Drug Target Review

FEBRUARY 19, 2024

In the early days of my biopharma career, I was able to industrialise the production of recombinant proteins for drug discovery purposes, by parallelising, miniaturising and automating protein expression and purification workflow. This made significant impact on accelerating lead discovery in the pharmaceutical industry.

Molecular Biology 110

Molecular Biology Science Protein Expression Production 110

Drug Discovery World

NOVEMBER 8, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. from engineered peptide and antibody libraries’. Harriman will present ‘Discovering functional modulators of the ion channel Kv1.3

Engineering 163

Engineering Protein Expression Therapies Science 163

The Pharma Data

JUNE 7, 2023

Datopotamab deruxtecan is a specifically engineered TROP2 directed DXd antibody drug conjugate (ADC) being jointly developed by Daiichi Sankyo (TSE: 4568) and AstraZeneca (LSE/STO/Nasdaq: AZN). 3,4,5 TROP2 is a protein expressed in more than 90% of NSCLC tumors. Rahway, NJ, USA), an anti-PD-1 therapy.

Trials 40

Trials Protein Expression Therapies Treatment 40

The Pharma Data

DECEMBER 8, 2020

The company’s product candidates consist of novel human cells engineered to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, diabetes and lysosomal storage disorders. co-founder, president and CSO of Remix Therapeutics and Atlas Venture Entrepreneur in Residence. .

RNA 52

RNA Protein Expression Therapies Disease 52

The Pharma Data

AUGUST 16, 2021

The vaccine candidate, presently at a preclinical development stage, is a non-chemically modified mRNA, encoding the prefusion stabilized full-length spike protein of the SARS-CoV-2 virus, and formulated within Lipid Nanoparticles (LNPs).

Immune Response 52

Immune Response Vaccine Virus RNA 52

Drug Discovery World

NOVEMBER 9, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Croasdale-Wood will then participate in a keynote chat, interviewed by Miho.

Engineering 130

Engineering Therapies Protein Production Science 130

The Pharma Data

JANUARY 13, 2021

TNX-1500 is a third generation anti-CD40-ligand mAb that has been designed by protein engineering to decrease Fc?RII CD40-ligand is a protein expressed on the surface of activated T lymphocytes that mediates T cell helper function. Second generation anti-CD40-ligand mAbs had dramatically reduced binding to Fc?RII,

Pharmaceuticals 52

Pharmaceuticals Small Molecule Vaccine Protein Expression 52

The Pharma Data

JANUARY 10, 2021

ILP100 is a genetically engineered Lactobacillus that acts as a small bioreactor on site in the wound, continuously introducing a chemokine, CXCL12, into the wound tissue. The study hit the mark on its primary biological endpoint of micro-dystrophin protein expression.

Clinical Trials 52

Clinical Trials Trials FDA Protein Expression 52

Drug Discovery World

JANUARY 23, 2023

Strand’s mRNA therapeutics enable precise control of the location, timing, intensity and duration of therapeutic protein expression for improved efficacy and lower toxicity. In that sense, it doesn’t matter where the mRNA is delivered, but ultimately where it is expressed. DS: What will 2023 hold for your company?

RNA 246

RNA Engineering Therapies Disease 246

Drug Discovery World

NOVEMBER 13, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Ali Madani, PhD, Founder and CEO, Profluent Bio, on: ‘Protein engineering with large language models’.

Engineering 148

Engineering Science Bioinformatics Vaccine 148

Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Previous research has shown that as little as 21 percent elimination of the protein can improve symptoms. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Drug Discovery World

NOVEMBER 30, 2023

This presentation covered three primary drivers for a protein expression model: speed, cost and sustainability. “It Sphere Fluidics presence on the exhibition floor was bolstered by a presentation from Richard Hammond: ‘Picodroplets for cell Line engineering: A novel automation approach’.

Protein Expression 148

Protein Expression Engineering DNA Therapies 148

Codon

DECEMBER 10, 2023

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Align to Innovate’s Open Datasets Initiative (one of us, Erika DeBenedictis, is the founder) roadmaps high-impact datasets in biology, and then hires automation engineers to collect them.

Protein Expression 97

Protein Expression DNA Laboratories Engineering 97

Drug Target Review

APRIL 5, 2024

Together, these attributes provide a strong foundation for protein expression with enough adaptability to produce much of the commercial and therapeutic protein market.

Protein Production 96

Protein Production Protein Expression Bioinformatics Production 96

Codon

DECEMBER 10, 2023

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Align to Innovate’s Open Datasets Initiative (one of us, Erika DeBenedictis, is the founder) roadmaps high-impact datasets in biology, and then hires automation engineers to collect them.

Protein Expression 74

Protein Expression DNA Laboratories Engineering 74

Drug Target Review

JULY 5, 2023

This selectable marker enables the identification of cells which have taken up the GOIs and aids the initial selection of recombinant protein expressing cell lines. A potential future for host cell lines There have been many recent advances in cell line engineering technologies and our understanding of CHO cells.

Engineering 105

Engineering DNA Laboratories Production 105

Codon

APRIL 9, 2023

LanzaTech announced a partnership with H&M Move to convert factory carbon emissions into fabrics using engineered microbes. Sponge cells double in population quite quickly — around 40 minutes — and could be engineered to manufacture drugs. Read Biological Engineering *Self-healable spider dragline silk materials.

Therapies 52

Therapies RNA Engineering Vaccine 52

Alta Sciences

APRIL 17, 2024

They work by binding to specific sequences of nucleotides present within the mRNA structure and can induce mechanisms that either decrease, restore, or modify protein expression. And since proteins are often linked to disease, there's huge potential to treat a broad range of diseases with this technology. Asia, and Europe.

Drug Development 52

Drug Development Treatment FDA Approval Drugs 52

The Pharma Data

AUGUST 9, 2021

We believe this highly sophisticated and specifically engineered ADC is fulfilling its promise to reshape the treatment of HER2-positive metastatic breast cancer, with the goal to move into earlier lines of treatment for HER2-positive breast cancer and many other HER2-expressing tumour types across our broad clinical trial programme.”.

Trials 52

Trials Treatment Clinical Trials Protein Expression 52

The Pharma Data

OCTOBER 26, 2020

Increased infiltrates, expression of immune related genes and higher PD-L1 protein expression were observed across all patients suggesting a remodeling of the tumor microenvironment consistent with a switch toward a “hot tumor” phenotype. Conclusions. About TG4001.

Vaccine 52

Vaccine Virus Trials Treatment 52

Broad Institute

SEPTEMBER 5, 2024

In recent years, increasingly sensitive mass spectrometers have paved the way for enormous progress: scientists are now able to detect and analyze nearly all proteins expressed in a sample, including ones present only in miniscule amounts. They're engineering problems that we just need to find a solution to.

Disease 59

Disease Protein Expression Engineering Treatment 59