SCIENMAG: Medicine & Health

JULY 6, 2023

In a new study, National Institutes of Health (NIH) researchers found that altered B cell function in children with mitochondrial disorders led to a weaker and less diverse antibody response to viral infections.

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Immune Response Research 85

Science Daily: Pharmacology News

JULY 10, 2024

Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

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Immune Response Disease 134

Science Daily: Pharmacology News

DECEMBER 12, 2024

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.

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Immune Response Regulations Therapies Research 112

BioPharma Drive: Drug Pricing

AUGUST 16, 2024

The vaccine didn’t spur a strong enough immune response against a particular flu strain in a Phase 3 trial, leading the companies to ponder adjustments.

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Immune Response Vaccine Trials 124

The Pharma Data

AUGUST 16, 2021

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. “In Induction of innate immunity was investigated via specific cytokine markers.

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Broad Institute

MARCH 20, 2024

doi: 10.1038/s41590-024-01792-2 (2024) Scientists used a microscope to visualize an immunity hub (yellow and green) in human lung tumor tissue (blue). Networks of cells are critical in mediating immune responses. How do immune cells organize within tumors to effectively eliminate cancer cells? Nature Immunology.

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Immune Response Hospitals Research Treatment 131

Science Daily: Pharmacology News

APRIL 29, 2024

The first study of the use of microarray patches to vaccinate children has shown that the method is safe and induces strong immune responses.

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Vaccine Trials Immune Response 124

Drugs.com

APRIL 12, 2024

FRIDAY, April 12, 2024 -- A chlamydia vaccine has triggered immune responses in an early trial, raising hopes that one day it might help curb the spread of the sexually transmitted infection (STI).There There is currently no vaccine for chlamydia, which.

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Vaccine Trials Immune Response 116

Science Daily: Pharmacology News

OCTOBER 17, 2024

difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection, according to researchers. In animal models, this first mRNA-LNP C.

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Vaccine Immune Response Clinical Trials Trials 126

Science Daily: Pharmacology News

JUNE 18, 2024

Tests, in mice, of a drug developed by the researchers showed that regulatory T cells can be attracted to specific body parts, boosted in number, and activated to suppress immune response and rebuild tissue.

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Treatment Disease Immune Response Clinical Trials 135

Drug Target Review

JANUARY 23, 2024

Individualised cancer vaccines are tailored to each patient’s tumour, helping the immune system mount cancer-specific immune responses that can boost checkpoint inhibitor efficacy. Espen integrates clinical and research expertise as Director of Medical Affairs.

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Treatment Immune Response Vaccine Therapies 122

Drugs.com

SEPTEMBER 14, 2023

14, 2023 -- An oral vaccine for COVID-19 appears to produce the sort of immune response that could quickly stamp out a developing infection, according to results from a small-scale primate study. THURSDAY, Sept. Some monkeys given an experimental.

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Vaccine Immune Response 119

Drug Discovery Today

APRIL 5, 2022

Researchers delve into the inner workings of the antibody immune response, finding key differences in the metabolism of two closely related immune cell subsets.

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Immune Response Regulations Research 113

Science Daily: Pharmacology News

OCTOBER 24, 2024

A strain of the bacterium harbored in the children's gut microbial communities possessed a previously unknown gene capable of producing and metabolizing key molecules involved in regulating many important functions ranging from appetite, immune responses, neuronal function, and the ability of pathogenic bacteria to produce disease.

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Immune Response Regulations Disease Research 113

Broad Institute

JANUARY 19, 2024

By examining the genomes of bacteria collected from hundreds of people with persistent Salmonella infections, they discovered genetic mutations that both reduce the bacteria’s “virulence,” or ability to infect, and dampen the host’s immune responses, creating a kind of molecular camouflage that shields the bacteria from the immune system’s gaze.

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Immune Response Treatment Disease Research 119

The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

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Drugs.com

OCTOBER 11, 2023

The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to. WEDNESDAY, Oct. 11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose.

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Vaccine Trials Immune Response Clinical Trials 114

BioPharma Drive: Drug Pricing

OCTOBER 24, 2023

Rampart Biosciences closed a Series A round that will fund its goal to develop more potent DNA-based medicines that avoid immune responses.

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DNA Immune Response 111

Drug Discovery Today

APRIL 15, 2021

176 volunteers will participate in the clinical trial the safety and immune response read-outs expected in Q2 2021 First subjects dosed with AKS-452, COVID-19 vaccine candidate in the Netherlands trial the vaccine is shelf-stable for 4 months at 25 degrees Celsius (77° Fahrenheit).

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Clinical Trials Vaccine Trials Immune Response 113

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- The nose appears to know when it comes to why children typically have milder cases of COVID-19 than seniors, a new study finds.Cells lining the inside of the nose are more likely to have a prompt immune response to COVID.

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The Pharma Data

MAY 16, 2021

Adjuvanted recombinant COVID-19 vaccine candidate triggered strong neutralizing antibody responses in all adult age groups. High immune response after a single dose in patients with prior infection shows strong booster potential. For media and investors only. Issued: London UK. About the Phase 2 study.

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Immune Response Vaccine Trials Treatment 52

Drug Target Review

MARCH 1, 2024

This antigen-spreading is critical to long-term protection because tumour often develop with inconsistent antigen expression – equipping the immune response to target many diverse tumour antigens may allow for more complete anti-tumour activity.

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Immune Response Therapies Vaccine Small Molecule 105

Drug Target Review

AUGUST 11, 2023

1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immune response. By selecting specific segments of proteins that elicit robust immune reactions, these vaccines could offer enhanced protection against diseases.

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Vaccine Immune Response Bioinformatics Virus 98

DrugBaron

APRIL 13, 2020

This gives a clear indication of current (or very recent) infection, but it tells us nothing about the cumulative number of people exposed, nor the degree or nature of their immune response to the virus. The solution is a test for the immune response to the virus (often called a “serology test”).

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Immune Response Virus Vaccine Production 100

SCIENMAG: Medicine & Health

FEBRUARY 2, 2024

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in “Science Immunology.” Credit: Elijah D.

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Immune Response Science Research 79

BioPharma Drive: Drug Pricing

JULY 27, 2023

The pharma said its latest shot, which covers 21 strains of bacteria, cleared two Phase 3 trials and in some cases spurred a stronger immune response than Pfizer’s Prevnar 20.

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Immune Response Vaccine Trials 98

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice.

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RNA Vaccine Engineering Immune Response 94

Drug Discovery Today

JULY 13, 2020

Excivion’s technology could help to prevent future pandemics of deadly viruses by avoiding the adverse immune responses common in current vaccine candidates for Zika and related viruses.

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Vaccine Immune Response Virus Production 100

ASPET

JANUARY 23, 2024

Damage-associated molecular patterns (DAMPs) may contribute to both innate and adaptive immune phases of IDRs, and changes in extracellular vesicle (EV) cargo have been detected post-exposure to several IDR-associated drugs.

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Immune Response Bioinformatics Regulations Drugs 100

addgene Blog

FEBRUARY 22, 2024

Join Abi as they explain what antibodies are, their role in the immune response, and the different antibody isotypes found in mammals. Ready to learn about antibodies? Our latest animation is here to help!

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Immune Response 86

The Pharma Data

JUNE 29, 2021

A sub-analysis from the Oxford-led COV001 and COV002 trials with Vaxzevria induced strong immune responses following either a prolonged second dose interval of up to 45 weeks or following a third boosting dose. There is an excellent response to a second dose, even after a 10 month delay from the first.”.

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Immune Response Vaccine Virus Trials 52

Science Daily: Pharmacology News

OCTOBER 18, 2023

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

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Therapies Immune Response Research Virus 88

SCIENMAG: Medicine & Health

OCTOBER 2, 2023

Osaka, Japan – Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.

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Immune Response Research 52

Chemical Biology and Drug Design

DECEMBER 5, 2024

It plays a key role in cancer cell survival and proliferation and regulates immune responses in cancer. ABSTRACT Mer-tyrosine kinase (MERTK), a member of the AXL, TYRO3, and MERTK (TAM) family, is one of the promising targets for cancer treatment.

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Immune Response Pharmacokinetics Regulations Treatment 100

The Pharma Data

JULY 15, 2021

Antibody and T-cell immune responses strong and stable at eight months after immunization Demonstrated neutralizing antibody activity against the Delta variant (B.1.617.2) In addition, the T-cell responses are especially strong and stable over time, which is also potentially important for activity against these variants.”.

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Science Daily: Pharmacology News

SEPTEMBER 29, 2023

Now, an article challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.

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ASPET

AUGUST 3, 2023

We utilized a six-compartment mechanistic model to describe a 20-week time course of humoral immune responses in 56 non-human primates (NHPs) elicited by vaccination with Ad26.COV2.S

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