Drug Target Review

APRIL 17, 2024

HLA are the critical molecules that our immune systems use to present peptides to T cells and facilitate recognition and killing in immune responses to pathogens. HLA-II presents peptides to CD4 T cells thought to be important for indirectly helping immune responses and facilitating antibody production.

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The Pharma Data

DECEMBER 16, 2020

(Nasdaq: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, today announced an Advance Purchase Agreement with the government of New Zealand for the purchase of 10.7 million doses of NVX-CoV2373, Novavax’ candidate vaccine against COVID-19. About Novavax. Novavax, Inc.?(Nasdaq:

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The Pharma Data

JULY 23, 2021

government has purchased an additional 200 million doses of the Pfizer-BioNTech COVID-19 Vaccine. government under its existing supply agreement to 500 million. government with 500 million doses of the companies’ COVID-19 vaccine for donation to the world’s poorest nations. This press release features multimedia. Eligible U.S.

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The Pharma Data

APRIL 15, 2022

Consistent with our responsibility as one of the world’s premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world.

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The Pharma Data

DECEMBER 11, 2020

The Australian government has scrapped a supply deal with CSL for 51 million doses of its COVID-19 vaccine co-developed with the University of Queensland, after trial participants falsely tested positive for HIV.

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The Pharma Data

DECEMBER 20, 2020

The company, along with partners University of Nottingham and Trent University, received a British government grant to support the study. . Source link.

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The Pharma Data

JANUARY 25, 2021

In a surprise move, Merck announced that it is giving up on its two coronavirus vaccine candidates after seeing a subpar immune response and shifting its focus to a pair of investigational coronavirus treatments. government for up to 100,000 doses ( DID, Dec. 28, 2020 ).

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Broad Institute

FEBRUARY 11, 2025

Studies of cancer immunotherapy have largely focused on T cells, but the Bod lab seeks to understand whether the immune system's antibody-producing B cells can also be leveraged for cancer treatment.

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The Pharma Data

OCTOBER 15, 2020

This user-friendly resource enables programme managers, government officials and researchers alike to access the entire knowledge library of best practices and resources for conducting micronutrient surveys through an interactive website.

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The Pharma Data

AUGUST 28, 2020

The government plans to train up an army of health professionals to be ready to give the coronavirus vaccine, if and when one is shown to work. Oxford coronavirus vaccine triggers immune response. Image copyright. Getty Images. This could include pharmacists, who already deliver flu vaccines, midwives and physiotherapists.

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The Pharma Data

OCTOBER 9, 2021

years of exposure 3 Design of a new open-label study assessing immune response to SARS-CoV-2 mRNA vaccines in MS-patients treated with Kesimpta 4 , and new findings from open-label study assessing immune response to SARS-CoV-2 mRNA vaccines in secondary progressive MS (SPMS) patients treated with Mayzent will be presented 5.

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The Pharma Data

DECEMBER 23, 2020

In the context of a substantial amount of COVID-19-related research and the launch of numerous clinical trials, the French government created this steering committee to prioritize and accelerate high potential clinical trials. PARIS–( BUSINESS WIRE )– Inotrem S.A., Marc Derive. www.inotrem.com. About TREM-1 pathway.

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The Pharma Data

SEPTEMBER 2, 2020

The randomised, double blind and placebo-controlled trial is designed to evaluate the safety, reactogenicity (tolerability) and immunogenicity (immune response) of the experimental COVID-19 vaccine candidate.

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The Pharma Data

FEBRUARY 22, 2021

New Phase 2 study assesses potential for refined antigen formulation to achieve optimal immune response, including in older adults. government in order to accelerate its development and manufacturing. Sanofi and GSK initiate new Phase 2 study of their adjuvanted recombinant protein-based COVID-19 vaccine candidate.

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The Pharma Data

SEPTEMBER 25, 2020

The UK government has already ordered 60 million doses in case it proves successful. Novavax are using traditional methods – proteins from the coronavirus that cannot replicate in the body and a chemical, called an adjuvant, to boost the immune response. ” The vaccine will be manufactured in Stockton-on-Tees.

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The Pharma Data

NOVEMBER 18, 2020

Azar said the government expects to have 40 million doses of the two vaccines available for distribution by the end of the year, enough to vaccinate about 20 million Americans, with production continuing to accelerate in the new year. James Miessler. Source link.

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The Pharma Data

DECEMBER 8, 2020

In August, the company reported the vaccine candidate triggered antibody-based immune responses in early and mid-stage trials. The government did not elaborate on trial parameters, including a breakdown of the number of patients who received the vaccine versus placebo. The vaccine was also demonstrating a strong safety profile.

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Codon

SEPTEMBER 29, 2024

The government had long since ceased to care about the potential of monopolization in the pharmaceutical industry, as by this point it had come to resemble a luxury service provider. Prior therapeutic viruses had had their replication capabilities crippled out of fear of severe immune responses.

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The Pharma Data

JUNE 17, 2022

In a Phase 2/3 clinical trial, the Pfizer-BioNTech COVID-19 Vaccine elicited a strong immune response in this age group Three 3-µg doses had favorable safety profile similar to placebo in young children ages 6 months through 4 years in Phase 2/3 clinical trial Pfizer-BioNTech COVID-19 Vaccine now authorized in the U.S. government.

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The Pharma Data

AUGUST 16, 2020

It has received almost £50,000 in funding from Innovate UK, a research scheme supported by the UK Government. The test was developed with Cardiff University and received UK government funding. Dr Hindley, whose PhD was in T cells, said: “They can live for a long time after the infection and give you that immune response.

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The Pharma Data

MARCH 8, 2021

, preliminary evidence suggests that canakinumab inhibits pro-tumor inflammation (PTI) to 1) enhance anti-tumor immune response; 2) reduce tumor cell proliferation, survival and invasiveness; and 3) impair angiogenesis 8. Canakinumab is a first-in-class interleukin-1beta (IL-1?)

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The Pharma Data

JANUARY 22, 2021

Once regulatory approval has been obtained, initial doses of the vaccine will be expected to be delivered in mid-2021, the company claimed after executing an Advance Purchase Agreement with the Australian government.

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The Pharma Data

JANUARY 22, 2021

Still, Sir Patrick Vallance, the British government’s chief scientific adviser, described the data so far as “not yet strong.” “This is the first time I’ve been concerned about a variant partially evading the immune response and partially evading the vaccine.” © 2021 HealthDay.

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The Pharma Data

NOVEMBER 9, 2020

NVX-CoV2373 was created using Novavax’ recombinant nanoparticle technology to generate antigen derived from the coronavirus spike (S) protein and contains Novavax’ patented saponin-based Matrix-M adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies. government. billion from the U.S.

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PLOS: DNA Science

MAY 16, 2024

The government recently evicted him from his lab, part of the crackdown on anything having to do with the “lab leak” hypothesis. • identifies parts of the virus to target to provoke an immune response from a vaccine. Keeping ahead of new mutations • provides compelling clues to the origin of the virus.

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The Pharma Data

DECEMBER 10, 2020

The vaccine targeted both the inner nucleocapsid (N) and the outer spike (S) proteins of the virus to maximize the immune response. The study showed this broad immune response led to the complete clearance of the virus in a matter of days after infection of previously-vaccinated primates. link] 1. About ImmunityBio.

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Drug Target Review

OCTOBER 10, 2024

In the context of preclinical research, using healthy cells to study disease-specific mechanisms, cell-cell interactions, and immune responses can result in faulty data, missed therapeutic targets, and unanticipated immune responses.

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The Pharma Data

NOVEMBER 27, 2020

This week, another pharma company revealed a new technology device that can detect if a patient is infectious or not, while the Russian government published results of its Sputnik V vaccine, claiming it is more than 95 per cent efficient 42 days after the first dose. Read on to for the full insight.

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The Pharma Data

NOVEMBER 23, 2020

government has already acquired millions of doses from the domestic and European companies and pledged to offer them free to the U.S. Interim results from its Phase I/IIa trial demonstrated a single dose of the vaccine induced a robust immune response and was generally well-tolerated. Also, the U.S. Type: Adenovirus-based.

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The Pharma Data

NOVEMBER 30, 2020

government to meet its Operation Warp Speed goals to expedite the delivery of millions of doses of safe, effective vaccines for COVID-19. Both vaccine candidates incorporate Novavax’ proprietary saponin-based Matrix-M adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies.?Novavax?is

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The Pharma Data

MARCH 29, 2022

Mene Pangalos, Executive Vice President, BioPharmaceuticals R&D, AstraZeneca, said: “The EU approval represents an important milestone in our efforts to help prevent COVID-19, and we will continue to work with governments across Europe to make Evusheld available as quickly as possible. Evusheld was generally well-tolerated in the trials.

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The Pharma Data

MARCH 25, 2022

Evusheld has the potential to provide long-lasting protection to vulnerable populations such as the immunocompromised who can’t mount an adequate response to a COVID-19 vaccine, and we’ll continue to work with governments in Europe to make Evusheld available as quickly as possible.”

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Drug Target Review

JANUARY 9, 2024

This discovery begins to solve a wider question posed by the lab: what governs how cells assemble and work together in the body, and can the cells be taken out of their natural context and recombined into different ‘body plans’ to do other functions by design?

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Drug Target Review

APRIL 3, 2024

Our research demonstrated that GDF-15 acts as a versatile tool for tumours to inhibit the mounting of an effective antitumoral immune response at various steps of its process, including antigen presentation, immune cell activation, and their migration and infiltration into the tumour.

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The Pharma Data

JUNE 25, 2021

Government.” government, including the Department of Defense, the Biomedical Advanced Research and Development Authority (BARDA), part of the Office of the Assistant Secretary for Preparedness and Response at the U.S. ” Results: Consistent, high efficacy among circulating variants. About Novavax. Novavax, Inc.

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The Pharma Data

NOVEMBER 24, 2020

“These are immune responses, so if you feel something after vaccination, you should expect to feel that. Vaccines work to fight disease by producing an immune response within the body. And sometimes that means flu-like symptoms, such as aches, headache and fever.

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The Pharma Data

DECEMBER 22, 2020

” Sala noted that “the time frame of the variant’s [spread] depends entirely on human behavior, including government-imposed travel restrictions.” It has already been detected in other countries.” ” What is known about the variant’s contagiousness and virulence?

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