Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

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Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Evolutionary-scale prediction of atomic-level protein structure with a language model. Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. O’Neill P.

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Codon

MARCH 24, 2024

In the first real test of delivering a complex biomolecule to over a billion people, little has changed from how Genentech first approached manufacturing in the 1980s; Cells are genetically engineered and then grown in steel tanks. But this isn’t a problem with extracts.

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Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome.

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Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome.

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PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Coincidence? I’ve never thought so. b) in an abandoned mine shaft?

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The Pharma Data

MARCH 23, 2022

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. “The virus hijacks this protein and makes it do something different than its normal job in cells.

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