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Repurposing FDA-approved drugs may help combat COVID-19

The Pharma Data

Several FDA-approved drugs – including for type 2 diabetes, hepatitis C and HIV – significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. 25) in the journal Communications Biology.

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De-risking drug discovery with predictive AI

Broad Institute

As of now, papers describing three of these machine learning tools have been published, in the Journal of Chemical Information and Modeling , Molecular Biology of the Cell , and Chemical Research in Toxicology. Molecular Biology of the Cell. A fourth is in the works. DOI: 10.1021/acs.chemrestox.4c00015. Seal S, et al.

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Leveraging ADCs in precision oncology strategy

Drug Target Review

At a base-layer, Caris’ comprehensive molecular profiling that we perform for patients today can identify predictive biomarkers for current FDA-approved ADCs. What role do ADCs play in Caris’ strategy for targeted cancer therapy, particularly in terms of patient-specific treatment plans?

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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

The project is a collaboration between the Broad and the African Center of Excellence for Genomics of Infectious Diseases (ACEGID) at Redeemer’s University outside Lagos in Nigeria, where Happi is a professor of molecular biology and genomics.

Virus 132
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Advancing CAR-T therapy: how CD5 modulation is shaping cancer treatment

Drug Target Review

MR : Chimeric antigen receptor T-cell (CAR-T) therapy is very effective in treating patients with B-cell lymphoma, leukemia, and multiple myeloma, where we have six FDA-approved drugs. What potential advantages does the CD5 modulation strategy offer over traditional CAR-T therapies?

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BioSpace Global Roundup: Cevec Licenses AAV Program to Biogen

The Pharma Data

Vivity received FDA approval in February 2020. based Mogrify Limited expanded its research collaboration with MRC Laboratory of Molecular Biology. This presbyopia-mitigating lens is available to patients undergoing cataract surgery. Cataracts are the most common cause of vision loss globally. Mogrify – U.K.-based

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CytoDel Announces Pre-Clinical Data on Cyto-111 as Antidote to Botulinum Neurotoxin (BoNT) Published in Science Translational Medicine

The Pharma Data

Standard antibodies cannot access toxin already inside neurons, and thus BAT® (Botulism AntiToxin, a product of Emergent BioSolutions), the only FDA-approved antitoxin, is only effective while the toxin remains in the circulation.

Science 52