Drug Target Review

OCTOBER 26, 2023

9 In addition, host immune responses further add to the complexity of developing cell-specific AAV capsids for clinical applications. It has been well established that exposure to wild-type AAV results in priming of the immune system against the virus.

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Engineering Virus Therapies Immune Response 105

Drug Target Review

NOVEMBER 6, 2023

For example, combining IO agents with ADCs to mount a two-pronged attack against cancer by activating an anti-cancer immune response and directly killing cancer cells may drive stronger and more durable responses in the clinic. References Blood Cancer UK. link] Accessed October 2023. Desai RH, Zandvakili N, Bohlander SK.

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Small Molecule Therapies Treatment Disease 111

Drug Target Review

SEPTEMBER 8, 2023

Enabling T cells to respond to threats To grasp the significance of this discovery, it’s useful to envision the internal layout of a T cell. Cheroutre remarks, “The TCR signalosome plays an immensely important role in facilitating communication between a cell’s external and internal environments.”

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Regulations Research DNA Immune Response 98

The Pharma Data

SEPTEMBER 14, 2020

This is then given to patients, immediately boosting their immune response. Leah Lipsich, from Regeneron, said: “There will be populations – the immunocompromised, the elderly – who may not mount a sufficient immune response to a vaccine and will require treatment. Follow Rebecca on Twitter.

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Trials Immune Response Virus Vaccine 52

The Pharma Data

NOVEMBER 27, 2020

One dose of the Sputnik V vaccine will cost less than $10 for international markets. The Russian Direct Investment Fund (RDIF) has announced the cost of the Russian Sputnik V vaccine for international markets will cost less than US$10 per dose and will be free of charge for all Russian citizens.

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Virus Vaccine International Immune Response 52

DrugBank

MAY 15, 2024

This direct intervention enables them to modulate internal processes, typically by binding to enzymes or receptors within the cell, impacting signal transduction pathways or metabolic processes directly linked to disease progression.

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Small Molecule Molecular Biology Drugs Disease 81

The Pharma Data

OCTOBER 23, 2020

A solidarity clinical trial “is one of the largest international randomized trials for Covid-19 treatments, enrolling almost 12,000 patients in 500 hospital sites in over 30 countries”, according to the World Health Organization (WHO), which launched the trail with a number of partners.

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Trials Immune Response Hospitals Clinical Trials 52

The Pharma Data

JUNE 30, 2021

Dr Karin Moestl, Vice President of the ABCD , presented the 2021 Young Scientist Award to the two winners during the ISFM ( International Society of Feline Medicine ) World Feline Congress 2021 , held virtually from June 25 to 27, 2021. .

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Immune Response Virus Disease Doctors 52

The Pharma Data

JUNE 25, 2021

Phase 1 interim data reported in November 2020 showed that CVnCoV was generally well tolerated across all tested doses and induced strong antibody responses in addition to first indication of T cell activation. A pivotal Phase 2b/3, the HERALD study, with a 12µg dose of CVnCoV was initiated in December 2020.

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Vaccine Trials Immune Response Virus 52

Codon

SEPTEMBER 29, 2024

Partially as a marketing stunt and partially to save money, several companies opted to do no further testing before phase I trials after the approval of their internal models. Prior therapeutic viruses had had their replication capabilities crippled out of fear of severe immune responses.

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Engineering Virus DNA Therapies 137

Drug Target Review

FEBRUARY 7, 2024

We had built a machine learning classifier that has been trained to identify amino acid sequences that have the potential to mimic ‘host defense peptides’ from the human innate immune system. Such peptides play a critical role in the machinery for amplifying innate immune responses.

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RNA Virus Immune Response Engineering 69

Broad Institute

JUNE 14, 2023

A trailblazer in cancer research, Glimcher's research identified key transcriptional regulators of protective immunity and the origin of pathophysiologic immune responses underlying autoimmune, infectious, and malignant diseases.

Medical Schools 52

Medical Schools Immune Response Science Hospitals 52

The Pharma Data

OCTOBER 14, 2020

APX005M is a novel, humanized monoclonal antibody that stimulates the anti-tumor immune response. APX005M targets CD40, a co-stimulatory receptor that is essential for activating both innate and adaptive immune systems. Binding of APX005M to CD40 on antigen presenting cells (i.e.,

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Treatment Immune Response Clinical Trials Clinical Development 40

Drug Target Review

OCTOBER 17, 2024

While its involvement in the do-not-eat-me signal from cancer has inspired therapeutic development of this pathway for oncology, the function of the innate immune checkpoint we identified in 2009 1 extends to both innate and adaptive immune responses. CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses.

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Immune Response Clinical Trials Trials Therapies 52

The Pharma Data

OCTOBER 22, 2020

The twenty-sixth meeting of the Emergency Committee under the International Health Regulations (2005) (IHR) on the international spread of poliovirus was convened and opened by the WHO Deputy Director-General on 14 October 2020 with committee members attending via video conference, supported by the WHO Secretariat.

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Vaccine International Immune Response Virus 52

The Pharma Data

NOVEMBER 18, 2020

.” Ming-Tain Lai, PhD, Chief Scientific Officer at OBI Pharma stated, “In the trial, OBI-833 demonstrated a favorable safety profile and generated detectable anti-Globo H IgM/IgG responses. Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan. ” Presentation number: 397P / Poster: ID 680. .”

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Vaccine Small Molecule Immune Response Hospitals 52

The Pharma Data

DECEMBER 23, 2020

All 38 subjects who were evaluable for immunogenicity had balanced cellular and humoral immune responses following the second dose of INO-4800. The company is currently in Phase 1/2a trials for INO-4800 in South Korea in partnership with The International Vaccine Institute and the Korea National Institute for Health.

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DNA Vaccine Clinical Trials Immune Response 40

PLOS: DNA Science

MAY 16, 2024

This allowed for early responses to mitigate the transmission of novel variants across borders, and for the amendment of testing and sequencing procedures to detect new variants. • identifies parts of the virus to target to provoke an immune response from a vaccine. • offers clues to how the virus might change.

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Virus DNA RNA Vaccine 98

Drug Target Review

OCTOBER 10, 2024

In the context of preclinical research, using healthy cells to study disease-specific mechanisms, cell-cell interactions, and immune responses can result in faulty data, missed therapeutic targets, and unanticipated immune responses.

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Therapies Immune Response Clinical Trials Disease 52

The Pharma Data

JANUARY 17, 2021

By inhibiting calcineurin, the drug blocks IL-2 expression and T-cell mediated immune responses. Myelosuppression happens when radiation damages internal organs, including bone marrow. Voclosporin is a novel and potentially best-in-class calcineurin inhibitor (CNI). As a result, it stabilizes the podocyte in the kidney.

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FDA Small Molecule Immune Response Hospitals 52

The Pharma Data

AUGUST 22, 2021

Bourne and UVA senior scientist Cameron Mura worked with an international team of researchers to analyze information from a database that holds the medical records of millions of COVID-19 patients living in 30 different countries. When faced with a global pandemic, it’s helpful to explore other options.

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Doctors Drugs Immune Response Virus 52

The Pharma Data

JANUARY 19, 2021

Other products include CLNB-049, a bispecific antibody against FLT3 and CD3 and CLN-619, a monoclonal antibody that simulates NK and T-cell responses. Neximmune – The company filed for an IPO to raise $86 million on January 19. It has two drugs in Phase I/II trials: NEXI-001 for acute myeloid leukemia and NEXI-002 for multiple myeloma.

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Small Molecule Trials Laboratories Immune Response 52

The Pharma Data

APRIL 22, 2023

When infused back into a mouse model of MS, the backpack-laden monocytes were able to affect MS-specific immune responses, and partially reverse hind limb paralysis and improve motor functions. The results are published in the Proceedings of the National Academy of Sciences (PNAS).

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Therapies Immune Response Small Molecule Engineering 40

PLOS: DNA Science

SEPTEMBER 5, 2024

This removes the cancer’s blocking of the immune response, so that T cells can fight the cancer. Keytruda’s classification based on mechanism, rather than its structure, is immune checkpoint inhibitor. It’s called CHIEF, for Clinical Histopathology Imaging Evaluation Foundation.

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Treatment FDA Approval DNA Small Molecule 71

The Pharma Data

SEPTEMBER 30, 2021

Although the thought of further reducing the amount of COVID-19 cases by enhancing immunity in vaccinated people is appealing, any decision to try to to so should be evidence-based and consider the advantages and risks for people and society. Considerations in boosting COVID-19 vaccine immune responses. The Lancet, 2021.

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Vaccine Immune Response Disease International 52

Drug Target Review

DECEMBER 13, 2024

Fcgamma Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates. Engineering sites on the antibody to enable specific and consistent attachment of the cytotoxic drug to achieve an optimal drug-to-antibody ratio (DAR). Discov Oncol. 2024;15(1):327. 2022;39(1):89-103.

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Therapies Treatment Clinical Trials Drugs 98

Codon

AUGUST 27, 2024

For example, many different filoviruses attack white blood cells and cause similar innate immune responses , which makes it difficult to identify a particular species from only their DNA. Previously, she was the Director of Advanced Technology at Stanford’s Institute for Economic Policy Research. Cite: Allison Berke.

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DNA Laboratories Hospitals Virus 93

The Pharma Data

MAY 15, 2023

The team at XinThera has developed research assets with the potential to target the DNA damage repair pathway in treating cancer and direct the body’s immune response in inflammatory diseases, both of which may improve outcomes for people living with these diseases,” said Flavius Martin, M.D., Qing Dong, Ph.D., and Gene Hung, M.D.,

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Small Molecule DNA Immune Response Science 40

NIH Director's Blog: Drug Development

OCTOBER 27, 2020

With the aim of developing such protein-targeted antiviral drugs, a large, international team of researchers, funded in part by the NIH, has precisely and exhaustively mapped all of the interactions that take place between SARS-CoV-2 proteins and the human proteins found within infected host cells.

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Drug Development Drugs Virus Science 52

NIH Director's Blog: Drug Development

MARCH 18, 2021

These days, the Veesler lab has been hard at work to understand SARS-CoV-2 and the human immune response to the virus. He’s also a member of the international research team that identified a human antibody, called S309, from a person who’d been infected with SARS in 2003.

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Virus Immune Response Clinical Trials Treatment 52

The Pharma Data

MARCH 3, 2022

After this important discovery, Pfizer tested numerous versions of the viral protein, and identified those that elicited a strong anti-viral immune response in pre-clinical evaluation. Pfizer will publish outcomes from this clinical trial at a future date.

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Virus Vaccine Clinical Trials Trials 52

NIH Director's Blog: Drug Development

MAY 21, 2020

In work described in the journal Nature , an international research team started with a set of neutralizing antibodies previously identified in a blood sample from a person who’d recovered from a different coronavirus-caused disease, called severe acute respiratory syndrome (SARS), in 2003 [3]. In the U.S. medRxiv.

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Virus Vaccine Laboratories Small Molecule 52

The Pharma Data

DECEMBER 31, 2020

“Antibody responses are not likely to be the sole determinant of someone’s outcome,” said Scott Boyd, associate professor of pathology at Stanford. Some of these patients mount a vigorous immune response, and others have a more moderate response. There are also other branches of the immune system involved.

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Research Virus Immune Response Cell Biology 52

The Pharma Data

JANUARY 5, 2021

Food and Drug Administration said Monday that any American who gets the Moderna or Pfizer coronavirus vaccines must get two full doses, despite international debate on possible ways to stretch vaccine supply. TUESDAY, Jan. 5, 2021 — Two top officials at the U.S. ” Changing the dosage could also hamper the U.S.

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Vaccine FDA Virus Immune Response 52

Drug Target Review

FEBRUARY 14, 2025

The KEGG Pathway database provides insights into metabolic pathways, genetic interactions and disease mechanisms, which are crucial for understanding how a dataset can inform our understanding of complex biological phenomena such as signal transduction, cell proliferation, or immune responses.

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Drugs Research Immune Response Science 52

Vial

DECEMBER 11, 2023

Other inhibitors, currently in different stages of development (including clinical trials ), mainly target viral non-structural proteins or the internal ribosome entry site (IRES). Drugs that have been discovered with the assistance of virtual screening include a protease inhibitor for the treatment of HCV (boceprevir).

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Clinical Research Therapies Research Vaccine 52

The Pharma Data

DECEMBER 20, 2020

This oncolytic virus has induced long-lasting antitumor immune responses and abscopal effects in several tumor models, and its activity is further enhanced through combination with an anti-PD-1 antibody treatment. BioInvent International AB (publ) Co. LUND, Sweden and STRASBOURG, France , Dec. About BioInvent.

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