Engineering Immune Response Packaging 
The Open Targets Blog
JANUARY 30, 2025
gget ( [link] ) is a free, open-source command-line tool and Python package designed to enable efficient querying of large genomic databases, such as Ensembl, UniProt, and NCBI. We chatted to the team about the module, and how it facilitates access to Open Targets Platform data. What is gget?
Broad Institute
JUNE 27, 2024
To deliver CHARM throughout the brain, the team collaborated with scientists in the lab of Ben Deverman , senior director of vector engineering at the Broad and a co-author of the study. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Online June 27, 2024.
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Drug Target Review
JUNE 9, 2023
As part of the TCR discovery process and preclinical data package, Adaptive performs rigorous functional characterisation and safety assessments of potent, therapeutic grade antigen-specific TCRs. Genentech is responsible for engineering adaptive-discovered TCRs into T cells and manufacturing the T cell therapy product candidate.
PLOS: DNA Science
OCTOBER 12, 2023
Can they deliver healing genes without triggering an overactive immune response? The details are disturbingly reminiscent of the famous case of Jesse Gelsinger , who died from a ferocious immune response to experimental gene therapy in September 1999. An immune response is two-tiered.
Codon
FEBRUARY 13, 2024
Such contaminants could have the same toxic effects as the bacterial infection, or provoke a severe immune response in the patient, and therefore the phage mixtures must go through extensive purification and testing procedures. The resulting data are fed into an analytical engine that runs millions of simulations. aeruginosa, S.
The Pharma Data
JUNE 25, 2021
NVX-CoV2373 is a protein-based vaccine candidate engineered from the genetic sequence of the first strain of SARS-CoV-2, the virus that causes COVID-19 disease. It is packaged in a ready-to-use liquid formulation in 10-dose vials. BARDA is providing up to $1.75 billion under a Department of Defense agreement. About NVX-CoV2373.
Codon
JULY 27, 2023
But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. a lower risk of immune responses. They don’t always break down PET into a form that is easily recycled.
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