Broad Institute

OCTOBER 17, 2024

An innovative diagnostic approach developed by researchers at the Broad Institute of MIT and Harvard and at Massachusetts General Hospital could one day help patients get the most effective treatment faster, which could reduce the need for broad-spectrum antibacterials. Bartlett Fellowship of the Antibiotic Resistance Leadership Group.

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RNA Hospitals Laboratories Medical Schools 69

Broad Institute

NOVEMBER 7, 2023

To more precisely define cellular drivers of RA, an international research consortium co-led by researchers from the Broad Institute of MIT and Harvard and Brigham and Women’s Hospital analyzed tissues from RA donors at the single-cell level, integrating multiple forms of analysis to stratify RA by six subtypes of inflammation.

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Treatment RNA Hospitals Disease 96

Broad Institute

MARCH 6, 2024

Related news New project aims to map cellular variation in the healthy human brain Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults. They analyzed 1.2

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Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

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Vaccine RNA Laboratories Molecular Biology 64

The Pharma Data

MARCH 8, 2021

Phase 2a study enrolled 202 non-hospitalized adults who had signs or symptoms of COVID-19 within 7 days and confirmed active SARS-CoV-2 infection. Findings from the primary efficacy and safety endpoints and additional secondary objectives will be presented at an upcoming medical meeting. This press release features multimedia.

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Trials Virus RNA Research Laboratories 69

Broad Institute

JULY 11, 2024

Reporting in Science , researchers at Massachusetts General Hospital and the Broad Institute of MIT and Harvard have made a surprising discovery about these drugs. IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA.

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The Pharma Data

NOVEMBER 30, 2020

from the New York City (NYC) Department of Health and Mental Hygiene (DOHMH), and colleagues used mandatory DOHMH reporting data to identify individuals younger than 21 years hospitalized in NYC (March 1 to June 30, 2020) with findings suggestive of MIS-C. percent of COVID-19 hospitalizations among younger patients, they accounted for 34.4

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The Pharma Data

NOVEMBER 7, 2020

Now a study from investigators at Hospital for Special Surgery (HSS) and Brigham and Women’s Hospital in Boston has found that the synovial fluid and blood of people experiencing checkpoint inhibitor-induced arthritis is populated by a type of T cells rarely seen in people with other types of inflammatory arthritis. www.hss.edu.

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Nurses Hospitals RNA Laboratories 52

Broad Institute

MARCH 8, 2024

Senegal has a very strong clinical infrastructure, including a strong hospital network with incredible resources like West Africa’s Reference Center for Infectious Disease Diagnostics. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications. Online January 25, 2024. DOI: 10.1038/s41467-024-44800-7.

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Research Disease Medical Schools RNA 111

Broad Institute

DECEMBER 13, 2023

One study was led by senior authors Evan Macosko , an institute member at the Broad and associate professor and attending psychiatrist at Massachusetts General Hospital, and Fei Chen , a core institute member at the Broad and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University.

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DNA Virus Research Engineering 140

Broad Institute

JUNE 30, 2023

Related Articles Study finds how a genetic variant raises diabetes risk through an unexpected mechanism Related People Anne Carpenter Melina Claussnitzer Related programs Imaging Platform Metabolism Program Novo Nordisk Foundation Center for Genomic Mechanisms of Disease The field of microscopy has advanced immensely over the last fifty years in its (..)

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Small Molecule Cell Based Assays Disease Assay Development 105

The Pharma Data

JULY 12, 2021

The Phase 3 portion of the global MOVe-OUT trial studying molnupiravir in non-hospitalized adult patients with laboratory-confirmed COVID-19 and at least one risk factor associated with poor disease outcomes is underway. About Molnupiravir.

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Clinical Trials Laboratories Research Laboratories RNA 52

The Pharma Data

OCTOBER 30, 2020

percent of viral RNA at day 11. The percentage of patients with a COVID-19-related hospitalization or emergency department visit was 1.6 The researchers found that the mean decrease from baseline in the log viral load for the entire population was ?3.81 at the time of the interim analysis, for elimination of more than 99.97 fold lower.

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RNA Virus Hospitals Trials 52

The Pharma Data

DECEMBER 21, 2020

Part 1 Trial Design Part 1 of the trial enrolled 24 hospitalized adults diagnosed with moderate to severe COVID-19 confirmed by PCR. Galidesivir treatment was associated with a more rapid decline in viral RNA levels in the respiratory tract in an apparent dose-dependent manner.

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Clinical Trials Virus RNA Trials 52

The Pharma Data

OCTOBER 19, 2020

” The Caris Precision Oncology Alliance comprises over 40 academic, hospital and community-based cancer institutions, including 17 NCI-designated Comprehensive Cancer Centers.

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Clinical Trials RNA DNA Science 52

The Pharma Data

DECEMBER 13, 2020

Dr. Zhang completed his postdoctoral fellowship at Harvard Medical School/Boston Children’s Hospital. She started her career as a General Surgeon at Zhongshan Hospital of Chongqing. Prior to that, he held various oncology research and development positions at Merrimack Pharmaceuticals and Archemix. He received his B.S.

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Medical Schools Clinical Development Therapies RNA 40

The Pharma Data

MARCH 5, 2021

This will be adapted to the needs of messenger RNA vaccine production for CureVac’s CVnCoV, the manufacturing of which is highly complex. Production will take place in a new high-tech production facility that was already under construction at the Novartis Kundl, Austria site.

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Vaccine Production Biosimilars Hospitals 52

Codon

JUNE 11, 2024

Hospitals harness this speed to sequence and analyze tumor DNA within 6 hours , more than twice as fast as similar analyses performed using traditional next-generation sequencing , such as Illumina. Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced.

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DNA Engineering RNA Small Molecule 93

Drug Target Review

FEBRUARY 5, 2024

Scientists from Cincinnati Children’s Hospital and the University of Kentucky have investigated how spiny mice can regenerate lost tissue. They are using this new understanding to initiate regeneration in other types of mice, which could be translated into humans in the future.

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The Pharma Data

APRIL 22, 2023

” Uncovering cancer immune system suppression: A three-part investigation As the basis of their investigation, the team profiled primary and metastatic lymph node tumours from 14 patients with head and neck squamous cell cancers, using single cell RNA sequencing. .”

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Medical Schools Therapies Treatment Hospitals 40

The Pharma Data

JUNE 26, 2021

Sanofi Pasteur, the vaccines global business unit of Sanofi and Translate Bio (NASDAQ: TBIO), a clinical-stage messenger RNA (mRNA) therapeutics company, have initiated a Phase 1 clinical trial evaluating an mRNA-based investigational vaccine against seasonal influenza. JUNE 22 , 2021.

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Drug Target Review

AUGUST 16, 2024

I graduated with my BS in physiology and later attended the University of Michigan Medical School.

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Medical Schools Nurses Research Production 111

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. Here are the twelve pieces of advice for college and early career STEM folks, using scientific metaphors to frame some life lessons I’ve picked up along the way. Remember life’s Central Dogma.

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Science Immune Response Molecular Biology RNA 90

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane.

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Small Molecule Cell Based Assays Medical Schools Disease 52

The Pharma Data

NOVEMBER 29, 2020

PH1 affects patients of all ages,” said Sally-Anne Hulton, consultant pediatric nephrologist, Birmingham Women’s and Children’s Hospital NHS Trust, UK. It is an RNA interference (RNAi) therapeutic. Typically, it is children who suffer from the disease. Oxlumo decreases oxalate production.

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Drug Target Review

JUNE 11, 2024

My PhD work was focused on understanding how different helicases – small machines that unwind DNA and RNA – work and characterise them using biochemistry and biophysics tools. Thanks to our work, the device will be usable in community care and at home, making sure patients remain stable and outside hospitals.

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The Pharma Data

OCTOBER 28, 2021

Dr Laurence Slama, CARISEL investigator, l’Hôtel Dieu Hospital, Paris, said “ Despite some original enterprises around enforcing long- acting cabotegravir and rilpivirine, the CARISEL study interim findings showed that healthcare brigades and people living with HIV continued to feel positive about the authority as the study progressed.

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Pharmaceutical Companies Treatment RNA Pharmaceuticals 52

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. Sinai Hospital, New York, and a Vascular Surgery Fellowship from Yale University.

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Treatment Clinical Trials Therapies Molecular Biology 59

The Pharma Data

JANUARY 13, 2021

“It certainly would be very helpful, having one dose instead of two,” said Dr. Aaron Glatt, chair of the department of medicine and a hospital epidemiologist at Mount Sinai South Nassau Hospital in Oceanside, N.Y. If you only have to give one dose, that would be great.”

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The Pharma Data

NOVEMBER 16, 2020

It combines Moderna’s mRNA (messenger RNA) delivery platform with the stabilized SARS-CoV-2 spike immunogen (S-2P) developed by NIAID scientists. principal investigator of the NIAID-funded Harvard HIV Vaccine Clinical Trials Unit at Brigham and Women’s Hospital in Boston; and Brandon Essink, M.D., El Sahly, M.D., Baden, M.D.,

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The Pharma Data

NOVEMBER 16, 2020

The stability at refrigerated conditions allows for storage at most pharmacies, hospitals, or physicians’ offices. CAMBRIDGE, Mass.–(BUSINESS –(BUSINESS WIRE)–Nov. 16, 2020– Moderna, Inc.

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Vaccine FDA Clinical Trials Pharmacy 52

Broad Institute

FEBRUARY 26, 2025

This study provides us with the data we need to create myeloid-targeting strategies to modulate these programs and make immunotherapies more effective for brain tumor patients, said Tyler Miller, co-first author on the study and a resident in clinical pathology at Massachusetts General Hospital when the study began.

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Broad Institute

DECEMBER 13, 2023

typeof="foaf:Image" /> New tool uses RNA sequencing to chart rich maps of cellular and tissue function When a scientist wants to study individual cells at the molecular level within an organ like the heart or brain, they usually break the tissue up to analyze the cells. However, some beads capture the RNA of multiple cells at once. “So

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RNA Research DNA Hospitals 145

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. What makes this study significant?

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Immune Response RNA Disease Medical Schools 138

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. When your code runs perfectly or you fix a bug, it feels very rewarding.

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Science Medical Schools Hospitals Disease 124

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

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DNA RNA Regulations Treatment 98

The Pharma Data

FEBRUARY 12, 2022

We need antiviral options that can help children recover briskly and leave the sanitarium sooner,” said Amina Ahmed, MD, FAPP, epidemiologist and professor of contagious complaint at Atrium Health’s Levine Children’s Hospital, North Carolina,U.S.

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Pharmacokinetics RNA Hospitals Laboratories 52