Fragment Screening, Pharmacokinetics and Research

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Fragment Screening

Pharmacokinetics

Research

The Nature of Nanodisc Lipids Influences Fragment‐Based Drug Discovery Results

Chemical Biology and Drug Design

MARCH 14, 2025

Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins.

Fragment Screening

Fragment Screening Pharmacokinetics Drugs Marketing

SARS-CoV-2 Protease Inhibitors: An Attractive Approach for Treating COVID-19

PerkinElmer

JUNE 3, 2022

Researchers are now studying the potential of protease inhibitors for the treatment of SARS-CoV-2. 2 In the present study, the researchers report that PF-07321332 demonstrated potent inhibition in FRET M pro assays representing M pro from all coronavirus types known to infect humans.

Fragment Screening

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The Nature of Nanodisc Lipids Influences Fragment‐Based Drug Discovery Results

SARS-CoV-2 Protease Inhibitors: An Attractive Approach for Treating COVID-19

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