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Driving efficiency across upstream bioprocess workflow

Drug Target Review

Advancements in genetic and protein engineering through technology innovation, automation, and more recently machine learning, have led to the development of more complex molecules such as bispecific antibodies and antibody drug conjugates. References Mistry RK, Kelsall E, Sou SN, et al. Budge JD, Knight TJ, Povey J, et al.

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Women in Stem with Dr Beate Mueller-Tiemann

Drug Target Review

I always found science fascinating, but I really fell in love with it in high school when I was introduced to biochemistry and molecular biology. Biochemistry and molecular biology fascinated me in school. Beate is an elected member of the Board of the Dechema, German Society for Chemical Engineering and Biotechnology.

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Enhancing gene therapy with Circio

Drug Target Review

Secondly, circRNAs can be engineered for more efficient protein expression by carefully selecting and optimising the IRES element, a sequence motif derived from viruses and used to initiate cap-independent translation from circRNA. What improvements in protein expression and durability have been demonstrated by the circVec 2.1