The Open Targets Blog

SEPTEMBER 21, 2023

After completing my PhD in organic chemistry at the University of Cambridge, I went to Canada as a Leverhulme Trust postdoctoral fellow. I then moved back to the UK to work as a process chemist at GSK, designing the manufacturing routes for small molecule drugs. I’m a chemist by training.

Organic Chemistry 82

Organic Chemistry Process Chemistry Small Molecule Science 82

Practical Cheminformatics

OCTOBER 8, 2024

Testing Claude’s Molecule Generation Ability To test the molecule generation ability of Claude, a general-purpose LLM from Anthropic, I prompted it to generate analogs for hits from fragment screens. These fragment hits are small molecules with between 11 and 21 heavy atoms.

Fragment Screening 132

Fragment Screening Packaging Organic Chemistry Small Molecule 132

Elrig

APRIL 29, 2024

There, I supported AI-enabled DD efforts in their small molecule portfolio. After graduating, Miles went on to work as a scientist on AstraZeneca’s Research and Development graduate programme, working on projects in biocatalysis, computational organic chemistry and machine learning for drug discovery.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59