The Pharma Data

OCTOBER 19, 2020

.–( BUSINESS WIRE )– Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced findings from two additional Phase 3 studies evaluating the safety, tolerability and immunogenicity of V114, the company’s investigational 15-valent pneumococcal conjugate vaccine. among adults 65 years of age or older.

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PLOS: DNA Science

MAY 16, 2024

That’s thanks to accelerated genome sequencing technologies, expanded laboratory capabilities, and interacting infrastructure on a global level. Had we grown complacent in a world freed from a list of once-deadly infectious diseases, thanks largely to vaccines and other public health measures? Work on vaccines ensued too.

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The Pharma Data

APRIL 22, 2023

The current COVID-19 vaccines are designed to trigger an antibody response to the SARS-CoV-2 spike protein, which is vulnerable to mutations that could make the vaccine less effective over time. of the mice that were vaccinated with the T-cell-based vaccine survived, while only one of the control-group mice survived.

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The Pharma Data

NOVEMBER 27, 2020

Vaccine development to cure coronavirus is at an all-time high after Pfizer and BioNTech announced they had success with a possible vaccine candidate. One dose of the Sputnik V vaccine will cost less than $10 for international markets.

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The Pharma Data

MARCH 25, 2021

European Medicines Agency to Conduct First-Ever Parallel Assessment of a Medicinal Product, Takeda’s Dengue Vaccine Candidate (TAK-003), for use in the EU; Countries Outside of the EU through the EU-M4all (Previously Article 58) Procedure. About TAK-003. 4,5 Efficacy varied by serotype.

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The Pharma Data

SEPTEMBER 17, 2020

This is the focus of vaccines in development and convalescent plasma therapy. 1 Specifically, the test targets antibodies which are directed against the particular region of the viral spike protein responsible for binding to the host cell receptor, which is required for the virus to enter the host cell.

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The Pharma Data

JULY 18, 2021

Clinical Data Supporting Approval Demonstrated Non-Inferior Immune Responses for the Serotypes Shared with PCV13 (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F). VAXNEUVANCE Elicited Superior Immune Responses for Serotypes 3, 22F and 33F Compared to PCV13, Which Are Major Causes of Disease. About VAXNEUVANCE.

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The Pharma Data

MARCH 11, 2021

(NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced real-world evidence demonstrating dramatically lower incidence rates of COVID-19 disease in individuals fully vaccinated with the Pfizer-BioNTech COVID-19 Vaccine (BNT162b2), underscoring the observed substantial public health impact of Israel’s nationwide immunization program.

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Creative Biolabs

JULY 12, 2020

Professor Florian Klein, the paper’s corresponding author, explained, “our goal is to better understand the immune response to SARS-CoV-2 and to identify highly potent antibodies that can be used to prevent and treat COVID-19.” They are expected to enter clinical development later this year.

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The Pharma Data

JANUARY 13, 2021

13, 2021 — A single-shot COVID-19 vaccine from Johnson & Johnson has shown very strong results in early clinical trials, potentially providing a significant boost to U.S. vaccination efforts. The new vaccine remains stable for a time in the refrigerator. WEDNESDAY, Jan. 13 in the New England Journal of Medicine.

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The Pharma Data

SEPTEMBER 14, 2020

Monoclonal antibodies, which are potent, laboratory-made antibodies, will be given to about 2,000 people to see if they are effective against coronavirus. This is then given to patients, immediately boosting their immune response. Do we still need treatments if we have a vaccine? Follow Rebecca on Twitter. Source link.

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Codon

AUGUST 27, 2024

For example, many different filoviruses attack white blood cells and cause similar innate immune responses , which makes it difficult to identify a particular species from only their DNA. New Yorkers wait to receive a monkeypox vaccine. At least nine laboratories outside the U.S.

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The Pharma Data

AUGUST 16, 2020

This means the immune system could remember how to fight Covid-19 even after original antibodies have faded. Indoor Biotechnologies is “hopeful” the test will help in vaccine development. Dr Hindley, whose PhD was in T cells, said: “They can live for a long time after the infection and give you that immune response.

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NIH Director's Blog: Drug Development

MAY 21, 2020

The research team, led by Yan Wu, Capital Medical University, Beijing, first isolated the pair of antibodies in the laboratory, starting with white blood cells from the patient. In laboratory experiments, the researchers used the RBD snippet as “bait” to attract antibody-producing B cells in a blood sample obtained from the COVID-19 survivor.

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The Pharma Data

JANUARY 29, 2021

January 29, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced topline efficacy and safety data from the Phase 3 ENSEMBLE clinical trial, demonstrating that the investigational single-dose COVID-19 vaccine in development at its Janssen Pharmaceutical Companies met all primary and key secondary endpoints.

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The Pharma Data

OCTOBER 26, 2020

Testing Therapies, Antivirals and Vaccines. Novavax will present data from an ongoing Phase I/II clinical trial, including new Phase II reactogenicity data from its COVID-19 vaccine candidate. CoV2373 on Friday during the CDC’s Advisory Committee on Immunization Practices’ (ACIP) meeting. Please read more here. .

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PerkinElmer

JANUARY 25, 2023

Laboratory professionals in all areas of science have experienced significant changes in recent years, and 2022 was no exception. Experts in the diagnostics and life sciences industry look back on 2022 and lend their insights on the major trends and technologies shaping laboratories in 2023.

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The Pharma Data

JANUARY 24, 2021

(NYSE: MRK), known as MSD outside the United States and Canada, today announced that the company is discontinuing development of its SARS-CoV-2/COVID-19 vaccine candidates, V590 and V591, and plans to focus its SARS-CoV-2/COVID-19 research strategy and production capabilities on advancing two therapeutic candidates, MK-4482 and MK-7110.

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Codon

DECEMBER 12, 2024

In 2021, scientists created a mirrored version of DNA polymerase , an enzyme responsible for copying a cell’s genome, and demonstrated that it could accurately replicate an entire “mirror-image gene.” Evading the immune system, a mirrored microbe could eventually find its way into the bloodstream. A culture of E.

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The Pharma Data

MARCH 16, 2021

Accurate detection and differentiation of SARS-CoV-2 mutations can help assess the spread of circulating variants and monitor their potential impact on therapeutics, vaccines and public health interventions. 1.351 carries another spike mutation E484K, which appears to evade the body’s immune response, possibly diminishing vaccine efficacy.

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Codon

JULY 14, 2024

As stored blood was often needed expediently in response to traumas, these early military blood banks only carried blood from the universally accepted O group of donors to circumvent the need for blood-typing in urgent situations. Karl Landsteiner in his New York laboratory. 5 There is a caveat in the linked studies, however.

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The Pharma Data

JUNE 17, 2022

Therefore, we are pretty confident that they represent premium candidates for pre-exposure prophylaxis in immunocompromised patients,” says Hugo Mouquet, head of the Laboratory of Humoral Immunology at the Institut Pasteur, who led the study.

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The Pharma Data

OCTOBER 22, 2020

The Emergency Committee reviewed the data on wild poliovirus (WPV1) and circulating vaccine derived polioviruses (cVDPV). Vaccine derived poliovirus (VDPV). . Vaccine management and supply has been significantly impacted. Vaccine management and supply has been significantly impacted.

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The Pharma Data

DECEMBER 23, 2020

The other, 69-70, leads to the loss of two amino acids in the spike protein and seems to help viruses evade the immune response in some immunocompromised patients. It is also the primary focus of the vaccines developed by Pfizer-BioNTech and Moderna and other companies. In research in South Africa in B.1.1.7,

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The Pharma Data

APRIL 22, 2023

It can work well, but we also want to trigger the immune system’s ability to remove the virus, which can be done through opsonizing antibodies that mark the virus so it can be eliminated,” explains Pontus Nordenfelt, associate professor and researcher in infectious medicine who led the study, published in PNAS.

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The Pharma Data

MAY 16, 2021

Every batch is certified by an independent, third-party laboratory for purity and integrity. You will also see an improvement in your immune. KetosisNOW contains clinically relevant amounts of ingredients that fight insulin resistance, inflammation and toxic build up inside the body. We are confident. work for you.

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Codon

APRIL 9, 2023

Marine sponges were cultured in the laboratory continuously for the first time. Read Efficacy and safety of a bivalent RSV prefusion F vaccine in older adults. Read Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine. npj Vaccines. Jerez-Longres C.

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Agency IQ

DECEMBER 1, 2023

It also stated that companies should consider whether an investigational product might interact with an administered vaccine for Covid-19. For such studies, the FDA recommended a primary endpoint of laboratory-confirmed SARS-CoV-2 infection with or without symptoms.

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The Pharma Data

JANUARY 3, 2021

Preclinical data from our laboratory have shown that the nasal administration of anti-CD3 stimulates Tregs that can suppress inflammation and ameliorate inflammatory diseases. Furthermore, nasal anti-CD3 dampens cytotoxic CD8 T cell responses that are known to cause lung damage in COVID-19 patients.”. “We

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The Pharma Data

NOVEMBER 20, 2020

The clinical evidence from Regeneron’s outpatient trial suggests that monoclonal antibodies such as casirivimab and imdevimab have the greatest benefit when given early after diagnosis and in patients who have not yet mounted their own immune response or who have high viral load.

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The Pharma Data

APRIL 28, 2021

PARIS – April 23, 2021 – New analyses from Dupixent ® (dupilumab) trials evaluated infection incidence reduction and reinforced the need for no laboratory monitoring in patients six years and older with moderate-to-severe atopic dermatitis. ESPD21-0308: Laboratory Safety of Dupilumab in Children Aged ?6–<12 About Sanofi. .

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Agency IQ

JUNE 9, 2023

Good Laboratory Practice (GLP)-adherent toxicology studies (carcinogenicity, developmental and reproductive toxicology, etc.) Cell and gene therapy products, adjuvanted vaccines, and blood products all fall outside the scope. increased tumor promotion or metastasis due to immunosuppression).

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The Pharma Data

OCTOBER 26, 2020

In addition, the observed median PFS shows that the regimen can induce a sustained and durable response, which is also shown consistently by the induction of a specific immune response. We developed TG4001, a viral based vaccine against the HPV E6 and E7 antigens. Methods. About TG4001.

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The Pharma Data

NOVEMBER 21, 2020

The clinical evidence from Regeneron’s outpatient trial suggests that monoclonal antibodies such as REGEN-COV2 have the greatest benefit when given early after diagnosis and in patients who have not yet mounted their own immune response or who have high viral load.

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The Pharma Data

APRIL 4, 2023

Immune-mediated adverse reactions, which may be severe or fatal, can occur in any organ system or tissue, can affect more than one body system simultaneously, and can occur at any time after starting treatment or after discontinuation of treatment.

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The Pharma Data

JANUARY 21, 2021

Pfizer-BioNTech COVID-19 Vaccine Effective Against UK Variant. Pfizer and BioNTech announced that their COVID-19 vaccine was probably just as effective against the variant strain of the virus, B.1.1.7, found in the U.K. Unusual Findings in ALS Population in Malta. It typically leads to complete paralysis.

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The Pharma Data

DECEMBER 17, 2020

“This study suggests that maybe we could predict or diagnose depression based on inflammatory scores,” said Samara Huckvale, an undergraduate at Columbia University working in the laboratory of UT Southwestern professor Sherwood Brown, senior author of both papers and professor of psychiatry and vice chair for clinical research at UTSW. “Or

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