PLOS: DNA Science

JULY 27, 2023

The owners of the felines all reported feeding their pets raw meat, and samples of the meat revealed not only flu virus genetic material, but also infectious virus. The fear is that a variant of the deadly virus might emerge that infects people, and, worst-case-scenario, passes from person to person. emerged in late 2021.

Disease 69

Disease DNA Virus RNA 69

NIH Director's Blog: Drug Development

NOVEMBER 16, 2021

The first indication that those hopes might be realized came from the announcement just a month ago of a 50 percent reduction in hospitalizations from the Merck and Ridgeback drug molnupiravir (originally developed with an NIH grant to Emory University, Atlanta). One percent (6 of 607) on the antiviral were hospitalized versus 6.7

Clinical Trials 52

Clinical Trials Virus Hospitals FDA 52

Drug Discovery World

AUGUST 1, 2023

1 August was first chosen as World RNA Day in 2018 as a play on AUG (adenine, uracil and guanine), a triple sequence of RNA (called a codon) that initiates protein synthesis by the cell. Since then, it has been observed to publicise the importance of this molecule in the generation of proteins in the body.

RNA 130

RNA Vaccine Drugs Disease 130

The Pharma Data

JULY 12, 2021

The Phase 3 portion of the global MOVe-OUT trial studying molnupiravir in non-hospitalized adult patients with laboratory-confirmed COVID-19 and at least one risk factor associated with poor disease outcomes is underway. About Molnupiravir.

Clinical Trials 52

Clinical Trials Laboratories Research Laboratories RNA 52

The Pharma Data

SEPTEMBER 1, 2021

MOVe-AHEAD (MK-4482-013) ( NCT04939428 ) is a Phase 3 multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of orally administered molnupiravir compared to placebo in preventing the spread of SARS-CoV-2, the virus that causes COVID-19, within households. About Molnupiravir.

Laboratories 52

Laboratories Virus Clinical Trials Research Laboratories 52

The Pharma Data

MARCH 22, 2022

Co-administration with a low dose of ritonavir helps slow the metabolism, or breakdown, of nirmatrelvir in order for it to remain active in the body for longer periods of time at higher concentrations to help combat the virus. In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions.

Treatment 52

Treatment Virus Hospitals RNA 52

The Pharma Data

NOVEMBER 17, 2020

After getting the virus under control, California Gov. Coronavirus infections in the state have doubled over the past month, and the number of hospitalized patients reached a new high on Monday. That fragment sets off alarms in the immune system and stimulates it to attack if the real virus shows up. Meanwhile, Brazil passed 5.8

Vaccine 52

Vaccine Virus RNA Hospitals 52

The Pharma Data

DECEMBER 16, 2020

The Moderna vaccine is similar to Pfizer and BioNTech’s vaccine in the sense that they both use an approach utilizing messenger RNA (mRNA). The technology leveraged to create the vaccine does not require the actual virus, according to CNN. Both vaccines have shown about 95% efficacy in preventing novel coronavirus infections.

Vaccine 52

Vaccine Immune Response FDA FDA Approval 52

The Pharma Data

MARCH 9, 2021

The study showed the antiviral activity of GSK’254, establishing a relationship between dose and antiviral response, with the 140 mg and 200 mg doses showing the greatest reduction in plasma HIV-1 RNA. These findings were presented today at the (virtual) 2021 Conference on Retroviruses and Opportunistic Infections (CROI). log 10 and -2.0

Treatment 52

Treatment RNA Pharmacokinetics Virus 52

The Pharma Data

NOVEMBER 18, 2020

Lab tests that look for the coronavirus’s genetic material using a technique called polymerase chain reaction (PCR) are still considered the gold standard for detecting the virus. That fragment sets off alarms in the immune system and stimulates it to attack if the real virus shows up. “I am hopeful that it works well.”

FDA Approval 52

FDA Approval FDA Vaccine Virus 52

The Pharma Data

OCTOBER 19, 2020

” The Caris Precision Oncology Alliance comprises over 40 academic, hospital and community-based cancer institutions, including 17 NCI-designated Comprehensive Cancer Centers.

Clinical Trials 52

Clinical Trials RNA DNA Science 52

The Pharma Data

DECEMBER 18, 2020

. “ With the availability of two vaccines now for the prevention of COVID-19, the FDA has taken another crucial step in the fight against this global pandemic that is causing vast numbers of hospitalizations and deaths in the United States each day,” said FDA Commissioner Stephen M. Hahn , M.D. It is mandatory for ModernaTX, Inc.

Vaccine 52

Vaccine FDA Clinical Trials FDA Approval 52

Broad Institute

JANUARY 30, 2024

He has also emerged in recent years as a skilled and relatable science communicator, renowned for his efforts at Broad and beyond during the COVID-19 pandemic to unpack the fast-moving research on the new virus in an accessible way and give practical advice about masking, vaccines, and other public health measures.

Hospitals 137

Hospitals Medical Schools Virus Science 137

The Pharma Data

JULY 29, 2021

Hepatitis B virus (“HBV”) and hepatitis delta virus (“HDV”) product sales increased 8% to $237 million for the second quarter 2021 compared to the same period in 2020. Sales of Veklury are generally affected by COVID-19 related rates of infections, hospitalizations and vaccinations. Total second quarter 2021 revenue of $6.2

Science 52

Science Production Treatment FDA 52

The Pharma Data

OCTOBER 21, 2020

The COVID-19 pandemic has highlighted the urgent need for a novel, oral antiviral to treat this highly infectious and often deadly virus,” said Jean-Pierre Sommadossi, Ph.D., “Roche shares our passion for delivering innovative new medicines to address great unmet medical needs. Chief Executive Officer and Founder of Atea Pharmaceuticals.

RNA 52

RNA Pharmaceuticals Virus Small Molecule 52

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. Because it turns out that at least half of them , in humans, also bind to RNA molecules. How do transcription factors couple up with the correct RNA molecule? The black bars denote untreated eyes, and the gray bars denote treated eyes.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. Because it turns out that at least half of them , in humans, also bind to RNA molecules. How do transcription factors couple up with the correct RNA molecule? The black bars denote untreated eyes, and the gray bars denote treated eyes.

Therapies 52

Therapies RNA DNA Engineering 52

The Pharma Data

DECEMBER 21, 2020

(Nasdaq:BCRX) today announced that data from part 1 of a clinical trial of its broad-spectrum antiviral, galidesivir, showed that galidesivir was safe and generally well tolerated in patients infected with SARS-CoV-2, the virus that causes COVID-19. It is in advanced development for the treatment of Marburg virus disease.

Virus 52

Virus Clinical Trials RNA Trials 52

Codon

JUNE 11, 2024

Hospitals harness this speed to sequence and analyze tumor DNA within 6 hours , more than twice as fast as similar analyses performed using traditional next-generation sequencing , such as Illumina. Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced.

DNA 104

DNA Engineering RNA Small Molecule 104

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. What makes this study significant?

Immune Response 138

Immune Response RNA Medical Schools Disease 138

The Pharma Data

JUNE 26, 2021

Sanofi Pasteur, the vaccines global business unit of Sanofi and Translate Bio (NASDAQ: TBIO), a clinical-stage messenger RNA (mRNA) therapeutics company, have initiated a Phase 1 clinical trial evaluating an mRNA-based investigational vaccine against seasonal influenza. We look forward to sharing initial results by year-end. ”. “

Clinical Trials 52

Clinical Trials Vaccine Trials Immune Response 52

Broad Institute

DECEMBER 13, 2023

One study was led by senior authors Evan Macosko , an institute member at the Broad and associate professor and attending psychiatrist at Massachusetts General Hospital, and Fei Chen , a core institute member at the Broad and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University.

DNA 140

DNA Virus Engineering Research 140

PLOS: DNA Science

MARCH 30, 2023

It is also difficult to identify with standard laboratory methods,” summed up Mahmoud Ghannoum, director of the Center for Medical Mycology at University Hospitals Cleveland Medical Center. Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA).

DNA 52

DNA Hospitals Laboratories Virus 52

Codon

APRIL 9, 2023

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. The new sequences might help de-extinction efforts.

Therapies 52

Therapies RNA Engineering Vaccine 52

The Pharma Data

OCTOBER 30, 2020

30, 2020 — Viral load was decreased at day 11 for patients with mild or moderate COVID-19 who received a single intravenous infusion of virus-neutralizing monoclonal antibody versus placebo, according to a study published online Oct. percent of viral RNA at day 11. FRIDAY, Oct. 28 in the New England Journal of Medicine.

RNA 52

RNA Virus Hospitals Trials 52

The Pharma Data

DECEMBER 27, 2020

Vir Biotechnology and GlaxoSmithKline dosed the first patient in a new sub-trial of a Phase III study of monoclonal antibody VIR-7831 for hospitalized adults with COVID-19. Galidesivir is a broad-spectrum antiviral, an adenosine nucleoside analog that blocks viral RNA polymerase. Here’s a look. COVID-19-Related.

Clinical Trials 52

Clinical Trials Trials Therapies RNA 52

The Pharma Data

MARCH 20, 2021

Biogazelle, an innovative bioanalytical services company offering RNA and. Ghent University Hospital for SARS-CoV-2 virus screening. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research. Bioinformatics in the Faculty.

Laboratories 52

Laboratories Virus RNA Bioinformatics 52

PLOS: DNA Science

MAY 4, 2023

Extracting information from her dental remains was possible because of the universality of the genetic code – in all organisms (and viruses), the same RNA triplets encode the same amino acids. Mary’s Hospital in London, where Fleming discovered that a substance from when he blew his nose killed certain types of bacteria.

DNA 52

DNA Production RNA Science 52

The Pharma Data

JANUARY 13, 2021

“It certainly would be very helpful, having one dose instead of two,” said Dr. Aaron Glatt, chair of the department of medicine and a hospital epidemiologist at Mount Sinai South Nassau Hospital in Oceanside, N.Y. If you only have to give one dose, that would be great.”

Vaccine 40

Vaccine Trials Immune Response Clinical Trials 40

The Pharma Data

NOVEMBER 30, 2020

Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced that the primary efficacy analysis of the Phase 3 study of mRNA-1273 conducted on 196 cases confirms the high efficacy observed at the first interim analysis.

Vaccine 52

Vaccine FDA Clinical Trials Disease 52

The Pharma Data

JANUARY 7, 2021

.” Armstrong told the Post that the CDC hopes to more than double the number of genomic sequences of the virus posted on public websites within the next two weeks. Herd immunity will be reached when the virus encounters enough people with immunity that it dies out. ” Hospitalizations reach new records.

Virus 52

Virus Hospitals Vaccine RNA 52

PerkinElmer

OCTOBER 26, 2021

However, the antiviral is only recommended for adults and certain pediatric patients who are sick enough to need hospitalization. 5 Studies have also explored the antiviral and antibacterial activity of these compounds on influenza 6 and herpes virus replication. mg/mL of PPE extract or water for 4 hours.

Virus 52

Virus RNA Research Hospitals 52

PLOS: DNA Science

DECEMBER 21, 2023

I am grateful to PLoS for giving me this voice for more than a decade, and free reign to cover anything that even remotely involves DNA or RNA. And as the virus mutated, I was thankful for my background in genetics. She died terribly, in the hospital, two weeks after she got sick. COVID posts number more than 100.

DNA 91

DNA Vaccine Science Therapies 91

The Pharma Data

OCTOBER 30, 2020

Previously approved under an Emergency Use Authorization (EUA), Veklury is now fully cleared for the treatment of hospitalized patients with COVID-19. Veklury is a nucleotide analog RNA polymerase inhibitor and works by stopping replication of SARS-CoV-2. hospitals. It is widely available in U.S.

FDA Approval 52

FDA Approval Hospitals FDA Treatment 52

The Pharma Data

NOVEMBER 9, 2020

With more people being exposed to the virus now, testing the vaccine becomes a speedier affair. The vaccine uses a technology never before used: Each injection contains lipid nanoparticles — fat bubbles — that surround a strip of genetic material called messenger RNA, the Post reported. Meanwhile, Brazil passed 5.6

Vaccine 52

Vaccine Virus RNA Hospitals 52

The Pharma Data

NOVEMBER 10, 2020

In a statement, the FDA said its approval of the antibody treatment, called bamlanivimib, is solely for people newly infected with coronavirus “who are at high risk for progressing to severe COVID-19 and/or hospitalization.” With more people being exposed to the virus now, testing the vaccine becomes a speedier affair.

Treatment 52

Treatment Vaccine Hospitals RNA 52

The Pharma Data

DECEMBER 23, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. Instead, it may have been identified there first because the British government has a strong monitoring system that has tracked tens of thousands of genomic sequences of virus samples.

Vaccine 52

Vaccine Government Virus Medical Schools 52