Codon

FEBRUARY 13, 2025

By training PLACER on structures stored in the Protein Data Bank, the team taught the model to predict atom arrangements that follow the physical and chemical rules governing protein-small molecule interactions. He also writes on a blog focused on the intersection of biology and AI at owlposting.com.

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Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. We have overcome many obstacles on this mission, inventing new concepts and methods where necessary and re-engineering known concepts and methods where possible.

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Small Molecule RNA Clinical Trials Drugs 52

Broad Institute

OCTOBER 4, 2023

By Allessandra DiCorato October 4, 2023 Credit: AbbVie The new small molecule inhibitor (green) sits inside the PTPN2 protein, where acidic sites are marked in red and basic sites are marked in blue. A new small-molecule drug candidate being tested in an early-stage clinical trial aims to improve patient responses to immunotherapy.

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Drug Target Review

OCTOBER 6, 2023

Could you explain how CoRegen engineers Tregs to target SRC-3 specifically while maintaining normal Treg functionality in the rest of the body? Our team has created proprietary techniques to engineer Tregs that specifically remove SRC-3 that is expressed in the nucleus. For what indications can this approach be used?

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Broad Institute

MARCH 14, 2024

In one approach, they mark targeted proteins with “destroy me” tags that work with small molecules known as molecular glues to prompt the cell’s own protein-clearing machinery to gobble up the proteins. By Leah Eisenstadt March 14, 2024 Credit: Courtesy of the authors.

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Targeted Protein Degradation Small Molecule Medical Schools Science 141

ASPET

SEPTEMBER 16, 2024

Here, we describe motor and sensory neuron dysfunction characteristic of clinical CMT type 2A in a CRISPR/Casp-engineered Mfn2 Thr105Met (T105M) mutant knock-in mouse. We further demonstrate that daily oral treatment with a novel mitofusin activator derived from the natural product piperine can reverse these neurological phenotypes.

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Drug Target Review

JULY 23, 2024

This laid the groundwork for my career in drug discovery using novel modalities like small molecule inhibitors, antibodies, RNA interference (RNAi) and, currently, small molecule protein degraders – which are opportunities to change how we think about medicines.

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Small Molecule Targeted Protein Degradation Science Disease 116

DrugBaron

FEBRUARY 7, 2022

Finding small molecule drugs is much harder than finding a needle in a haystack – discovering the right arrangement of atoms to bind precisely to a protein target to elicit a particular response is a problem of vast dimensionality. Yet the situation with small molecules is even worse.

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Small Molecule Synthetic Chemistry Pharma Companies Pharmacokinetics 100

Drug Hunter

MAY 18, 2023

Dian eventually made her way to Shanghai, where she encountered a much bigger world while earning degrees in pharmaceutical engineering and medicinal chemistry. In her small molecule DMPK research, proteomics also served to identify reactive metabolites (e.g., Dian recalls. But I didn’t want to take that as my fate.” Proteomics!

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Small Molecule DNA Pharmacokinetics Engineering 131

DrugBaron

FEBRUARY 16, 2021

Small molecules are well-suited to inhibiting enzymes, such as kinases or proteases, but they struggle to block protein:protein interactions. As a result, many drug discovery companies have defaulted to regularly using both library and engineered animal technologies in parallel on high priority projects.

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Molecular Biology Small Molecule Engineering Laboratories 130

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Sheng Professor of Biomedical Engineering. ” An Effective On/Off Switch.

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Engineering Drugs Small Molecule Therapies 52

Drug Target Review

JULY 13, 2023

They found that although the targets themselves may not be easily druggable due to their disordered nature, their ability to condense can be modulated using small molecules. By focusing on molecules that modulate the condensate formation, they identified tractable chemical matter that specifically impacted the target of interest.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

DrugBank

OCTOBER 17, 2024

Data Science in Lead Optimization and Drug Design Data science accelerates the lead optimization and drug design process, transforming how molecules are engineered for therapeutic applications. These complex molecules require precise engineering to ensure optimal efficacy and safety.

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Drug Development Metabolic Stability Clinical Trials Drugs 98

Drug Target Review

SEPTEMBER 11, 2024

How does morADC technology combine the properties of small molecules and monoclonal antibodies to enhance anti-aggregation effects for CNS applications? The morADC are able to cross the blood-brain barrier more efficiently and offer higher potency than individual parent molecules.

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Small Molecule Disease Therapies Drugs 52

Dark Matter Blog

JUNE 21, 2023

On the other hand, if you have a platform designed to be an engine for a standalone enterprise, capable of generating dozens of future drugs, then you might plot a course that brings you into the close orbit of multiple complementary partners. We all share a common understanding of the benefits and challenges of small molecule therapeutics.

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Small Molecule RNA Pharma Companies Science 52

Drug Target Review

APRIL 16, 2024

Peptides are relatively small molecules compared to mAbs, making them easier and less costly to produce and modulate. Nevertheless, mAbs are often considered superior to peptides or small molecules in RLT if their long accumulation and excretion profile could be accelerated.

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The Pharma Data

JULY 15, 2021

Protomer’s proprietary peptide- and protein-engineering platform is used to identify and synthesize molecules that can sense glucose or other endogenous modulators of protein activity. Eli Lilly and Company (NYSE: LLY) today announced the acquisition of Protomer Technologies (“Protomer”), a private biotech company.

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Small Molecule Engineering Therapies Science 52

Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

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Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

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RNA Small Molecule Bioinformatics Computational Chemistry 52

The Pharma Data

APRIL 28, 2021

OSAKA, Japan, April 28, 2021 – Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) (“Takeda”) today announced that it was awarded by the International Society for Pharmaceutical Engineering (ISPE) for the 2021 Facility Of the Year Awards (FOYA) in two categories. About the ISPE Facility of the Year Awards Program.

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Packaging Small Molecule Pharmaceutical Companies Pharmaceuticals 52

Broad Institute

OCTOBER 17, 2023

Deik received her bachelor's degree in botany from Connecticut College and immediately went to work at International Paper, a paper manufacturing company, where she engineered trees to grow faster. At 11 years old, she knew she wanted to be a botanist. I run our lipid method, which annotates over 250 different lipids.

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Research Small Molecule Science Disease 98

The Pharma Data

MAY 31, 2022

BIIB122 is an investigational small molecule inhibitor of LRRK2 that was discovered and developed by Denali. BIIB122 is a selective, central nervous system-penetrant small molecule inhibitor of LRRK2 that is hypothesized to improve lysosomal dysfunction.

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The Pharma Data

NOVEMBER 9, 2021

They found that this “therapeutic” antibody, as well as another small molecule, powerfully blocked the induction of the ACE2 receptor. “So in that way, the virus cannot enter into the host system,” said Kamle, a Brown investigator in molecular microbiology and immunology as well as antibody engineering.

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Small Molecule Virus Molecular Biology Disease 52

sptlabtech

JUNE 9, 2023

This where SPT Labtech steps in – our scientific and engineering experts have developed a suite of automated solutions dedicated to making your life in the laboratory easier. Implementing the right automated solution for your workflows makes it easier than ever to ensure smooth operations in your laboratory.

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Laboratories Small Molecule Production Engineering 97

Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Biological Engineering Generation of functional oocytes from male mice in vitro. Marine biofilm engineered to produce current in response to small molecules. Metabolic Engineering. Metabolic Engineering.

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Virus Engineering RNA Small Molecule 52

Practical Cheminformatics

OCTOBER 8, 2024

Testing Claude’s Molecule Generation Ability To test the molecule generation ability of Claude, a general-purpose LLM from Anthropic, I prompted it to generate analogs for hits from fragment screens. These fragment hits are small molecules with between 11 and 21 heavy atoms.

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Fragment Screening Packaging Organic Chemistry Small Molecule 132

Drug Target Review

JUNE 12, 2023

The current version of Chemistry42 uses over 40 generative models, including generative autoencoders and generative adversarial networks as well as both structure-based and ligand-based drug design to generate and optimise de novo small molecules.

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Metabolic Stability Clinical Trials Small Molecule Pharmacokinetics 92

The Pharma Data

JANUARY 19, 2021

But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts. And in 2019, Caribou co-founder and CRISPR pioneer Jennifer Doudna co-authored a Nature Communications paper describing a system of activating and deactivating single guide RNAs using small-molecule ligands.

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Research RNA Molecular Biology Small Molecule 52

The Pharma Data

DECEMBER 15, 2020

In our early hit identification work at Enveda, we access the tremendous diversity that exists in natural products from plants, which are often attractive, drug-like small molecules—what we call good hits!” Enveda Biosciences is a biotechnology company engineering new drugs from nature. About Enveda Biosciences.

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Practical Cheminformatics

JANUARY 8, 2024

No member company will agree to use a representation that can potentially be reverse-engineered to reveal the chemical structures of its molecules. In each example, the authors use a modified version of their open source package MolPAL to design molecules with a specified selectivity profile.

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Drugs Small Molecule Bioinformatics Packaging 139

The Open Targets Blog

SEPTEMBER 21, 2023

I then moved back to the UK to work as a process chemist at GSK, designing the manufacturing routes for small molecule drugs. You need engineers to ensure that what you build in the lab can be made in a factory. You need factory teams to implement the processes.

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Organic Chemistry Process Chemistry Small Molecule Science 82

Sygnature Discovery

SEPTEMBER 14, 2023

For further information, visit www.sygnaturediscovery.com About River BioMedics River BioMedics, is a cardiovascular drug discovery company focused on integrating in-house, cutting-edge bio-engineering technologies, with novel cardiac biology and drug discovery expertise to develop life-transforming medicines for cardiovascular disease.

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Drug Target Review

JULY 31, 2023

I went to Genentech and postdoc-ed for Jim Wells in protein engineering. If you are collaborating with all of these different people, if you’re providing the small molecule tools for lots of different projects, how can I evaluate you as an independent scientist?” That was a very hot field and a really exciting area.

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DNA Small Molecule Science Cell Biology 98

The Pharma Data

JANUARY 17, 2021

CLR 131 is a small-molecule Phospholipid Drug Conjugate engineered to deliver iodine-131, a radioisotope directly to cancer cells while limiting exposure to healthy cells. AB680 is a potent and selective small-molecule CD73 inhibitor. The drug is an oral plasma kallikrein inhibitor. Most Read Today. Source link.

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Immune Response Small Molecule Clinical Trials Trials 52

Advarra

JANUARY 11, 2024

Some of these approaches involve directly isolating the patient’s immune cells and simply expanding their quantity, while other treatments involve genetically engineering their immune cells to enhance cancer-fighting capabilities. Monoclonal Antibodies Monoclonal antibodies are lab-engineered immune system proteins.

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The Pharma Data

DECEMBER 17, 2020

Kurtz brings more than 26 years of experience in global manufacturing, engineering, supply chain, CMC development and program management for drugs and devices at various stages of development. Prior to Aktana, Daveynis served as vice president of engineering at Verint and held prior leadership roles at Capsilon, Quantros, HP, and Kodak.

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LifeSciVC

DECEMBER 6, 2022

As Darnell observed, the prospect of being able to regulate Transcription Factor function holds the potential to reframe the way we treat disease but achieving that goal with traditional small molecule screening approaches is impossible.

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