Broad Institute

MAY 16, 2024

By Allessandra DiCorato May 16, 2024 Credit: Deverman lab Brain vasculature (in blue) surrounded by RNA (in orange) transcribed from the gene delivered to the brain in humanized mice using an engineered AAV targeting the human transferrin receptor. This engineered capsid opens up a world of possibilities."

Therapies 137

Therapies FDA Approval Engineering Disease 137

The Open Targets Blog

JANUARY 30, 2025

gget ( [link] ) is a free, open-source command-line tool and Python package designed to enable efficient querying of large genomic databases, such as Ensembl, UniProt, and NCBI. We chatted to the team about the module, and how it facilitates access to Open Targets Platform data. What is gget?

Bioinformatics 76

Bioinformatics Immune Response RNA Packaging 76

Broad Institute

JULY 10, 2024

The new method, published today in Nature Biomedical Engineering , precisely and durably corrects the mutation in human lung cells, restoring cell function to levels similar to that of Trikafta. Next, researchers will need to develop ways to package and deliver the prime editing machinery to the airways in mice and ultimately humans.

Engineering 145

Engineering Packaging DNA Treatment 145

Broad Institute

JULY 19, 2023

By Allessandra DiCorato July 19, 2023 Credit: Kevin Middleton, Broad Communications A three-dimensional model of adeno-associated viruses (AAVs), which scientists have engineered to package and deliver gene therapies to cells in the body. Qin Huang, a senior research scientist in Deverman’s group, is the first author on the study.

Therapies 98

Therapies Research Engineering Virus 98

Broad Institute

JUNE 27, 2024

To deliver CHARM throughout the brain, the team collaborated with scientists in the lab of Ben Deverman , senior director of vector engineering at the Broad and a co-author of the study. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Online June 27, 2024.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Broad Institute

AUGUST 7, 2024

Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient. Now, researchers at the Broad Institute of MIT and Harvard have developed a machine-learning approach that promises to speed up AAV engineering for gene therapy. Nature Communications.

Therapies 84

Therapies Research Engineering Packaging 84

SCIENMAG: Medicine & Health

JULY 21, 2023

Katy Börner’s team from the Luddy School of Informatics, Computing, and Engineering’s Cyberinfrastructure for Network Science Center has made significant contributions to constructing a Human Reference Atlas and has led or co-authored six research articles in a just-released HuBMAP package in Nature. Börner, Victor H.

Research 66

Research Packaging Engineering Science 66

Perficient: Drug Development

MARCH 12, 2024

They might include data dictionaries, SQL query tools, python packages, data visualization tools, data manipulation tools like PySpark and analytics, and perhaps machine learning tools. Bigquery decreases the cost of specialty computing engines for SQL, Python, and Machine learning.

Production 104

Production Packaging Engineering Science 104

Perficient: Drug Development

AUGUST 9, 2023

Node.js, built on the V8 JavaScript engine, offers asynchronous, non-blocking I/O, making it well-suited for handling multiple connections simultaneously. You can download it from the official Redis website or use package managers like apt or brew. You can use the redis package available via npm: npm install redis Now, in your Node.js

Packaging 96

Packaging Engineering 96

Drug Target Review

JUNE 9, 2023

As part of the TCR discovery process and preclinical data package, Adaptive performs rigorous functional characterisation and safety assessments of potent, therapeutic grade antigen-specific TCRs. Genentech is responsible for engineering adaptive-discovered TCRs into T cells and manufacturing the T cell therapy product candidate.

Treatment 105

Treatment Packaging Clinical Research Therapies 105

Perficient: Drug Development

AUGUST 1, 2023

Content Management Systems and Templating In the past, I have worked with various Content Management Systems, including Drupal, which utilized the Twig templating engine to generate the HTML for web pages. The App was built on top of the “HTL Engine for JavaScript” library written by Adobe. This was exactly what I needed!

Engineering 52

Engineering Packaging Licensing Licensing 52

Broad Institute

DECEMBER 13, 2023

The other study was led by senior authors Xiao Wang , a Broad core institute member, a Merkin Institute Fellow, and an assistant professor of chemistry at MIT, and Jia Liu, an assistant professor of engineering at Harvard University. They shared their interactive atlas openly with the scientific community.

DNA 140

DNA Virus Research Engineering 140

Drug Target Review

JULY 7, 2023

The molecular machinery of the epigenetic system can selectively package specific regions of DNA away, making them inaccessible and less active. This platform opens the door to treating complex multigenic diseases, effective tissue engineering, and fine-tuning immune cell differentiation.

DNA 105

DNA Engineering Therapies Regulations 105

Translation

OCTOBER 26, 2022

Leading packaging providers, an innovative American biotech company, and a biomaterials research company join Halo to bring new innovations to the world and move science forward. and Canada, Altium strives to magnify client brands through creative packaging solutions. With over 60 plants throughout the U.S.

Packaging 52

Packaging Production Engineering Pharmaceuticals 52

The Pharma Data

APRIL 28, 2021

OSAKA, Japan, April 28, 2021 – Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) (“Takeda”) today announced that it was awarded by the International Society for Pharmaceutical Engineering (ISPE) for the 2021 Facility Of the Year Awards (FOYA) in two categories. About the ISPE Facility of the Year Awards Program.

Packaging 52

Packaging Small Molecule Pharmaceutical Companies Pharmaceuticals 52

Codon

APRIL 23, 2024

Two years ago, a friend took me out to coffee in Boston and said, “I think we can engineer an organism to terraform Mars.” The feat could be achieved with something as direct as engineering a microbe that can survive on the Martian surface, and then letting it grow and spread over the planet. (* = probably.)

Engineering 94

Engineering DNA Hospitals International 94

Practical Cheminformatics

OCTOBER 8, 2024

One could argue that the poor performance of the LLM is due to my lack of “prompt engineering” skills. Over the last few years, dozens of valid and valuable approaches to analog generation have been published and are available as open-source software packages. I divide these generative approaches into three categories.

Fragment Screening 132

Fragment Screening Packaging Organic Chemistry Small Molecule 132

Perficient: Drug Development

FEBRUARY 29, 2024

I visited my favorite search engine with the hopes of finding code repositories from developers who have accomplished this very thing. Reverse Engineering the Existing SPA Editor The front-end portion of the SPA Editor is composed of five NPM packages. Of these five packages, three were specific to React or Angular.

Packaging 52

Packaging Engineering International Production 52

Codon

MAY 8, 2024

Other essays tell of a scientist's seven-year effort to engineer ants and decipher the neurons underlying their communication, or attempt to answer the question: If phages are so good at killing microbes, why aren’t they used to treat antibiotic-resistant infections in the West? If you are based outside the U.S.

Packaging 52

Packaging Engineering Vaccine Drugs 52

Broad Institute

SEPTEMBER 13, 2023

Some are focused on viruses called adeno-associated viruses (AAVs), which have been engineered to act only as a one-time delivery vehicle and not cause disease. Broad researchers are further engineering AAVs to efficiently deliver gene-based therapies to tissues that have been difficult to reach, such as the muscle and brain.

Therapies 52

Therapies Engineering Virus Packaging 52

The Pharma Data

OCTOBER 19, 2020

“The SDNA-1000 was engineered to innovate molecular diagnostic applications using saliva,” said Jeremy Johnson, VP of Engineering at Spectrum Solutions. A single-source provider of on-site medical device development and manufacturing, custom packaging, kitting, and direct-to-consumer fulfillment.

RNA 52

RNA DNA Engineering Virus 52

FDA Law Blog: Biosimilars

JULY 10, 2023

The AI response package must respond completely to all parts of the deficiencies and include all information needed to address the deficiencies; in other words, a firm cannot submit a partially completed response package and plan to submit another AI response package at a later date to address remaining deficiencies.

FDA 75

FDA Packaging Laboratories Engineering 75

Drug Target Review

AUGUST 6, 2024

Cardiovascular diseases : Atherosclerosis : ADCs could be engineered to target and deliver drugs to atherosclerotic plaques, potentially stabilising them and preventing cardiovascular events. They invest in cutting-edge technologies and engage in continuous improvement practices, enhancing ADC production efficiency and quality.

Therapies 119

Therapies Pharmaceutical Companies Disease Treatment 119

Perficient: Drug Development

JUNE 6, 2023

Optimizely Configured Commerce (formerly Optimizely B2B Commerce) comes packaged with SEO features built-in, providing SEO configuration settings without requiring development code. Generally, companies expose all of the content on their website to search engines to earn top hits.

Engineering 52

Engineering Production Packaging 52

Perficient: Drug Development

AUGUST 2, 2023

Some key features available for the subscription plan are remote engine start, locking and unlocking, remote light flash and horn feature, automatic collision notifications, Nissan door-to-door navigation, Nissan concierge, vehicle locater, valet service, and emergency roadside access. Both are currently priced at $80/year separately.

Packaging 52

Packaging Engineering 52

The Pharma Data

NOVEMBER 5, 2021

The final product assembly and packaging plant will support the growing demand for Amgen’s medicines in the United States and is expected to be operational by 2024. “In building this site, we expect to invest $365 million,” said Sam Guhan, vice president of Engineering at Amgen.

Packaging 52

Packaging Engineering Disease International 52

Codon

MARCH 24, 2024

In the first real test of delivering a complex biomolecule to over a billion people, little has changed from how Genentech first approached manufacturing in the 1980s; Cells are genetically engineered and then grown in steel tanks. To make matters worse, many companies struggled with engineering problems on the path to scale.

Engineering 87

Engineering Vaccine Production RNA 87

Perficient: Drug Development

JULY 24, 2023

Data professionals can perform Data profiling to understand the data and then integrate the cleaning rules within data engineering pipelines. Additionally, data cleaning plays a crucial role in removing inconsistent or incorrect values from the dataset, ensuring its integrity and reliability.

Packaging 52

Packaging Engineering 52

Perficient: Drug Development

JULY 21, 2023

Data professionals can perform Data profiling to understand the data and then integrate the cleaning rules within data engineering pipelines. Additionally, data cleaning plays a crucial role in removing inconsistent or incorrect values from the dataset, ensuring its integrity and reliability.

Packaging 52

Packaging Engineering 52

Perficient: Drug Development

NOVEMBER 7, 2023

The framework is equipped with both Python and JavaScript packages. print('nn-->', qa.run(query)) query = "Summarize the document" print('nn-->', qa.run(query)) query = "What do we need to become an NLP engineer?" print('nn-->', qa.run(query)) """ query = "What are the responsibilities and salaries of an NLP engineer?"

Packaging 52

Packaging Engineering Research 52

Perficient: Drug Development

OCTOBER 12, 2023

yaml configuration file, add the shim configuration for the Coveo Headless package. You can also verify this in your browser’s console as shown in the screenshot below: Now you can use the CoveoHeadless variable within your OpenUI5 project to initialize the Coveo search engine and start building advanced search functionality.

Engineering 52

Engineering Packaging 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies.

DNA 52

DNA RNA Engineering Vaccine 52

The Open Targets Blog

JUNE 21, 2022

I'm a software engineer focused on front end. The use of OT-UI was complicated by issues such as handling third-party library versions, developing in a local environment using NPM (node package manager), and integrating custom components. We will even be able to generate new UIs with our package scheme quickly.

Packaging 52

Packaging Engineering 52

Codon

FEBRUARY 13, 2024

The resulting data are fed into an analytical engine that runs millions of simulations. Broad-acting, marketable cocktails may become available for common infections, but more personalized or bespoke phage treatments using engineered or synthetic phages will be needed for acute, rare, or complex conditions. aeruginosa, S. pneumoniae.

Therapies 128

Therapies Virus DNA Clinical Trials 128

Practical Cheminformatics

JANUARY 8, 2024

No member company will agree to use a representation that can potentially be reverse-engineered to reveal the chemical structures of its molecules. In each example, the authors use a modified version of their open source package MolPAL to design molecules with a specified selectivity profile.

Drugs 139

Drugs Small Molecule Bioinformatics Packaging 139

The Pharma Data

DECEMBER 9, 2020

Full and complete packages resulting from this collaboration are expected to be made available in 2021 towards the end of the year. NexGen and SOLABS are already collaborating on client initiatives to deliver solutions to streamline decision processes and provide more visibility in the area of CAPAs, Change Control, Training Management, etc.

Science 52

Science Pharma Companies Packaging Engineering 52