Codon

FEBRUARY 13, 2024

The resulting data are fed into an analytical engine that runs millions of simulations. ” A Global View Even as advances in computing and molecular biology usher in the era of a new, high-tech “phage therapy 2.0”, Locus has products in development targeting four common sources of bacterial infections: E.

Therapies 129

Therapies Virus DNA Clinical Trials 129

Drug Target Review

MAY 22, 2024

Secondly, circRNAs can be engineered for more efficient protein expression by carefully selecting and optimising the IRES element, a sequence motif derived from viruses and used to initiate cap-independent translation from circRNA. We are now running follow-up experiments to track the advantage long-term.

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

APRIL 2, 2024

A gene encoding green fluorescent protein was placed alongside one of the three promoters, and as the engineered cells cycled from one gene to the next, they blinked between green—dark—green—dark. These papers became the standard-bearers for a new scientific field: synthetic biology.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. Another paper recently reported an engineered Cas protein that is “up to 11.3-fold

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. Another paper recently reported an engineered Cas protein that is “up to 11.3-fold

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. And it’s been my life for the last few weeks. A Mycoplasma cell.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. And it’s been my life for the last few weeks. A Mycoplasma cell.

DNA 52

DNA Therapies Engineering Clinical Trials 52