Science

OCTOBER 12, 2023

Can they deliver healing genes without triggering an overactive immune response? The details are disturbingly reminiscent of the famous case of Jesse Gelsinger , who died from a ferocious immune response to experimental gene therapy in September 1999. An immune response is two-tiered.

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Therapies Immune Response DNA Virus 69

The Pharma Data

DECEMBER 17, 2020

Merck will select cancer targets and harness Janux’s proprietary Tumor Activated T Cell Engager (TRACTr) technology to engineer novel, T cell engager drug candidates. Janux technology can be applied to immunotherapies that target all three stages of an anti-tumor immune response.

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Immune Response Pharmacokinetics Engineering Licensing 52

Drug Target Review

DECEMBER 13, 2023

The genes unique to the severe long COVID patients were found to be associated with immune pathways such as myeloid differentiation, macrophage foam cells and lipid signalling pathways. She is a computational biologist with a background in bioprocess engineering and biotechnology.

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Bioinformatics Disease Regulations Immune Response 145

Broad Institute

AUGUST 7, 2023

MIT biology PhD student Bingxu Liu and Rebecca Carlson PhD ’23, a recent graduate of the Medical Engineering and Medical Physics program through the Harvard-MIT Division of Health Sciences and Technology, are the lead authors of the paper, which appears in Science.

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Regulations Clinical Trials Engineering DNA 91

Drug Target Review

NOVEMBER 7, 2024

Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors. In these conditions, the goal of therapy is typically to suppress or mitigate immune activity.

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Disease Immune Response Regulations Engineering 52

Broad Institute

OCTOBER 4, 2023

Researchers from the Tumor Immunotherapy Discovery Engine ( TIDE ) at the Broad Institute of MIT and Harvard, AbbVie, and Calico Life Sciences report that the molecule simultaneously makes tumors more sensitive to immune attack and boosts the activity of immune cells to fight tumors in mice.

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Small Molecule Clinical Trials Engineering Trials 128

The Pharma Data

DECEMBER 16, 2020

Currently in Phase 3 clinical testing in the United Kingdom for the prevention of COVID-19, NVX-CoV2373 is a recombinant protein vaccine adjuvanted with Novavax’ proprietary Matrix-M to enhance the immune response. About Novavax. Novavax, Inc.?(Nasdaq: Novavax Forward Looking Statements.

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Vaccine Government Immune Response Clinical Trials 52

Drug Target Review

JUNE 9, 2023

Genentech is responsible for engineering adaptive-discovered TCRs into T cells and manufacturing the T cell therapy product candidate. An antigen is a protein that can induce an immune response in the body. What types of diseases or conditions were targeted in the pre-clinical research phase?

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Treatment Packaging Clinical Research Therapies 105

Drug Target Review

FEBRUARY 28, 2024

These include engineering the cells to express cytokines that promote their maturation and/or differentiation, and engineering drug-resistant γδ T cells that can be combined with chemotherapies, which stress cancer cells but would otherwise also deplete the T-cell population. References Fichtner A, Ravens S, Prinz I.

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Therapies Engineering Molecular Biology Science 105

Drug Target Review

OCTOBER 2, 2024

Tissue engineering techniques using induced pluripotent stem cells (iPSC), which are differentiated into cardiomyocytes, are being developed to create functional cardiac tissues from patient-derived cells. While commonly used, AAVs have limitations, including immune reactions and difficulties with re-dosing due to pre-existing antibodies.

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Therapies Disease Engineering RNA 98

The Pharma Data

NOVEMBER 22, 2020

The Agreement extends an existing relationship between the companies and gives Pandion the option to use standard phage display or mammalian display as the engines for the discovery of next generation antibodies.

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Immune Response Engineering Clinical Research Disease 52

Drug Target Review

NOVEMBER 17, 2023

NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immune response’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).

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Therapies Cell Biology Clinical Trials Trials 118

Drug Target Review

DECEMBER 4, 2024

The MC4R-based ConfoGen was used to immunize llamas, resulting in an immune response that generated a highly diverse panel of MC4R-specific agonists. For example, the team engineered the MC4R agonists as humanized heavy-chain only antibodies with human Fc domains to improve their overall drug-like properties.

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Pharmacokinetics Small Molecule Therapies Engineering 78

PLOS: DNA Science

OCTOBER 3, 2024

The idea to redirect an immune response against a pathogen to fight cancer goes back to 1891, when Manhattan bone surgeon William Coley became intrigued by a man’s neck tumor that melted away after he contracted a nasty Streptococcus skin infection. The fishy strategy is both fast and patient-specific.

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Vaccine Immune Response DNA Treatment 52

The Pharma Data

DECEMBER 13, 2020

SYNB1891 is an investigational drug for the intra-tumoral treatment of solid tumors and lymphoma, composed of an engineered Synthetic Biotic designed to activate the STING pathway in the tumor microenvironment in order to upregulate the patient’s immune response. Synlogic’s President and Chief Executive Officer.

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Immune Response Treatment Engineering Clinical Trials 40

Codon

JULY 14, 2024

This is particularly beneficial for those who need chronic transfusions and are therefore at risk of developing an immune response to transfusion products from other people, or for those with religious beliefs, like Jehovah’s Witnesses, whose faith prohibits blood transfusions from another person.

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Production Clinical Trials Trials Therapies 133

Drug Target Review

FEBRUARY 7, 2024

We had built a machine learning classifier that has been trained to identify amino acid sequences that have the potential to mimic ‘host defense peptides’ from the human innate immune system. Such peptides play a critical role in the machinery for amplifying innate immune responses.

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RNA Virus Immune Response Engineering 69

PerkinElmer

MAY 6, 2022

One approach currently being explored involves stimulating innate immune response pathways. For example, the STimulator of InterferoN Genes (STING) pathway, which is known to play a critical role in innate immunity in response to viral and bacterial DNA, has also been shown to promote anti-tumor immune responses.

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Immune Response DNA Clinical Trials Engineering 52

The Pharma Data

SEPTEMBER 30, 2021

Anderson Professor of Chemical and Biomolecular Engineering, and his colleagues, are reporting in iScience the event of an intranasal subunit vaccine that gives durable local immunity against inhaled pathogens. A fundamental limitation of intramuscular vaccines is that they’re not designed to elicit mucosal immunity.

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Vaccine Disease Immune Response Virus 52

The Pharma Data

JANUARY 17, 2021

Johnson & Johnson published interim Phase I/IIa data in the New England Journal of Medicine showing its single-dose COVID-19 vaccine candidate created an immune response that lasted at least 71 days. The data showed that the vaccine induced an immune response and was generally well-tolerated.

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Immune Response Small Molecule Clinical Trials Trials 52

The Pharma Data

JUNE 1, 2022

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests. Previous research has shown that caspase 11 in mice has many of the same immune-response functions as caspase 4 in humans.

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