Immune Response RNA Small Molecule 
Drug Discovery World
DECEMBER 16, 2022
The investment allows the company to focus on discovering and developing novel small molecule therapies targeting RNA modifying enzymes (RMEs) for oncology and other diseases. . STC-15 triggers both direct cytotoxic and immune response-based efficacy mechanisms in solid tumour and leukaemia models.
DrugBank
MAY 15, 2024
Researchers are experimenting with biologics—larger biological molecules that can do things small molecules can't, like targeting larger, more complex structures on cell surfaces or even inside cells. Understanding why these targets are resistant to current therapeutic strategies is crucial.
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Drug Target Review
DECEMBER 7, 2023
Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. In bacteria , cGAS-like cyclases are central parts of the CBASS immune response.
Drug Discovery World
JULY 8, 2024
Beard Distinguished Professor of Experimental Surgery and the Founding Director of the Translational Research Institute at Duke University, explores the rise of RNA therapeutics. However, the RNA landscape has drastically changed in recent years and we now know that the molecule is more than just a transient, linear carrier of information.
Dark Matter Blog
JULY 16, 2021
As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. Arrakis is the capstone of my career.
Drug Discovery World
SEPTEMBER 6, 2022
The fact that these benefits “may not be attainable with small molecules or even simpler biologics, as well as long periods of market exclusivity,” Scharenberg says, means that “more complicated compounds are harder to copy and require more investment to compete with making them strong continued investment targets.” .
Drug Discovery World
OCTOBER 17, 2023
Spatial omics offers a new way of understanding these systems by providing a holistic view of healthy and diseased cells, pathogens, and the immune response. The first step to reach this goal will be to generate protein and RNA data from the same sample. RA: What have been some recent insights discovered using spatial biology?
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