Sygnature Discovery

MARCH 14, 2025

Sygnature Discovery offers high throughput screening along with additional hit identification tools including virtual screening, knowledge-based design, and fragment screening. Compounds are drug-like with high chirality and FSP3 and the library contains novel natural product inspired scaffolds.

Biochemical Assays 52

Biochemical Assays Fragment Screening Computational Chemistry Assay Development 52

Drug Target Review

NOVEMBER 1, 2023

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. For example, in the screening stage of a project we are trying to find initial starting points for optimisation by our medicinal and computational chemistry colleagues.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Sygnature Discovery

SEPTEMBER 12, 2024

Fragment Based Drug Discovery Crystallographic fragment screening using a high solubility curated fragment library devoid of soluble aggregates. Curated covalent fragment library also available. Fragment analogs identified for rapid follow-up. PANDDA analysis for rapid delivery of a hit list.

Fragment Screening 52

Fragment Screening RNA Protein Production DNA 52

Sygnature Discovery

APRIL 26, 2022

Following an extensive partnership between the two companies, this deal will enable seamless integration of protein production and related structure determination projects within Sygnature. Sygnature have acquired Peak Proteins Ltd. The Peak Proteins leadership team will also remain with the business.

Fragment Screening 40

Fragment Screening Protein Production Protein Expression Production 40

Sygnature Discovery

JUNE 17, 2024

Our skilled protein science team can provide in-house production of proteins to support all these assay formats if needed. At Sygnature Discovery, we utilise various biophysical technologies to create assays for diverse targets, integral to every stage of the drug discovery process, from hit identification to candidate selection.

Small Molecule 52

Small Molecule Fragment Screening DNA Science 52