Broad Institute

JUNE 28, 2023

They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. The new study demonstrates that RNA-guided DNA-cutting mechanisms are present across all kingdoms of life. said Zhang.

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RNA DNA Research Engineering 139

Drug Target Review

JUNE 6, 2023

At Alkermes , our interdisciplinary team of protein engineers, immunologists, pharmacologists, and analytical scientists is investigating the biology of several immunomodulatory cytokines including IL-12 and IL-18 to develop novel versions of these molecules with the goal of harnessing their therapeutic potential.

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Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Drug Target Review

JANUARY 24, 2024

Scientists from Northwestern Medicine have demonstrated that RNA interference could have a crucial role in the onset and development of Alzheimer’s disease (AD). sRNAs Cellular functions rely on numerous protein-coding and noncoding RNAs and the RNA-binding proteins associated with them, which form ribonucleoprotein complexes (RNPs).

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RNA Disease DNA Engineering 64

Drug Target Review

JANUARY 2, 2024

Forging the toolkit for subcellular omics Cellular components known as organelles, consisting of RNA and protein, exert vital influences on human wellbeing and ailments by sustaining equilibrium, managing growth and ageing, and producing energy.

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RNA Immune Response Therapies Disease 128

addgene Blog

JUNE 4, 2024

Have you ever designed a CRISPR guide RNA and wondered why it is limited to only 20 bases, or why it’s so important to choose a target sequence with a nearby protospacer-adjacent motif (PAM) ?

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RNA Engineering 98

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

Engineering 140

Engineering Protein Production RNA Vaccine 140

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

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DNA RNA Engineering Laboratories 145

Broad Institute

NOVEMBER 23, 2023

The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. The new systems could potentially be harnessed to edit mammalian cells with fewer off-target effects than current Cas9 systems.

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RNA DNA Engineering Science 135

Fierce BioTech

JULY 1, 2024

Streamlining the Path from Discovery to Patient – Simpler RNA Manufacturing with Aldevron’s Codex® HiCap RNA Polymerase swheeler Mon, 07/01/2024 - 17:17 Wed, 08/07/2024 - 10:00 Resource Type Webinar Kyle Studey, M.S. Codex ® is a trademark of Codexis, Inc. Listing Image aldevron 250x190.png

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RNA Engineering Research 40

Dark Matter Blog

AUGUST 31, 2020

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

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RNA Small Molecule Bioinformatics Computational Chemistry 52

Drug Target Review

JULY 5, 2023

At PEGS Europe, Drug Target Review spoke to Victoria Goldenshtein, a PhD candidate in Biomedical Engineering at Duke University, US, who presented an engaging poster on her lab’s novel in vitro library display platform for directed protein evolution termed GRIP Display, which entails Gluing RNA to Its Proteins.

RNA 97

RNA Engineering Disease Drugs 97

Broad Institute

MAY 16, 2024

By Allessandra DiCorato May 16, 2024 Credit: Deverman lab Brain vasculature (in blue) surrounded by RNA (in orange) transcribed from the gene delivered to the brain in humanized mice using an engineered AAV targeting the human transferrin receptor. This engineered capsid opens up a world of possibilities."

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Therapies FDA Approval Engineering Disease 137

The Open Targets Blog

JANUARY 30, 2025

  “Sam has an exceptional talent in software engineering, and his contributions reflect a deep understanding of both the technical and biological aspects required for bioinformatics tool development,” says Laura Luebbert, now a postdoctoral fellow in the Sabeti lab at the Broad Institute of MIT and Harvard and Harvard University.

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Bioinformatics Immune Response RNA Packaging 76

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs.

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RNA Medical Schools Engineering Disease 98

Drug Target Review

AUGUST 28, 2024

Delivered as an autologous cell therapy, these macrophages have been engineered to increase their anti-inflammatory and anti-fibrotic properties, with the aim of delivering more potent and durable clinical effect to patients with end-stage liver disease.

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Therapies Disease Engineering Medical Schools 116

Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. We have overcome many obstacles on this mission, inventing new concepts and methods where necessary and re-engineering known concepts and methods where possible.

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Small Molecule RNA Clinical Trials Drugs 52

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials. Why Does the IBC Need to do a Risk Assessment?

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Engineering Clinical Research Research Virus 52

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Senior Director, R&D Strategy, will be delivering a presentation highlighting how Strateos' smart lab platform accelerated riboswitch engineering to develop novel biosensors. Owing to their modular organization, riboswitches are ideal for engineering de novo sensing elements for use in synthetic biology.

Engineering 52

Engineering Protein Expression Research Laboratories RNA 52

Broad Institute

JUNE 27, 2024

To deliver CHARM throughout the brain, the team collaborated with scientists in the lab of Ben Deverman , senior director of vector engineering at the Broad and a co-author of the study. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Online June 27, 2024.

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Disease Therapies Clinical Trials Engineering 142

Codon

AUGUST 26, 2024

Remdesivir and other broad-spectrum antivirals work by jamming up RNA-dependent RNA polymerase (RdRp), an enzyme that nearly all RNA viruses use to replicate their genomes. Other efforts to build broad-spectrum antivirals have focused on another conserved feature of viruses: double-stranded RNA.

RNA 99

RNA Virus DNA Vaccine 99

Codon

JULY 11, 2023

All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It moves along RNA and reads three letters at a time, called codons, to build the amino acid sequence of a protein. Blueprints The first step is to build a loop of RNA that encodes all the different codons.

RNA 71

RNA DNA Engineering Laboratories 71

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. Paper cited Cui A et al.

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Immune Response RNA Disease Medical Schools 138

Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. When combined with our in-house GMP-level RNA chemistry lab, Ochre Bio is able to progress from a new target to generating human data on a lead therapy in days. How do you approach building a team of talented biologists, engineers and chemists?

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Therapies Disease RNA Engineering 102

Drug Target Review

JULY 7, 2023

This level of control is not achievable with gene editing and is a severe limitation in applications such as T-cell engineering, where precise epigenetic remodelling during differentiation 3 fundamentally shapes the phenotype and function of the cell. RNA-guided transcriptional silencing in vivo with S. Molecular Therapy.

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DNA Engineering Therapies Regulations 105

Broad Institute

FEBRUARY 24, 2025

Although this ancestral replicase appears to have been lost, key aspects of RNA-catalyzed RNA replication can be studied by proxy with the use of modern RNA enzymes (ribozymes) generated by in vitro evolution. However, none of these RPRs was capable of self-replication.

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RNA Molecular Biology Laboratories Engineering 52

Drug Target Review

JULY 5, 2023

iPSC-derived lymphocytes, eg, T cells and natural killer (NK) cells, engineered to express targeting molecules such as chimeric antigen receptors (CARs) have shown clinical promise to treat haematological malignancies. We believe this lays the groundwork for engineering these kinds of myeloid cells to potentially target any cancer antigen.

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Therapies DNA Engineering Virus 103

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). Most crops were now genetically-engineered to tolerate flood, drought, pests, and disease. Above all else, models of life found their home in large-scale ecological engineering.

Engineering 140

Engineering Virus DNA Therapies 140

Codon

FEBRUARY 20, 2024

It also gave me a new appreciation for biology, and the incredible exactitude that one must have to engineer it — let alone engineer it successfully. of a Boeing 737 jet engine. If scientists wanted to engineer cells to divide faster, then, they should start with the ribosomes. Always free. Richly storied.

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RNA DNA Engineering Cell Biology 98

Molecule Blog

MARCH 17, 2023

In this regard, BioDAOs can be viewed as collaborative research translation engines and a novel form of biotech organization that develops IP through an online-native approach. By fostering a community of stakeholders with aligned incentives and diverse backgrounds, BioDAOs facilitate the translation of technologies.

Engineering 52

Engineering Research Clinical Trials Government 52

Drug Target Review

OCTOBER 2, 2024

Tissue engineering techniques using induced pluripotent stem cells (iPSC), which are differentiated into cardiomyocytes, are being developed to create functional cardiac tissues from patient-derived cells. RNA-based therapies, including mRNA and RNA interference (RNAi), are being explored to modulate gene expression in heart cells.

Therapies 98

Therapies Disease RNA Engineering 98

Broad Institute

DECEMBER 13, 2023

The other study was led by senior authors Xiao Wang , a Broad core institute member, a Merkin Institute Fellow, and an assistant professor of chemistry at MIT, and Jia Liu, an assistant professor of engineering at Harvard University. Related news Researchers map brain cell changes in Alzheimer’s disease Courtesy of the Chen and Macosko labs.

DNA 140

DNA Virus Research Engineering 140

Codon

JULY 11, 2023

All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It moves along RNA and reads three letters at a time, called codons, to build the amino acid sequence of a protein. Blueprints The first step is to build a loop of RNA that encodes all the different codons.

RNA 52

RNA DNA Engineering Laboratories 52

Dark Matter Blog

JUNE 21, 2023

On the other hand, if you have a platform designed to be an engine for a standalone enterprise, capable of generating dozens of future drugs, then you might plot a course that brings you into the close orbit of multiple complementary partners. We all share a common understanding of the benefits and challenges of small molecule therapeutics.

Small Molecule 52

Small Molecule RNA Pharma Companies Science 52

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. As Richard Dawkins said of biological wheels : “the engineering solution can be seen in plain view, yet [it is] unattainable in evolution because it lies [on] the other side of a deep valley.”

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DNA RNA Vaccine Virus 104

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

RNA 52

RNA DNA Engineering Virus 52

Broad Institute

FEBRUARY 11, 2025

Mapping mRNA through its life cycle within a cell By Corie Lok February 11, 2025 Breadcrumb Home Mapping mRNA through its life cycle within a cell Xiao Wangs studies of how and where RNA is translated could lead to the development of better RNA therapeutics and vaccines. I wasnt trained at MIT, and I had never lived in Boston before.

RNA 52

RNA DNA Science Vaccine 52

Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Biological Engineering Generation of functional oocytes from male mice in vitro. Metabolic Engineering.

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Virus Engineering RNA Small Molecule 52