Drug Target Review

NOVEMBER 8, 2023

Ruella’s research indicated that the removal of CD5 from engineered T cell therapies resulted in increased cytotoxicity and improved anti-tumor efficacy in animal models. By harnessing the fundamental biology of T cells, Senza5 can be used to improve the efficacy of almost any CAR-T therapy.

Therapies 116

Therapies Engineering Treatment Molecular Biology 116

Broad Institute

APRIL 22, 2024

Jennifer Listgarten By Rose Circeo April 22, 2024 Jennifer Listgarten Jennifer Listgarten is a Professor in the Department of Electrical Engineering and Computer Science, the Center for Computational Biology, and the Bioengineering program at the University of California, Berkeley. Previous Jenn Nava Next Jesse Boehm

Molecular Biology 52

Molecular Biology Engineering Science Research 52

Drug Target Review

FEBRUARY 19, 2024

I always found science fascinating, but I really fell in love with it in high school when I was introduced to biochemistry and molecular biology. Biochemistry and molecular biology fascinated me in school. Beate is an elected member of the Board of the Dechema, German Society for Chemical Engineering and Biotechnology.

Molecular Biology 110

Molecular Biology Science Protein Expression Production 110

Broad Institute

DECEMBER 13, 2023

Hung Group, Infectious Disease and Microbiome Program Michael Bogaev Princeton University Molecular Biology (major), B.A., Spanish (minor) Genetic Pertubation Platform (GPP) Mohammed Mutaher Harvard University Human Developmental and Regenerative Biology (major), B.A.,

Molecular Biology 52

Molecular Biology Cell Biology Science Engineering 52

sptlabtech

JUNE 9, 2023

Using our innovative true positive displacement technology, firefly is fully compatible with all molecular biology reagents, viscous and volatile, as well as bead suspension, making it an ideal solution for genomics workflows. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Laboratories 98

Laboratories Molecular Biology DNA Engineering 98

Broad Institute

AUGUST 7, 2023

MIT biology PhD student Bingxu Liu and Rebecca Carlson PhD ’23, a recent graduate of the Medical Engineering and Medical Physics program through the Harvard-MIT Division of Health Sciences and Technology, are the lead authors of the paper, which appears in Science. Paper Cited Liu B, Carlson R, et al. Human STING is a proton channel.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Drug Target Review

SEPTEMBER 22, 2023

She received her Doctor of Philosophy in Biochemistry & Molecular Biology at the Graduate University of Chinese Academy of Sciences, Beijing, China, and a Master of Medicine in Toxicology at The Academy of Military Medical Sciences, Beijing, China. Engineering organoids. CMGH [Internet]. 2022;13(1):195–7.

Clinical Research 116

Clinical Research Research Drug Development Molecular Biology 116

Broad Institute

FEBRUARY 24, 2025

In this talk the speaker will describe the more recent engineering and de novo discovery of RPRs that utilize trinucleotide triphosphates as their main substrates. However, none of these RPRs was capable of self-replication.

RNA 52

RNA Molecular Biology Laboratories Engineering 52

BMG Labtech

JANUARY 23, 2024

Our knowledge of the deep-sea, the largest biome on Earth, is in its infancy. Water covers more than 70% of the planet and the deep-sea accounts for more than 300 million km 2 of the Earth’s surface. 1,2 Scientists have only scratched the surface of life in the ocean depths but there are intriguing benefits to studying its organisms and ecosystems.

Engineering 52

Engineering Molecular Biology Cell Biology Research 52

Drug Target Review

FEBRUARY 28, 2024

These include engineering the cells to express cytokines that promote their maturation and/or differentiation, and engineering drug-resistant γδ T cells that can be combined with chemotherapies, which stress cancer cells but would otherwise also deplete the T-cell population. and MBA students with real-world consulting experiences.

Therapies 105

Therapies Engineering Molecular Biology Science 105

The Pharma Data

JANUARY 19, 2021

But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts. The authors found that tracr-L redirects Cas9 in S. pyogenes to repress its own promoter, functionally decreasing the amount of cutting that occurs. And removing tracr-L altogether greatly increased CRISPR-Cas9 expression.

Research 52

Research RNA Molecular Biology Small Molecule 52

Drug Target Review

AUGUST 29, 2024

By simultaneously deleting CD5 and expressing a CD5-targeting CAR into engineered patient T cells, VIPER-101 offers a novel approach for treating T-cell lymphoma. Can you explain the key features and benefits of the Senza5 platform developed by Vittoria Biotherapeutics?

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

Codon

JUNE 18, 2024

When these engineered cells are then placed into a mouse, one can use ultrasound to “hear” the cells as they move around. One can even explode the gas vesicles using high pressure soundwaves, akin to molecular warheads, with astounding implications for medicine. coli cell that had been engineered to express gas vesicles.

Engineering 70

Engineering Laboratories International Clinical Trials 70

Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. I had my first scientific encyclopaedia around the age of seven.

Engineering 64

Engineering Science Molecular Biology Doctors 64

Broad Institute

NOVEMBER 17, 2023

Ben Deverman (Broad), Director, Viral Vector Engineering, Stanley Center CNS gene delivery, computatational Neurobiology Director of Viral Vector Engineering Program. His lab studies gene delivery solutions with the aim of uncovering new avenues for treating psychiatric disorders.

Engineering 52

Engineering Organic Chemistry Molecular Biology Disease 52

Codon

JULY 11, 2023

It is the untouchable foundation of molecular biology. The ribosome is a molecular printer that threads ‘beads’ onto a protein string. The ribosome would then be engineered to ‘hop’ from one codon to the next to build custom proteins. But we will try to convince you that, perhaps, we can do better.

RNA 71

RNA DNA Engineering Laboratories 71

The Pharma Data

MARCH 16, 2022

Johnsson has been Director of the Chemical Biology Department at the Max Planck Institute for Medical Research in Heidelberg since 2017. Prior to taking up this appointment, he was Professor at the Institute of Chemical Sciences and Engineering at EFPL, the Swiss Federal Institute of Technology Lausanne.

Cell Biology 52

Cell Biology Molecular Biology Science Laboratories 52

Codon

DECEMBER 17, 2023

Molecular biology, as the field came to be called 3 , pushed biology from an object of study, driven forward by gentleman scientists and precocious country clergymen, into a tool with which to solve urgent problems. Simple solutions are often the best solutions; no engineering required. Laundry is one example.

Engineering 52

Engineering Molecular Biology Doctors DNA 52

The Pharma Data

NOVEMBER 22, 2021

State-of-the-art R&D facility designed to foster collaboration across world-class science ecosystem Sustainable environmental engineering aligned to Company’s zero carbon future. Over the once century, roughly 50 Nobel Prize winners in chemistry and physiology or drug have been associated with Cambridge.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

DrugBaron

NOVEMBER 22, 2022

Regulated cleavage is central to some of the most important signalling cascades in biology, such as blood coagulation and complement activation. In one study, ProQuant has been used to study an engineered protein that was intended to be cleaved in two different places, one yielding activation and then at a second site to deactivate it.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Codon

FEBRUARY 13, 2024

The resulting data are fed into an analytical engine that runs millions of simulations. ” A Global View Even as advances in computing and molecular biology usher in the era of a new, high-tech “phage therapy 2.0”, Locus has products in development targeting four common sources of bacterial infections: E.

Therapies 128

Therapies Virus DNA Clinical Trials 128

Elrig

APRIL 29, 2024

Jasmine has a background in neuroscience and genetic manipulation, with early works focused on using a combined structural and molecular biology approach to assess disease-associated proteins implicated in Alzheimer’s disease. Bioinformatics is all about bringing together different areas of knowledge.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Drug Target Review

AUGUST 29, 2023

At Alltrna, we are developing tRNA medicines where one engineered tRNA medicine can precisely correct a type of mutation across thousands of genetic diseases driven by the same genetic mutation, thereby providing precision treatment to patients, agnostic to the prevalence of the disease. Before joining Flagship, Theonie received her Ph.D.

Science 98

Science Disease Molecular Biology Therapies 98

The Pharma Data

JANUARY 21, 2021

“Finalists are the top young scientists and engineers in the United States who will someday solve some of the world’s most vexing problems. Our most significant philanthropic commitments are in the area of science education, including the Regeneron Science Talent Search and Regeneron International Science and Engineering Fair.

Science 40

Science Engineering Molecular Biology Bioinformatics 40

Codon

APRIL 2, 2024

A gene encoding green fluorescent protein was placed alongside one of the three promoters, and as the engineered cells cycled from one gene to the next, they blinked between green—dark—green—dark. These papers became the standard-bearers for a new scientific field: synthetic biology.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

Codon

JULY 11, 2023

It is the untouchable foundation of molecular biology. The ribosome is a molecular printer that threads ‘beads’ onto a protein string. The ribosome would then be engineered to ‘hop’ from one codon to the next to build custom proteins. But we will try to convince you that, perhaps, we can do better.

RNA 52

RNA DNA Engineering Laboratories 52

Drug Target Review

MAY 22, 2024

Secondly, circRNAs can be engineered for more efficient protein expression by carefully selecting and optimising the IRES element, a sequence motif derived from viruses and used to initiate cap-independent translation from circRNA.

Therapies 59

Therapies RNA Protein Expression DNA 59

The Open Targets Blog

APRIL 25, 2023

Although the estate was undoubtedly pretty, the Hall had seen better days and was rather dominated by a 1950s building that provided laboratories for the light engineering company that had owned the site. ranging from university academics through engineers and clerical staff to the military. The same went for analysis tools.

DNA 52

DNA Government Engineering Laboratories 52

The Pharma Data

NOVEMBER 9, 2021

Elias is part of a National Institutes of Health-funded laboratory that focuses on the cell and molecular biology of lung injury and repair. “So in that way, the virus cannot enter into the host system,” said Kamle, a Brown investigator in molecular microbiology and immunology as well as antibody engineering.

Small Molecule 52

Small Molecule Virus Molecular Biology Disease 52

The Pharma Data

SEPTEMBER 15, 2020

” BigHat Biosciences: BigHat Biosciences is an early-stage Bay Area startup reimagining antibody discovery and engineering to create better antibodies faster and undertake novel designs far beyond what’s possible today. Congratulations to both companies and their scientific entrepreneurs.”

Targeted Protein Degradation 52

Targeted Protein Degradation Molecular Biology Science Small Molecule 52

Codon

JUNE 25, 2024

Kamal Nahas highlights the biological limits on cell division speed and explores how we might engineer cells to grow faster. coli to clone DNA, engineering this microbe to divide more quickly would greatly accelerate research. natriegens proves simpler to engineer than its wild counterpart. This article is part of Issue 03.

DNA 79

DNA RNA Laboratories Research 79

Elrig

APRIL 6, 2023

Ron discussed three major challenges when developing an organoid model for drug discovery work, as well as taking Artificial Intelligence and neuronal networks full circle, using molecular biology to engineer logic switches in hiPSCs.

Research 40

Research Molecular Biology Science Drugs 40

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. Another paper recently reported an engineered Cas protein that is “up to 11.3-fold

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. Another paper recently reported an engineered Cas protein that is “up to 11.3-fold

Therapies 52

Therapies RNA DNA Engineering 52

Codon

MARCH 12, 2023

Berg’s work set the stage for the entirety of synthetic biology and genetic engineering. I recently asked for recommendations of “classic” papers in molecular biology. It showed that a single dose of an AAV8-based therapy could successfully engineer cells to overexpress a gene that breaks down glycogen.

DNA 52

DNA Engineering Therapies RNA 52

The Pharma Data

JANUARY 4, 2021

Longwood has a robust research department with 7 post doctorates conducting research in molecular biology, microbiology, genomics, cancer biology, and immunology and publishing over 75 publications in different scientific journals in the past 5 years. Barber also serves on Kiromic’s Scientific Advisory Board.

Therapies 40

Therapies Molecular Biology Immune Response Science 40

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. And it’s been my life for the last few weeks. A Mycoplasma cell.

DNA 52

DNA Therapies Engineering Clinical Trials 52