DrugBank

OCTOBER 17, 2024

By harnessing the vast amounts of data generated throughout the development pipeline, pharmaceutical companies can accelerate the discovery of novel therapies, optimize clinical trial design, enhance drug safety monitoring, and deliver personalized medicine, ultimately improving patient outcomes and transforming the future of healthcare.

Drug Development 98

Drug Development Metabolic Stability Clinical Trials Drugs 98

Drug Target Review

JUNE 12, 2023

With 13 preclinical candidates and three AI-designed drugs currently undergoing clinical trials, Insilico is spearheading a revolution in cancer treatment and beyond. The system optimised the molecules that were most likely to succeed in terms of potency, metabolic stability, synthetic accessibility, and more.

Metabolic Stability 92

Metabolic Stability Clinical Trials Small Molecule Pharmacokinetics 92

Drug Target Review

JANUARY 16, 2025

Phase III trials for MK-0616 commenced in the second half of 2023. 11 Macrocycles can also be engineered in other ways to become more cell permeable; for example, by incorporating N-methyl groups in macrocyclic peptides. Phase 2b randomized trial of the oral PCSK9 inhibitor MK-0616. 8 Why are there not more macrocyclic drugs?

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52