Drug Discovery World

AUGUST 30, 2022

The Phacilitate Advanced Therapies Europe 2022 conference will take place from 30 August to 1 September at the Royal Lancaster in London, UK. The conference is the European twin to Phacilitate Advanced Therapies Week, an event held in January in Florida, US. Here are a few of many discussions and events to earmark.

Therapies 246

Therapies Hospitals Clinical Trials Clinical Development 246

Drug Discovery World

APRIL 11, 2024

Biopharmaceutical company EpiEndo has completed a Phase IIA clinical trial for its therapy addressing chronic obstructive pulmonary disease (COPD). However, in contrast to antibiotic macrolides, GI adverse events were comparable between the EP395 and placebo-treated participants, and no adverse events related to hearing were reported.

Therapies 130

Therapies Clinical Trials Disease Trials 130

Drug Discovery World

FEBRUARY 8, 2024

In 2023, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers. How is the titer determined?

Therapies 147

Therapies Bioinformatics Packaging Molecular Biology 147

Drug Discovery World

APRIL 19, 2024

Askbio’s AB-1005 (also known as AAV2-GDNF), an investigational gene therapy for the treatment of Parkinson’s disease, was well tolerated with no serious adverse events in a Phase Ib clinical trial. mL) were well tolerated, with no SAEs associated with the investigational gene therapy or contrast agent.

Therapies 130

Therapies Disease Clinical Trials Trials 130

Drug Discovery World

OCTOBER 3, 2023

Earlier this year, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

Therapies 130

Therapies Bioinformatics Packaging Molecular Biology 130

Drug Discovery World

JUNE 29, 2023

Join DDW for this exclusive free event , A Comprehensive Guide to Using Adeno-Associated Virus (AAV) Vectors in Gene Therapy, which is supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

Virus 130

Virus Therapies Bioinformatics Packaging 130

Drug Discovery World

JUNE 22, 2023

Join DDW for this exclusive free event , A Comprehensive Guide to Using Adeno-Associated Virus (AAV) Vectors in Gene Therapy, which is supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

Virus 130

Virus Therapies Bioinformatics Packaging 130

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

The 7th World Conference on Targeting Phage Therapy 2024, two-day event dedicated to advancing the field of phage research and therapy will be hosted at Corinthia Palace Malta on June 20-21.

Therapies 89

Therapies Clinical Trials Research Trials 89

Drug Discovery World

NOVEMBER 24, 2022

DDW’s Diana Spencer asks what will be needed for Europe to compete in the growing global market for advanced therapies. . In terms of ATMPs, other countries are ramping up support for these innovative therapies. China has meanwhile grown its share from 1% to 8%. . Boosting digital capabilities.

Therapies 245

Therapies Clinical Trials Pharmaceuticals Government 245

Drug Discovery World

JANUARY 25, 2023

Cell and gene therapies are transforming the way diseases are treated. As research progresses it is hoped that cell and gene therapies will offer innovation for the future. autologous therapies/solid tumours/ indications outside of oncology?) Register for free now.

Therapies 130

Therapies Drug Development Marketing Disease 130

Drug Discovery World

MAY 24, 2023

Moderna has reported encouraging interim data from its Phase I/II trial of mRNA-3927, an mRNA therapy for rare metabolic disorder propionic acidemia (PA). The data was presented at the 2023 American Society of Gene & Cell Therapy (ASGCT) Annual Meeting.

Therapies 130

Therapies Clinical Trials Pharmacokinetics Trials 130

Drug Discovery World

DECEMBER 11, 2023

The US Food and Drug Administration (FDA) has approved the first cell-based gene therapies for the treatment of sickle cell disease (SCD), Casgevy and Lyfgenia. Casgevy Casgevy, a cell-based gene therapy, is approved for the treatment of SCD in patients 12 years of age and older with recurrent vaso-occlusive crises (VOCs).

FDA Approval 130

FDA Approval Therapies FDA Disease 130

Drug Discovery World

AUGUST 29, 2023

Join DDW for this free event, ‘Discover how iPSC derived cells can be used to support the development of drug and gene therapies’, which is supported by DefiniGEN. The event will take place on 28 September 4PM BST, 5PM CEST, EDT 11AM, PDT 8AM. appeared first on Drug Discovery World (DDW).

Therapies 130

Therapies Disease Drugs 130

Drug Discovery World

SEPTEMBER 26, 2022

UMC Utrecht and its partners have received a research grant to unravel how the intestinal microbiota can be exploited to boost cancer immunotherapy and limit therapy side-effects. . These adverse events often present in the intestinal tract as severe inflammation. USA) and MicroViable Therapeutics (Spain). .

Therapies 130

Therapies Research Treatment Disease 130

Drug Discovery World

JUNE 15, 2023

A Phase I clinical trial testing a CAR-T cell therapy treatment in children with acute myeloid leukaemia (AML) has been paused due to a patient’s death. The PLAT-08 clinical trial is a Phase I study of 2seventy bio’s cell therapy SC-DARIC33 in patients with AML.

Clinical Trials 130

Clinical Trials Therapies Trials FDA 130

Drug Discovery World

FEBRUARY 15, 2024

DDW Editor Reece Armstrong speaks to Tracy M Woody , President and Chief Executive Officer of Cessation Therapeutics, about the company’s goal to develop an antibody therapy to prevent fentanyl overdoses. The post Can an antibody therapy prevent fentanyl overdoses? The antibodies stay in the bloodstream and never enter the brain.

Therapies 147

Therapies FDA Approval FDA Government 147

Drug Discovery World

AUGUST 29, 2023

A stem cell derived investigational therapy for treating Parkinson’s disease has shown promise in early clinical trials. The post Stem cell derived Parkinson’s therapy shows promise appeared first on Drug Discovery World (DDW).

Therapies 130

Therapies Clinical Trials Trials Disease 130

Drug Discovery World

DECEMBER 19, 2022

Researchers have found that a topical gene therapy gel helps heal wounds in patients with life-threatening blistering skin disease epidermolysis bullosa (EB). . This was a life-changing event for Vincenzo,” said Peter Marinkovich, Associate Professor of Dermatology and Director of Stanford Medicine’s Blistering Disease Clinic.

Therapies 130

Therapies Clinical Trials Trials Virus 130

Drug Discovery World

SEPTEMBER 6, 2022

In recent years the advanced therapy industry has been the most significant disruptor in medicine. Cell and gene therapies are not only transforming the way diseases are treated but are also aiming to cure entirely new patient populations. Record breaking investments in 2021 fuel an industry on fire . billion raised.

Therapies 130

Therapies Clinical Trials Production Disease 130

Drug Discovery World

NOVEMBER 14, 2023

Of the more than three million people with HeFH in the US and Europe, very few are currently at LDL-C goal, due in part to a care model that requires lifetime therapies. The post Single-course in vivo base editing therapy proven to lower cholesterol appeared first on Drug Discovery World (DDW).

Therapies 130

Therapies Trials Clinical Trials Disease 130

Drug Discovery World

APRIL 3, 2024

“Our objective will be to evaluate the tolerance and safety of CM-352 in patients undergoing scheduled total knee replacement surgery (total knee arthroplasty) to prevent possible haemorrhagic complications, which constitute a serious associated adverse event.

Therapies 130

Therapies Laboratories Pharmacokinetics Treatment 130

Chemical Biology and Drug Design

JULY 26, 2023

Abstract Noncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly. However, there are several limitations, including delivery, uptake, and short half-life, in the application of ncRNAs in cancer treatment.

Engineering 100

Engineering Therapies Cell Biology Drugs 100

Drug Discovery World

SEPTEMBER 6, 2022

DDW Editor Reece Armstrong looks at the cell and gene therapy landscape, examining the challenges facing developers and the trends we can expect to see throughout the year. . There’s no doubt that cell and gene therapies present some of the most exciting opportunities for emerging drugs. million price point per dose.

Therapies 130

Therapies Clinical Trials Vaccine Disease 130

Drug Discovery World

APRIL 16, 2023

Patients with treatment-naïve resectable non-small cell lung cancer (NSCLC) who received neoadjuvant durvalumab (Imfinzi) plus chemotherapy and adjuvant durvalumab monotherapy had improved event-free survival (EFS) and pathological complete response (pCR) compared with those who received neoadjuvant chemotherapy alone. Overall, 77.6%

Treatment 130

Treatment Therapies Clinical Trials Trials 130

SCIENMAG: Medicine & Health

AUGUST 28, 2023

military veterans with coronary artery disease, suboptimal lipid-lowering therapy was prevalent in the clinical setting. Optimization of statin therapy was projected to produce clinically relevant reductions in the risks of death and cardiovascular events. About The Study: In this study of 111,000 U.S.

Therapies 84

Therapies Disease 84

Drug Discovery World

MAY 1, 2024

Join DDW for this exclusive free event, ‘ rAAV genome sequencing with Oxford Nanopore uncovers transgene integrity and packaging impurities ’. The event will be supported by Oxford Nanopore Technologies. Recombinant adeno-associated viruses (rAAVs) are considered a promising delivery system for gene therapy medicines.

Packaging 130

Packaging DNA Virus International 130

Drug Discovery World

APRIL 24, 2024

Join DDW for this exclusive free event, ‘ rAAV genome sequencing with Oxford Nanopore uncovers transgene integrity and packaging impurities ’. The event will be supported by Oxford Nanopore Technologies. Recombinant adeno-associated viruses (rAAVs) are considered a promising delivery system for gene therapy medicines.

DNA 130

DNA Packaging Virus International 130

Drug Discovery World

NOVEMBER 24, 2023

Grade 3 or 4 treatment-related adverse events (AEs) were experienced by 60.9% Grade 3 or 4 treatment-related adverse events (AEs) were experienced by 60.9% The post Combination therapy recommended for NHS use for advanced biliary tract cancer appeared first on Drug Discovery World (DDW). for chemotherapy). for chemotherapy).

Therapies 130

Therapies Licensing Licensing Treatment 130

Drug Discovery World

FEBRUARY 22, 2024

Join DDW for this free event, Implementing rapid microbial identification in biotherapy manufacturing: Enhancing quality control and regulatory compliance , which is supported by Thermo Fisher Scientific. This event will examine focused environmental monitoring within a cGMP facility.

Production 130

Production Compliance Laboratories Vaccine 130

Alta Sciences

JUNE 11, 2024

My Attendance at the 2024 Boston Society Cell and Gene Therapy Conference pmjackson Tue, 06/11/2024 - 20:49 , via Wikimedia Commons" data-entity-type="file" data-entity-uuid="c7a7fa8b-b2fe-4d84-a75e-d1ba3a4e2caf" src="[link] width="742" height="249" loading="lazy" /> Ecm85, CC BY-SA 3.0

Therapies 52

Therapies Molecular Biology Immune Response Science 52

Drug Discovery World

FEBRUARY 15, 2024

Join DDW for this free event, Implementing rapid microbial identification in biotherapy manufacturing: Enhancing quality control and regulatory compliance , which is supported by Thermo Fisher Scientific. This event will examine focused environmental monitoring within a cGMP facility.

Production 130

Production Compliance Laboratories Vaccine 130

Drug Discovery World

FEBRUARY 8, 2024

Join DDW for this free event, Implementing rapid microbial identification in biotherapy manufacturing: Enhancing quality control and regulatory compliance , which is supported by Thermo Fisher Scientific. The event will take place on 26 February 3 pm GMT / 4 pm CET / 10 am EST / 7 am PST.

Compliance 130

Compliance Laboratories Vaccine Therapies 130

Drug Discovery World

FEBRUARY 1, 2024

Join DDW for this free event, Implementing rapid microbial identification in biotherapy manufacturing: Enhancing quality control and regulatory compliance , which is supported by Thermo Fisher Scientific. The event will take place on 26 February 3 pm GMT / 4 pm CET / 10 am EST / 7 am PST.

Compliance 130

Compliance Laboratories Vaccine Therapies 130

Drug Discovery World

NOVEMBER 30, 2023

The reports were received from clinical trials and postmarketing adverse event (AE) data sources. In the event that a new malignancy occurs following treatment with these products, clinicians should contact the manufacturer. The post FDA investigates safety of CAR-T cell immunotherapies appeared first on Drug Discovery World (DDW).

FDA 162

FDA Clinical Trials Therapies Production 162

Drug Discovery World

APRIL 16, 2024

Recombinant adeno-associated viruses (rAAVs) are considered a promising delivery system for gene therapy medicines. This webinar will highlight how long-read nanopore sequencing as a comprehensive and sensitive QC method for rAAVs were evaluated — which is supporting internal research activities at AstraZeneca.

Packaging 130

Packaging DNA Virus International 130

Vial

DECEMBER 8, 2023

With technological innovation and scientific research propelling the development of new therapies, anticipation for the future is high. As we look forward to 2024, several groundbreaking therapies are poised to radically change the landscape of ophthalmology, providing hope and improved treatment options for patients with ocular conditions.

Therapies 52

Therapies Clinical Trials Trials Treatment 52

Drug Discovery World

MAY 10, 2024

291 patients were randomised to treatment either with evenamide or placebo as add-on to their current antipsychotic therapy. There was no difference in the incidence of CNS, psychiatric, gastrointestinal or other adverse events between evenamide and placebo. points, compared to 7.6

International 182

International Pharmaceuticals Treatment Trials 182