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Prevention of Invasive Pneumococcal Disease in Adults 18 Years and Older Caused by 15 Serotypes

The Pharma Data

Clinical Data Supporting Approval Demonstrated Non-Inferior Immune Responses for the Serotypes Shared with PCV13 (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F). VAXNEUVANCE Elicited Superior Immune Responses for Serotypes 3, 22F and 33F Compared to PCV13, Which Are Major Causes of Disease.

Disease 52
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FDA Approves Merck’s KEYTRUDA® (pembrolizumab) in Combination With Padcev® (enfortumab vedotin-ejfv) for First-Line Treatment of Certain Patients With Locally Advanced or Metastatic Urothelial Cancer

The Pharma Data

Immune-mediated adverse reactions, which may be severe or fatal, can occur in any organ system or tissue, can affect more than one body system simultaneously, and can occur at any time after starting treatment or after discontinuation of treatment.

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Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer

Broad Institute

Kerry Reynolds: The first immune checkpoint inhibitor was FDA-approved in 2011 to treat melanoma, with nearly a dozen more ICIs approved for various cancers since then. That gives us a lot of hope, because we can think about targeting the inflamed organ that is failing without halting the immune response to the tumor.

Research 131
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The Quest for Universal Flu Vaccines

Codon

Over time, antigenic drift leads to new strains that partially or completely evade pre-existing immunity in the population. Jonas Salk in his Virus Research Laboratory (1954), together with assistant J.S. The vaccine must cross the mucosal barrier, ignite a robust immune response, yet not cause excessive inflammation.

Vaccine 87