Broad Institute

SEPTEMBER 13, 2023

Some are focused on viruses called adeno-associated viruses (AAVs), which have been engineered to act only as a one-time delivery vehicle and not cause disease. Broad researchers are further engineering AAVs to efficiently deliver gene-based therapies to tissues that have been difficult to reach, such as the muscle and brain.

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The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. “The SDNA-1000 was engineered to innovate molecular diagnostic applications using saliva,” said Jeremy Johnson, VP of Engineering at Spectrum Solutions.

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RNA DNA Engineering Virus 52

Drug Target Review

DECEMBER 5, 2024

2,3 Engineering both the capsid and DNA cargo improves the safety and efficacy of rAAV vectors and expands their clinical applications. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Adeno-associated virus-based gene therapy for lifelong correction of genetic disease. Labcompare. 2024;9(1):78.

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PLOS: DNA Science

OCTOBER 12, 2023

The package insert for the drug, Elevidys , warns of adverse effects of acute liver injury and inflammation around the heart and muscles. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Cardiac markers were okay.

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Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies.

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DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies.

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DNA RNA Engineering Vaccine 52

Drug Target Review

MAY 22, 2024

Secondly, circRNAs can be engineered for more efficient protein expression by carefully selecting and optimising the IRES element, a sequence motif derived from viruses and used to initiate cap-independent translation from circRNA. We are now running follow-up experiments to track the advantage long-term.

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Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. Read Biological Engineering mScarlet3: a brilliant and fast-maturing red fluorescent protein. Read Inhalable nanoparticles, packaged with mRNA or CRISPR systems, efficiently edit lung cells. Gungabeesoon J.

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DNA RNA Engineering Licensing 52

Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Two of these proteins are about 30% the size of Cas9 , and thus much easier to package into viruses for gene therapy.

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Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Two of these proteins are about 30% the size of Cas9 , and thus much easier to package into viruses for gene therapy.

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Therapies RNA DNA Engineering 52

The Pharma Data

JUNE 25, 2021

“These data show consistent, high levels of efficacy and reaffirm the ability of the vaccine to prevent COVID-19 amid ongoing genetic evolution of the virus. Variant Virus Strains. against the original virus strain, 86.3% It is packaged in a ready-to-use liquid formulation in 10-dose vials. Glenn, M.D.,

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Vaccine Trials Disease Immune Response 40

Agency IQ

JANUARY 19, 2024

Prevention of viral contamination is especially important as it may not be apparent that cells have been contaminated with a virus using conventional detection methods. Likewise, the selection of a cell line that was developed using a virus increases the risk of potential viral contamination.

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Virus Science Production FDA 40

The Pharma Data

OCTOBER 14, 2020

The research is part of an ongoing collaboration between Columbia University and Tonix that focuses on T cell and antibody responses to SARS-CoV-2 (CoV-2), the virus that causes COVID-19. The research encompasses two projects. The study led by Dr. Ilya Trakht, Ph.D., About TNX-1800.

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Agency IQ

NOVEMBER 3, 2023

The prebiotic may either feed the probiotic that it is packaged with, or it may feed another beneficial microbe that is intended to complement the activity of the probiotic. However, the term synthetic biotic is typically reserved for genetically engineered bacteria that intend to target a specific condition.

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Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. A phage is a virus that infects bacteria. ” So take it easy!

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DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. A phage is a virus that infects bacteria. ” So take it easy!

DNA 52

DNA Therapies Engineering Clinical Trials 52

The Pharma Data

FEBRUARY 22, 2021

1,7-14 It was engineered to have greater inhibitory potency for JAK1 versus JAK2, JAK3 and TYK2. RINVOQ (upadacitinib) [Package Insert]. Discovered and developed by AbbVie scientists, RINVOQ is an oral, once daily, selective and reversible JAK inhibitor studied in several immune-mediated inflammatory diseases. ClinicalTrials.gov.

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Codon

MAY 2, 2023

Once the mosquito factory has made all these insects, they are packaged into boxes or cups and then released in “strategic” areas within a city, like near swampy water or in dengue-ridden neighborhoods. But I do know this: Genetic engineering has endowed us with a radical ability to control our environments.

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Engineering Packaging Licensing Licensing 52

Codon

MAY 2, 2023

Once the mosquito factory has made all these insects, they are packaged into boxes or cups and then released in “strategic” areas within a city, like near swampy water or in dengue-ridden neighborhoods. But I do know this: Genetic engineering has endowed us with a radical ability to control our environments.

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Engineering Packaging Licensing Licensing 52

Codon

NOVEMBER 1, 2024

Making a computer-designed protein in the laboratory requires, first, that scientists synthesize a string of DNA encoding the protein, insert that DNA into living cells, and then isolate the proteins churned out by the engineered cells. The world’s supply of insulin is now made by engineered microbes.

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DNA RNA Molecular Biology Laboratories 107

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” in bioRxiv.

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Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” in bioRxiv.

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Vaccine DNA Virus Engineering 52

Drug & Device Law

JULY 31, 2023

Smith rejected plaintiff’s analogy between books and drug package inserts. May 13, 2015) (contract involving multiple, identical “software package[s]” governed by UCC). Page Engineering Co. , So far, the would-be liability expanders haven’t done very well. 1145, 1165 n.135 1989), aff’d mem. , 2d 309 (Pa. 2d 641, 663 (Wyo.

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Production International Trials Government 52

Drug & Device Law

DECEMBER 19, 2022

one HDPE resin to another HDPE resin) of a packaging component that may affect the impurity profile of the drug product. All of these changes to genetically engineered products could affect their safety and effectiveness. glass to high density polyethylene (HDPE), HDPE to polyvinyl chloride, vial to syringe) or composition (e.g.,

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FDA Regulations Production Drugs 59