The Pharma Data

OCTOBER 28, 2020

In the overall patient group with detectable virus at baseline, the average daily reduction in viral load through day 7 was a 0.36 Serious adverse events were numerically more frequent with placebo than REGN-COV2 treatment (0.8% There was a 1.08 REGN-COV2 was well tolerated in the trial. high dose, 1.6% low dose; 2.3%

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The Pharma Data

MARCH 14, 2021

Following a recent concern raised around thrombotic events, AstraZeneca would like to offer its reassurance on the safety of its COVID-19 vaccine based on clear scientific evidence. Furthermore, in clinical trials, even though the number of thrombotic events was small, these were lower in the vaccinated group.

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Drug Target Review

SEPTEMBER 8, 2023

However, recent insights indicate that it also operates beyond the nucleus, orchestrating initial events at the cell surface that trigger the activation of T cells. There are hundreds to thousands of dynamic phosphorylation events that occur during the first hour or so of T cell stimulation,” says Myers.

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The Pharma Data

JULY 28, 2021

Incidence of very rare thromboembolic events was far lower than in people diagnosed with COVID-19 infection. 1 Follow-up time was not sufficient to report rates after two doses of Vaxzevria , though other studies have shown rates of rare blood clotting events to be lower after a second dose.

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The Pharma Data

SEPTEMBER 5, 2021

Member States will be provided with regular delivery schedules, and capped rebates will apply in the event of any delayed doses. Early diagnosis allows appropriate treatment of these events 4,5 and there is no elevation of the risk of TTS at the second dose, compared to the rates expected in the general population.

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FDA Law Blog: Drug Discovery

DECEMBER 7, 2022

This was despite the 6-month data also demonstrating clinical benefits in reduction of bleeding events and declines in the use of FIX replacement therapy. At the same time, it is understandably important to be able to measure and characterize a treatment’s effect over time.

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The Pharma Data

JANUARY 13, 2021

The researchers found that the most frequent adverse events were fatigue, headache, myalgia, and injection-site pain after administration of the first vaccine dose in 805 participants in cohorts 1 and 3 and after the second dose in cohort 1. Fever was the most frequent systemic adverse event.

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Drug Target Review

DECEMBER 5, 2024

Challenges of viral capsids in gene therapy efficiency A widely used production method of rAAV vectors requires co-transfection of host cell lines with three plasmids, including one carrying the transgene of interest, one carrying the capsid and replication sequences, and a helper virus to circumvent the inability of rAAV to self-amplify.

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The Pharma Data

NOVEMBER 10, 2020

S, following a pause last month to investigate an adverse event. S is derived from a common cold virus that is modified to carry a gene from the SARS-CoV-2 virus which causes COVID-19, prompting the immune system to develop resistance to the virus. Source link.

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The Pharma Data

JANUARY 8, 2021

While speaking at a virtual event hosted by Oddo BHF, a financial service group, Bancel said the “nightmare scenario” that the vaccine will not work is now in the past. FRIDAY, Jan. 8, 2021 — Moderna CEO Stéphane Bancel said the company’s COVID-19 vaccine may prevent infection for years, CBS News reported Thursday.

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The Pharma Data

DECEMBER 3, 2020

No serious adverse events related to the vaccine candidates studied were reported. The majority of adverse events were mild and transient. Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope.

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The Pharma Data

SEPTEMBER 3, 2020

S, prevented severe clinical disease in Syrian golden hamsters, upon challenge with SARS-CoV-2, the virus that causes COVID-19 in people. Four weeks later, the animals were exposed to a high dose of SARS-CoV-2 virus. These statements are based on current expectations of future events. Source link.

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The Pharma Data

JANUARY 31, 2021

No serious adverse events related to the vaccine candidates studied were reported. Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. The candidate vaccines were given in two doses, three weeks apart.

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The Pharma Data

NOVEMBER 22, 2020

There were no serious adverse safety events. They use mRNA that codes for the spike protein in the SARS-CoV-2 virus, which is embedded in a nanolipid particle—basically a minuscule fat molecule. When injected into the body, cells churn out the spike protein, which causes the body’s immune system to recognize the virus.

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The Pharma Data

OCTOBER 15, 2020

15, 2020 — A single pick-up hockey game in Tampa Bay in June wound up becoming a COVID-19 superspreader event, with one player infecting as many as 15 other people on the ice, Florida public health officials report. THURSDAY, Oct. The other two sick people were not tested for COVID.

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The Pharma Data

SEPTEMBER 7, 2020

The event at Burnside Working Men’s Club (WMC), in Fencehouses on the border of Sunderland and Durham, took place on 30 August. “This is essential if we are to stop the spread of the virus in this community as quickly as possible.” The outbreak is linked to a charity match at Burnside Working Men’s Club.

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Nvidia Developer: Drug Discovery

APRIL 20, 2020

To help make the process for scientists more accessible, we’re spotlighting a few of the GPU-accelerated applications that developers can use right now in the fight against this virus. For example, events such as folding and docking can take micro- and milliseconds to occur.

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The Pharma Data

OCTOBER 26, 2020

Hasan Jafri , Chief Medical Officer of Aridis Pharmaceuticals, will be a speaker on a panel entitled “Direct Antivirals and Other Agents Against SARS-CoV2 Virus.” ” Panel: Direct Antivirals and Other Agents Against SARS-CoV2 Virus Date: Wednesday, October 28, 2020 Time: 10:30AM- 11:50AM ET.

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The Pharma Data

NOVEMBER 9, 2020

Data from the event-driven trial could support global authorization and approval, including in the U.S. Depending on the overall COVID-19 attack rate, interim data in the UK trial, which is also event-driven, are expected as soon as early first quarter 2021. and globally.”. About NVX-CoV2373.

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The Pharma Data

SEPTEMBER 30, 2021

That’s how easy it’s for SARS-CoV-2, the virus that causes COVID-19, to enter your nose. Anderson Professor of Chemical and Biomolecular Engineering, and his colleagues, are reporting in iScience the event of an intranasal subunit vaccine that gives durable local immunity against inhaled pathogens. Breathe in, exhale.

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The Pharma Data

SEPTEMBER 9, 2020

The law also allows for 30 people to gather for a community event or a wedding, but police have had no powers to stop general gatherings of up to 30 and they believe the rules have frequently been abused. . From Monday, this will change to reduce the maximum to six people both inside and outside.

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The Pharma Data

DECEMBER 28, 2020

We undertake no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events. . HOUSTON , Dec. 29, 2020 /PRNewswire/ — Moleculin Biotech , Inc., Moleculin Biotech, Inc.

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The Pharma Data

DECEMBER 17, 2020

In the initial 275 patients, rates of adverse events (AEs) were similar among groups. The event began within 1 hour of completion of the infusion, and required treatment including epinephrine. The event resolved. All events resolved. Serious AEs occurred in 2 placebo patients, 1 low-dose patient and 0 high-dose patients.

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The Pharma Data

DECEMBER 11, 2020

11, 2020 — More than 15 million Americans have been infected by the COVID-19 virus, and many may be questioning whether they need to receive one of the two coronavirus vaccines now on the verge of approval from U.S. FRIDAY, Dec. regulators. Short answer: Yes.

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The Pharma Data

NOVEMBER 10, 2020

The Quebec City-based vaccine developer said that an interim analysis from the phase 1 study also showed no severe adverse events, and generally mild-to-moderate and brief reactogenicity events. Based on the promising phase 1 data, the company plans to proceed with a phase 2/3 clinical trial. “We Martin Berman-Gorvine.

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The Pharma Data

NOVEMBER 17, 2021

It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein. Available at: [link] [Accessed August 2021] 6. Available at SSRN: [link] [Accessed July 2021] 7.

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The Pharma Data

JANUARY 29, 2021

It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein.

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The Pharma Data

JANUARY 29, 2021

It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein.

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The Pharma Data

OCTOBER 30, 2020

About REGN-COV2 REGN-COV2 is a combination of two monoclonal antibodies (REGN10933 and REGN10987) and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19.

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The Pharma Data

JANUARY 31, 2021

” Dr. Richard Hatchett , Chief Executive Officer of CEPI, commented: “To end the acute phase of this pandemic, and to control the virus in the longer term, the world needs multiple safe and effective vaccines which can be deployed in a range of populations and countries. Securities and Exchange Commission.

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The Pharma Data

NOVEMBER 23, 2020

No serious safety events related to the vaccine have been confirmed. Trial participants to date are aged 18 years or over, who are healthy or have medically stable chronic diseases and are at increased risk for being exposed to the SARS-CoV-2 virus. AZD1222 was well tolerated across both dosing regimens. AstraZeneca.

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The Pharma Data

DECEMBER 30, 2020

It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein. The overall reported rates of serious adverse events were 0.7% in the vaccine group and 0.8%

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The Pharma Data

SEPTEMBER 25, 2020

Based on these findings, the single dose of the Janssen COVID-19 vaccine candidate of 5×10 10 virus particles (vp) has been selected for further evaluation in the Phase 3 ENSEMBLE clinical trial. These statements are based on current expectations of future events. Source link.

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The Pharma Data

DECEMBER 28, 2020

BetterLife is refining and developing drug candidates from a broad set of complementary interferon-based technologies which have the potential to engage the immune system to fight virus infections, such as the coronavirus disease (COVID-19) and human papillomavirus (HPV), and/or to directly inhibit tumours to treat specific types of cancer.

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The Pharma Data

SEPTEMBER 5, 2021

The analyses compared specific health events among all COVID-19 mRNA-vaccinated people during the first 3 weeks after inoculation with health events among similar types of patients during the 3 to 6 weeks after mRNA vaccination. Surveillance for Adverse Events After COVID-19 mRNA Vaccination. million for the second dose. .

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The Pharma Data

JANUARY 24, 2021

” Therma Bright is not making any express or implied claims that its product, SCV2, has the ability to eliminate or cure COVID-19 (or SARS-CoV-2 virus). The test can help identify infected individuals in 15 minutes and is designed for at-home or point-of-need settings such as long-term care facilities, schools, or sporting events.

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Alta Sciences

JANUARY 11, 2024

The in vivo nonclinical study of cell and gene therapies includes a thorough understanding of on-and-off-target activity, immune responses, and other adverse events just to name a few. There are three primary vectors employed in gene therapy: adeno-associated virus (AAV), adenovirus, or lentivirus vectors.

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