Covalent Modifiers

AUGUST 14, 2024

Rullo Molecular Therapy 2024 DOI: [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. The molecules, termed covalent immune recruiters (CIRs), were designed to affinity label and covalently engage SARs.

Small Molecule 72

Small Molecule Engineering Science Therapies 72

ASPET

SEPTEMBER 16, 2024

Here, we describe motor and sensory neuron dysfunction characteristic of clinical CMT type 2A in a CRISPR/Casp-engineered Mfn2 Thr105Met (T105M) mutant knock-in mouse. We further demonstrate that daily oral treatment with a novel mitofusin activator derived from the natural product piperine can reverse these neurological phenotypes.

Small Molecule 100

Small Molecule Pharmacokinetics Engineering Disease 100

Drug Target Review

JULY 23, 2024

This laid the groundwork for my career in drug discovery using novel modalities like small molecule inhibitors, antibodies, RNA interference (RNAi) and, currently, small molecule protein degraders – which are opportunities to change how we think about medicines.

Small Molecule 115

Small Molecule Targeted Protein Degradation Science Disease 115

DrugBaron

FEBRUARY 7, 2022

Finding small molecule drugs is much harder than finding a needle in a haystack – discovering the right arrangement of atoms to bind precisely to a protein target to elicit a particular response is a problem of vast dimensionality. Yet the situation with small molecules is even worse.

Small Molecule 100

Small Molecule Synthetic Chemistry Pharma Companies Pharmacokinetics 100

Drug Hunter

MAY 18, 2023

Dian eventually made her way to Shanghai, where she encountered a much bigger world while earning degrees in pharmaceutical engineering and medicinal chemistry. In her small molecule DMPK research, proteomics also served to identify reactive metabolites (e.g., Dian recalls. But I didn’t want to take that as my fate.” Proteomics!

Small Molecule 131

Small Molecule DNA Pharmacokinetics Engineering 131

DrugBaron

FEBRUARY 16, 2021

Small molecules are well-suited to inhibiting enzymes, such as kinases or proteases, but they struggle to block protein:protein interactions. As a result, many drug discovery companies have defaulted to regularly using both library and engineered animal technologies in parallel on high priority projects.

Molecular Biology 130

Molecular Biology Small Molecule Engineering Laboratories 130

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Sheng Professor of Biomedical Engineering. ” An Effective On/Off Switch.

Engineering 52

Engineering Drugs Small Molecule Therapies 52

Drug Target Review

JULY 13, 2023

They found that although the targets themselves may not be easily druggable due to their disordered nature, their ability to condense can be modulated using small molecules. By focusing on molecules that modulate the condensate formation, they identified tractable chemical matter that specifically impacted the target of interest.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

Covalent Modifiers

JUNE 24, 2024

Rullo, Molecular Therapy: Oncology , 2024 , 200842, [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. The molecules, termed covalent immune recruiters (CIRs), were designed to affinity label and covalently engage SARs.

Small Molecule 52

Small Molecule Engineering Science Therapies 52

Covalent Modifiers

OCTOBER 7, 2023

This method allows site-specific modification of proteins with therapeutic agents, improving their effectiveness without extensive engineering. To overcome these obstacles, proximity-induced chemistry has emerged as a next-generation strategy for advancing protein therapeutics.

Small Molecule 64

Small Molecule Engineering Treatment Drugs 64

Drug Target Review

DECEMBER 4, 2024

In addition to generating agonistic antibodies, Confo is also successfully applying the ConfoBody/ConfoChimer technology to drugging GPCR with small molecules. For example, the team engineered the MC4R agonists as humanized heavy-chain only antibodies with human Fc domains to improve their overall drug-like properties.

Pharmacokinetics 78

Pharmacokinetics Small Molecule Therapies Engineering 78

Drug Target Review

SEPTEMBER 11, 2024

How does morADC technology combine the properties of small molecules and monoclonal antibodies to enhance anti-aggregation effects for CNS applications? The morADC are able to cross the blood-brain barrier more efficiently and offer higher potency than individual parent molecules.

Small Molecule 52

Small Molecule Disease Therapies Clinical Trials 52

Dark Matter Blog

JUNE 21, 2023

On the other hand, if you have a platform designed to be an engine for a standalone enterprise, capable of generating dozens of future drugs, then you might plot a course that brings you into the close orbit of multiple complementary partners. We all share a common understanding of the benefits and challenges of small molecule therapeutics.

Small Molecule 52

Small Molecule RNA Pharma Companies Science 52

The Pharma Data

JULY 15, 2021

Protomer’s proprietary peptide- and protein-engineering platform is used to identify and synthesize molecules that can sense glucose or other endogenous modulators of protein activity. Eli Lilly and Company (NYSE: LLY) today announced the acquisition of Protomer Technologies (“Protomer”), a private biotech company.

Small Molecule 52

Small Molecule Engineering Therapies Science 52

Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

Small Molecule 52

Small Molecule Drugs Clinical Trials DNA 52

DrugBank

OCTOBER 17, 2024

Data Science in Lead Optimization and Drug Design Data science accelerates the lead optimization and drug design process, transforming how molecules are engineered for therapeutic applications. These complex molecules require precise engineering to ensure optimal efficacy and safety.

Drug Development 71

Drug Development Metabolic Stability Clinical Trials Drugs 71

Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

The Pharma Data

APRIL 28, 2021

OSAKA, Japan, April 28, 2021 – Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) (“Takeda”) today announced that it was awarded by the International Society for Pharmaceutical Engineering (ISPE) for the 2021 Facility Of the Year Awards (FOYA) in two categories. About the ISPE Facility of the Year Awards Program.

Packaging 52

Packaging Small Molecule Pharmaceutical Companies Engineering 52

Broad Institute

OCTOBER 17, 2023

Deik received her bachelor's degree in botany from Connecticut College and immediately went to work at International Paper, a paper manufacturing company, where she engineered trees to grow faster. At 11 years old, she knew she wanted to be a botanist. I run our lipid method, which annotates over 250 different lipids.

Research 98

Research Small Molecule Science Disease 98

The Pharma Data

MAY 31, 2022

BIIB122 is an investigational small molecule inhibitor of LRRK2 that was discovered and developed by Denali. BIIB122 is a selective, central nervous system-penetrant small molecule inhibitor of LRRK2 that is hypothesized to improve lysosomal dysfunction.

Disease 52

Disease Small Molecule Engineering Biosimilars 52

sptlabtech

JUNE 9, 2023

This where SPT Labtech steps in – our scientific and engineering experts have developed a suite of automated solutions dedicated to making your life in the laboratory easier. Implementing the right automated solution for your workflows makes it easier than ever to ensure smooth operations in your laboratory.

Laboratories 98

Laboratories Small Molecule Production Engineering 98

The Pharma Data

NOVEMBER 9, 2021

They found that this “therapeutic” antibody, as well as another small molecule, powerfully blocked the induction of the ACE2 receptor. “So in that way, the virus cannot enter into the host system,” said Kamle, a Brown investigator in molecular microbiology and immunology as well as antibody engineering.

Small Molecule 52

Small Molecule Virus Molecular Biology Disease 52

Practical Cheminformatics

OCTOBER 8, 2024

Testing Claude’s Molecule Generation Ability To test the molecule generation ability of Claude, a general-purpose LLM from Anthropic, I prompted it to generate analogs for hits from fragment screens. These fragment hits are small molecules with between 11 and 21 heavy atoms.

Fragment Screening 136

Fragment Screening Packaging Organic Chemistry Small Molecule 136

Practical Cheminformatics

JANUARY 8, 2024

No member company will agree to use a representation that can potentially be reverse-engineered to reveal the chemical structures of its molecules. In each example, the authors use a modified version of their open source package MolPAL to design molecules with a specified selectivity profile.

Drugs 141

Drugs Small Molecule Bioinformatics Packaging 141

Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Biological Engineering Generation of functional oocytes from male mice in vitro. Marine biofilm engineered to produce current in response to small molecules. Metabolic Engineering. Metabolic Engineering.

Virus 52

Virus Engineering RNA Small Molecule 52

Drug Target Review

JUNE 12, 2023

The current version of Chemistry42 uses over 40 generative models, including generative autoencoders and generative adversarial networks as well as both structure-based and ligand-based drug design to generate and optimise de novo small molecules.

Metabolic Stability 92

Metabolic Stability Clinical Trials Small Molecule Pharmacokinetics 92

The Pharma Data

JANUARY 19, 2021

But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts. And in 2019, Caribou co-founder and CRISPR pioneer Jennifer Doudna co-authored a Nature Communications paper describing a system of activating and deactivating single guide RNAs using small-molecule ligands.

Research 52

Research RNA Molecular Biology Small Molecule 52

The Pharma Data

DECEMBER 15, 2020

In our early hit identification work at Enveda, we access the tremendous diversity that exists in natural products from plants, which are often attractive, drug-like small molecules—what we call good hits!” Enveda Biosciences is a biotechnology company engineering new drugs from nature. About Enveda Biosciences.

Small Molecule 52

Small Molecule Production Laboratories Engineering 52

Advarra

JANUARY 11, 2024

Some of these approaches involve directly isolating the patient’s immune cells and simply expanding their quantity, while other treatments involve genetically engineering their immune cells to enhance cancer-fighting capabilities. Monoclonal Antibodies Monoclonal antibodies are lab-engineered immune system proteins.

Vaccine 52

Vaccine Therapies Clinical Trials Small Molecule 52

Nvidia Developer: Drug Discovery

FEBRUARY 14, 2024

Using foundation models for protein folding, molecular docking, and molecular generation, researchers, engineers, and drug hunters can scale and customize their development and deployment of large biomolecular generative AI applications through easy-to-use APIs. Receptor.AI has curated a vast library consisting of approximately 4.3

Drugs 121

Drugs Small Molecule Pharma Companies Therapies 121

Drug Target Review

JULY 31, 2023

I went to Genentech and postdoc-ed for Jim Wells in protein engineering. If you are collaborating with all of these different people, if you’re providing the small molecule tools for lots of different projects, how can I evaluate you as an independent scientist?” That was a very hot field and a really exciting area.

DNA 98

DNA Small Molecule Science Cell Biology 98

The Pharma Data

JANUARY 17, 2021

CLR 131 is a small-molecule Phospholipid Drug Conjugate engineered to deliver iodine-131, a radioisotope directly to cancer cells while limiting exposure to healthy cells. AB680 is a potent and selective small-molecule CD73 inhibitor. The drug is an oral plasma kallikrein inhibitor. Most Read Today. Source link.

Immune Response 52

Immune Response Small Molecule Clinical Trials Trials 52

The Pharma Data

DECEMBER 17, 2020

Kurtz brings more than 26 years of experience in global manufacturing, engineering, supply chain, CMC development and program management for drugs and devices at various stages of development. Prior to Aktana, Daveynis served as vice president of engineering at Verint and held prior leadership roles at Capsilon, Quantros, HP, and Kodak.

Small Molecule 52

Small Molecule Engineering Clinical Development Pharmaceuticals 52

LifeSciVC

DECEMBER 6, 2022

As Darnell observed, the prospect of being able to regulate Transcription Factor function holds the potential to reframe the way we treat disease but achieving that goal with traditional small molecule screening approaches is impossible.

Small Molecule 40

Small Molecule DNA Regulations Science 40

The Pharma Data

JANUARY 13, 2021

TNX-1500 is a third generation anti-CD40-ligand mAb that has been designed by protein engineering to decrease Fc?RII Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing small molecules and biologics to treat and prevent human disease and alleviate suffering.

Pharmaceuticals 52

Pharmaceuticals Small Molecule Vaccine Protein Expression 52

Drug Target Review

AUGUST 10, 2023

In the top row, human lung cancer cells were engineered to over-express GRP78 in the nucleus. Researchers from the Keck School of Medicine of USC used imaging techniques to study how the protein GRP78 controls cancer cell behavior. In the bottom row, cells lacked GRP78 in the nucleus.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. It opens up a whole new class of biological engineering. Please send me your feedback. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52