The Pharma Data

OCTOBER 27, 2020

Primmune aims to advance the development of their novel orally-administered, small molecule toll-like receptor 7 agonists as therapeutic-adjuvants for acute viral diseases and cancer. Primmune’s early data shows the potential for PRTX007 to drive the natural innate immune response to combat systemic diseases. .

Small Molecule 52

Small Molecule Immune Response Pharmacokinetics Clinical Development 52

Drug Discovery World

JULY 8, 2024

This RNA system is based upon the one-dimensional, linear structure of RNA and utilises a singular sequence of information, prompting the creation of viral protein and triggering an immune response to them. Two such FDA-approved RNA aptamers are pegaptanib and avacincaptad pegol, indicated for the treatment of macular degeneration.

RNA 147

RNA Small Molecule Vaccine FDA Approval 147

Drug Target Review

OCTOBER 4, 2023

Groundbreaking strategies like proteolysis-targeting chimeric molecules (PROTACs) are also being explored. 6 Combining the effect of payloads with different mechanisms of action – an approach that revolutionised small molecule chemotherapy – also holds the promise of enhanced therapeutic activity for ADCs.

Small Molecule 126

Small Molecule Drugs Immune Response Targeted Protein Degradation 126

Agency IQ

JUNE 9, 2023

However, this guideline is primarily intended to provide recommendations on evaluating the immune system’s response to small molecule drugs. The guidance contains recommendations for small molecule drugs, as well as any biological products that fall within CDER’s purview.

FDA 40

FDA Science Small Molecule Immune Response 40

Drug Discovery World

APRIL 12, 2023

Testing new modality drugs poses additional challenges The drug development pipeline is no longer predominantly composed of small molecule drugs. Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the western world 4. In a study by Long et al.,

Drug Development 130

Drug Development Drugs Small Molecule Immune Response 130

Drug Discovery World

JANUARY 20, 2023

Testing new modality drugs poses additional challenges The drug development pipeline is no longer predominantly composed of small molecule drugs. Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the western world 4. In a study by Long et al.,

Drug Development 130

Drug Development Drugs Small Molecule Immune Response 130

The Pharma Data

DECEMBER 15, 2020

Small Molecule Inhibitors. NMD670 is a first-in-class small molecule inhibitor of the muscle specific chloride ion channel, the ClC-1 ion channel. The secondary outcome involves pharmacokinetic endpoints. Oral, Small Molecules. The primary outcome includes safety and tolerability endpoints.

Disease 52

Disease Clinical Trials Small Molecule Trials 52