Drug Discovery World

MAY 6, 2024

Immune B cells could be used to develop cancer targeting immunotherapies, following new research by scientists at The Institute of Cancer Research, London, the University of Oxford and University of Cambridge.

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Drug Discovery World

JUNE 19, 2024

Researchers at the University of Turku in Finland have discovered that the protein TIMP-1 plays a critical role in the immune system’s defence against cancer. TIMP-1 is produced by dendritic cells, which are responsible for initiating immune responses and boosting the immune system’s ability to recognise and destroy cancer cells.

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Drug Discovery World

JULY 5, 2023

Global Cancer Segment Market Manager at Agilent Technologies, recently sat down with DDW Editor Reece Armstrong to tell us about the developments in the ‘golden age’ of cancer research. MG: I am responsible for Agilent’s cancer segment. RA: What is the current state of the cancer research industry? Mark Garner, PhD.,

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Drug Discovery World

JUNE 19, 2024

New research has uncovered how different people respond to sepsis based on their genetics, which could lead to the development of targeted therapies. The ultimate aim is for patients to receive the most effective treatment for their sepsis more quickly, based on their immune response rather than their symptoms.

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Drug Discovery World

OCTOBER 4, 2023

By analysing gene interactions in mice subjected to behavioural tests, the researchers from Korea University Anam Hospital, Konkuk University, and Sahmyook University identified 141 genes primarily linked to immune responses correlating with depressive behaviours.

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Drug Discovery World

FEBRUARY 28, 2024

Lu Rahman selects some of the year’s interesting and noteworthy advances in cancer research drug discovery and development. In the UK, according to Cancer Research UK, around 167,000 people die from cancer in the UK each year. Research into new drugs and therapeutics is on-going and is helping drive mortality rates down.

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The Pharma Data

DECEMBER 4, 2021

The first peer-reviewed study in North America examining the timing between the first and second doses of COVID-19 mRNA vaccines shows that a longer dose interval leads to a stronger immune response. The study is funded by the Government of Canada through its COVID-19 Immunity Task Force (CITF).

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Drug Discovery World

AUGUST 7, 2023

Evox Therapeutics has agreed a research collaboration and option agreement with the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) in New York, NY, US. The collaboration will work on developing exosome-encapsulated AAV (exoAAV) vectors as a novel gene delivery technology aimed at improving treatments for heart disease.

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The Pharma Data

OCTOBER 26, 2020

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, elicited immune responses in older coronavirus patients similar to ones generated in younger adults, lending more promise to a vaccine that’s seen as one of the leading contenders in the race to become the first approved COVID-19 vaccine. Source link.

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The Pharma Data

OCTOBER 22, 2020

AstraZeneca’s COVID-19 vaccine candidate, AZD1222, currently being evaluated in phase 3 global trials, delivers a strong immune response, according to a new UK study. Source link.

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Drug Discovery World

OCTOBER 7, 2022

Researchers from King’s College London and The Institute of Cancer Research, London, have performed a deep dive into the different immune markers within tumour tissue and blood samples of early breast cancer patients whose cancer failed to respond to chemotherapy given to them prior to surgery.

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Drug Discovery World

SEPTEMBER 9, 2022

Researchers have found that RP2 – a modified version of the herpes simplex virus – showed signs of effectiveness in a quarter of patients with a range of advanced cancers. RP2 injections led to more immune cells in the area, including CD8+ T-cells, and ‘switched on’ genes linked to the ‘anti-cancer’ immune response.

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Drug Discovery World

MAY 2, 2024

For developing new treatments and vaccines, researchers create Controlled Human Infection Models (CHIMs), where they deliberately infect healthy volunteers under very carefully controlled clinical conditions. The data from this COVCHIM01 study showed durable immunity post-infection/vaccination against the original Covid-19 virus.

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Drug Discovery World

MAY 15, 2024

Researchers have developed a new vaccine technology that can provide protection against a broad range of coronaviruses with potential for future disease outbreaks – including ones we don’t know about yet. The study demonstrated that the new vaccine raises a broad immune response, even in mice that were pre-immunised with SARS-CoV-2.

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Drug Discovery World

AUGUST 6, 2024

The research was led by Senior Researcher Dr Vanessa Conn and Professor Simon Conn, who leads the Circular RNAs in Cancer Laboratory at the Flinders Health and Medical Research Institute (FHMRI). We’ve also discovered that high levels of circRNAs in certain people can cause mutations in their DNA which results in leukaemia.”

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SCIENMAG: Medicine & Health

OCTOBER 2, 2023

Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells. Osaka, Japan – Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process.

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Drug Discovery World

JULY 29, 2022

A team led by researchers at HMS and the Broad has just accomplished the rare feat of connecting those dots for one important gut bacterium. The researchers show in a report published July 27 in Nature that the links begin with a lipid—a fat—in A. muciniphila’s ability to manipulate the immune system and fight disease.

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Drug Discovery World

APRIL 9, 2024

A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendritic cells directly into cancerous lung tumours can help promote a stronger immune response.

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The Pharma Data

SEPTEMBER 10, 2020

Pfizer-BioNTech announced Wednesday that preliminary preclinical data from mouse and macaque monkey models showed a strong immune response from its mRNA COVID-19 vaccine. . Photo by Md. Tareq Aziz Touhid.

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Science Daily: Pharmacology News

OCTOBER 18, 2023

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

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Plenge Gen

APRIL 7, 2020

Here, I focus on a specific clinical inflection point in COVID-19 disease progression – hospitalized patients early in their disease course and with signs of a maladaptive immune response, with the intervention intended to prevent disease progression and admission to the ICU. appeared first on Plenge Gen @rplenge.

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Drug Discovery World

JULY 12, 2023

Researchers tested more than 1000 potential drugs and identified that an existing one – cimetidine – improved spinal repair in zebrafish. However, drugs that reduce inflammation by suppressing the whole immune response also inhibit the immune cells which promote repair.

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The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

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The Pharma Data

NOVEMBER 10, 2020

Canadian biopharmaceutical company Medicago has announced that its investigational COVID-19 vaccine generated “significant antibody and cellular immune responses” after two doses in all subjects in an early-stage clinical trial. The interim analysis from the phase 1 trial has been published online at the preprint server, medRxiv.

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Broad Institute

MARCH 20, 2024

doi: 10.1038/s41590-024-01792-2 (2024) Scientists used a microscope to visualize an immunity hub (yellow and green) in human lung tumor tissue (blue). Networks of cells are critical in mediating immune responses. How do immune cells organize within tumors to effectively eliminate cancer cells? Nature Immunology.

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Drug Discovery World

MAY 28, 2024

Researchers from The University of Queensland and the Queensland Children’s Hospital (QCH) have successfully tested the first-in-class drug in mice. A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient’s blood vessels.

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Drug Discovery World

APRIL 12, 2024

The cancer research news has been coming thick and fast from the American Association of Cancer Research (AACR) Annual Meeting in San Diego this week, so our Friday round-up focuses on drug discovery in oncology. News round-up for 8-12 April by DDW Digital Content Editor Diana Spencer.

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Drug Discovery World

MAY 23, 2024

The researchers will use a genetically engineered herpes simplex virus type 1 to eliminate cancer cells. The virus is engineered to enter the cancer cells and replicate rapidly, which breaks the cells open and exposes them to the immune system, effectively destroying them. million of funding for this research project.

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Drug Target Review

JANUARY 23, 2024

Individualised cancer vaccines are tailored to each patient’s tumour, helping the immune system mount cancer-specific immune responses that can boost checkpoint inhibitor efficacy. Espen integrates clinical and research expertise as Director of Medical Affairs.

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SCIENMAG: Medicine & Health

FEBRUARY 2, 2024

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in “Science Immunology.”

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Drug Discovery World

MARCH 8, 2024

. “Proteomics represents a dynamic and fast-growing market with significant opportunity for disruption as new platforms providing both higher sensitivity and multiplex capability are needed to accelerate proteomics research and translation,” said Ian Ratcliffe, Executive Managing Partner of Sands Capital.

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Drug Discovery World

MARCH 17, 2023

Researchers have shown for the first time that malfunctioning behaviour of a type of immune cell is linked to specific symptoms of Long Covid. Normally functioning monocytes, made in the bone marrow, would travel through the blood to the lungs where they surround and kill the virus and boost the immune response.

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Drug Discovery World

MARCH 4, 2024

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumour activity in individuals with advanced cancer. Both medications tested in the trial support immune responses against tumour cells.

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Drugs.com

OCTOBER 11, 2023

11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose. The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to. WEDNESDAY, Oct.

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Drug Discovery World

JUNE 20, 2024

Researchers have revealed that auto-antibodies block interferon signalling, contributing to severe Covid-19 by impairing the patient’s immune response. Scientists have found that some people who suffered from Covid-19 had auto-antibodies targeting their own type 1 interferons, which are important immune signalling proteins.

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Drug Discovery World

JANUARY 10, 2023

The American Association for Cancer Research (AACR) Annual Meeting 2023 will be held April 14-19 at the Orange County Convention Center in Orlando, Florida. Advance registration rates are available until Friday, February 24 for either in-person or virtual participation. View the full programme here.

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Drug Discovery World

JUNE 8, 2023

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses.

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